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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:diclofenac
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Accession:CHEBI:47381 term browser browse the term
Definition:A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.
Synonyms:exact_synonym: {2-[(2,6-dichlorophenyl)amino]phenyl}acetic acid
 related_synonym: 2-[2,6-DICHLOROPHENYL)AMINO]BENZENEACETIC ACID;   Formula=C14H11Cl2NO2;   InChI=1S/C14H11Cl2NO2/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19/h1-7,17H,8H2,(H,18,19);   InChIKey=DCOPUUMXTXDBNB-UHFFFAOYSA-N;   SMILES=C1(Cl)=CC=CC(=C1NC2=CC=CC=C2CC(=O)O)Cl;   [2-(2,6-dichloroanilino)phenyl]acetic acid;   diclofenac acid;   diclofenaco;   diclofenacum;   diclofenamic acid
 alt_id: CHEBI:4507;   CHEBI:47380
 xref: CAS:15307-86-5;   DrugBank:DB00586;   Drug_Central:865;   HMDB:HMDB0014724;   KEGG:C01690;   KEGG:D07816;   LINCS:LSM-2160
 xref_mesh: MESH:D004008
 xref: PDBeChem:DIF;   PMID:11322639;   PMID:1502708;   PMID:23777257;   PMID:27967303;   PMID:7838674;   Patent:NL6604752;   Patent:US3558690;   Reaxys:2146636;   VSDB:1933;   Wikipedia:Diclofenac
 cyclic_relationship: is_conjugate_acid_of CHEBI:48311


show annotations for term's descendants           Sort by:
diclofenac term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2M alpha-2-macroglobulin increases expression ISO Diclofenac results in increased expression of A2M mRNA; Diclofenac results in increased expression of A2ML1 mRNA CTD PMID:26934552 NCBI chr12:9,067,708...9,116,229
Ensembl chr12:9,067,664...9,116,229 		JBrowse link
G AACS acetoacetyl-CoA synthetase decreases expression ISO Diclofenac results in decreased expression of AACS mRNA CTD PMID:26934552 NCBI chr12:125,065,435...125,143,316
Ensembl chr12:125,065,434...125,143,333 		JBrowse link
G AARS1 alanyl-tRNA synthetase 1 decreases expression ISO Diclofenac results in decreased expression of AARS1 mRNA CTD PMID:35537566 NCBI chr16:70,252,298...70,289,506
Ensembl chr16:70,251,983...70,289,707 		JBrowse link
G ABCB1 ATP binding cassette subfamily B member 1 decreases activity
decreases response to substance
increases expression		 ISO
EXP		 Diclofenac results in decreased activity of ABCB1A protein
ABCB1A gene mutant form results in decreased susceptibility to Diclofenac
Diclofenac results in increased expression of ABCB1B mRNA		 CTD PMID:15458769 PMID:19022234 PMID:28193520 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323 		JBrowse link
G ABCB11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity		 EXP Diclofenac inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Diclofenac results in decreased activity of ABCB11 protein		 CTD PMID:24014644 PMID:28437613 NCBI chr 2:168,915,390...169,031,324
Ensembl chr 2:168,915,498...169,031,324 		JBrowse link
G ABCB4 ATP binding cassette subfamily B member 4 decreases expression
decreases activity		 EXP Diclofenac results in decreased expression of ABCB4 mRNA
Diclofenac results in decreased activity of ABCB4 protein		 CTD PMID:19022234 PMID:28437613 NCBI chr 7:87,365,896...87,476,027
Ensembl chr 7:87,401,696...87,480,435 		JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 decreases activity
increases expression
multiple interactions		 EXP
ISO		 Diclofenac results in decreased activity of ABCC2 protein
Diclofenac results in increased expression of ABCC2 mRNA
ABCC2 protein results in increased transport of and results in increased metabolism of and results in increased susceptibility to Diclofenac		 CTD PMID:19022234 PMID:22646477 PMID:25450747 NCBI chr10:99,782,640...99,852,594
Ensembl chr10:99,782,640...99,852,594 		JBrowse link
G ABCC4 ATP binding cassette subfamily C member 4 (PEL blood group) affects expression EXP Diclofenac affects the expression of ABCC4 mRNA CTD PMID:24752500 NCBI chr13:95,019,835...95,301,451
Ensembl chr13:95,019,835...95,301,475 		JBrowse link
G ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase affects expression EXP Diclofenac affects the expression of ABL2 mRNA CTD PMID:24752500 NCBI chr 1:179,099,330...179,229,677
Ensembl chr 1:179,099,330...179,229,684 		JBrowse link
G ACE2 angiotensin converting enzyme 2 decreases expression EXP Diclofenac results in decreased expression of ACE2 mRNA CTD PMID:32808185 NCBI chr  X:15,518,197...15,607,211
Ensembl chr  X:15,494,566...15,607,236 		JBrowse link
G ACIN1 apoptotic chromatin condensation inducer 1 affects expression EXP Diclofenac affects the expression of ACIN1 mRNA CTD PMID:24752500 NCBI chr14:23,058,564...23,095,614
Ensembl chr14:23,058,564...23,095,614 		JBrowse link
G ACKR3 atypical chemokine receptor 3 decreases expression EXP Diclofenac results in decreased expression of ACKR3 mRNA CTD PMID:19192274 NCBI chr 2:236,537,122...236,582,354
Ensembl chr 2:236,567,787...236,582,354 		JBrowse link
G ACOT2 acyl-CoA thioesterase 2 decreases expression ISO Diclofenac results in decreased expression of ACOT2 mRNA CTD PMID:26934552 NCBI chr14:73,567,620...73,575,658
Ensembl chr14:73,567,620...73,575,658 		JBrowse link
G ACOX1 acyl-CoA oxidase 1 increases expression ISO Diclofenac results in increased expression of ACOX1 mRNA CTD PMID:19022234 NCBI chr17:75,941,507...75,979,166
Ensembl chr17:75,941,507...75,979,177 		JBrowse link
G ACP3 acid phosphatase 3 increases expression ISO Diclofenac results in increased expression of ACP3 mRNA CTD PMID:26934552 NCBI chr 3:132,317,407...132,368,302
Ensembl chr 3:132,317,369...132,368,302 		JBrowse link
G ACTA1 actin alpha 1, skeletal muscle affects expression EXP Diclofenac affects the expression of ACTA1 mRNA CTD PMID:24752500 NCBI chr 1:229,431,245...229,434,094
Ensembl chr 1:229,430,365...229,434,104 		JBrowse link
G ACTL9 actin like 9 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of ACTL9 mRNA CTD PMID:37844793 NCBI chr19:8,697,400...8,698,795
Ensembl chr19:8,697,400...8,698,795 		JBrowse link
G ACTN1 actinin alpha 1 affects expression ISO Diclofenac affects the expression of ACTN1 mRNA CTD PMID:19022234 NCBI chr14:68,874,128...68,979,302
Ensembl chr14:68,874,123...68,979,440 		JBrowse link
G ACVR1 activin A receptor type 1 affects expression EXP Diclofenac affects the expression of ACVR1 mRNA CTD PMID:24752500 NCBI chr 2:157,736,446...157,876,330
Ensembl chr 2:157,736,251...157,876,330 		JBrowse link
G ACVR1B activin A receptor type 1B affects expression
multiple interactions		 EXP
ISO		 Diclofenac affects the expression of ACVR1B mRNA
[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of ACVR1B mRNA		 CTD PMID:24752500 PMID:37844793 NCBI chr12:51,951,699...51,997,078
Ensembl chr12:51,951,699...51,997,078 		JBrowse link
G ACVR2B activin A receptor type 2B affects expression EXP Diclofenac affects the expression of ACVR2B mRNA CTD PMID:24752500 NCBI chr 3:38,453,890...38,493,142
Ensembl chr 3:38,453,890...38,493,142 		JBrowse link
G ADAMDEC1 ADAM like decysin 1 increases expression ISO Diclofenac results in increased expression of ADAMDEC1 mRNA CTD PMID:26934552 NCBI chr 8:24,384,285...24,406,013
Ensembl chr 8:24,384,285...24,406,013 		JBrowse link
G ADCY6 adenylate cyclase 6 affects expression EXP Diclofenac affects the expression of ADCY6 mRNA CTD PMID:24752500 NCBI chr12:48,766,194...48,789,974
Ensembl chr12:48,766,194...48,789,089 		JBrowse link
G ADCY9 adenylate cyclase 9 affects expression
decreases expression		 EXP
ISO		 Diclofenac affects the expression of ADCY9 mRNA
Diclofenac results in decreased expression of ADCY9 mRNA		 CTD PMID:24752500 PMID:26934552 NCBI chr16:3,953,387...4,116,442
Ensembl chr16:3,953,387...4,116,442 		JBrowse link
G ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide increases expression ISO Diclofenac results in increased expression of ADH1 protein CTD PMID:25772430 NCBI chr 4:99,336,497...99,352,746
Ensembl chr 4:99,336,497...99,352,746 		JBrowse link
G ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide decreases expression ISO Diclofenac results in decreased expression of ADH7 mRNA CTD PMID:35537566 NCBI chr 4:99,412,263...99,435,342
Ensembl chr 4:99,412,261...99,435,510 		JBrowse link
G ADK adenosine kinase increases expression
decreases expression		 EXP
ISO		 Diclofenac results in increased expression of ADK mRNA
Diclofenac results in decreased expression of ADK mRNA		 CTD PMID:19022234 NCBI chr10:74,151,221...74,709,290
Ensembl chr10:74,151,202...74,709,963 		JBrowse link
G ADORA2A adenosine A2a receptor increases expression ISO Diclofenac results in increased expression of ADORA2A mRNA CTD PMID:26934552 NCBI chr22:24,423,597...24,442,357
Ensembl chr22:24,417,879...24,442,357 		JBrowse link
G ADORA2B adenosine A2b receptor increases expression ISO Diclofenac results in increased expression of ADORA2B mRNA CTD PMID:26934552 NCBI chr17:15,850,362...15,975,746
Ensembl chr17:15,945,130...15,975,746 		JBrowse link
G ADRB2 adrenoceptor beta 2 increases expression ISO Diclofenac results in increased expression of ADRB2 mRNA CTD PMID:26934552 NCBI chr 5:148,826,611...148,828,623
Ensembl chr 5:148,826,611...148,828,623 		JBrowse link
G AEN apoptosis enhancing nuclease increases expression ISO Diclofenac results in increased expression of AEN mRNA CTD PMID:35537566 NCBI chr15:88,604,683...88,632,281
Ensembl chr15:88,621,337...88,632,281 		JBrowse link
G AGER advanced glycosylation end-product specific receptor increases expression ISO
EXP		 Diclofenac results in increased expression of AGER mRNA CTD PMID:24747151 PMID:28138970 NCBI chr 6:32,180,969...32,184,253
Ensembl chr 6:32,180,968...32,184,322 		JBrowse link
G AGGF1 angiogenic factor with G-patch and FHA domains 1 affects expression EXP Diclofenac affects the expression of AGGF1 mRNA CTD PMID:24752500 NCBI chr 5:77,030,404...77,065,234
Ensembl chr 5:77,029,251...77,065,234 		JBrowse link
G AGO2 argonaute RISC catalytic component 2 affects expression EXP Diclofenac affects the expression of AGO2 mRNA CTD PMID:24752500 NCBI chr 8:140,520,156...140,642,313
Ensembl chr 8:140,520,156...140,635,633 		JBrowse link
G AGO3 argonaute RISC catalytic component 3 affects expression EXP Diclofenac affects the expression of AGO3 mRNA CTD PMID:24752500 NCBI chr 1:35,930,718...36,072,500
Ensembl chr 1:35,930,718...36,072,500 		JBrowse link
G AGO4 argonaute RISC component 4 affects expression EXP Diclofenac affects the expression of AGO4 mRNA CTD PMID:24752500 NCBI chr 1:35,807,636...35,857,890
Ensembl chr 1:35,808,016...35,857,890 		JBrowse link
G AGRP agouti related neuropeptide increases expression ISO Diclofenac results in increased expression of AGRP mRNA CTD PMID:30723492 NCBI chr16:67,482,571...67,483,547
Ensembl chr16:67,482,571...67,483,547 		JBrowse link
G AHR aryl hydrocarbon receptor increases expression ISO Diclofenac results in increased expression of AHR mRNA CTD PMID:26934552 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152 		JBrowse link
G AHSG alpha 2-HS glycoprotein multiple interactions ISO [Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of AHSG protein CTD PMID:25772430 NCBI chr 3:186,613,060...186,621,318
Ensembl chr 3:186,613,060...186,621,318 		JBrowse link
G AIFM1 apoptosis inducing factor mitochondria associated 1 affects expression EXP Diclofenac affects the expression of AIFM1 mRNA CTD PMID:24752500 NCBI chr  X:130,129,362...130,165,841
Ensembl chr  X:130,124,666...130,165,879 		JBrowse link
G AIM2 absent in melanoma 2 increases expression ISO Diclofenac results in increased expression of AIM2 mRNA CTD PMID:26934552 NCBI chr 1:159,055,051...159,147,132
Ensembl chr 1:159,056,129...159,187,843 		JBrowse link
G AKNA AT-hook transcription factor decreases expression ISO Diclofenac results in decreased expression of AKNA mRNA CTD PMID:35537566 NCBI chr 9:114,330,504...114,398,472
Ensembl chr 9:114,334,156...114,394,405 		JBrowse link
G AKR1B15 aldo-keto reductase family 1 member B15 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of AKR1B7 mRNA CTD PMID:37844793 NCBI chr 7:134,549,110...134,579,869
Ensembl chr 7:134,549,110...134,579,875 		JBrowse link
G AKT1 AKT serine/threonine kinase 1 affects expression EXP Diclofenac affects the expression of AKT1 mRNA CTD PMID:24752500 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,759 		JBrowse link
G AKT2 AKT serine/threonine kinase 2 affects expression EXP Diclofenac affects the expression of AKT2 mRNA CTD PMID:24752500 NCBI chr19:40,230,317...40,285,345
Ensembl chr19:40,230,317...40,285,536 		JBrowse link
G ALAS1 5'-aminolevulinate synthase 1 decreases expression ISO Diclofenac results in decreased expression of ALAS1 mRNA CTD PMID:26934552 NCBI chr 3:52,198,083...52,214,327
Ensembl chr 3:52,198,086...52,214,327 		JBrowse link
G ALAS2 5'-aminolevulinate synthase 2 affects expression EXP Diclofenac affects the expression of ALAS2 mRNA CTD PMID:24752500 NCBI chr  X:55,009,055...55,030,977
Ensembl chr  X:55,009,055...55,030,977 		JBrowse link
G ALB albumin affects binding
decreases secretion
multiple interactions
decreases expression
increases expression		 EXP
ISO		 Diclofenac binds to ALB protein
Diclofenac results in decreased secretion of ALB protein
[Ranitidine co-treated with Diclofenac] results in decreased expression of ALB protein; Quercetin inhibits the reaction [[Ranitidine co-treated with Diclofenac] results in decreased expression of ALB protein]
Diclofenac results in decreased expression of ALB protein
Diclofenac results in increased expression of ALB mRNA		 CTD PMID:9353694 PMID:19022234 PMID:28400101 PMID:36442613 NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482 		JBrowse link
G ALDH18A1 aldehyde dehydrogenase 18 family member A1 increases expression
decreases expression		 ISO Diclofenac results in increased expression of ALDH18A1 mRNA
Diclofenac results in decreased expression of ALDH18A1 mRNA		 CTD PMID:26934552 PMID:35537566 NCBI chr10:95,605,941...95,656,711
Ensembl chr10:95,605,941...95,656,711 		JBrowse link
G ALDH1B1 aldehyde dehydrogenase 1 family member B1 increases expression ISO Diclofenac results in increased expression of ALDH1B1 mRNA CTD PMID:26934552 NCBI chr 9:38,392,702...38,398,661
Ensembl chr 9:38,392,702...38,398,661 		JBrowse link
G ALDH1L2 aldehyde dehydrogenase 1 family member L2 decreases expression ISO Diclofenac results in decreased expression of ALDH1L2 mRNA CTD PMID:26934552 NCBI chr12:105,019,790...105,084,458
Ensembl chr12:105,019,784...105,107,643 		JBrowse link
G ALDH3A2 aldehyde dehydrogenase 3 family member A2 decreases expression ISO Diclofenac results in decreased expression of ALDH3A2 mRNA CTD PMID:26934552 NCBI chr17:19,648,136...19,677,596
Ensembl chr17:19,648,136...19,685,760 		JBrowse link
G ALDOC aldolase, fructose-bisphosphate C increases expression ISO Diclofenac results in increased expression of ALDOC mRNA CTD PMID:30723492 NCBI chr17:28,573,120...28,576,895
Ensembl chr17:28,573,115...28,576,948 		JBrowse link
G ALOX15 arachidonate 15-lipoxygenase increases expression
multiple interactions		 ISO Diclofenac results in increased expression of ALOX15 mRNA
[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of ALOX15 mRNA		 CTD PMID:23939143 PMID:37844793 NCBI chr17:4,630,919...4,641,678
Ensembl chr17:4,630,919...4,642,294 		JBrowse link
G AMH anti-Mullerian hormone increases expression
multiple interactions		 ISO Diclofenac results in increased expression of AMH mRNA
[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of AMH mRNA		 CTD PMID:35537566 PMID:37844793 NCBI chr19:2,249,323...2,252,073
Ensembl chr19:2,249,309...2,252,073 		JBrowse link
G AMOTL2 angiomotin like 2 decreases expression ISO Diclofenac results in decreased expression of AMOTL2 mRNA CTD PMID:35537566 NCBI chr 3:134,355,345...134,375,417
Ensembl chr 3:134,355,347...134,375,479 		JBrowse link
G ANG angiogenin increases expression ISO Diclofenac results in increased expression of ANG mRNA CTD PMID:26934552 NCBI chr14:20,684,177...20,694,186
Ensembl chr14:20,684,177...20,698,971 		JBrowse link
G ANXA8 annexin A8 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of ANXA8 mRNA CTD PMID:37844793 NCBI chr10:47,467,993...47,991,796
Ensembl chr10:47,460,162...47,484,158 		JBrowse link
G AOC3 amine oxidase copper containing 3 decreases expression ISO Diclofenac results in decreased expression of AOC3 mRNA CTD PMID:26934552 NCBI chr17:42,851,199...42,858,124
Ensembl chr17:42,851,184...42,858,130 		JBrowse link
G APAF1 apoptotic peptidase activating factor 1 affects expression EXP Diclofenac affects the expression of APAF1 mRNA CTD PMID:24752500 NCBI chr12:98,645,290...98,735,433
Ensembl chr12:98,645,149...98,735,433 		JBrowse link
G APCS amyloid P component, serum multiple interactions
increases expression		 ISO [Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of APCS protein
Diclofenac results in increased expression of APCS mRNA; Diclofenac results in increased expression of APCS protein		 CTD PMID:25772430 PMID:26934552 NCBI chr 1:159,587,826...159,588,865
Ensembl chr 1:159,587,826...159,588,865 		JBrowse link
G APOA4 apolipoprotein A4 affects expression ISO Diclofenac affects the expression of APOA4 mRNA CTD PMID:26934552 NCBI chr11:116,820,700...116,823,304
Ensembl chr11:116,820,700...116,823,304 		JBrowse link
G AQP2 aquaporin 2 decreases expression ISO Diclofenac results in decreased expression of AQP2 protein CTD PMID:15579502 NCBI chr12:49,950,737...49,958,878
Ensembl chr12:49,950,737...49,958,878 		JBrowse link
G AQP9 aquaporin 9 decreases expression ISO Diclofenac results in decreased expression of AQP9 mRNA CTD PMID:35537566 NCBI chr15:58,138,169...58,185,911
Ensembl chr15:58,138,169...58,185,911 		JBrowse link
G AQR aquarius intron-binding spliceosomal factor affects expression EXP Diclofenac affects the expression of AQR mRNA CTD PMID:24752500 NCBI chr15:34,851,782...34,969,742
Ensembl chr15:34,851,782...34,969,742 		JBrowse link
G AR androgen receptor affects activity EXP Diclofenac affects the activity of AR protein CTD PMID:29777833 NCBI chr  X:67,544,021...67,730,619
Ensembl chr  X:67,544,021...67,730,619 		JBrowse link
G ARAF A-Raf proto-oncogene, serine/threonine kinase affects expression EXP Diclofenac affects the expression of ARAF mRNA CTD PMID:24752500 NCBI chr  X:47,561,205...47,571,908
Ensembl chr  X:47,561,205...47,571,908 		JBrowse link
G ARHGAP20 Rho GTPase activating protein 20 increases expression ISO Diclofenac results in increased expression of ARHGAP20 mRNA CTD PMID:30723492 NCBI chr11:110,577,043...110,713,189
Ensembl chr11:110,577,042...110,713,189 		JBrowse link
G ARHGAP26 Rho GTPase activating protein 26 affects expression EXP Diclofenac affects the expression of ARHGAP26 mRNA CTD PMID:24752500 NCBI chr 5:142,770,377...143,229,011
Ensembl chr 5:142,770,377...143,229,011 		JBrowse link
G ARHGEF2 Rho/Rac guanine nucleotide exchange factor 2 affects expression EXP Diclofenac affects the expression of ARHGEF2 mRNA CTD PMID:24752500 NCBI chr 1:155,946,854...155,979,617
