Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1349265
Species: Homo sapiens
RGD Object: Gene
Symbol: MIR21
Name: microRNA 21
Acc ID: CHEBI:33007
Term: chromium(6+)
Definition: A monoatomic hexacation that has formula Cr.
Chemical ID: MESH:C074702
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MIR21increases expressionEXP 6480464CTDchromium hexavalent ion results in increased expression of MIR21 mRNAPMID:27323401 PMID:27344173 PMID:28881718
MIR21increases response to substanceEXP 6480464CTDMIR21 mRNA results in increased susceptibility to chromium hexavalent ionPMID:27344173
MIR21multiple interactionsEXP 6480464CTDAcetylcysteine inhibits the reaction [chromium hexavalent ion results in increased expression of MIR21 mRNA]; CAT protein inhibits the reaction [chromium hexavalent ion results in increased expression of MIR21 mRNA]; chromium hexavalent ion promotes the reaction [STAT3 protein binds to MIR21 promoter]; MIR21 mRNA affects the reaction [chromium hexavalent ion results in decreased expression of PDCD4 protein]; Quercetin inhibits the reaction [chromium hexavalent ion results in increased expression of MIR21 mRNA]; STAT3 protein affects the reaction [chromium hexavalent ion results in increased expression of MIR21 mRNA]PMID:27323401 PMID:27344173 PMID:28881718
MIR21increases expressionISOMir21a (Mus musculus)6480464CTDchromium hexavalent ion results in increased expression of MIR21 mRNAPMID:27323401
Go Back to source page   Continue to Ontology report