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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1348646
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP3A5
Name: cytochrome P450 family 3 subfamily A member 5
Acc ID: CHEBI:47381
Term: diclofenac
Definition: A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.
Chemical ID: MESH:D004008
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP3A5decreases activityISOCyp3a13 (Mus musculus)6480464CTDDiclofenac metabolite results in decreased activity of CYP3A13 proteinPMID:28960974
CYP3A5increases expressionISOCyp3a13 (Mus musculus)6480464CTDDiclofenac results in increased expression of CYP3A13 mRNAPMID:26934552
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