Ensembl chr 1:155,946,851...156,007,070 		JBrowse link
G ARHGEF3 Rho guanine nucleotide exchange factor 3 affects expression
decreases expression		 EXP
ISO		 Diclofenac affects the expression of ARHGEF3 mRNA
Diclofenac results in decreased expression of ARHGEF3 mRNA		 CTD PMID:24752500 PMID:35537566 NCBI chr 3:56,727,420...57,079,268
Ensembl chr 3:56,727,418...57,079,329 		JBrowse link
G ARHGEF7 Rho guanine nucleotide exchange factor 7 affects expression EXP Diclofenac affects the expression of ARHGEF7 mRNA CTD PMID:24752500 NCBI chr13:111,114,619...111,305,734
Ensembl chr13:111,114,559...111,305,737 		JBrowse link
G ARID4A AT-rich interaction domain 4A multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of ARID4A mRNA CTD PMID:37844793 NCBI chr14:58,298,555...58,373,876
Ensembl chr14:58,298,504...58,373,887 		JBrowse link
G ARID5A AT-rich interaction domain 5A decreases expression ISO Diclofenac results in decreased expression of ARID5A mRNA CTD PMID:35537566 NCBI chr 2:96,536,752...96,552,638
Ensembl chr 2:96,536,743...96,552,638 		JBrowse link
G ARID5B AT-rich interaction domain 5B decreases expression ISO Diclofenac results in decreased expression of ARID5B mRNA CTD PMID:26934552 NCBI chr10:61,901,699...62,096,944
Ensembl chr10:61,901,684...62,096,944 		JBrowse link
G ARL11 ARF like GTPase 11 decreases expression ISO Diclofenac results in decreased expression of ARL11 mRNA CTD PMID:35537566 NCBI chr13:49,628,507...49,633,872
Ensembl chr13:49,628,507...49,633,872 		JBrowse link
G ARMCX1 armadillo repeat containing X-linked 1 increases expression ISO Diclofenac results in increased expression of ARMCX1 mRNA CTD PMID:30723492 NCBI chr  X:101,550,547...101,554,700
Ensembl chr  X:101,550,547...101,554,700 		JBrowse link
G ARNT aryl hydrocarbon receptor nuclear translocator affects expression EXP Diclofenac affects the expression of ARNT mRNA CTD PMID:24752500 NCBI chr 1:150,809,713...150,876,599
Ensembl chr 1:150,809,713...150,876,708 		JBrowse link
G ARRB1 arrestin beta 1 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of ARRB1 mRNA CTD PMID:37844793 NCBI chr11:75,260,122...75,351,661
Ensembl chr11:75,260,122...75,351,705 		JBrowse link
G ARRDC3 arrestin domain containing 3 increases expression ISO Diclofenac results in increased expression of ARRDC3 mRNA CTD PMID:35537566 NCBI chr 5:91,368,631...91,383,317
Ensembl chr 5:91,368,631...91,383,317 		JBrowse link
G ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 affects expression EXP Diclofenac affects the expression of ASAP1 mRNA CTD PMID:24752500 NCBI chr 8:130,052,104...130,443,674
Ensembl chr 8:130,052,104...130,443,674 		JBrowse link
G ASH2L ASH2 like, histone lysine methyltransferase complex subunit affects expression EXP Diclofenac affects the expression of ASH2L mRNA CTD PMID:24752500 NCBI chr 8:38,105,493...38,140,080
Ensembl chr 8:38,105,493...38,144,076 		JBrowse link
G ASIC1 acid sensing ion channel subunit 1 decreases expression ISO Diclofenac results in decreased expression of ASIC1 mRNA CTD PMID:11588175 NCBI chr12:50,057,596...50,083,622
Ensembl chr12:50,057,548...50,083,611 		JBrowse link
G ASIC2 acid sensing ion channel subunit 2 decreases expression ISO Diclofenac results in decreased expression of ASIC2 mRNA CTD PMID:11588175 NCBI chr17:33,013,087...34,156,768
Ensembl chr17:33,013,087...34,174,964 		JBrowse link
G ASIC3 acid sensing ion channel subunit 3 decreases expression
decreases activity		 ISO Diclofenac results in decreased expression of ASIC3 mRNA
Diclofenac results in decreased activity of ASIC3 protein		 CTD PMID:11588175 NCBI chr 7:151,048,292...151,052,756
Ensembl chr 7:151,048,292...151,052,756 		JBrowse link
G ASL argininosuccinate lyase affects expression EXP Diclofenac affects the expression of ASL mRNA CTD PMID:24752500 NCBI chr 7:66,075,819...66,093,576
Ensembl chr 7:66,075,800...66,094,697 		JBrowse link
G ASNS asparagine synthetase (glutamine-hydrolyzing) decreases expression
increases expression		 EXP
ISO		 Diclofenac results in decreased expression of ASNS mRNA
Diclofenac results in increased expression of ASNS mRNA		 CTD PMID:19192274 PMID:26934552 PMID:35537566 NCBI chr 7:97,851,677...97,928,441
Ensembl chr 7:97,851,677...97,872,542 		JBrowse link
G ASS1 argininosuccinate synthase 1 decreases expression ISO Diclofenac results in decreased expression of ASS1 mRNA CTD PMID:26934552 NCBI chr 9:130,444,707...130,501,274
Ensembl chr 9:130,444,961...130,501,274 		JBrowse link
G ATF2 activating transcription factor 2 affects expression EXP Diclofenac affects the expression of ATF2 mRNA CTD PMID:24752500 NCBI chr 2:175,072,259...175,168,203
Ensembl chr 2:175,072,250...175,168,382 		JBrowse link
G ATF4 activating transcription factor 4 affects expression
decreases expression
increases expression		 EXP
ISO		 Diclofenac affects the expression of ATF4 mRNA
Diclofenac results in decreased expression of ATF4 mRNA
Diclofenac results in increased expression of ATF4 mRNA		 CTD PMID:24752500 PMID:27313093 PMID:35537566 NCBI chr22:39,520,559...39,522,686
Ensembl chr22:39,519,695...39,522,686 		JBrowse link
G ATF5 activating transcription factor 5 decreases expression ISO Diclofenac results in decreased expression of ATF5 mRNA CTD PMID:35537566 NCBI chr19:49,928,906...49,933,935
Ensembl chr19:49,928,702...49,933,935 		JBrowse link
G ATP11A ATPase phospholipid transporting 11A increases expression ISO Diclofenac results in increased expression of ATP11A mRNA CTD PMID:26934552 NCBI chr13:112,690,038...112,887,168
Ensembl chr13:112,690,038...112,887,168 		JBrowse link
G ATP5F1A ATP synthase F1 subunit alpha multiple interactions
increases expression		 ISO [Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of ATP5F1A protein
Diclofenac results in increased expression of ATP5F1A protein		 CTD PMID:25772430 NCBI chr18:46,080,248...46,104,227
Ensembl chr18:46,080,248...46,104,334 		JBrowse link
G ATP5F1B ATP synthase F1 subunit beta multiple interactions
increases expression		 ISO [Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of ATP5F1B protein
Diclofenac results in increased expression of ATP5F1B protein		 CTD PMID:25772430 NCBI chr12:56,638,175...56,645,984
Ensembl chr12:56,638,175...56,645,984 		JBrowse link
G ATP5PF ATP synthase peripheral stalk subunit F6 multiple interactions
increases expression		 ISO [Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of ATP5PF protein
Diclofenac results in increased expression of ATP5PF protein		 CTD PMID:25772430 NCBI chr21:25,724,500...25,735,653
Ensembl chr21:25,716,503...25,735,673 		JBrowse link
G AURKAIP1 aurora kinase A interacting protein 1 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of AURKAIP1 mRNA CTD PMID:37844793 NCBI chr 1:1,373,736...1,375,207
Ensembl chr 1:1,373,730...1,375,207 		JBrowse link
G AZIN1 antizyme inhibitor 1 affects expression EXP Diclofenac affects the expression of AZIN1 mRNA CTD PMID:24752500 NCBI chr 8:102,826,302...102,864,200
Ensembl chr 8:102,826,111...102,893,864 		JBrowse link
G B3GALT1 beta-1,3-galactosyltransferase 1 increases expression ISO Diclofenac results in increased expression of B3GALT1 mRNA CTD PMID:26934552 NCBI chr 2:167,293,001...167,874,045
Ensembl chr 2:167,293,001...167,874,045 		JBrowse link
G BACH1 BTB domain and CNC homolog 1 affects expression EXP Diclofenac affects the expression of BACH1 mRNA CTD PMID:24752500 NCBI chr21:29,298,922...29,361,894
Ensembl chr21:29,194,071...29,630,751 		JBrowse link
G BAK1 BCL2 antagonist/killer 1 increases activity EXP Diclofenac results in increased activity of BAK1 protein CTD PMID:18191430 NCBI chr 6:33,572,552...33,580,276
Ensembl chr 6:33,572,547...33,580,293 		JBrowse link
G BARD1 BRCA1 associated RING domain 1 affects expression EXP Diclofenac affects the expression of BARD1 mRNA CTD PMID:24752500 NCBI chr 2:214,725,646...214,809,683
Ensembl chr 2:214,725,646...214,809,683 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator increases activity
increases expression
affects localization		 EXP
ISO		 Diclofenac results in increased activity of BAX protein
Diclofenac results in increased expression of BAX mRNA
Diclofenac affects the localization of BAX protein		 CTD PMID:18191430 PMID:29027214 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798 		JBrowse link
G BCAR3 BCAR3 adaptor protein, NSP family member decreases expression ISO Diclofenac results in decreased expression of BCAR3 mRNA CTD PMID:35537566 NCBI chr 1:93,561,741...93,848,151
Ensembl chr 1:93,561,741...93,847,150 		JBrowse link
G BCL2 BCL2 apoptosis regulator increases expression EXP
ISO		 Diclofenac results in increased expression of BCL2 mRNA CTD PMID:29027214 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G BCL2A1 BCL2 related protein A1 decreases expression EXP Diclofenac results in decreased expression of BCL2A1 mRNA CTD PMID:19192274 NCBI chr15:79,960,892...79,971,196
Ensembl chr15:79,960,892...79,971,196 		JBrowse link
G BCL2L1 BCL2 like 1 increases expression
affects expression		 EXP Diclofenac results in increased expression of BCL2L1 mRNA alternative form
Diclofenac affects the expression of BCL2L1 mRNA		 CTD PMID:14609740 PMID:24752500 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989 		JBrowse link
G BCL2L11 BCL2 like 11 affects expression EXP Diclofenac affects the expression of BCL2L11 mRNA CTD PMID:24752500 NCBI chr 2:111,120,914...111,168,445
Ensembl chr 2:111,119,378...111,168,444 		JBrowse link
G BCL3 BCL3 transcription coactivator increases expression ISO Diclofenac results in increased expression of BCL3 mRNA CTD PMID:26934552 NCBI chr19:44,747,705...44,760,044
Ensembl chr19:44,747,705...44,760,044 		JBrowse link
G BCL6 BCL6 transcription repressor decreases expression ISO Diclofenac results in decreased expression of BCL6 mRNA CTD PMID:26934552 NCBI chr 3:187,721,377...187,745,468
Ensembl chr 3:187,721,377...187,745,725 		JBrowse link
G BDH1 3-hydroxybutyrate dehydrogenase 1 decreases expression ISO Diclofenac results in decreased expression of BDH1 mRNA CTD PMID:26934552 NCBI chr 3:197,509,783...197,573,343
Ensembl chr 3:197,509,783...197,573,323 		JBrowse link
G BID BH3 interacting domain death agonist multiple interactions
affects expression
increases activity		 EXP 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Diclofenac results in increased activity of BID protein]
Diclofenac affects the expression of BID mRNA		 CTD PMID:18191430 PMID:24752500 NCBI chr22:17,734,138...17,774,665
Ensembl chr22:17,734,138...17,774,770 		JBrowse link
G BMP4 bone morphogenetic protein 4 affects expression EXP Diclofenac affects the expression of BMP4 mRNA CTD PMID:24752500 NCBI chr14:53,949,736...53,956,891
Ensembl chr14:53,949,736...53,958,761 		JBrowse link
G BMP6 bone morphogenetic protein 6 decreases expression
increases expression		 ISO
EXP		 Diclofenac results in decreased expression of BMP6 mRNA
Diclofenac results in increased expression of BMP6 mRNA		 CTD PMID:26934552 PMID:32816093 NCBI chr 6:7,726,099...7,881,728
Ensembl chr 6:7,726,099...7,881,728 		JBrowse link
G BRAF B-Raf proto-oncogene, serine/threonine kinase affects expression EXP Diclofenac affects the expression of BRAF mRNA CTD PMID:24752500 NCBI chr 7:140,713,328...140,924,929
Ensembl chr 7:140,719,327...140,924,929 		JBrowse link
G BRCA1 BRCA1 DNA repair associated increases expression ISO Diclofenac results in increased expression of BRCA1 mRNA CTD PMID:26934552 NCBI chr17:43,044,295...43,170,327
Ensembl chr17:43,044,295...43,170,245 		JBrowse link
G BRCA2 BRCA2 DNA repair associated multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of BRCA2 mRNA CTD PMID:37844793 NCBI chr13:32,315,077...32,400,268
Ensembl chr13:32,315,086...32,400,268 		JBrowse link
G BRD3OS BRD3 opposite strand decreases expression ISO Diclofenac results in decreased expression of BRD3OS mRNA CTD PMID:35537566 NCBI chr 9:134,025,481...134,031,587
Ensembl chr 9:134,025,481...134,034,666 		JBrowse link
G BRDT bromodomain testis associated decreases expression ISO Diclofenac results in decreased expression of BRDT mRNA CTD PMID:35537566 NCBI chr 1:91,949,371...92,014,428
Ensembl chr 1:91,949,343...92,014,426 		JBrowse link
G BRIP1 BRCA1 interacting DNA helicase 1 affects expression EXP Diclofenac affects the expression of BRIP1 mRNA CTD PMID:24752500 NCBI chr17:61,679,139...61,863,528
Ensembl chr17:61,679,139...61,863,559 		JBrowse link
G BTG1 BTG anti-proliferation factor 1 decreases expression ISO Diclofenac results in decreased expression of BTG1 mRNA CTD PMID:26934552 NCBI chr12:92,140,278...92,145,846
Ensembl chr12:92,140,278...92,145,846 		JBrowse link
G C1QA complement C1q A chain increases expression ISO Diclofenac results in increased expression of C1QA mRNA CTD PMID:26934552 NCBI chr 1:22,636,463...22,639,678
Ensembl chr 1:22,635,077...22,639,678 		JBrowse link
G C1QB complement C1q B chain increases expression ISO Diclofenac results in increased expression of C1QB mRNA CTD PMID:26934552 NCBI chr 1:22,653,236...22,661,637
Ensembl chr 1:22,652,762...22,661,637 		JBrowse link
G C1QC complement C1q C chain increases expression ISO Diclofenac results in increased expression of C1QC mRNA CTD PMID:26934552 NCBI chr 1:22,643,633...22,648,108
Ensembl chr 1:22,643,014...22,648,110 		JBrowse link
G C2 complement C2 increases expression ISO Diclofenac results in increased expression of C2 mRNA CTD PMID:26934552 NCBI chr 6:31,897,783...31,945,672
Ensembl chr 6:31,897,785...31,945,673 		JBrowse link
G C4B complement C4B (Chido/Rodgers blood group) increases expression ISO Diclofenac results in increased expression of C4B mRNA CTD PMID:26934552 NCBI chr 6:32,014,795...32,035,418
Ensembl chr 6:32,014,795...32,035,418 		JBrowse link
G CA1 carbonic anhydrase 1 decreases expression ISO Diclofenac results in decreased expression of CAR1 mRNA CTD PMID:26934552 NCBI chr 8:85,327,608...85,378,113
Ensembl chr 8:85,327,608...85,379,014 		JBrowse link
G CA13 carbonic anhydrase 13 decreases expression ISO Diclofenac results in decreased expression of CAR13 mRNA CTD PMID:26934552 NCBI chr 8:85,245,458...85,284,073
Ensembl chr 8:85,220,587...85,284,073 		JBrowse link
G CA3 carbonic anhydrase 3 decreases expression
increases secretion		 ISO Diclofenac results in decreased expression of CAR3 mRNA
Diclofenac results in increased secretion of CAR3 protein		 CTD PMID:24038040 PMID:26934552 NCBI chr 8:85,438,859...85,449,040
Ensembl chr 8:85,373,436...85,449,040 		JBrowse link
G CACNA1B calcium voltage-gated channel subunit alpha1 B decreases expression ISO Diclofenac results in decreased expression of CACNA1B mRNA CTD PMID:26934552 NCBI chr 9:137,877,782...138,124,619
Ensembl chr 9:137,877,782...138,124,624 		JBrowse link
G CALCA calcitonin related polypeptide alpha decreases expression ISO Diclofenac results in decreased expression of CALCA mRNA CTD PMID:11588175 NCBI chr11:14,966,668...14,972,351
Ensembl chr11:14,966,622...14,972,354 		JBrowse link
G CALM1 calmodulin 1 affects expression EXP Diclofenac affects the expression of CALM1 mRNA CTD PMID:24752500 NCBI chr14:90,396,502...90,408,268
Ensembl chr14:90,396,502...90,408,268 		JBrowse link
G CALML3 calmodulin like 3 increases expression ISO Diclofenac results in increased expression of CALML3 mRNA CTD PMID:30723492 NCBI chr10:5,524,961...5,526,771
Ensembl chr10:5,524,961...5,526,771 		JBrowse link
G CALR calreticulin affects expression
decreases expression		 ISO Diclofenac affects the expression of CALR mRNA
Diclofenac results in decreased expression of CALR mRNA		 CTD PMID:18246545 NCBI chr19:12,938,609...12,944,489
Ensembl chr19:12,938,578...12,944,489 		JBrowse link
G CAMK1D calcium/calmodulin dependent protein kinase ID increases expression ISO Diclofenac results in increased expression of CAMK1D mRNA CTD PMID:26934552 NCBI chr10:12,349,547...12,835,545
Ensembl chr10:12,349,547...12,835,545 		JBrowse link
G CAMK2B calcium/calmodulin dependent protein kinase II beta increases expression ISO Diclofenac results in increased expression of CAMK2B mRNA CTD PMID:30723492 NCBI chr 7:44,217,154...44,326,013
Ensembl chr 7:44,210,019...44,334,577 		JBrowse link
G CAMP cathelicidin antimicrobial peptide increases expression ISO Diclofenac results in increased expression of CAMP mRNA CTD PMID:26934552 NCBI chr 3:48,223,495...48,225,485
Ensembl chr 3:48,223,347...48,225,491 		JBrowse link
G CAPN10 calpain 10 affects expression EXP Diclofenac affects the expression of CAPN10 mRNA CTD PMID:24752500 NCBI chr 2:240,586,734...240,599,104
Ensembl chr 2:240,586,734...240,617,705 		JBrowse link
G CARS1 cysteinyl-tRNA synthetase 1 decreases expression ISO Diclofenac results in decreased expression of CARS1 mRNA CTD PMID:35537566 NCBI chr11:3,000,929...3,057,423
Ensembl chr11:3,000,922...3,057,613 		JBrowse link
G CASP1 caspase 1 multiple interactions
increases cleavage		 ISO diacerein inhibits the reaction [Diclofenac results in increased cleavage of CASP1 protein]; Diclofenac inhibits the reaction [Freund's Adjuvant results in increased cleavage of CASP1 protein] CTD PMID:25450234 PMID:38582345 NCBI chr11:105,025,443...105,036,686
Ensembl chr11:105,025,397...105,035,250 		JBrowse link
G CASP10 caspase 10 multiple interactions
affects expression		 EXP [Diclofenac co-treated with Hyaluronic Acid] results in increased activity of CASP10 protein
Diclofenac affects the expression of CASP10 mRNA		 CTD PMID:20237495 PMID:24752500 NCBI chr 2:201,183,141...201,229,406
Ensembl chr 2:201,182,872...201,229,428 		JBrowse link
G CASP2 caspase 2 multiple interactions
affects expression		 EXP Diclofenac inhibits the reaction [Thapsigargin results in increased activity of CASP2 protein]; Diclofenac inhibits the reaction [Tunicamycin results in increased activity of CASP2 protein]
Diclofenac affects the expression of CASP2 mRNA		 CTD PMID:16388830 PMID:24752500 NCBI chr 7:143,288,351...143,307,696
Ensembl chr 7:143,288,215...143,307,696 		JBrowse link
G CASP3 caspase 3 increases activity
multiple interactions		 ISO
EXP		 Diclofenac results in increased activity of CASP3 protein
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[TNF protein co-treated with IFNG protein] promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Diclofenac results in increased activity of CASP3 protein]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [IFNG protein promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [TNF protein promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; 2-aminoethoxydiphenyl borate inhibits the reaction [[TNF protein co-treated with IFNG protein] promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; 2-aminoethoxydiphenyl borate inhibits the reaction [TNF protein promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; [TNF protein co-treated with IFNG protein] promotes the reaction [Diclofenac results in increased activity of CASP3 protein]; Diclofenac inhibits the reaction [Thapsigargin results in increased activity of CASP3 protein]; Diclofenac inhibits the reaction [Tunicamycin results in increased activity of CASP3 protein]; IFNG protein promotes the reaction [Diclofenac results in increased activity of CASP3 protein]; TNF protein promotes the reaction [Diclofenac results in increased activity of CASP3 protein]
2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinone inhibits the reaction [Diclofenac results in increased activity of CASP3 protein]; [Water deficiency co-treated with Diclofenac] results in increased expression of CASP3 protein; alpha-Tocopherol inhibits the reaction [Diclofenac results in increased activity of CASP3 protein]; Cyclosporine inhibits the reaction [Diclofenac results in increased activity of CASP3 protein]; Gum Arabic inhibits the reaction [[Water deficiency co-treated with Diclofenac] results in increased expression of CASP3 protein]; Thiourea analog inhibits the reaction [Diclofenac results in increased activity of CASP3 protein]		 CTD PMID:12826271 PMID:14599462 PMID:14609740 PMID:16388830 PMID:24770551 More... NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CASP6 caspase 6 affects expression EXP Diclofenac affects the expression of CASP6 mRNA CTD PMID:24752500 NCBI chr 4:109,664,388...109,709,767
Ensembl chr 4:109,688,622...109,703,583 		JBrowse link
G CASP8 caspase 8 increases activity
affects expression
multiple interactions		 ISO
EXP		 Diclofenac results in increased activity of CASP8 protein
Diclofenac affects the expression of CASP8 mRNA
[Diclofenac co-treated with Hyaluronic Acid] results in increased activity of CASP8 protein; [TNF protein co-treated with Diclofenac] results in increased activity of CASP8 protein; Acetylcysteine inhibits the reaction [[TNF protein co-treated with Diclofenac] results in increased activity of CASP8 protein]; Acetylcysteine inhibits the reaction [Diclofenac results in increased activity of CASP8 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [[TNF protein co-treated with Diclofenac] results in increased activity of CASP8 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [Diclofenac results in increased activity of CASP8 protein]		 CTD PMID:14609740 PMID:20237495 PMID:24752500 PMID:27313093 NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836 		JBrowse link
G CASP9 caspase 9 multiple interactions
increases expression
increases activity		 EXP
ISO		 [TNF protein co-treated with Diclofenac] results in increased activity of CASP9 protein; Acetylcysteine inhibits the reaction [[TNF protein co-treated with Diclofenac] results in increased activity of CASP9 protein]; Acetylcysteine inhibits the reaction [Diclofenac results in increased activity of CASP9 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [[TNF protein co-treated with Diclofenac] results in increased activity of CASP9 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [Diclofenac results in increased activity of CASP9 protein]; Diclofenac inhibits the reaction [Thapsigargin results in increased activity of CASP9 protein]; Diclofenac inhibits the reaction [Tunicamycin results in increased activity of CASP9 protein]
Diclofenac results in increased expression of CASP9 mRNA		 CTD PMID:14609740 PMID:16388830 PMID:25014874 PMID:27313093 PMID:29027214 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534 		JBrowse link
G CAT catalase increases activity
decreases activity
multiple interactions		 ISO Diclofenac results in increased activity of CAT protein
Diclofenac results in decreased activity of CAT protein
Ondansetron promotes the reaction [Diclofenac results in decreased activity of CAT protein]
[Water deficiency co-treated with Diclofenac] results in decreased activity of CAT protein; Acetylcysteine inhibits the reaction [Diclofenac results in decreased activity of CAT protein]; Diclofenac inhibits the reaction [Freund's Adjuvant results in decreased activity of CAT protein]; Gum Arabic inhibits the reaction [[Water deficiency co-treated with Diclofenac] results in decreased activity of CAT protein]; Silymarin inhibits the reaction [Diclofenac results in decreased activity of CAT protein]		 CTD PMID:17274466 PMID:23994749 PMID:28535741 PMID:31042592 PMID:31332906 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060 		JBrowse link
G CBL Cbl proto-oncogene affects expression EXP Diclofenac affects the expression of CBL mRNA CTD PMID:24752500 NCBI chr11:119,206,339...119,308,149
Ensembl chr11:119,206,298...119,313,926 		JBrowse link
G CBR1 carbonyl reductase 1 affects expression EXP Diclofenac affects the expression of CBR1 mRNA CTD PMID:24752500 NCBI chr21:36,070,024...36,073,164
Ensembl chr21:36,069,941...36,073,166 		JBrowse link
G CBS cystathionine beta-synthase affects expression EXP Diclofenac affects the expression of CBS mRNA CTD PMID:24752500 NCBI chr21:43,053,191...43,076,873
Ensembl chr21:43,053,191...43,076,943 		JBrowse link
G CCDC137 coiled-coil domain containing 137 increases expression ISO Diclofenac results in increased expression of CCDC137 mRNA CTD PMID:35537566 NCBI chr17:81,666,737...81,673,899
Ensembl chr17:81,666,737...81,673,904 		JBrowse link
G CCL15 C-C motif chemokine ligand 15 increases expression ISO Diclofenac results in increased expression of CCL6 mRNA CTD PMID:26934552 NCBI chr17:35,997,582...36,001,553
Ensembl chr17:35,996,440...36,001,553 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 multiple interactions
increases secretion
increases expression
affects expression		 ISO
EXP		 [Water deficiency co-treated with Diclofenac] results in increased expression of CCL2 protein; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 mRNA]; Gum Arabic inhibits the reaction [[Water deficiency co-treated with Diclofenac] results in increased expression of CCL2 protein]
Diclofenac analog results in increased secretion of CCL2 protein
SB 203580 inhibits the reaction [Diclofenac analog results in increased expression of CCL2 mRNA]; U 0126 inhibits the reaction [Diclofenac analog results in increased expression of CCL2 mRNA]
Diclofenac results in increased expression of CCL2 protein
Diclofenac affects the expression of CCL2 mRNA
Diclofenac results in increased expression of CCL2 mRNA		 CTD PMID:22285467 PMID:23939143 PMID:24104198 PMID:25051504 PMID:27671914 More... NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208 		JBrowse link
G CCL23 C-C motif chemokine ligand 23 increases expression ISO Diclofenac results in increased expression of CCL9 mRNA CTD PMID:26934552 NCBI chr17:36,013,058...36,017,972
Ensembl chr17:36,013,056...36,017,972 		JBrowse link
G CCL3 C-C motif chemokine ligand 3 multiple interactions
decreases expression		 ISO Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL3 mRNA]
Diclofenac results in decreased expression of CCL3 mRNA		 CTD PMID:23939143 PMID:35537566 NCBI chr17:36,088,256...36,090,143
Ensembl chr17:36,088,256...36,090,169 		JBrowse link
G CCN1 cellular communication network factor 1 affects expression
increases expression		 EXP Diclofenac affects the expression of CCN1 mRNA
Diclofenac results in increased expression of CCN1 mRNA		 CTD PMID:19192274 PMID:24752500 NCBI chr 1:85,580,761...85,583,950
Ensembl chr 1:85,580,761...85,584,589 		JBrowse link
G CCND1 cyclin D1 multiple interactions
affects expression
decreases expression
increases expression		 EXP
ISO		 Diclofenac inhibits the reaction [TNF protein results in increased expression of CCND1 protein]
Diclofenac affects the expression of CCND1 mRNA
Diclofenac results in decreased expression of CCND1 mRNA
Diclofenac results in increased expression of CCND1 mRNA
Diclofenac results in decreased expression of CCND1 protein		 CTD PMID:15188006 PMID:15489888 PMID:19022234 PMID:26934552 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474 		JBrowse link
G CCND3 cyclin D3 affects expression EXP Diclofenac affects the expression of CCND3 mRNA CTD PMID:24752500 NCBI chr 6:41,934,933...42,050,035
Ensembl chr 6:41,934,934...42,050,357 		JBrowse link
G CCNE1 cyclin E1 affects expression EXP Diclofenac affects the expression of CCNE1 mRNA CTD PMID:24752500 NCBI chr19:29,811,991...29,824,312
Ensembl chr19:29,811,991...29,824,312 		JBrowse link
G CCNE2 cyclin E2 affects expression EXP Diclofenac affects the expression of CCNE2 mRNA CTD PMID:24752500 NCBI chr 8:94,880,224...94,896,693
Ensembl chr 8:94,879,770...94,896,678 		JBrowse link
G CCNF cyclin F affects expression EXP Diclofenac affects the expression of CCNF mRNA CTD PMID:24752500 NCBI chr16:2,429,447...2,458,854
Ensembl chr16:2,429,394...2,458,854 		JBrowse link
G CCNG1 cyclin G1 increases expression ISO Diclofenac results in increased expression of CCNG1 mRNA CTD PMID:19022234 NCBI chr 5:163,437,571...163,457,640
Ensembl chr 5:163,437,569...163,448,199 		JBrowse link
G CCNH cyclin H affects expression EXP Diclofenac affects the expression of CCNH mRNA CTD PMID:24752500 NCBI chr 5:87,311,471...87,412,930
Ensembl chr 5:87,318,416...87,413,029 		JBrowse link
G CCR1 C-C motif chemokine receptor 1 increases expression ISO Diclofenac results in increased expression of CCR1 mRNA CTD PMID:26934552 NCBI chr 3:46,201,711...46,208,313
Ensembl chr 3:46,201,711...46,208,313 		JBrowse link
G CCR5 C-C motif chemokine receptor 5 increases expression ISO Diclofenac results in increased expression of CCR5 mRNA CTD PMID:26934552 NCBI chr 3:46,370,142...46,376,206
Ensembl chr 3:46,370,946...46,376,206 		JBrowse link
G CD14 CD14 molecule increases expression ISO Diclofenac results in increased expression of CD14 mRNA CTD PMID:26934552 NCBI chr 5:140,631,732...140,633,701
Ensembl chr 5:140,631,728...140,633,700 		JBrowse link
G CD163 CD163 molecule increases expression ISO Diclofenac results in increased expression of CD163 mRNA CTD PMID:26934552 NCBI chr12:7,470,811...7,503,777
Ensembl chr12:7,470,811...7,503,893 		JBrowse link
G CD200R1L CD200 receptor 1 like decreases expression ISO Diclofenac results in decreased expression of CD200R4 mRNA CTD PMID:35537566 NCBI chr 3:112,815,711...112,846,864
Ensembl chr 3:112,815,709...112,846,864 		JBrowse link
G CD244 CD244 molecule decreases expression ISO Diclofenac results in decreased expression of CD244 mRNA CTD PMID:35537566 NCBI chr 1:160,830,160...160,862,887
Ensembl chr 1:160,830,160...160,862,887 		JBrowse link
G CD28 CD28 molecule increases expression ISO Diclofenac results in increased expression of CD28 mRNA CTD PMID:26934552 NCBI chr 2:203,706,482...203,738,912
Ensembl chr 2:203,706,517...203,739,756 		JBrowse link
G CD44 CD44 molecule (IN blood group) increases expression ISO Diclofenac results in increased expression of CD44 mRNA CTD PMID:26934552 NCBI chr11:35,139,171...35,232,402
Ensembl chr11:35,138,882...35,232,402 		JBrowse link
G CD55 CD55 molecule (Cromer blood group) increases expression ISO Diclofenac results in increased expression of CD55 mRNA CTD PMID:26934552 NCBI chr 1:207,321,678...207,360,966
Ensembl chr 1:207,321,519...207,386,804 		JBrowse link
G CD5L CD5 molecule like increases expression ISO Diclofenac results in increased expression of CD5L mRNA CTD PMID:26934552 NCBI chr 1:157,827,068...157,841,808
Ensembl chr 1:157,830,911...157,898,256 		JBrowse link
G CD9 CD9 molecule increases expression ISO Diclofenac results in increased expression of CD9 mRNA CTD PMID:26934552 NCBI chr12:6,199,946...6,238,266
Ensembl chr12:6,199,715...6,238,271 		JBrowse link
G CDC42EP5 CDC42 effector protein 5 decreases expression ISO Diclofenac results in decreased expression of CDC42EP5 mRNA CTD PMID:26934552 NCBI chr19:54,465,026...54,473,296
Ensembl chr19:54,465,026...54,473,296 		JBrowse link
G CDC6 cell division cycle 6 affects expression EXP Diclofenac affects the expression of CDC6 mRNA CTD PMID:24752500 NCBI chr17:40,287,879...40,304,657
Ensembl chr17:40,287,879...40,304,657 		JBrowse link
G CDC7 cell division cycle 7 affects expression EXP Diclofenac affects the expression of CDC7 mRNA CTD PMID:24752500 NCBI chr 1:91,500,851...91,525,764
Ensembl chr 1:91,500,851...91,525,764 		JBrowse link
G CDCA5 cell division cycle associated 5 increases expression ISO Diclofenac results in increased expression of CDCA5 mRNA CTD PMID:26934552 NCBI chr11:65,061,093...65,084,040
Ensembl chr11:65,066,300...65,084,164 		JBrowse link
G CDH1 cadherin 1 increases expression
affects expression
decreases expression		 EXP
ISO		 Diclofenac results in increased expression of CDH1 protein
Diclofenac affects the expression of CDH1 mRNA
Diclofenac results in decreased expression of CDH1 mRNA		 CTD PMID:19022234 PMID:19628293 PMID:24752500 NCBI chr16:68,737,292...68,835,537
Ensembl chr16:68,737,292...68,835,537 		JBrowse link
G CDK2 cyclin dependent kinase 2 affects expression EXP Diclofenac affects the expression of CDK2 mRNA CTD PMID:24752500 NCBI chr12:55,966,830...55,972,789
Ensembl chr12:55,966,781...55,972,789 		JBrowse link
G CDK5 cyclin dependent kinase 5 affects expression EXP Diclofenac affects the expression of CDK5 mRNA CTD PMID:24752500 NCBI chr 7:151,053,815...151,057,897
Ensembl chr 7:151,053,815...151,057,897 		JBrowse link
G CDK5R1 cyclin dependent kinase 5 regulatory subunit 1 increases expression ISO Diclofenac results in increased expression of CDK5R1 mRNA CTD PMID:30723492 NCBI chr17:32,486,993...32,491,253
Ensembl chr17:32,486,993...32,491,253 		JBrowse link
G CDK6 cyclin dependent kinase 6 affects expression EXP Diclofenac affects the expression of CDK6 mRNA CTD PMID:24752500 NCBI chr 7:92,604,921...92,836,573
Ensembl chr 7:92,604,921...92,836,573 		JBrowse link
G CDK7 cyclin dependent kinase 7 affects expression EXP Diclofenac affects the expression of CDK7 mRNA CTD PMID:24752500 NCBI chr 5:69,234,795...69,277,430
Ensembl chr 5:69,234,795...69,277,430 		JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A increases expression EXP
ISO		 Diclofenac results in increased expression of CDKN1A mRNA CTD PMID:19022234 PMID:26934552 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,397 		JBrowse link
G CDKN1B cyclin dependent kinase inhibitor 1B affects expression EXP Diclofenac affects the expression of CDKN1B mRNA CTD PMID:24752500 NCBI chr12:12,717,368...12,722,369
Ensembl chr12:12,685,498...12,722,369 		JBrowse link
G CDT1 chromatin licensing and DNA replication factor 1 affects expression EXP Diclofenac affects the expression of CDT1 mRNA CTD PMID:24752500 NCBI chr16:88,803,789...88,809,258
Ensembl chr16:88,803,789...88,809,258 		JBrowse link
G CEBPB CCAAT enhancer binding protein beta increases expression
affects expression		 EXP
ISO		 Diclofenac results in increased expression of CEBPB mRNA
Diclofenac affects the expression of CEBPB mRNA		 CTD PMID:19022234 PMID:24752500 NCBI chr20:50,190,583...50,192,690
Ensembl chr20:50,190,734...50,192,690 		JBrowse link
G CEBPG CCAAT enhancer binding protein gamma decreases expression ISO Diclofenac results in decreased expression of CEBPG mRNA CTD PMID:35537566 NCBI chr19:33,373,709...33,382,686
Ensembl chr19:33,373,685...33,382,686 		JBrowse link
G CEP162 centrosomal protein 162 decreases expression ISO Diclofenac results in decreased expression of CEP162 mRNA CTD PMID:35537566 NCBI chr 6:84,124,250...84,227,643
Ensembl chr 6:84,124,241...84,227,643 		JBrowse link
G CERS6 ceramide synthase 6 increases expression ISO Diclofenac results in increased expression of CERS6 mRNA CTD PMID:26934552 NCBI chr 2:168,456,272...168,775,134
Ensembl chr 2:168,456,249...168,775,134 		JBrowse link
G CES1 carboxylesterase 1 decreases expression ISO Diclofenac results in decreased expression of CES1D mRNA CTD PMID:26934552 NCBI chr16:55,802,851...55,833,096
Ensembl chr16:55,802,851...55,833,337 		JBrowse link
G CFAP97D1 CFAP97 domain containing 1 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of CFAP97D1 mRNA CTD PMID:37844793 NCBI chr17:43,780,435...43,787,620
Ensembl chr17:43,780,435...43,787,620 		JBrowse link
G CFH complement factor H increases expression ISO Diclofenac results in increased expression of CFH mRNA CTD PMID:26934552 NCBI chr 1:196,652,043...196,747,504
Ensembl chr 1:196,651,754...196,752,476 		JBrowse link
G CFLAR CASP8 and FADD like apoptosis regulator multiple interactions
affects expression		 EXP [Diclofenac co-treated with Hyaluronic Acid] results in decreased expression of CFLAR protein
Diclofenac affects the expression of CFLAR mRNA		 CTD PMID:20237495 PMID:24752500 NCBI chr 2:201,116,164...201,176,687
Ensembl chr 2:201,116,154...201,176,687 		JBrowse link
G CGREF1 cell growth regulator with EF-hand domain 1 decreases expression ISO Diclofenac results in decreased expression of CGREF1 mRNA CTD PMID:26934552 NCBI chr 2:27,099,353...27,119,128
Ensembl chr 2:27,098,889...27,119,128 		JBrowse link
G CHAC1 ChaC glutathione specific gamma-glutamylcyclotransferase 1 increases expression
decreases expression		 ISO Diclofenac results in increased expression of CHAC1 mRNA
Diclofenac results in decreased expression of CHAC1 mRNA		 CTD PMID:26934552 PMID:35537566 NCBI chr15:40,953,471...40,956,512
Ensembl chr15:40,952,962...40,956,512 		JBrowse link
G CHCHD1 coiled-coil-helix-coiled-coil-helix domain containing 1 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of CHCHD1 mRNA CTD PMID:37844793 NCBI chr10:73,782,048...73,783,652
Ensembl chr10:73,782,047...73,783,652 		JBrowse link
G CHDH choline dehydrogenase affects expression EXP Diclofenac affects the expression of CHDH mRNA CTD PMID:24752500 NCBI chr 3:53,812,335...53,846,419
Ensembl chr 3:53,812,335...53,846,419 		JBrowse link
G CHEK1 checkpoint kinase 1 affects expression EXP Diclofenac affects the expression of CHEK1 mRNA CTD PMID:24752500 NCBI chr11:125,625,136...125,681,124
Ensembl chr11:125,625,163...125,676,255 		JBrowse link
G CHKA choline kinase alpha affects expression EXP Diclofenac affects the expression of CHKA mRNA CTD PMID:24752500 NCBI chr11:68,052,859...68,121,388
Ensembl chr11:68,052,859...68,121,444 		JBrowse link
G CHKB choline kinase beta affects expression EXP Diclofenac affects the expression of CHKB mRNA CTD PMID:24752500 NCBI chr22:50,578,963...50,582,849
Ensembl chr22:50,578,959...50,601,455 		JBrowse link
G CHL1 cell adhesion molecule L1 like increases expression ISO Diclofenac results in increased expression of CHL1 mRNA CTD PMID:26934552 NCBI chr 3:196,763...409,417
Ensembl chr 3:196,763...409,417 		JBrowse link
G CHST4 carbohydrate sulfotransferase 4 decreases expression ISO Diclofenac results in decreased expression of CHST4 mRNA CTD PMID:26934552 NCBI chr16:71,526,120...71,538,748
Ensembl chr16:71,525,233...71,538,748 		JBrowse link
G CHUK component of inhibitor of nuclear factor kappa B kinase complex multiple interactions EXP
ISO		 Diclofenac inhibits the reaction [TNF protein results in increased activity of CHUK protein]
Diclofenac inhibits the reaction [Freund's Adjuvant results in increased phosphorylation of CHUK protein]		 CTD PMID:15489888 PMID:25935278 NCBI chr10:100,186,319...100,229,596
Ensembl chr10:100,188,300...100,229,596 		JBrowse link
G CIB1 calcium and integrin binding 1 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of CIB1 mRNA CTD PMID:37844793 NCBI chr15:90,229,975...90,265,759
Ensembl chr15:90,229,975...90,234,047 		JBrowse link
G CLEC2D C-type lectin domain family 2 member D decreases expression ISO Diclofenac results in decreased expression of CLEC2H mRNA CTD PMID:26934552 NCBI chr12:9,669,713...9,699,553
Ensembl chr12:9,664,969...9,699,553 		JBrowse link
G CLEC6A C-type lectin domain containing 6A increases expression ISO Diclofenac results in increased expression of CLEC4N mRNA CTD PMID:26934552 NCBI chr12:8,455,962...8,478,330
Ensembl chr12:8,455,962...8,478,330 		JBrowse link
G CLU clusterin increases expression
multiple interactions		 ISO Diclofenac results in increased expression of CLU protein
[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of CLU protein		 CTD PMID:23506792 PMID:25772430 NCBI chr 8:27,596,917...27,614,700
Ensembl chr 8:27,596,917...27,614,700 		JBrowse link
G CMPK2 cytidine/uridine monophosphate kinase 2 affects expression EXP Diclofenac affects the expression of CMPK2 mRNA CTD PMID:24752500 NCBI chr 2:6,840,553...6,866,635
Ensembl chr 2:6,840,570...6,866,635 		JBrowse link
G COL3A1 collagen type III alpha 1 chain decreases expression
multiple interactions		 ISO Diclofenac results in decreased expression of COL3A1 mRNA
[Water deficiency co-treated with Diclofenac] results in increased expression of COL3A1 protein; Gum Arabic inhibits the reaction [[Water deficiency co-treated with Diclofenac] results in increased expression of COL3A1 protein]		 CTD PMID:26934552 PMID:31042592 NCBI chr 2:188,974,373...189,012,746
Ensembl chr 2:188,974,373...189,012,746 		JBrowse link
G COTL1 coactosin like F-actin binding protein 1 increases expression ISO Diclofenac results in increased expression of COTL1 mRNA CTD PMID:26934552 NCBI chr16:84,565,596...84,618,078
Ensembl chr16:84,565,596...84,618,078 		JBrowse link
G COX4I2 cytochrome c oxidase subunit 4I2 increases expression ISO Diclofenac results in increased expression of COX4I2 mRNA CTD PMID:35537566 NCBI chr20:31,637,912...31,645,006
Ensembl chr20:31,637,912...31,645,006 		JBrowse link
G COX6A2 cytochrome c oxidase subunit 6A2 decreases expression ISO Diclofenac results in decreased expression of COX6A2 mRNA CTD PMID:35537566 NCBI chr16:31,427,731...31,428,360
Ensembl chr16:31,427,731...31,428,360 		JBrowse link
G CPB2 carboxypeptidase B2 increases expression ISO Diclofenac results in increased expression of CPB2 mRNA CTD PMID:26934552 NCBI chr13:46,053,186...46,105,033
Ensembl chr13:46,053,186...46,105,033 		JBrowse link
G CPLX1 complexin 1 increases expression ISO Diclofenac results in increased expression of CPLX1 mRNA CTD PMID:30723492 NCBI chr 4:784,957...826,129
Ensembl chr 4:784,957...826,129 		JBrowse link
G CPLX4 complexin 4 increases expression ISO Diclofenac results in increased expression of CPLX4 mRNA CTD PMID:30723492 NCBI chr18:59,295,402...59,318,649
Ensembl chr18:59,275,156...59,318,649 		JBrowse link
G CPNE8 copine 8 increases expression ISO Diclofenac results in increased expression of CPNE8 mRNA CTD PMID:26934552 NCBI chr12:38,652,203...38,906,835
Ensembl chr12:38,646,822...38,907,430 		JBrowse link
G CPSF6 cleavage and polyadenylation specific factor 6 affects expression EXP Diclofenac affects the expression of CPSF6 mRNA CTD PMID:24752500 NCBI chr12:69,239,569...69,274,358
Ensembl chr12:69,239,569...69,274,358 		JBrowse link
G CPT1A carnitine palmitoyltransferase 1A increases expression EXP
ISO		 Diclofenac results in increased expression of CPT1A mRNA CTD PMID:19022234 NCBI chr11:68,754,620...68,844,277
Ensembl chr11:68,754,620...68,844,410 		JBrowse link
G CR1L complement C3b/C4b receptor 1 like multiple interactions ISO [Water deficiency co-treated with Diclofenac] results in decreased expression of CR1L protein; Gum Arabic inhibits the reaction [[Water deficiency co-treated with Diclofenac] results in decreased expression of CR1L protein] CTD PMID:31042592 NCBI chr 1:207,645,133...207,723,703
Ensembl chr 1:207,645,113...207,738,416 		JBrowse link
G CR2 complement C3d receptor 2 affects expression ISO Diclofenac affects the expression of CR2 mRNA CTD PMID:26934552 NCBI chr 1:207,454,328...207,489,892
Ensembl chr 1:207,453,024...207,489,895 		JBrowse link
G CREB3L2 cAMP responsive element binding protein 3 like 2 increases expression ISO Diclofenac results in increased expression of CREB3L2 mRNA CTD PMID:26934552 NCBI chr 7:137,874,979...138,002,086
Ensembl chr 7:137,874,979...138,002,086 		JBrowse link
G CREB3L4 cAMP responsive element binding protein 3 like 4 affects expression EXP Diclofenac affects the expression of CREB3L4 mRNA CTD PMID:24752500 NCBI chr 1:153,967,487...153,974,359
Ensembl chr 1:153,967,534...153,974,361 		JBrowse link
G CRP C-reactive protein multiple interactions
decreases expression		 ISO
EXP		 [Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of CRP protein; Diclofenac inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CRP protein]; lipopolysaccharide, E coli O55-B5 inhibits the reaction [Diclofenac results in decreased expression of CRP protein]
Diclofenac inhibits the reaction [TNF protein results in increased expression of CRP mRNA]; Diclofenac inhibits the reaction [TNF protein results in increased secretion of CRP protein]		 CTD PMID:25772430 PMID:27313093 NCBI chr 1:159,712,289...159,714,589
Ensembl chr 1:159,712,289...159,714,589 		JBrowse link
G CRY1 cryptochrome circadian regulator 1 decreases expression ISO Diclofenac results in decreased expression of CRY1 mRNA CTD PMID:26934552 NCBI chr12:106,991,364...107,093,549
Ensembl chr12:106,991,364...107,093,549 		JBrowse link
G CSF1 colony stimulating factor 1 decreases expression ISO Diclofenac results in decreased expression of CSF1 mRNA CTD PMID:26934552 PMID:35537566 NCBI chr 1:109,910,506...109,930,992
Ensembl chr 1:109,910,242...109,930,992 		JBrowse link
G CSF1R colony stimulating factor 1 receptor increases secretion
increases expression		 ISO Diclofenac results in increased secretion of CSF1R protein
Diclofenac results in increased expression of CSF1R mRNA		 CTD PMID:26934552 NCBI chr 5:150,053,295...150,113,365
Ensembl chr 5:150,053,291...150,113,372 		JBrowse link
G CSF2RB colony stimulating factor 2 receptor subunit beta increases expression ISO Diclofenac results in increased expression of CSF2RB mRNA; Diclofenac results in increased expression of CSF2RB2 mRNA CTD PMID:26934552 NCBI chr22:36,913,628...36,940,439
Ensembl chr22:36,913,628...36,940,439 		JBrowse link
G CSNK2A1 casein kinase 2 alpha 1 affects expression EXP Diclofenac affects the expression of CSNK2A1 mRNA CTD PMID:24752500 NCBI chr20:472,498...543,790
Ensembl chr20:472,498...543,835 		JBrowse link
G CSNK2A2 casein kinase 2 alpha 2 affects expression EXP Diclofenac affects the expression of CSNK2A2 mRNA CTD PMID:24752500 NCBI chr16:58,157,907...58,198,106
Ensembl chr16:58,157,907...58,198,106 		JBrowse link
G CSRNP3 cysteine and serine rich nuclear protein 3 increases expression ISO Diclofenac results in increased expression of CSRNP3 mRNA CTD PMID:30723492 NCBI chr 2:165,469,698...165,689,407
Ensembl chr 2:165,469,647...165,689,407 		JBrowse link
G CSTF2 cleavage stimulation factor subunit 2 affects expression EXP Diclofenac affects the expression of CSTF2 mRNA CTD PMID:24752500 NCBI chr  X:100,820,391...100,841,520
Ensembl chr  X:100,820,391...100,841,520 		JBrowse link
G CSTF3 cleavage stimulation factor subunit 3 affects expression EXP Diclofenac affects the expression of CSTF3 mRNA CTD PMID:24752500 NCBI chr11:33,084,584...33,161,480
Ensembl chr11:33,077,188...33,162,371 		JBrowse link
G CTBP2 C-terminal binding protein 2 affects expression EXP Diclofenac affects the expression of CTBP2 mRNA CTD PMID:24752500 NCBI chr10:124,984,317...125,162,463
Ensembl chr10:124,984,317...125,161,170 		JBrowse link
G CTH cystathionine gamma-lyase affects expression
decreases expression		 EXP
ISO		 Diclofenac affects the expression of CTH mRNA
Diclofenac results in decreased expression of CTH mRNA		 CTD PMID:24752500 PMID:35537566 NCBI chr 1:70,411,268...70,439,851
Ensembl chr 1:70,411,218...70,439,851 		JBrowse link
G CTLA4 cytotoxic T-lymphocyte associated protein 4 increases expression ISO Diclofenac results in increased expression of CTLA4 protein CTD PMID:26934552 NCBI chr 2:203,867,771...203,873,965
Ensembl chr 2:203,853,888...203,873,965 		JBrowse link
G CTNNB1 catenin beta 1 affects expression EXP Diclofenac affects the expression of CTNNB1 mRNA CTD PMID:24752500 NCBI chr 3:41,199,505...41,240,443
Ensembl chr 3:41,194,741...41,260,096 		JBrowse link
G CTPS1 CTP synthase 1 affects expression EXP Diclofenac affects the expression of CTPS1 mRNA CTD PMID:24752500 NCBI chr 1:40,979,696...41,012,565
Ensembl chr 1:40,979,300...41,012,565 		JBrowse link
G CTPS2 CTP synthase 2 affects expression EXP Diclofenac affects the expression of CTPS2 mRNA CTD PMID:24752500 NCBI chr  X:16,587,999...16,712,910
Ensembl chr  X:16,587,999...16,712,936 		JBrowse link
G CTSC cathepsin C increases expression ISO Diclofenac results in increased expression of CTSC mRNA CTD PMID:26934552 NCBI chr11:88,293,592...88,337,736
Ensembl chr11:88,265,069...88,359,684 		JBrowse link
G CTSE cathepsin E decreases expression ISO Diclofenac results in decreased expression of CTSE mRNA CTD PMID:35537566 NCBI chr 1:206,009,264...206,023,895
Ensembl chr 1:206,008,535...206,023,909 		JBrowse link
G CTSS cathepsin S increases expression ISO Diclofenac results in increased expression of CTSS mRNA CTD PMID:26934552 NCBI chr 1:150,730,188...150,765,778
Ensembl chr 1:150,730,079...150,765,957 		JBrowse link
G CUL3 cullin 3 affects expression EXP Diclofenac affects the expression of CUL3 mRNA CTD PMID:24752500 NCBI chr 2:224,470,150...224,585,363
Ensembl chr 2:224,470,150...224,585,397 		JBrowse link
G CUL7 cullin 7 decreases expression ISO Diclofenac results in decreased expression of CUL7 mRNA CTD PMID:26934552 NCBI chr 6:43,037,617...43,053,851
Ensembl chr 6:43,037,617...43,053,943 		JBrowse link
G CXCL1 C-X-C motif chemokine ligand 1 multiple interactions
decreases expression
increases expression		 ISO Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CXCL1 mRNA]; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CXCL1 protein]
Diclofenac results in decreased expression of CXCL1 mRNA
Diclofenac results in increased expression of CXCL1 mRNA; Diclofenac results in increased expression of CXCL1 protein		 CTD PMID:23939143 PMID:26934552 PMID:27671914 NCBI chr 4:73,869,393...73,871,308
Ensembl chr 4:73,869,393...73,871,308 		JBrowse link
G CXCL13 C-X-C motif chemokine ligand 13 increases expression ISO Diclofenac results in increased expression of CXCL13 mRNA CTD PMID:26934552 NCBI chr 4:77,511,753...77,611,834
Ensembl chr 4:77,511,753...77,611,834 		JBrowse link
G CXCL14 C-X-C motif chemokine ligand 14 increases expression ISO Diclofenac results in increased expression of CXCL14 mRNA CTD PMID:26934552 NCBI chr 5:135,570,679...135,578,991
Ensembl chr 5:135,570,679...135,579,279 		JBrowse link
G CXCL2 C-X-C motif chemokine ligand 2 multiple interactions
increases expression		 ISO Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CXCL2 mRNA]
Diclofenac results in increased expression of CXCL2 mRNA; Diclofenac results in increased expression of CXCL2 protein		 CTD PMID:22285467 PMID:23939143 PMID:24747151 PMID:26934552 PMID:27671914 NCBI chr 4:74,097,040...74,099,195
Ensembl chr 4:74,097,040...74,099,196 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 affects expression
increases secretion
increases expression
multiple interactions
decreases expression		 EXP Diclofenac affects the expression of CXCL8 mRNA
Diclofenac analog results in increased secretion of CXCL8 protein
Diclofenac analog results in increased expression of CXCL8 mRNA; Diclofenac results in increased expression of CXCL8 mRNA
Diclofenac inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; Diclofenac inhibits the reaction [TNF protein results in increased secretion of CXCL8 protein]; Diclofenac promotes the reaction [Mustard Gas results in increased secretion of CXCL8 protein]; pyrazolanthrone inhibits the reaction [Diclofenac analog results in increased expression of CXCL8 mRNA]; SB 203580 inhibits the reaction [Diclofenac analog results in increased expression of CXCL8 mRNA]
Diclofenac results in decreased expression of CXCL8 mRNA; Diclofenac results in decreased expression of CXCL8 protein		 CTD PMID:17379860 PMID:19192274 PMID:24104198 PMID:24752500 PMID:27313093 More... NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716 		JBrowse link
G CXCR4 C-X-C motif chemokine receptor 4 decreases expression EXP
ISO		 Diclofenac results in decreased expression of CXCR4 mRNA CTD PMID:19192274 PMID:35537566 NCBI chr 2:136,114,349...136,118,149
Ensembl chr 2:136,114,349...136,119,177 		JBrowse link
G CYB561 cytochrome b561 increases expression ISO Diclofenac results in increased expression of CYB561 mRNA CTD PMID:26934552 NCBI chr17:63,432,304...63,446,639
Ensembl chr17:63,432,304...63,446,354 		JBrowse link
G CYBA cytochrome b-245 alpha chain increases expression ISO Diclofenac results in increased expression of CYBA mRNA CTD PMID:26934552 NCBI chr16:88,643,289...88,651,053
Ensembl chr16:88,643,275...88,651,083 		JBrowse link
G CYBB cytochrome b-245 beta chain increases expression ISO Diclofenac results in increased expression of CYBB mRNA CTD PMID:26934552 NCBI chr  X:37,780,059...37,813,461
Ensembl chr  X:37,780,018...37,813,461 		JBrowse link
G CYCS cytochrome c, somatic affects expression EXP Diclofenac affects the expression of CYCS mRNA CTD PMID:24752500 NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260 		JBrowse link
G CYP17A1 cytochrome P450 family 17 subfamily A member 1 increases expression ISO Diclofenac results in increased expression of CYP17A1 mRNA CTD PMID:26934552 NCBI chr10:102,830,531...102,837,413
Ensembl chr10:102,830,531...102,837,472 		JBrowse link
G CYP19A1 cytochrome P450 family 19 subfamily A member 1 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of CYP19A1 mRNA CTD PMID:37844793 NCBI chr15:51,208,057...51,338,596
Ensembl chr15:51,208,057...51,338,601 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 increases expression
decreases activity		 EXP
ISO		 Diclofenac results in increased expression of CYP1A1 mRNA; Diclofenac results in increased expression of CYP1A1 protein
Diclofenac results in decreased activity of CYP1A1 protein		 CTD PMID:18420780 PMID:21784029 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536 		JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 increases expression
decreases activity
multiple interactions		 EXP Diclofenac results in increased expression of CYP1A2 mRNA; Diclofenac results in increased expression of CYP1A2 protein
Diclofenac metabolite results in decreased activity of CYP1A2 protein
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Diclofenac		 CTD PMID:21784029 PMID:23397584 PMID:28960974 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607 		JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 decreases activity ISO Diclofenac results in decreased activity of CYP1B1 protein CTD PMID:18420780 NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902 		JBrowse link
G CYP26A1 cytochrome P450 family 26 subfamily A member 1 decreases expression ISO Diclofenac results in decreased expression of CYP26A1 mRNA CTD PMID:26934552 NCBI chr10:93,073,475...93,077,885
Ensembl chr10:93,073,475...93,077,885 		JBrowse link
G CYP26B1 cytochrome P450 family 26 subfamily B member 1 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of CYP26B1 mRNA CTD PMID:37844793 NCBI chr 2:72,129,238...72,147,862
Ensembl chr 2:72,129,238...72,147,862 		JBrowse link
G CYP2A6 cytochrome P450 family 2 subfamily A member 6 affects expression ISO Diclofenac affects the expression of CYP2A5 mRNA CTD PMID:26934552 NCBI chr19:40,843,541...40,850,447
Ensembl chr19:40,843,541...40,850,447 		JBrowse link
G CYP2A7 cytochrome P450 family 2 subfamily A member 7 affects expression
decreases activity		 ISO Diclofenac affects the expression of CYP2A4 mRNA
Diclofenac results in decreased activity of CYP2A4 protein		 CTD PMID:18420780 PMID:26934552 NCBI chr19:40,875,439...40,882,231
Ensembl chr19:40,875,439...40,882,752 		JBrowse link
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 decreases activity ISO Diclofenac results in decreased activity of CYP2B10 protein CTD PMID:18420780 NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398 		JBrowse link
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 multiple interactions
increases response to substance
increases hydroxylation		 EXP
ISO		 [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Diclofenac; [CYP2C19 protein co-treated with CYP2C9 protein] results in increased hydroxylation of Diclofenac
CYP2C19 protein results in increased susceptibility to Diclofenac
CYP2C6 protein results in increased hydroxylation of Diclofenac
CYP2C19 protein results in increased hydroxylation of Diclofenac		 CTD PMID:11911841 PMID:15486075 PMID:18511451 PMID:23397584 PMID:28762043 NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547 		JBrowse link
G CYP2C23P cytochrome P450 family 2 subfamily C member 23, pseudogene decreases expression ISO Diclofenac results in decreased expression of CYP2C23 mRNA CTD PMID:26934552 NCBI chr10:100,105,754...100,140,151
Ensembl chr10:100,105,754...100,140,151 		JBrowse link
G CYP2C8 cytochrome P450 family 2 subfamily C member 8 decreases activity ISO Diclofenac results in decreased activity of CYP2C29 protein CTD PMID:18420780 NCBI chr10:95,036,772...95,069,497
Ensembl chr10:95,036,772...95,069,497 		JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 decreases hydroxylation
decreases activity
increases hydroxylation
increases metabolic processing
multiple interactions
increases hydrolysis
affects hydrolysis
increases activity
increases oxidation
affects binding
affects metabolic processing		 EXP
ISO		 CYP2C9 gene polymorphism results in decreased hydroxylation of Diclofenac
Diclofenac results in decreased activity of CYP2C9 protein
CYP2C9 protein results in increased hydroxylation of Diclofenac
CYP2C9 mRNA results in increased metabolism of Diclofenac; CYP2C9 protein results in increased metabolism of Diclofenac
1-aminobenzotriazole inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Diclofenac]; 4-methylimidazole inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]; [5-bromotryptamine analog results in decreased activity of CYP2C9 protein] which results in decreased metabolism of Diclofenac; [5-chlorotryptamine analog results in decreased activity of CYP2C9 protein] which results in decreased metabolism of Diclofenac; [5-fluoro-alpha-methyltryptamine results in decreased activity of CYP2C9 protein] which results in decreased metabolism of Diclofenac; [5-fluorotryptamine analog results in decreased activity of CYP2C9 protein] which results in decreased metabolism of Diclofenac; [5-methyltryptamine analog results in decreased activity of CYP2C9 protein] which results in decreased metabolism of Diclofenac; [7-methyltryptamine analog results in decreased activity of CYP2C9 protein] which results in decreased metabolism of Diclofenac; [[CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [[Ticrynafen results in decreased activity of CYP2C9 protein] which affects the metabolism of Diclofenac] which affects the abundance of 4'-hydroxydiclofenac; [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Diclofenac; [CYP2C19 protein co-treated with CYP2C9 protein] results in increased hydroxylation of Diclofenac; [CYP2C9 mRNA results in increased metabolism of Diclofenac] which results in increased chemical synthesis of 4'-hydroxydiclofenac; [CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac; [CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased metabolism of Diclofenac; [CYP2C9 protein results in increased hydroxylation of Diclofenac] which results in increased chemical synthesis of 4'-hydroxydiclofenac; [CYP2C9 protein results in increased metabolism of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [CYP2C9 protein results in increased metabolism of Diclofenac] which results in increased chemical synthesis of 4'-hydroxydiclofenac; [CYP3A4 protein co-treated with CYP2C9 protein co-treated with UGT2B7 protein] results in increased susceptibility to Diclofenac; [CYP3A4 protein co-treated with CYP2C9 protein] results in increased susceptibility to Diclofenac; [Fluconazole results in decreased activity of CYP2C9 protein] which results in decreased metabolism of Diclofenac; [Sulfaphenazole results in decreased activity of CYP2C9 protein] which results in decreased metabolism of Diclofenac; [Ticrynafen results in decreased activity of CYP2C9 protein] which affects the metabolism of Diclofenac; [Tryptamines analog results in decreased activity of CYP2C9 protein] which results in decreased metabolism of Diclofenac; Amiodarone inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]; Benzbromarone inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]; Clotrimazole inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]; Cyclohexenes analog inhibits the reaction [CYP2C9 protein results in increased metabolism of Diclofenac]; CYP2C9 gene mutant form inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Diclofenac]; CYP2C9 protein results in increased hydroxylation of and results in increased susceptibility to Diclofenac; Fluconazole inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]; Fluvastatin inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]; Ibuprofen inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]; Ketoconazole inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]; Lansoprazole inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Diclofenac]; methysticin inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Diclofenac]; Miconazole inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]; Omeprazole inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Diclofenac]; Pantoprazole inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Diclofenac]; perfluorooctane sulfonic acid inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Diclofenac]; Piroxicam inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]; Quinine inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]; rabeprazole-thioether inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Diclofenac]; Sertraline inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]; sitaxsentan inhibits the reaction [CYP2C9 protein results in increased metabolism of Diclofenac]; Sulfaphenazole inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]; Sulfaphenazole inhibits the reaction [CYP2C9 protein results in increased metabolism of Diclofenac]; Sulfinpyrazone inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]; Ticrynafen inhibits the reaction [CYP2C9 protein results in increased metabolism of Diclofenac]; Tolbutamide inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]; Warfarin inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]; zafirlukast inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]
CYP2C9 protein results in increased hydrolysis of Diclofenac
CYP2C9 gene polymorphism affects the hydrolysis of Diclofenac
Diclofenac results in increased activity of CYP2C9 protein
CYP2C9 protein results in increased oxidation of Diclofenac
CYP2C9 protein binds to Diclofenac		 CTD PMID:9110362 PMID:9241660 PMID:9698079 PMID:10975605 PMID:10991840 More... NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091 		JBrowse link
G CYP2D6 cytochrome P450 family 2 subfamily D member 6 (gene/pseudogene) multiple interactions EXP [[CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Diclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac CTD PMID:23397584 PMID:24246759 NCBI chr22:42,126,499...42,130,810
Ensembl chr22:42,126,499...42,130,865 		JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 decreases activity EXP Diclofenac metabolite results in decreased activity of CYP2E1 protein CTD PMID:28960974 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220 		JBrowse link
G CYP39A1 cytochrome P450 family 39 subfamily A member 1 increases expression ISO Diclofenac results in increased expression of CYP39A1 mRNA CTD PMID:26934552 NCBI chr 6:46,549,580...46,652,818
Ensembl chr 6:46,549,580...46,652,830 		JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 increases expression
increases response to substance
increases metabolic processing
multiple interactions
decreases activity		 EXP Diclofenac results in increased expression of CYP3A4 mRNA
CYP3A4 protein results in increased susceptibility to Diclofenac
CYP3A4 protein results in increased metabolism of Diclofenac
[[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 5-hydroxydiclofenac; [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Diclofenac; [CYP3A4 protein co-treated with CYP2C9 protein co-treated with UGT2B7 protein] results in increased susceptibility to Diclofenac; [CYP3A4 protein co-treated with CYP2C9 protein] results in increased susceptibility to Diclofenac; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of Diclofenac; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac
Diclofenac metabolite results in decreased activity of CYP3A4 protein; Diclofenac results in decreased activity of CYP3A4 protein		 CTD PMID:15135088 PMID:19022234 PMID:23397584 PMID:24104198 PMID:24246759 More... NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248 		JBrowse link
G CYP3A5 cytochrome P450 family 3 subfamily A member 5 increases expression
decreases activity		 ISO Diclofenac results in increased expression of CYP3A13 mRNA
Diclofenac metabolite results in decreased activity of CYP3A13 protein		 CTD PMID:26934552 PMID:28960974 NCBI chr 7:99,648,194...99,679,996
Ensembl chr 7:99,648,194...99,679,996 		JBrowse link
G CYP46A1 cytochrome P450 family 46 subfamily A member 1 increases hydroxylation EXP CYP46A1 protein results in increased hydroxylation of Diclofenac CTD PMID:14640697 NCBI chr14:99,684,298...99,727,301
Ensembl chr14:99,684,298...99,727,301 		JBrowse link
G CYP4A11 cytochrome P450 family 4 subfamily A member 11 affects activity EXP Diclofenac affects the activity of CYP4A11 protein CTD PMID:37499995 NCBI chr 1:46,929,188...46,941,476
Ensembl chr 1:46,929,177...46,941,484 		JBrowse link
G CYP4A22 cytochrome P450 family 4 subfamily A member 22 decreases expression ISO Diclofenac results in decreased expression of CYP4A31 mRNA CTD PMID:26934552 NCBI chr 1:47,137,441...47,149,727
Ensembl chr 1:47,137,435...47,149,727 		JBrowse link
G CYP4F22 cytochrome P450 family 4 subfamily F member 22 decreases expression ISO Diclofenac results in decreased expression of CYP4F39 mRNA CTD PMID:35537566 NCBI chr19:15,508,525...15,552,317
Ensembl chr19:15,508,525...15,552,317 		JBrowse link
G CYP4V2 cytochrome P450 family 4 subfamily V member 2 decreases expression ISO Diclofenac results in decreased expression of CYP4V3 mRNA CTD PMID:26934552 NCBI chr 4:186,191,567...186,213,463
Ensembl chr 4:186,191,567...186,213,463 		JBrowse link
G CYP51A1 cytochrome P450 family 51 subfamily A member 1 decreases activity
increases expression		 ISO Diclofenac metabolite results in decreased activity of CYP51A1 protein
Diclofenac results in increased expression of CYP51 mRNA		 CTD PMID:26934552 PMID:28960974 NCBI chr 7:92,112,153...92,134,803
Ensembl chr 7:92,084,987...92,134,803 		JBrowse link
G CYP7A1 cytochrome P450 family 7 subfamily A member 1 increases expression ISO Diclofenac results in increased expression of CYP7A1 mRNA CTD PMID:26934552 NCBI chr 8:58,490,178...58,500,163
Ensembl chr 8:58,490,178...58,500,163 		JBrowse link
G CYP8B1 cytochrome P450 family 8 subfamily B member 1 decreases expression ISO Diclofenac results in decreased expression of CYP8B1 mRNA CTD PMID:26934552 NCBI chr 3:42,872,192...42,875,879
Ensembl chr 3:42,856,005...42,875,898 		JBrowse link
G DAP death associated protein increases expression ISO Diclofenac results in increased expression of DAP mRNA CTD PMID:26934552 NCBI chr 5:10,679,230...10,761,234
Ensembl chr 5:10,679,230...10,761,234 		JBrowse link
G DBT dihydrolipoamide branched chain transacylase E2 affects expression EXP Diclofenac affects the expression of DBT mRNA CTD PMID:24752500 NCBI chr 1:100,186,919...100,249,834
Ensembl chr 1:100,186,919...100,249,834 		JBrowse link
G DCTPP1 dCTP pyrophosphatase 1 affects expression EXP Diclofenac affects the expression of DCTPP1 mRNA CTD PMID:24752500 NCBI chr16:30,423,615...30,430,030
Ensembl chr16:30,423,615...30,430,030 		JBrowse link
G DDIT3 DNA damage inducible transcript 3 increases response to substance
decreases expression
increases expression		 ISO
EXP		 DDIT3 results in increased susceptibility to Diclofenac
Diclofenac results in decreased expression of DDIT3 mRNA
Diclofenac results in increased expression of DDIT3 mRNA; Diclofenac results in increased expression of DDIT3 protein		 CTD PMID:18172885 PMID:20668000 PMID:24752500 PMID:27313093 PMID:27358234 More... NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737 		JBrowse link
G DDIT4 DNA damage inducible transcript 4 increases expression ISO Diclofenac results in increased expression of DDIT4 mRNA CTD PMID:26934552 NCBI chr10:72,273,924...72,276,036
Ensembl chr10:72,273,919...72,276,036 		JBrowse link
G DDR1 discoidin domain receptor tyrosine kinase 1 affects expression EXP Diclofenac affects the expression of DDR1 mRNA CTD PMID:24752500 NCBI chr 6:30,880,970...30,900,156
Ensembl chr 6:30,876,421...30,900,156 		JBrowse link
G DDT D-dopachrome tautomerase decreases expression ISO Diclofenac results in decreased expression of DDT mRNA CTD PMID:26934552 NCBI chr22:23,971,370...23,980,504
Ensembl chr22:23,970,542...23,980,525 		JBrowse link
G DDX5 DEAD-box helicase 5 affects expression EXP Diclofenac affects the expression of DDX5 mRNA CTD PMID:24752500 NCBI chr17:64,498,254...64,506,866
Ensembl chr17:64,498,254...64,508,199 		JBrowse link
G DECR1 2,4-dienoyl-CoA reductase 1 increases expression ISO Diclofenac results in increased expression of DECR1 protein CTD PMID:25772430 NCBI chr 8:90,001,477...90,053,633
Ensembl chr 8:90,001,405...90,053,633 		JBrowse link
G DENND2D DENN domain containing 2D decreases expression ISO Diclofenac results in decreased expression of DENND2D mRNA CTD PMID:35537566 NCBI chr 1:111,185,969...111,204,578
Ensembl chr 1:111,185,969...111,204,535 		JBrowse link
G DERL1 derlin 1 increases expression ISO Diclofenac results in increased expression of DERL1 mRNA CTD PMID:26934552 NCBI chr 8:123,013,170...123,042,302
Ensembl chr 8:123,013,170...123,042,302 		JBrowse link
G DERL3 derlin 3 increases expression ISO Diclofenac results in increased expression of DERL3 mRNA CTD PMID:26934552 NCBI chr22:23,834,503...23,839,006
Ensembl chr22:23,834,503...23,839,128 		JBrowse link
G DFFA DNA fragmentation factor subunit alpha affects expression EXP Diclofenac affects the expression of DFFA mRNA CTD PMID:24752500 NCBI chr 1:10,456,522...10,472,529
Ensembl chr 1:10,456,522...10,472,529 		JBrowse link
G DHCR24 24-dehydrocholesterol reductase increases expression ISO Diclofenac results in increased expression of DHCR24 mRNA CTD PMID:26934552 NCBI chr 1:54,849,627...54,887,195
Ensembl chr 1:54,849,627...54,887,195 		JBrowse link
G DHFR dihydrofolate reductase affects expression EXP Diclofenac affects the expression of DHFR mRNA CTD PMID:24752500 NCBI chr 5:80,626,226...80,654,983
Ensembl chr 5:80,626,226...80,654,983 		JBrowse link
G DHRS3 dehydrogenase/reductase 3 decreases expression ISO Diclofenac results in decreased expression of DHRS3 mRNA CTD PMID:35537566 NCBI chr 1:12,567,910...12,618,210
Ensembl chr 1:12,567,909...12,620,133 		JBrowse link
G DKK1 dickkopf WNT signaling pathway inhibitor 1 affects expression EXP Diclofenac affects the expression of DKK1 mRNA CTD PMID:24752500 NCBI chr10:52,314,281...52,317,657
Ensembl chr10:52,314,281...52,318,042 		JBrowse link
G DNAAF2 dynein axonemal assembly factor 2 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of DNAAF2 mRNA CTD PMID:37844793 NCBI chr14:49,625,174...49,635,244
Ensembl chr14:49,625,174...49,635,244 		JBrowse link
G DNAJA1 DnaJ heat shock protein family (Hsp40) member A1 affects expression EXP Diclofenac affects the expression of DNAJA1 mRNA CTD PMID:24752500 NCBI chr 9:33,025,273...33,039,907
Ensembl chr 9:33,025,273...33,039,907 		JBrowse link
G DNAJA2 DnaJ heat shock protein family (Hsp40) member A2 affects expression EXP Diclofenac affects the expression of DNAJA2 mRNA CTD PMID:24752500 NCBI chr16:46,955,362...46,973,674
Ensembl chr16:46,955,362...46,973,674 		JBrowse link
G DNAJA3 DnaJ heat shock protein family (Hsp40) member A3 affects expression
decreases expression		 EXP
ISO		 Diclofenac affects the expression of DNAJA3 mRNA
Diclofenac results in decreased expression of DNAJA3 mRNA		 CTD PMID:24752500 PMID:26934552 NCBI chr16:4,425,868...4,456,775
Ensembl chr16:4,425,805...4,456,775 		JBrowse link
G DNAJB1 DnaJ heat shock protein family (Hsp40) member B1 affects expression EXP Diclofenac affects the expression of DNAJB1 mRNA CTD PMID:24752500 NCBI chr19:14,514,769...14,560,391
Ensembl chr19:14,513,789...14,560,391 		JBrowse link
G DNAJB14 DnaJ heat shock protein family (Hsp40) member B14 affects expression EXP Diclofenac affects the expression of DNAJB14 mRNA CTD PMID:24752500 NCBI chr 4:99,896,248...99,946,618
Ensembl chr 4:99,896,248...99,946,618 		JBrowse link
G DNAJB4 DnaJ heat shock protein family (Hsp40) member B4 affects expression EXP Diclofenac affects the expression of DNAJB4 mRNA CTD PMID:24752500 NCBI chr 1:77,979,175...78,017,964
Ensembl chr 1:77,979,175...78,017,964 		JBrowse link
G DNAJB6 DnaJ heat shock protein family (Hsp40) member B6 affects expression EXP Diclofenac affects the expression of DNAJB6 mRNA CTD PMID:24752500 NCBI chr 7:157,337,004...157,417,439
Ensembl chr 7:157,335,381...157,417,439 		JBrowse link
G DNAJB7 DnaJ heat shock protein family (Hsp40) member B7 increases expression ISO Diclofenac results in increased expression of DNAJB7 mRNA CTD PMID:30723492 NCBI chr22:40,859,549...40,862,113
Ensembl chr22:40,859,549...40,862,113 		JBrowse link
G DNAJB9 DnaJ heat shock protein family (Hsp40) member B9 affects expression
increases expression		 EXP
ISO		 Diclofenac affects the expression of DNAJB9 mRNA
Diclofenac results in increased expression of DNAJB9 mRNA		 CTD PMID:24752500 PMID:26934552 NCBI chr 7:108,569,874...108,574,850
Ensembl chr 7:108,569,867...108,574,850 		JBrowse link
G DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 affects expression
increases expression		 EXP
ISO		 Diclofenac affects the expression of DNAJC10 mRNA
Diclofenac results in increased expression of DNAJC10 mRNA		 CTD PMID:24752500 PMID:26934552 NCBI chr 2:182,716,257...182,794,464
Ensembl chr 2:182,716,255...182,794,464 		JBrowse link
G DNAJC11 DnaJ heat shock protein family (Hsp40) member C11 affects expression EXP Diclofenac affects the expression of DNAJC11 mRNA CTD PMID:24752500 NCBI chr 1:6,634,170...6,701,816
Ensembl chr 1:6,634,168...6,701,924 		JBrowse link
G DNAJC12 DnaJ heat shock protein family (Hsp40) member C12 increases expression
decreases expression		 ISO Diclofenac results in increased expression of DNAJC12 mRNA
Diclofenac results in decreased expression of DNAJC12 mRNA		 CTD PMID:26934552 NCBI chr10:67,796,669...67,838,188
Ensembl chr10:67,796,669...67,838,188 		JBrowse link
G DNAJC15 DnaJ heat shock protein family (Hsp40) member C15 affects expression EXP Diclofenac affects the expression of DNAJC15 mRNA CTD PMID:24752500 NCBI chr13:43,023,586...43,114,213
Ensembl chr13:43,023,203...43,114,213 		JBrowse link
G DNAJC18 DnaJ heat shock protein family (Hsp40) member C18 affects expression EXP Diclofenac affects the expression of DNAJC18 mRNA CTD PMID:24752500 NCBI chr 5:139,410,203...139,439,525
Ensembl chr 5:139,408,588...139,444,491 		JBrowse link
G DNAJC21 DnaJ heat shock protein family (Hsp40) member C21 affects expression EXP Diclofenac affects the expression of DNAJC21 mRNA CTD PMID:24752500 NCBI chr 5:34,929,559...34,958,964
Ensembl chr 5:34,929,559...34,958,964 		JBrowse link
G DNAJC3 DnaJ heat shock protein family (Hsp40) member C3 increases expression ISO Diclofenac results in increased expression of DNAJC3 mRNA CTD PMID:26934552 NCBI chr13:95,677,139...95,794,988
Ensembl chr13:95,677,139...95,794,988 		JBrowse link
G DNAJC5 DnaJ heat shock protein family (Hsp40) member C5 affects expression EXP Diclofenac affects the expression of DNAJC5 mRNA CTD PMID:24752500 NCBI chr20:63,895,126...63,936,011
Ensembl chr20:63,895,126...63,936,031 		JBrowse link
G DNAJC6 DnaJ heat shock protein family (Hsp40) member C6 affects expression EXP Diclofenac affects the expression of DNAJC6 mRNA CTD PMID:24752500 NCBI chr 1:65,264,749...65,415,871
Ensembl chr 1:65,248,219...65,415,871 		JBrowse link
G DNAJC7 DnaJ heat shock protein family (Hsp40) member C7 affects expression EXP Diclofenac affects the expression of DNAJC7 mRNA CTD PMID:24752500 NCBI chr17:41,976,435...42,017,439
Ensembl chr17:41,976,421...42,021,376 		JBrowse link
G DNAJC8 DnaJ heat shock protein family (Hsp40) member C8 affects expression EXP Diclofenac affects the expression of DNAJC8 mRNA CTD PMID:24752500 NCBI chr 1:28,200,278...28,233,029
Ensembl chr 1:28,199,456...28,233,029 		JBrowse link
G DNAJC9 DnaJ heat shock protein family (Hsp40) member C9 affects expression EXP Diclofenac affects the expression of DNAJC9 mRNA CTD PMID:24752500 NCBI chr10:73,232,272...73,247,255
Ensembl chr10:73,183,362...73,247,255 		JBrowse link
G DND1 DND microRNA-mediated repression inhibitor 1 increases expression ISO Diclofenac results in increased expression of DND1 mRNA CTD PMID:35537566 NCBI chr 5:140,670,794...140,673,576
Ensembl chr 5:140,670,794...140,673,576 		JBrowse link
G DNER delta/notch like EGF repeat containing decreases expression ISO Diclofenac results in decreased expression of DNER mRNA CTD PMID:35537566 NCBI chr 2:229,357,629...229,714,555
Ensembl chr 2:229,357,629...229,714,555 		JBrowse link
G DPYSL2 dihydropyrimidinase like 2 affects expression EXP Diclofenac affects the expression of DPYSL2 mRNA CTD PMID:24752500 NCBI chr 8:26,514,031...26,658,175
Ensembl chr 8:26,514,031...26,658,178 		JBrowse link
G DRD1 dopamine receptor D1 increases expression ISO Diclofenac results in increased expression of DRD1 mRNA CTD PMID:26934552 NCBI chr 5:175,440,036...175,444,182
Ensembl chr 5:175,440,036...175,444,182 		JBrowse link
G DTYMK deoxythymidylate kinase affects expression EXP Diclofenac affects the expression of DTYMK mRNA CTD PMID:24752500 NCBI chr 2:241,675,747...241,686,815
Ensembl chr 2:241,675,747...241,686,944 		JBrowse link
G DUSP1 dual specificity phosphatase 1 affects expression
decreases expression		 EXP
ISO		 Diclofenac affects the expression of DUSP1 mRNA
Diclofenac results in decreased expression of DUSP1 mRNA		 CTD PMID:24752500 PMID:26934552 NCBI chr 5:172,768,096...172,771,195
Ensembl chr 5:172,768,096...172,771,195 		JBrowse link
G DUT deoxyuridine triphosphatase affects expression EXP Diclofenac affects the expression of DUT mRNA CTD PMID:24752500 NCBI chr15:48,331,095...48,343,373
Ensembl chr15:48,331,011...48,343,373 		JBrowse link
G DYNC1I1 dynein cytoplasmic 1 intermediate chain 1 increases expression ISO Diclofenac results in increased expression of DYNC1I1 mRNA CTD PMID:30723492 NCBI chr 7:95,772,554...96,110,322
Ensembl chr 7:95,772,506...96,110,322 		JBrowse link
G E2F1 E2F transcription factor 1 affects expression EXP Diclofenac affects the expression of E2F1 mRNA CTD PMID:24752500 NCBI chr20:33,675,477...33,686,385
Ensembl chr20:33,675,477...33,686,385 		JBrowse link
G E2F2 E2F transcription factor 2 affects expression EXP Diclofenac affects the expression of E2F2 mRNA CTD PMID:24752500 NCBI chr 1:23,505,212...23,531,233
Ensembl chr 1:23,506,438...23,531,233 		JBrowse link
G E2F5 E2F transcription factor 5 affects expression EXP Diclofenac affects the expression of E2F5 mRNA CTD PMID:24752500 NCBI chr 8:85,177,154...85,214,518
Ensembl chr 8:85,177,154...85,217,158 		JBrowse link
G EBLN1 endogenous Bornavirus like nucleoprotein 1 increases expression ISO Diclofenac results in increased expression of IGKV8-24 mRNA CTD PMID:30723492 NCBI chr10:22,208,475...22,218,015
Ensembl chr10:22,208,475...22,218,015 		JBrowse link
G ECM1 extracellular matrix protein 1 decreases expression ISO Diclofenac results in decreased expression of ECM1 mRNA CTD PMID:26934552 NCBI chr 1:150,508,109...150,513,789
Ensembl chr 1:150,508,062...150,513,789 		JBrowse link
G ECT2 epithelial cell transforming 2 increases expression ISO Diclofenac results in increased expression of ECT2 mRNA CTD PMID:26934552 NCBI chr 3:172,750,726...172,829,265
Ensembl chr 3:172,750,682...172,821,474 		JBrowse link
G EDEM1 ER degradation enhancing alpha-mannosidase like protein 1 increases expression ISO Diclofenac results in increased expression of EDEM1 mRNA CTD PMID:26934552 NCBI chr 3:5,187,707...5,219,958
Ensembl chr 3:5,187,646...5,219,958 		JBrowse link
G EDIL3 EGF like repeats and discoidin domains 3 decreases expression ISO Diclofenac results in decreased expression of EDIL3 mRNA CTD PMID:26934552 NCBI chr 5:83,940,554...84,384,880
Ensembl chr 5:83,940,554...84,384,880 		JBrowse link
G EDN1 endothelin 1 multiple interactions ISO Diclofenac inhibits the reaction [EDN1 protein results in decreased transport of Potassium] CTD PMID:15083534 NCBI chr 6:12,230,516...12,297,194
Ensembl chr 6:12,290,361...12,297,194 		JBrowse link
G EDN2 endothelin 2 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of EDN2 mRNA CTD PMID:37844793 NCBI chr 1:41,478,775...41,484,683
Ensembl chr 1:41,478,775...41,484,683 		JBrowse link
G EEF2K eukaryotic elongation factor 2 kinase decreases expression ISO Diclofenac results in decreased expression of EEF2K mRNA CTD PMID:35537566 NCBI chr16:22,206,278...22,288,738
Ensembl chr16:22,206,278...22,288,738 		JBrowse link
G EGF epidermal growth factor increases expression ISO Diclofenac results in increased expression of EGF protein CTD PMID:23506792 NCBI chr 4:109,912,883...110,013,766
Ensembl chr 4:109,912,883...110,013,766 		JBrowse link
G EGFR epidermal growth factor receptor increases expression ISO Diclofenac results in increased expression of EGFR mRNA CTD PMID:26934552 NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628 		JBrowse link
G EGR1 early growth response 1 increases expression
multiple interactions
affects expression		 EXP
ISO		 Diclofenac results in increased expression of EGR1 mRNA
[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of EGR1 mRNA
Diclofenac affects the expression of EGR1 mRNA		 CTD PMID:15509713 PMID:26934552 PMID:37844793 NCBI chr 5:138,465,479...138,469,303
Ensembl chr 5:138,465,479...138,469,303 		JBrowse link
G EIF1 eukaryotic translation initiation factor 1 affects expression EXP Diclofenac affects the expression of EIF1 mRNA CTD PMID:24752500 NCBI chr17:41,688,885...41,692,668
Ensembl chr17:41,688,885...41,692,668 		JBrowse link
G EIF1AX eukaryotic translation initiation factor 1A X-linked affects expression EXP Diclofenac affects the expression of EIF1AX mRNA CTD PMID:24752500 NCBI chr  X:20,124,525...20,141,838
Ensembl chr  X:20,124,525...20,141,838 		JBrowse link
G EIF2A eukaryotic translation initiation factor 2A affects expression EXP Diclofenac affects the expression of EIF2A mRNA CTD PMID:24752500 NCBI chr 3:150,546,787...150,586,016
Ensembl chr 3:150,546,678...150,586,016 		JBrowse link
G EIF2AK1 eukaryotic translation initiation factor 2 alpha kinase 1 affects expression
decreases expression		 EXP
ISO		 Diclofenac affects the expression of EIF2AK1 mRNA
Diclofenac results in decreased expression of EIF2AK1 mRNA		 CTD PMID:24752500 PMID:26934552 NCBI chr 7:6,022,247...6,059,175
Ensembl chr 7:6,022,247...6,059,175 		JBrowse link
G EIF2AK3 eukaryotic translation initiation factor 2 alpha kinase 3 affects expression
increases expression
increases phosphorylation
multiple interactions
increases activity		 EXP
ISO		 Diclofenac affects the expression of EIF2AK3 mRNA
Diclofenac results in increased expression of EIF2AK3 mRNA
Diclofenac results in increased phosphorylation of EIF2AK3 protein
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Diclofenac results in increased phosphorylation of EIF2AK3 protein]; 2-aminoethoxydiphenyl borate inhibits the reaction [Diclofenac results in increased phosphorylation of EIF2AK3 protein]; Calcium promotes the reaction [Diclofenac results in increased phosphorylation of EIF2AK3 protein]
Diclofenac results in increased activity of EIF2AK3 protein		 CTD PMID:24752500 PMID:26609140 PMID:26934552 NCBI chr 2:88,556,741...88,628,145
Ensembl chr 2:88,556,741...88,691,518 		JBrowse link
G EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4 affects expression EXP Diclofenac affects the expression of EIF2AK4 mRNA CTD PMID:24752500 NCBI chr15:39,934,115...40,035,591
Ensembl chr15:39,934,115...40,035,591 		JBrowse link
G EIF2B1 eukaryotic translation initiation factor 2B subunit alpha affects expression EXP Diclofenac affects the expression of EIF2B1 mRNA CTD PMID:24752500 NCBI chr12:123,620,406...123,633,686
Ensembl chr12:123,620,406...123,633,766 		JBrowse link
G EIF2S1 eukaryotic translation initiation factor 2 subunit alpha affects expression
multiple interactions		 EXP Diclofenac affects the expression of EIF2S1 mRNA
[TNF protein co-treated with Diclofenac] results in increased phosphorylation of EIF2S1 protein		 CTD PMID:24752500 PMID:27313093 NCBI chr14:67,360,328...67,386,516
Ensembl chr14:67,360,328...67,386,516 		JBrowse link
G EIF2S2 eukaryotic translation initiation factor 2 subunit beta affects expression EXP Diclofenac affects the expression of EIF2S2 mRNA CTD PMID:24752500 NCBI chr20:34,088,309...34,112,243
Ensembl chr20:34,088,309...34,112,243 		JBrowse link
G EIF3A eukaryotic translation initiation factor 3 subunit A affects expression EXP Diclofenac affects the expression of EIF3A mRNA CTD PMID:24752500 NCBI chr10:119,033,670...119,080,817
Ensembl chr10:119,033,670...119,080,817 		JBrowse link
G EIF3B eukaryotic translation initiation factor 3 subunit B affects expression EXP Diclofenac affects the expression of EIF3B mRNA CTD PMID:24752500 NCBI chr 7:2,354,086...2,380,745
Ensembl chr 7:2,354,086...2,380,745 		JBrowse link
G EIF3C eukaryotic translation initiation factor 3 subunit C affects expression EXP Diclofenac affects the expression of EIF3C mRNA CTD PMID:24752500 NCBI chr16:28,688,558...28,735,730
Ensembl chr16:28,688,558...28,735,727 		JBrowse link
G EIF4A1 eukaryotic translation initiation factor 4A1 affects expression EXP Diclofenac affects the expression of EIF4A1 mRNA CTD PMID:24752500 NCBI chr17:7,572,825...7,579,006
Ensembl chr17:7,572,824...7,579,006 		JBrowse link
G EIF4A2 eukaryotic translation initiation factor 4A2 affects expression EXP Diclofenac affects the expression of EIF4A2 mRNA CTD PMID:24752500 NCBI chr 3:186,783,577...186,789,897
Ensembl chr 3:186,783,205...186,789,897 		JBrowse link
G EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 increases expression
decreases expression
affects expression		 ISO
EXP		 Diclofenac results in increased expression of EIF4EBP1 mRNA
Diclofenac results in decreased expression of EIF4EBP1 mRNA
Diclofenac affects the expression of EIF4EBP1 mRNA		 CTD PMID:18172885 PMID:24752500 PMID:35537566 NCBI chr 8:38,030,534...38,060,365
Ensembl chr 8:38,030,534...38,060,365 		JBrowse link
G EIF4G1 eukaryotic translation initiation factor 4 gamma 1 affects expression EXP Diclofenac affects the expression of EIF4G1 mRNA CTD PMID:24752500 NCBI chr 3:184,314,606...184,335,358
Ensembl chr 3:184,314,495...184,335,358 		JBrowse link
G EIF4G3 eukaryotic translation initiation factor 4 gamma 3 affects expression EXP Diclofenac affects the expression of EIF4G3 mRNA CTD PMID:24752500 NCBI chr 1:20,806,292...21,176,897
Ensembl chr 1:20,806,292...21,177,285 		JBrowse link
G EIF5 eukaryotic translation initiation factor 5 affects expression EXP Diclofenac affects the expression of EIF5 mRNA CTD PMID:24752500 NCBI chr14:103,334,237...103,345,025
Ensembl chr14:103,333,544...103,345,025 		JBrowse link
G ELF2 E74 like ETS transcription factor 2 affects expression EXP Diclofenac affects the expression of ELF2 mRNA CTD PMID:24752500 NCBI chr 4:139,057,220...139,177,915
Ensembl chr 4:139,028,112...139,177,218 		JBrowse link
G ELF3 E74 like ETS transcription factor 3 affects expression EXP Diclofenac affects the expression of ELF3 mRNA CTD PMID:24752500 NCBI chr 1:202,010,587...202,017,183
Ensembl chr 1:202,007,945...202,017,183 		JBrowse link
G ELOVL2 ELOVL fatty acid elongase 2 affects expression EXP Diclofenac affects the expression of ELOVL2 mRNA CTD PMID:24752500 NCBI chr 6:10,980,759...11,044,305
Ensembl chr 6:10,980,759...11,044,305 		JBrowse link
G ELOVL6 ELOVL fatty acid elongase 6 increases expression ISO Diclofenac results in increased expression of ELOVL6 mRNA CTD PMID:35537566 NCBI chr 4:110,045,846...110,199,202
Ensembl chr 4:110,045,846...110,199,199 		JBrowse link
G EME2 essential meiotic structure-specific endonuclease subunit 2 increases expression ISO Diclofenac results in increased expression of EME2 mRNA CTD PMID:26934552 NCBI chr16:1,772,810...1,781,702
Ensembl chr16:1,772,810...1,781,708 		JBrowse link
G ENDOG endonuclease G affects expression EXP Diclofenac affects the expression of ENDOG mRNA CTD PMID:24752500 NCBI chr 9:128,818,500...128,822,676
Ensembl chr 9:128,818,500...128,822,676 		JBrowse link
G ENO1 enolase 1 increases expression ISO Diclofenac results in increased expression of ENO1 mRNA CTD PMID:26934552 NCBI chr 1:8,861,000...8,878,686
Ensembl chr 1:8,861,000...8,879,190 		JBrowse link
G ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 affects expression EXP Diclofenac affects the expression of ENPP1 mRNA CTD PMID:24752500 NCBI chr 6:131,808,020...131,895,155
Ensembl chr 6:131,808,016...131,895,155 		JBrowse link
G ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 increases expression ISO Diclofenac results in increased expression of ENPP2 mRNA CTD PMID:26934552 NCBI chr 8:119,557,086...119,673,390
Ensembl chr 8:119,557,086...119,673,453 		JBrowse link
G ENTPD4 ectonucleoside triphosphate diphosphohydrolase 4 affects expression EXP Diclofenac affects the expression of ENTPD4 mRNA CTD PMID:24752500 NCBI chr 8:23,429,162...23,457,647
Ensembl chr 8:23,385,783...23,457,695 		JBrowse link
G ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5 (inactive) affects expression EXP Diclofenac affects the expression of ENTPD5 mRNA CTD PMID:24752500 NCBI chr14:73,955,329...74,019,288
Ensembl chr14:73,958,010...74,019,399 		JBrowse link
G ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 affects expression EXP Diclofenac affects the expression of ENTPD7 mRNA CTD PMID:24752500 NCBI chr10:99,659,509...99,711,241
Ensembl chr10:99,659,509...99,711,241 		JBrowse link
G EPAS1 endothelial PAS domain protein 1 decreases expression EXP Diclofenac results in decreased expression of EPAS1 protein CTD PMID:12912967 NCBI chr 2:46,297,407...46,386,697
Ensembl chr 2:46,293,667...46,386,697 		JBrowse link
G EPC2 enhancer of polycomb homolog 2 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of EPC2 mRNA CTD PMID:37844793 NCBI chr 2:148,644,751...148,787,569
Ensembl chr 2:148,644,440...148,788,495 		JBrowse link
G EPHX1 epoxide hydrolase 1 decreases expression ISO Diclofenac results in decreased expression of EPHX1 mRNA CTD PMID:17202759 NCBI chr 1:225,810,124...225,845,563
Ensembl chr 1:225,810,124...225,845,563 		JBrowse link
G EPN2 epsin 2 affects expression EXP Diclofenac affects the expression of EPN2 mRNA CTD PMID:24752500 NCBI chr17:19,237,366...19,336,715
Ensembl chr17:19,215,615...19,336,715 		JBrowse link
G EPN3 epsin 3 affects expression EXP Diclofenac affects the expression of EPN3 mRNA CTD PMID:24752500 NCBI chr17:50,532,735...50,543,750
Ensembl chr17:50,532,682...50,543,750 		JBrowse link
G EPO erythropoietin affects expression EXP Diclofenac affects the expression of EPO mRNA CTD PMID:24752500 NCBI chr 7:100,720,468...100,723,700
Ensembl chr 7:100,720,468...100,723,700 		JBrowse link
G ERBB4 erb-b2 receptor tyrosine kinase 4 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of ERBB4 mRNA CTD PMID:37844793 NCBI chr 2:211,375,717...212,538,802
Ensembl chr 2:211,375,717...212,538,841 		JBrowse link
G EREG epiregulin increases expression EXP Diclofenac results in increased expression of EREG mRNA CTD PMID:32816093 NCBI chr 4:74,365,145...74,388,749
Ensembl chr 4:74,365,145...74,388,749 		JBrowse link
G ERN1 endoplasmic reticulum to nucleus signaling 1 affects expression EXP Diclofenac affects the expression of ERN1 mRNA CTD PMID:24752500 NCBI chr17:64,039,142...64,130,144
Ensembl chr17:64,039,080...64,130,819 		JBrowse link
G ERO1A endoplasmic reticulum oxidoreductase 1 alpha increases expression ISO Diclofenac results in increased expression of ERO1A mRNA CTD PMID:26934552 NCBI chr14:52,639,915...52,695,558
Ensembl chr14:52,639,915...52,695,900 		JBrowse link
G ESR1 estrogen receptor 1 affects activity EXP Diclofenac affects the activity of ESR1 protein CTD PMID:29777833 NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619 		JBrowse link
G ETNPPL ethanolamine-phosphate phospho-lyase decreases expression ISO Diclofenac results in decreased expression of ETNPPL mRNA CTD PMID:26934552 NCBI chr 4:108,742,053...108,763,053
Ensembl chr 4:108,742,048...108,763,054 		JBrowse link
G EVI5 ecotropic viral integration site 5 decreases expression ISO Diclofenac results in decreased expression of EVI5 mRNA CTD PMID:35537566 NCBI chr 1:92,508,696...92,792,410
Ensembl chr 1:92,508,696...92,792,404 		JBrowse link
G EXTL1 exostosin like glycosyltransferase 1 decreases expression ISO Diclofenac results in decreased expression of EXTL1 mRNA CTD PMID:35537566 NCBI chr 1:26,021,775...26,036,464
Ensembl chr 1:26,019,884...26,036,464 		JBrowse link
G EYA4 EYA transcriptional coactivator and phosphatase 4 decreases expression ISO Diclofenac results in decreased expression of EYA4 mRNA CTD PMID:26934552 NCBI chr 6:133,240,593...133,532,128
Ensembl chr 6:133,240,514...133,532,128 		JBrowse link
G F13A1 coagulation factor XIII A chain increases expression ISO Diclofenac results in increased expression of F13A1 mRNA CTD PMID:26934552 NCBI chr 6:6,144,084...6,320,662
Ensembl chr 6:6,144,084...6,321,013 		JBrowse link
G FAAP24 FA core complex associated protein 24 increases expression ISO Diclofenac results in increased expression of FAAP24 mRNA CTD PMID:26934552 NCBI chr19:32,972,242...32,978,229
Ensembl chr19:32,972,209...32,978,229 		JBrowse link
G FABP1 fatty acid binding protein 1 decreases expression
increases expression		 EXP
ISO		 Diclofenac results in decreased expression of FABP1 mRNA
Diclofenac results in increased expression of FABP1 protein		 CTD PMID:19022234 PMID:23506792 NCBI chr 2:88,122,982...88,128,062
Ensembl chr 2:88,122,982...88,128,062 		JBrowse link
G FABP2 fatty acid binding protein 2 decreases expression ISO Diclofenac results in decreased expression of FABP2 mRNA CTD PMID:19022234 PMID:26934552 NCBI chr 4:119,317,250...119,322,138
Ensembl chr 4:119,317,250...119,322,138 		JBrowse link
G FABP3 fatty acid binding protein 3 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of FABP3 mRNA CTD PMID:37844793 NCBI chr 1:31,359,588...31,373,076
Ensembl chr 1:31,365,253...31,376,850 		JBrowse link
G FABP4 fatty acid binding protein 4 decreases expression ISO Diclofenac results in decreased expression of FABP4 mRNA CTD PMID:35537566 NCBI chr 8:81,478,419...81,483,233
Ensembl chr 8:81,478,419...81,483,236 		JBrowse link
G FABP5 fatty acid binding protein 5 increases expression ISO Diclofenac results in increased expression of FABP5 mRNA CTD PMID:26934552 NCBI chr 8:81,280,536...81,284,775
Ensembl chr 8:81,280,536...81,284,777 		JBrowse link
G FADS1 fatty acid desaturase 1 decreases expression ISO Diclofenac results in decreased expression of FADS1 mRNA CTD PMID:26934552 NCBI chr11:61,799,627...61,817,003
Ensembl chr11:61,799,627...61,829,318 		JBrowse link
G FAM209B family with sequence similarity 209 member B multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of FAM209 mRNA CTD PMID:37844793 NCBI chr20:56,533,246...56,536,520
Ensembl chr20:56,533,246...56,536,520 		JBrowse link
G FANCB FA complementation group B affects expression EXP Diclofenac affects the expression of FANCB mRNA CTD PMID:24752500 NCBI chr  X:14,689,524...14,873,069
Ensembl chr  X:14,690,388...14,873,255 		JBrowse link
G FANCC FA complementation group C affects expression EXP Diclofenac affects the expression of FANCC mRNA CTD PMID:24752500 NCBI chr 9:95,099,054...95,317,709
Ensembl chr 9:95,099,054...95,426,796 		JBrowse link
G FANCE FA complementation group E increases expression ISO Diclofenac results in increased expression of FANCE mRNA CTD PMID:26934552 NCBI chr 6:35,452,338...35,467,102
Ensembl chr 6:35,452,338...35,467,104 		JBrowse link
G FANCF FA complementation group F affects expression EXP Diclofenac affects the expression of FANCF mRNA CTD PMID:24752500 NCBI chr11:22,622,533...22,625,823
Ensembl chr11:22,622,533...22,625,823 		JBrowse link
G FANCG FA complementation group G affects expression EXP Diclofenac affects the expression of FANCG mRNA CTD PMID:24752500 NCBI chr 9:35,073,839...35,079,942
Ensembl chr 9:35,073,835...35,080,004 		JBrowse link
G FANCL FA complementation group L affects expression EXP Diclofenac affects the expression of FANCL mRNA CTD PMID:24752500 NCBI chr 2:58,159,243...58,241,380
Ensembl chr 2:58,159,243...58,241,410 		JBrowse link
G FANCM FA complementation group M affects expression EXP Diclofenac affects the expression of FANCM mRNA CTD PMID:24752500 NCBI chr14:45,135,930...45,200,890
Ensembl chr14:45,135,930...45,200,890 		JBrowse link
G FAS Fas cell surface death receptor affects expression
increases expression		 EXP
ISO		 Diclofenac affects the expression of FAS mRNA
Diclofenac results in increased expression of FAS mRNA		 CTD PMID:24752500 PMID:26934552 NCBI chr10:88,964,050...89,017,059
Ensembl chr10:88,953,813...89,029,605 		JBrowse link
G FASLG Fas ligand increases expression ISO Diclofenac results in increased expression of FASL mRNA CTD PMID:22285467 NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876 		JBrowse link
G FASN fatty acid synthase decreases expression ISO Diclofenac results in decreased expression of FASN mRNA CTD PMID:19022234 NCBI chr17:82,078,338...82,098,236
Ensembl chr17:82,078,338...82,098,294 		JBrowse link
G FASTK Fas activated serine/threonine kinase multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of FASTK mRNA CTD PMID:37844793 NCBI chr 7:151,076,624...151,080,809
Ensembl chr 7:151,076,624...151,080,866 		JBrowse link
G FASTKD2 FAST kinase domains 2 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of FASTKD2 mRNA CTD PMID:37844793 NCBI chr 2:206,765,606...206,796,189
Ensembl chr 2:206,765,357...206,796,189 		JBrowse link
G FBXO33 F-box protein 33 increases expression ISO Diclofenac results in increased expression of FBXO33 mRNA CTD PMID:35537566 NCBI chr14:39,397,684...39,432,433
Ensembl chr14:39,397,684...39,432,466 		JBrowse link
G FBXO5 F-box protein 5 decreases expression ISO Diclofenac results in decreased expression of FBXO5 mRNA CTD PMID:35537566 NCBI chr 6:152,970,535...152,983,579
Ensembl chr 6:152,970,519...152,983,579 		JBrowse link
G FCER1G Fc epsilon receptor Ig increases expression ISO Diclofenac results in increased expression of FCER1G mRNA CTD PMID:26934552 NCBI chr 1:161,215,295...161,219,245
Ensembl chr 1:161,215,234...161,220,699 		JBrowse link
G FCGR2B Fc gamma receptor IIb decreases expression ISO Diclofenac results in decreased expression of FCGR2B mRNA CTD PMID:35537566 NCBI chr 1:161,647,243...161,678,654
Ensembl chr 1:161,663,143...161,678,654 		JBrowse link
G FEN1 flap structure-specific endonuclease 1 increases expression ISO Diclofenac results in increased expression of FEN1 mRNA CTD PMID:26934552 NCBI chr11:61,792,911...61,797,238
Ensembl chr11:61,792,911...61,797,238 		JBrowse link
G FER FER tyrosine kinase affects expression EXP Diclofenac affects the expression of FER mRNA CTD PMID:24752500 NCBI chr 5:108,747,897...109,196,841
Ensembl chr 5:108,747,841...109,196,841 		JBrowse link
G FERMT1 FERM domain containing kindlin 1 increases expression ISO Diclofenac results in increased expression of FERMT1 mRNA CTD PMID:30723492 NCBI chr20:6,074,845...6,123,030
Ensembl chr20:6,074,845...6,123,214 		JBrowse link
G FGB fibrinogen beta chain multiple interactions
increases expression		 ISO [Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of FGB protein
Diclofenac results in increased expression of FGB mRNA		 CTD PMID:25772430 PMID:26934552 NCBI chr 4:154,562,980...154,572,807
Ensembl chr 4:154,563,011...154,572,807 		JBrowse link
G FGF1 fibroblast growth factor 1 decreases expression ISO Diclofenac results in decreased expression of FGF1 mRNA CTD PMID:26934552 NCBI chr 5:142,592,178...142,698,070
Ensembl chr 5:142,592,178...142,698,070 		JBrowse link
G FGF3 fibroblast growth factor 3 increases expression ISO Diclofenac results in increased expression of FGF3 mRNA CTD PMID:26934552 NCBI chr11:69,809,968...69,819,416
Ensembl chr11:69,809,968...69,819,416 		JBrowse link
G FGFR1 fibroblast growth factor receptor 1 affects expression EXP Diclofenac affects the expression of FGFR1 mRNA CTD PMID:24752500 NCBI chr 8:38,411,143...38,468,635
Ensembl chr 8:38,400,215...38,468,834 		JBrowse link
G FGFR1OP2 FGFR1 oncogene partner 2 decreases expression ISO Diclofenac results in decreased expression of FGFR1OP2 mRNA CTD PMID:26934552 NCBI chr12:26,938,470...26,966,648
Ensembl chr12:26,938,470...26,966,650 		JBrowse link
G FGG fibrinogen gamma chain multiple interactions
decreases expression		 ISO [Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of FGG protein; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of FGG protein]; lipopolysaccharide, E coli O55-B5 promotes the reaction [Diclofenac results in decreased expression of FGG protein] CTD PMID:25772430 NCBI chr 4:154,604,136...154,612,656
Ensembl chr 4:154,604,134...154,612,967 		JBrowse link
G FGL1 fibrinogen like 1 increases expression ISO Diclofenac results in increased expression of FGL1 mRNA CTD PMID:26934552 NCBI chr 8:17,864,389...17,895,538
Ensembl chr 8:17,864,380...17,910,365 		JBrowse link
G FMOD fibromodulin decreases expression ISO Diclofenac results in decreased expression of FMOD mRNA CTD PMID:26934552 NCBI chr 1:203,340,628...203,351,122
Ensembl chr 1:203,340,628...203,351,758 		JBrowse link
G FN1 fibronectin 1 increases expression ISO Diclofenac results in increased expression of FN1 mRNA; Diclofenac results in increased expression of FN1 protein CTD PMID:26934552 NCBI chr 2:215,360,865...215,436,068
Ensembl chr 2:215,360,440...215,436,073 		JBrowse link
G FNBP1 formin binding protein 1 affects expression EXP Diclofenac affects the expression of FNBP1 mRNA CTD PMID:24752500 NCBI chr 9:129,887,187...130,053,879
Ensembl chr 9:129,887,187...130,043,189 		JBrowse link
G FNDC3B fibronectin type III domain containing 3B increases expression ISO Diclofenac results in increased expression of FNDC3B mRNA CTD PMID:26934552 NCBI chr 3:172,039,578...172,401,669
Ensembl chr 3:172,039,578...172,401,669 		JBrowse link
G FNIP1 folliculin interacting protein 1 decreases expression ISO Diclofenac results in decreased expression of FNIP1 mRNA CTD PMID:26934552 NCBI chr 5:131,641,714...131,797,017
Ensembl chr 5:131,641,714...131,797,017 		JBrowse link
G FNIP2 folliculin interacting protein 2 decreases expression ISO Diclofenac results in decreased expression of FNIP2 mRNA CTD PMID:26934552 NCBI chr 4:158,769,026...158,908,050
Ensembl chr 4:158,769,026...158,908,050 		JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions
affects expression		 EXP
ISO		 Diclofenac results in increased expression of FOS mRNA
[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of FOS mRNA
Diclofenac affects the expression of FOS mRNA		 CTD PMID:12730611 PMID:24752500 PMID:37844793 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,283,190 		JBrowse link
G FOSL2 FOS like 2, AP-1 transcription factor subunit increases expression ISO Diclofenac results in increased expression of FOSL2 mRNA CTD PMID:26934552 NCBI chr 2:28,392,858...28,417,317
Ensembl chr 2:28,392,448...28,417,317 		JBrowse link
G FOXA1 forkhead box A1 affects expression EXP Diclofenac affects the expression of FOXA1 mRNA CTD PMID:24752500 NCBI chr14:37,589,552...37,595,249
Ensembl chr14:37,589,552...37,596,059 		JBrowse link
G FOXA3 forkhead box A3 increases expression ISO Diclofenac results in increased expression of FOXA3 mRNA CTD PMID:26934552 NCBI chr19:45,864,326...45,873,797
Ensembl chr19:45,863,989...45,873,797 		JBrowse link
G FOXO1 forkhead box O1 affects expression EXP Diclofenac affects the expression of FOXO1 mRNA CTD PMID:24752500 NCBI chr13:40,555,667...40,666,641
Ensembl chr13:40,555,667...40,666,641 		JBrowse link
G FOXO3 forkhead box O3 affects expression
decreases expression		 EXP
ISO		 Diclofenac affects the expression of FOXO3 mRNA
Diclofenac results in decreased expression of FOXO3 mRNA		 CTD PMID:24752500 PMID:26934552 NCBI chr 6:108,559,825...108,684,774
Ensembl chr 6:108,559,835...108,684,774 		JBrowse link
G FPR2 formyl peptide receptor 2 increases expression ISO Diclofenac results in increased expression of FPR2 mRNA CTD PMID:26934552 NCBI chr19:51,761,180...51,770,531
Ensembl chr19:51,752,026...51,770,531 		JBrowse link
G FRAT2 FRAT regulator of WNT signaling pathway 2 decreases expression ISO Diclofenac results in decreased expression of FRAT2 mRNA CTD PMID:35537566 NCBI chr10:97,332,497...97,334,729
Ensembl chr10:97,332,497...97,334,729 		JBrowse link
G FRS2 fibroblast growth factor receptor substrate 2 affects expression EXP Diclofenac affects the expression of FRS2 mRNA CTD PMID:24752500 NCBI chr12:69,470,388...69,579,793
Ensembl chr12:69,470,349...69,579,793 		JBrowse link
G FTCD formimidoyltransferase cyclodeaminase affects expression EXP Diclofenac affects the expression of FTCD mRNA CTD PMID:24752500 NCBI chr21:46,136,262...46,155,579
Ensembl chr21:46,136,160...46,155,579 		JBrowse link
G FYB1 FYN binding protein 1 increases expression ISO Diclofenac results in increased expression of FYB1 mRNA CTD PMID:26934552 NCBI chr 5:39,105,252...39,274,528
Ensembl chr 5:39,105,252...39,274,528 		JBrowse link
G FZD3 frizzled class receptor 3 affects expression EXP Diclofenac affects the expression of FZD3 mRNA CTD PMID:24752500 NCBI chr 8:28,494,212...28,574,258
Ensembl chr 8:28,494,205...28,574,267 		JBrowse link
G FZD4 frizzled class receptor 4 affects expression EXP Diclofenac affects the expression of FZD4 mRNA CTD PMID:24752500 NCBI chr11:86,945,679...86,955,395
Ensembl chr11:86,945,679...86,955,395 		JBrowse link
G FZD5 frizzled class receptor 5 affects expression EXP Diclofenac affects the expression of FZD5 mRNA CTD PMID:24752500 NCBI chr 2:207,762,598...207,769,906
Ensembl chr 2:207,762,598...207,769,906 		JBrowse link
G FZD6 frizzled class receptor 6 affects expression EXP Diclofenac affects the expression of FZD6 mRNA CTD PMID:24752500 NCBI chr 8:103,298,494...103,332,866
Ensembl chr 8:103,298,433...103,332,866 		JBrowse link
G FZD7 frizzled class receptor 7 affects expression EXP Diclofenac affects the expression of FZD7 mRNA CTD PMID:24752500 NCBI chr 2:202,033,855...202,038,441
Ensembl chr 2:202,033,855...202,038,441 		JBrowse link
G GAB1 GRB2 associated binding protein 1 affects expression EXP Diclofenac affects the expression of GAB1 mRNA CTD PMID:24752500 NCBI chr 4:143,336,876...143,474,565
Ensembl chr 4:143,336,876...143,474,565 		JBrowse link
G GAB2 GRB2 associated binding protein 2 affects expression EXP Diclofenac affects the expression of GAB2 mRNA CTD PMID:24752500 NCBI chr11:78,215,293...78,417,820
Ensembl chr11:78,215,293...78,418,348 		JBrowse link
G GABRA5 gamma-aminobutyric acid type A receptor subunit alpha5 decreases expression ISO Diclofenac results in decreased expression of GABRA5 mRNA CTD PMID:26934552 NCBI chr15:26,866,719...26,949,208
Ensembl chr15:26,866,911...26,949,208 		JBrowse link
G GADD45A growth arrest and DNA damage inducible alpha increases expression
decreases expression
affects expression		 EXP
ISO		 Diclofenac results in increased expression of GADD45A mRNA
Diclofenac results in decreased expression of GADD45A mRNA
Diclofenac affects the expression of GADD45A mRNA		 CTD PMID:18172885 PMID:19022234 PMID:24752500 PMID:26934552 PMID:35537566 NCBI chr 1:67,685,201...67,688,334
Ensembl chr 1:67,685,201...67,688,334 		JBrowse link
G GADD45G growth arrest and DNA damage inducible gamma increases expression ISO Diclofenac results in increased expression of GADD45G mRNA CTD PMID:26934552 NCBI chr 9:89,605,012...89,606,555
Ensembl chr 9:89,605,012...89,606,555 		JBrowse link
G GALNT3 polypeptide N-acetylgalactosaminyltransferase 3 increases expression ISO Diclofenac results in increased expression of GALNT3 mRNA CTD PMID:30723492 NCBI chr 2:165,747,588...165,794,692
Ensembl chr 2:165,747,588...165,846,201 		JBrowse link
G GARS1 glycyl-tRNA synthetase 1 affects expression
decreases expression		 EXP
ISO		 Diclofenac affects the expression of GARS1 mRNA
Diclofenac results in decreased expression of GARS1 mRNA		 CTD PMID:24752500 PMID:35537566 NCBI chr 7:30,594,735...30,634,033
Ensembl chr 7:30,580,533...30,634,033 		JBrowse link
G GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase affects expression EXP Diclofenac affects the expression of GART mRNA CTD PMID:24752500 NCBI chr21:33,503,931...33,542,893
Ensembl chr21:33,503,931...33,543,491 		JBrowse link
G GAS1 growth arrest specific 1 decreases expression ISO Diclofenac results in decreased expression of GAS1 mRNA CTD PMID:26934552 NCBI chr 9:86,944,362...86,947,506
Ensembl chr 9:86,944,362...86,947,506 		JBrowse link
G GATA4 GATA binding protein 4 affects expression EXP Diclofenac affects the expression of GATA4 mRNA CTD PMID:24752500 NCBI chr 8:11,676,935...11,760,002
Ensembl chr 8:11,676,959...11,760,002 		JBrowse link
G GATA6 GATA binding protein 6 increases expression ISO Diclofenac results in increased expression of GATA6 mRNA CTD PMID:26934552 NCBI chr18:22,169,589...22,202,528
Ensembl chr18:22,169,589...22,202,528 		JBrowse link
G GBP1 guanylate binding protein 1 decreases expression EXP Diclofenac results in decreased expression of GBP1 mRNA CTD PMID:19192274 NCBI chr 1:89,052,319...89,065,208
Ensembl chr 1:89,051,882...89,065,360 		JBrowse link
G GBP4 guanylate binding protein 4 increases expression ISO Diclofenac results in increased expression of GBP3 mRNA CTD PMID:26934552 NCBI chr 1:89,181,144...89,198,942
Ensembl chr 1:89,181,144...89,198,942 		JBrowse link
G GC GC vitamin D binding protein multiple interactions ISO [Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of GC protein CTD PMID:25772430 NCBI chr 4:71,741,693...71,805,520
Ensembl chr 4:71,741,696...71,804,041 		JBrowse link
G GCK glucokinase affects expression ISO Diclofenac affects the expression of GCK mRNA CTD PMID:26934552 NCBI chr 7:44,143,213...44,189,439
Ensembl chr 7:44,143,213...44,198,170 		JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit decreases expression
affects expression
affects response to substance		 ISO
EXP		 Diclofenac results in decreased expression of GCLC mRNA
Diclofenac affects the expression of GCLC mRNA
GCLC protein affects the susceptibility to Diclofenac		 CTD PMID:17202759 PMID:19481141 PMID:24752500 NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970 		JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit affects expression EXP Diclofenac affects the expression of GCLM mRNA CTD PMID:24752500 NCBI chr 1:93,885,199...93,909,430
Ensembl chr 1:93,885,199...93,909,456 		JBrowse link
G GDF15 growth differentiation factor 15 increases expression ISO
EXP		 Diclofenac results in increased expression of GDF15 mRNA
Diclofenac results in increased expression of GDF15 protein		 CTD PMID:15555568 PMID:18076062 NCBI chr19:18,386,158...18,389,176
Ensembl chr19:18,374,731...18,389,176 		JBrowse link
G GDF6 growth differentiation factor 6 increases expression ISO Diclofenac results in increased expression of GDF6 mRNA CTD PMID:30723492 NCBI chr 8:96,142,333...96,160,806
Ensembl chr 8:96,142,333...96,160,806 		JBrowse link
G GDF9 growth differentiation factor 9 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of GDF9 mRNA CTD PMID:37844793 NCBI chr 5:132,861,185...132,866,651
Ensembl chr 5:132,861,181...132,866,884 		JBrowse link
G GFPT1 glutamine--fructose-6-phosphate transaminase 1 increases expression ISO Diclofenac results in increased expression of GFPT1 mRNA CTD PMID:26934552 NCBI chr 2:69,319,780...69,387,227
Ensembl chr 2:69,319,780...69,387,250 		JBrowse link
G GGT1 gamma-glutamyltransferase 1 multiple interactions ISO [lipopolysaccharide, E coli O55-B5 co-treated with Diclofenac] results in increased activity of GGT1 protein CTD PMID:23939143 NCBI chr22:24,583,750...24,628,996
Ensembl chr22:24,594,811...24,629,005 		JBrowse link
G GHR growth hormone receptor affects expression ISO Diclofenac affects the expression of GHR protein CTD PMID:26934552 NCBI chr 5:42,423,439...42,721,878
Ensembl chr 5:42,423,439...42,721,878 		JBrowse link
G GIT2 GIT ArfGAP 2 affects expression EXP Diclofenac affects the expression of GIT2 mRNA CTD PMID:24752500 NCBI chr12:109,929,804...110,000,164
Ensembl chr12:109,929,804...109,996,389 		JBrowse link
G GJA1 gap junction protein alpha 1 increases expression ISO Diclofenac results in increased expression of GJA1 mRNA CTD PMID:26934552 PMID:35537566 NCBI chr 6:121,435,646...121,449,727
Ensembl chr 6:121,435,595...121,449,727 		JBrowse link
G GJA3 gap junction protein alpha 3 increases expression ISO Diclofenac results in increased expression of GJA3 mRNA CTD PMID:26934552 NCBI chr13:20,138,255...20,161,565
Ensembl chr13:20,138,255...20,161,052 		JBrowse link
G GLDC glycine decarboxylase affects expression EXP Diclofenac affects the expression of GLDC mRNA CTD PMID:24752500 NCBI chr 9:6,532,467...6,645,729
Ensembl chr 9:6,532,467...6,645,729 		JBrowse link
G GLYCTK glycerate kinase affects expression EXP Diclofenac affects the expression of GLYCTK mRNA CTD PMID:24752500 NCBI chr 3:52,287,828...52,295,257
Ensembl chr 3:52,287,089...52,295,257 		JBrowse link
G GNA13 G protein subunit alpha 13 affects expression EXP Diclofenac affects the expression of GNA13 mRNA CTD PMID:24752500 NCBI chr17:65,009,289...65,056,740
Ensembl chr17:65,009,289...65,056,740 		JBrowse link
G GNAQ G protein subunit alpha q affects expression EXP Diclofenac affects the expression of GNAQ mRNA CTD PMID:24752500 NCBI chr 9:77,716,097...78,031,811
Ensembl chr 9:77,716,097...78,031,811 		JBrowse link
G GNAS GNAS complex locus affects expression EXP Diclofenac affects the expression of GNAS mRNA CTD PMID:24752500 NCBI chr20:58,839,748...58,911,192
Ensembl chr20:58,839,718...58,911,192 		JBrowse link
G GNAT1 G protein subunit alpha transducin 1 increases expression ISO Diclofenac results in increased expression of GNAT1 mRNA CTD PMID:26934552 NCBI chr 3:50,191,610...50,197,696
Ensembl chr 3:50,191,610...50,197,696 		JBrowse link
G GNB5 G protein subunit beta 5 affects expression EXP Diclofenac affects the expression of GNB5 mRNA CTD PMID:24752500 NCBI chr15:52,115,100...52,191,392
Ensembl chr15:52,115,100...52,191,392 		JBrowse link
G GNG4 G protein subunit gamma 4 affects expression EXP Diclofenac affects the expression of GNG4 mRNA CTD PMID:24752500 NCBI chr 1:235,547,685...235,650,608
Ensembl chr 1:235,547,685...235,650,754 		JBrowse link
G GOT1 glutamic-oxaloacetic transaminase 1 affects expression
increases secretion		 EXP Diclofenac affects the expression of GOT1 mRNA
Diclofenac results in increased secretion of GOT1 protein		 CTD PMID:24752500 PMID:36442613 NCBI chr10:99,396,870...99,430,624
Ensembl chr10:99,396,870...99,430,624 		JBrowse link
G GPD1 glycerol-3-phosphate dehydrogenase 1 multiple interactions ISO Diclofenac inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of GPD1 protein] CTD PMID:25772430 NCBI chr12:50,104,008...50,111,313
Ensembl chr12:50,103,982...50,111,313 		JBrowse link
G GPLD1 glycosylphosphatidylinositol specific phospholipase D1 affects expression EXP Diclofenac affects the expression of GPLD1 mRNA CTD PMID:24752500 NCBI chr 6:24,423,969...24,495,287
Ensembl chr 6:24,424,565...24,495,205 		JBrowse link
G GPR176 G protein-coupled receptor 176 decreases expression ISO Diclofenac results in decreased expression of GPR176 mRNA CTD PMID:35537566 NCBI chr15:39,799,008...39,920,266
Ensembl chr15:39,799,008...39,920,936 		JBrowse link
G GPR20 G protein-coupled receptor 20 decreases expression ISO Diclofenac results in decreased expression of GPR20 mRNA CTD PMID:30723492 NCBI chr 8:141,356,470...141,367,286
Ensembl chr 8:141,356,470...141,367,286 		JBrowse link
G GPT glutamic--pyruvic transaminase multiple interactions
increases secretion
increases expression
increases activity		 ISO
EXP		 [lipopolysaccharide, E coli O55-B5 co-treated with Diclofenac] results in increased activity of GPT protein; Diclofenac promotes the reaction [endotoxin, Escherichia coli results in increased activity of GPT protein]; Heparin inhibits the reaction [Diclofenac promotes the reaction [endotoxin, Escherichia coli results in increased activity of GPT protein]]
Diclofenac results in increased secretion of GPT protein
Diclofenac results in increased expression of GPT protein
Diclofenac results in increased activity of GPT protein
eritoran inhibits the reaction [Diclofenac results in increased expression of GPT protein]		 CTD PMID:23939143 PMID:24747151 PMID:26934552 PMID:27671914 PMID:30925002 More... NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174 		JBrowse link
G GPT2 glutamic--pyruvic transaminase 2 decreases expression ISO Diclofenac results in decreased expression of GPT2 mRNA CTD PMID:35537566 NCBI chr16:46,884,362...46,931,289
Ensembl chr16:46,884,362...46,931,289 		JBrowse link
G GPX1 glutathione peroxidase 1 increases expression ISO
EXP		 Diclofenac results in increased expression of GPX1 mRNA; Diclofenac results in increased expression of GPX1 protein CTD PMID:25772430 PMID:29027214 NCBI chr 3:49,357,176...49,358,353
Ensembl chr 3:49,357,174...49,358,605 		JBrowse link
G GPX2 glutathione peroxidase 2 affects expression EXP Diclofenac affects the expression of GPX2 mRNA CTD PMID:24752500 NCBI chr14:64,939,158...64,942,745
Ensembl chr14:64,939,152...64,942,746 		JBrowse link
G GRB10 growth factor receptor bound protein 10 affects expression EXP Diclofenac affects the expression of GRB10 mRNA CTD PMID:24752500 NCBI chr 7:50,590,068...50,793,453
Ensembl chr 7:50,590,063...50,793,462 		JBrowse link
G GRID2 glutamate ionotropic receptor delta type subunit 2 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of GRID2 mRNA CTD PMID:37844793 NCBI chr 4:92,303,966...93,810,456
Ensembl chr 4:92,303,966...93,810,157 		JBrowse link
G GRM7 glutamate metabotropic receptor 7 increases expression ISO Diclofenac results in increased expression of GRM7 mRNA CTD PMID:26934552 NCBI chr 3:6,861,115...7,741,533
Ensembl chr 3:6,770,001...7,741,533 		JBrowse link
G GSDMD gasdermin D increases cleavage
multiple interactions		 ISO Diclofenac results in increased cleavage of GSDMD protein
diacerein inhibits the reaction [Diclofenac results in increased cleavage of GSDMD protein]		 CTD PMID:38582345 NCBI chr 8:143,553,387...143,563,062
Ensembl chr 8:143,553,207...143,563,062 		JBrowse link
G GSK3B glycogen synthase kinase 3 beta affects expression EXP Diclofenac affects the expression of GSK3B mRNA CTD PMID:24752500 NCBI chr 3:119,821,321...120,094,447
Ensembl chr 3:119,821,321...120,094,994 		JBrowse link
G GSN gelsolin decreases expression ISO Diclofenac results in decreased expression of GSN mRNA CTD PMID:26934552 NCBI chr 9:121,201,483...121,332,842
Ensembl chr 9:121,207,794...121,332,843 		JBrowse link
G GSTA1 glutathione S-transferase alpha 1 decreases activity EXP Diclofenac results in decreased activity of GSTA1 protein CTD PMID:27183920 NCBI chr 6:52,791,371...52,803,816
Ensembl chr 6:52,791,371...52,803,860 		JBrowse link
G GSTA3 glutathione S-transferase alpha 3 decreases activity EXP Diclofenac results in decreased activity of GSTA3 protein CTD PMID:27183920 NCBI chr 6:52,896,646...52,909,698
Ensembl chr 6:52,896,639...52,909,698 		JBrowse link
G GSTA4 glutathione S-transferase alpha 4 decreases activity EXP Diclofenac results in decreased activity of GSTA4 protein CTD PMID:27183920 NCBI chr 6:52,977,953...52,995,284
Ensembl chr 6:52,977,948...52,995,304 		JBrowse link
G GSTA5 glutathione S-transferase alpha 5 increases expression
multiple interactions		 ISO Diclofenac results in increased expression of GSTA5 protein
[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of GSTA5 protein		 CTD PMID:25772430 NCBI chr 6:52,831,692...52,846,245
Ensembl chr 6:52,831,655...52,840,843 		JBrowse link
G GSTM1 glutathione S-transferase mu 1 decreases activity
decreases expression		 EXP
ISO		 Diclofenac results in decreased activity of GSTM1 protein
Diclofenac results in decreased expression of GSTM1 mRNA		 CTD PMID:26934552 PMID:27183920 NCBI chr 1:109,687,817...109,693,745
Ensembl chr 1:109,687,814...109,709,039 		JBrowse link
G GSTM2 glutathione S-transferase mu 2 decreases activity EXP Diclofenac results in decreased activity of GSTM2 protein CTD PMID:27183920 NCBI chr 1:109,668,057...109,683,997
Ensembl chr 1:109,668,022...109,709,551 		JBrowse link
G GSTM3 glutathione S-transferase mu 3 increases expression ISO Diclofenac results in increased expression of GSTM3 mRNA CTD PMID:26934552 NCBI chr 1:109,733,937...109,741,038
Ensembl chr 1:109,733,932...109,741,038 		JBrowse link
G GSTM4 glutathione S-transferase mu 4 affects activity EXP Diclofenac affects the activity of GSTM4 protein CTD PMID:27183920 NCBI chr 1:109,656,099...109,667,727
Ensembl chr 1:109,656,099...109,665,496 		JBrowse link
G GSTP1 glutathione S-transferase pi 1 multiple interactions
affects activity
affects metabolic processing		 EXP [[CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [[CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 5-hydroxydiclofenac; [CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac; [CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased metabolism of Diclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of Diclofenac; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac
Diclofenac affects the activity of GSTP1 protein
GSTP1 protein affects the metabolism of Diclofenac metabolite; GSTP1 protein polymorphism affects the metabolism of Diclofenac metabolite		 CTD PMID:24185126 PMID:24246759 PMID:27183920 NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656 		JBrowse link
G GSTT1 glutathione S-transferase theta 1 affects expression
affects activity		 EXP Diclofenac affects the expression of GSTT1 mRNA
Diclofenac affects the activity of GSTT1 protein		 CTD PMID:24752500 PMID:27183920
G GSTT3P glutathione S-transferase theta 3, pseudogene decreases expression ISO Diclofenac results in decreased expression of GSTT3 mRNA CTD PMID:26934552
G GTF2H4 general transcription factor IIH subunit 4 affects expression EXP Diclofenac affects the expression of GTF2H4 mRNA CTD PMID:24752500 NCBI chr 6:30,908,207...30,914,106
Ensembl chr 6:30,908,207...30,914,106 		JBrowse link
G GTF2H5 general transcription factor IIH subunit 5 affects expression EXP Diclofenac affects the expression of GTF2H5 mRNA CTD PMID:24752500 NCBI chr 6:158,168,350...158,199,344
Ensembl chr 6:158,168,350...158,199,344 		JBrowse link
G GTPBP2 GTP binding protein 2 decreases expression ISO Diclofenac results in decreased expression of GTPBP2 mRNA CTD PMID:35537566 NCBI chr 6:43,620,494...43,631,333
Ensembl chr 6:43,605,316...43,629,264 		JBrowse link
G H2AX H2A.X variant histone increases expression EXP Diclofenac results in increased expression of H2AX protein CTD PMID:32087850 NCBI chr11:119,093,874...119,095,465
Ensembl chr11:119,093,874...119,095,465 		JBrowse link
G H2BC4 H2B clustered histone 4 decreases expression ISO Diclofenac results in decreased expression of H2BC21 mRNA CTD PMID:26934552 NCBI chr 6:26,113,170...26,123,926
Ensembl chr 6:26,086,317...26,123,926 		JBrowse link
G HAMP hepcidin antimicrobial peptide affects expression
decreases secretion		 ISO Diclofenac affects the expression of HAMP mRNA
Diclofenac results in decreased secretion of HAMP protein		 CTD PMID:24038040 PMID:26934552 NCBI chr19:35,282,528...35,285,143
Ensembl chr19:35,280,716...35,285,143 		JBrowse link
G HAT1 histone acetyltransferase 1 affects expression EXP Diclofenac affects the expression of HAT1 mRNA CTD PMID:24752500 NCBI chr 2:171,922,461...171,983,686
Ensembl chr 2:171,922,448...171,983,686 		JBrowse link
G HAVCR1 hepatitis A virus cellular receptor 1 increases expression
increases secretion
multiple interactions		 EXP
ISO		 Diclofenac results in increased expression of HAVCR1 mRNA
Diclofenac results in increased secretion of HAVCR1 protein
diacerein inhibits the reaction [Diclofenac results in increased secretion of HAVCR1 protein]		 CTD PMID:23506792 PMID:38582345 NCBI chr 5:157,029,413...157,069,407
Ensembl chr 5:157,026,742...157,069,396 		JBrowse link
G HBA1 hemoglobin subunit alpha 1 increases expression ISO Diclofenac results in increased expression of HBA-A2 protein CTD PMID:14565772 NCBI chr16:176,680...177,522
Ensembl chr16:176,680...177,522 		JBrowse link
G HBB hemoglobin subunit beta increases expression ISO Diclofenac results in increased expression of HBB protein CTD PMID:14565772 NCBI chr11:5,225,464...5,227,071
Ensembl chr11:5,225,464...5,229,395 		JBrowse link
G HBEGF heparin binding EGF like growth factor affects expression
decreases expression
increases expression		 EXP
ISO		 Diclofenac affects the expression of HBEGF mRNA
Diclofenac results in decreased expression of HBEGF mRNA
Diclofenac results in increased expression of HBEGF mRNA		 CTD PMID:24752500 PMID:26934552 PMID:35537566 NCBI chr 5:140,332,843...140,346,603
Ensembl chr 5:140,332,843...140,346,603 		JBrowse link
G HCK HCK proto-oncogene, Src family tyrosine kinase increases expression ISO Diclofenac results in increased expression of HCK mRNA CTD PMID:26934552 NCBI chr20:32,052,242...32,101,856
Ensembl chr20:32,052,197...32,101,856 		JBrowse link
G HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 decreases expression EXP Diclofenac results in decreased expression of HERC5 mRNA CTD PMID:19192274 NCBI chr 4:88,457,119...88,506,163
Ensembl chr 4:88,457,119...88,506,163 		JBrowse link
G HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 decreases expression
increases expression		 EXP
ISO		 Diclofenac results in decreased expression of HERC6 mRNA
Diclofenac results in increased expression of HERC6 mRNA		 CTD PMID:19192274 PMID:26934552 NCBI chr 4:88,378,852...88,443,097
Ensembl chr 4:88,378,739...88,443,097 		JBrowse link
G HERPUD1 homocysteine inducible ER protein with ubiquitin like domain 1 affects expression
decreases expression		 EXP
ISO		 Diclofenac affects the expression of HERPUD1 mRNA
Diclofenac results in decreased expression of HERPUD1 mRNA		 CTD PMID:24752500 PMID:26934552 PMID:35537566 NCBI chr16:56,932,142...56,944,864
Ensembl chr16:56,932,142...56,944,864 		JBrowse link
G HES6 hes family bHLH transcription factor 6 decreases expression ISO Diclofenac results in decreased expression of HES6 mRNA CTD PMID:26934552 NCBI chr 2:238,238,267...238,240,038
Ensembl chr 2:238,238,267...238,240,662 		JBrowse link
G HHEX hematopoietically expressed homeobox decreases expression ISO Diclofenac results in decreased expression of HHEX mRNA CTD PMID:26934552 NCBI chr10:92,689,955...92,695,647
Ensembl chr10:92,689,955...92,695,647 		JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha decreases expression EXP Diclofenac results in decreased expression of HIF1A protein CTD PMID:12912967 NCBI chr14:61,695,513...61,748,258
Ensembl chr14:61,695,513...61,748,259 		JBrowse link
G HK1 hexokinase 1 increases expression ISO Diclofenac results in increased expression of HK1 mRNA CTD PMID:26934552 NCBI chr10:69,270,000...69,401,882
Ensembl chr10:69,269,984...69,401,884 		JBrowse link
G HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 decreases expression ISO Diclofenac results in decreased expression of RT1-BB mRNA CTD PMID:17202759 NCBI chr 6:32,659,467...32,666,657
Ensembl chr 6:32,659,467...32,668,383 		JBrowse link
G HLA-DRB1 major histocompatibility complex, class II, DR beta 1 affects expression EXP Diclofenac affects the expression of HLA-DRB1 mRNA CTD PMID:25811541 NCBI chr 6:32,578,775...32,589,848
Ensembl chr 6:32,577,902...32,589,848 		JBrowse link
G HMGB1 high mobility group box 1 multiple interactions
increases expression
affects expression		 ISO
EXP		 Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of HMGB1 protein]
Diclofenac results in increased expression of HMGB1 mRNA; Diclofenac results in increased expression of HMGB1 protein
Diclofenac affects the expression of HMGB1 mRNA		 CTD PMID:23939143 PMID:24747151 PMID:24752500 PMID:26934552 NCBI chr13:30,456,704...30,617,597
Ensembl chr13:30,456,704...30,617,597 		JBrowse link
G HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 decreases expression ISO Diclofenac results in decreased expression of HMGCS2 mRNA CTD PMID:26934552 NCBI chr 1:119,747,996...119,768,932
Ensembl chr 1:119,748,002...119,768,905 		JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions
decreases expression
increases expression
affects expression		 EXP
ISO		 1-aminobenzotriazole inhibits the reaction [[Diclofenac co-treated with Buthionine Sulfoximine] results in increased expression of HMOX1 mRNA]; Buthionine Sulfoximine promotes the reaction [Diclofenac results in increased expression of HMOX1 mRNA]
Diclofenac results in decreased expression of HMOX1 protein
Diclofenac results in increased expression of HMOX1 mRNA; Diclofenac results in increased expression of HMOX1 protein
Acetylcysteine inhibits the reaction [Diclofenac results in increased expression of HMOX1 protein]; Buthionine Sulfoximine promotes the reaction [Diclofenac results in increased expression of HMOX1 protein]; Diclofenac promotes the reaction [Buthionine Sulfoximine results in increased expression of HMOX1 protein]
Acetylcysteine inhibits the reaction [Diclofenac results in increased expression of HMOX1 mRNA]; Dactinomycin inhibits the reaction [Diclofenac results in increased expression of HMOX1 mRNA]; diacerein inhibits the reaction [Diclofenac results in decreased expression of HMOX1 protein]; Diclofenac promotes the reaction [Poly I-C results in increased expression of HMOX1 mRNA]; Ketoconazole inhibits the reaction [Diclofenac results in increased expression of HMOX1 mRNA]; Sulfaphenazole inhibits the reaction [Diclofenac results in increased expression of HMOX1 mRNA]; Tranylcypromine inhibits the reaction [Diclofenac results in increased expression of HMOX1 mRNA]
Diclofenac affects the expression of HMOX1 protein		 CTD PMID:12763371 PMID:18172885 PMID:18227147 PMID:19022234 PMID:19952508 More... NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214 		JBrowse link
G HMX3 H6 family homeobox 3 decreases expression ISO Diclofenac results in decreased expression of HMX3 mRNA CTD PMID:35537566 NCBI chr10:123,135,970...123,139,423
Ensembl chr10:123,135,970...123,139,423 		JBrowse link
G HNF1A HNF1 homeobox A affects expression EXP Diclofenac affects the expression of HNF1A mRNA CTD PMID:24752500 NCBI chr12:120,978,543...121,002,512
Ensembl chr12:120,978,543...121,002,512 		JBrowse link
G HNF4A hepatocyte nuclear factor 4 alpha decreases expression ISO Diclofenac results in decreased expression of HNF4A mRNA CTD PMID:19022234 NCBI chr20:44,355,699...44,434,596
Ensembl chr20:44,355,699...44,432,845 		JBrowse link
G HNRNPD heterogeneous nuclear ribonucleoprotein D affects expression EXP Diclofenac affects the expression of HNRNPD mRNA CTD PMID:24752500 NCBI chr 4:82,352,498...82,373,991
Ensembl chr 4:82,352,498...82,374,503 		JBrowse link
G HOATZ HOATZ cilia and flagella associated protein multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of HOATZ mRNA CTD PMID:37844793 NCBI chr11:111,514,778...111,537,043
Ensembl chr11:111,514,778...111,537,043 		JBrowse link
G HP haptoglobin increases expression
decreases expression		 ISO Diclofenac results in increased expression of HP mRNA
Diclofenac results in decreased expression of HP mRNA		 CTD PMID:26934552 NCBI chr16:72,054,505...72,061,055
Ensembl chr16:72,054,505...72,061,055 		JBrowse link
G HPGD 15-hydroxyprostaglandin dehydrogenase increases activity
multiple interactions
increases expression		 EXP Diclofenac results in increased activity of HPGD protein
[Diclofenac co-treated with NAD] binds to HPGD protein
Diclofenac results in increased expression of HPGD mRNA		 CTD PMID:19501039 PMID:25526675 NCBI chr 4:174,490,175...174,522,893
Ensembl chr 4:174,490,175...174,523,154 		JBrowse link
G HRAS HRas proto-oncogene, GTPase affects expression EXP Diclofenac affects the expression of HRAS mRNA CTD PMID:24752500 NCBI chr11:532,242...535,576
Ensembl chr11:532,242...537,321 		JBrowse link
G HS3ST3B1 heparan sulfate-glucosamine 3-sulfotransferase 3B1 decreases expression ISO Diclofenac results in decreased expression of HS3ST3B1 mRNA CTD PMID:35537566 NCBI chr17:14,301,081...14,349,404
Ensembl chr17:14,301,081...14,349,404 		JBrowse link
G HS6ST2 heparan sulfate 6-O-sulfotransferase 2 increases expression ISO Diclofenac results in increased expression of HS6ST2 mRNA CTD PMID:26934552 NCBI chr  X:132,626,015...132,961,370
Ensembl chr  X:132,626,015...132,961,395 		JBrowse link
G HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 decreases expression ISO Diclofenac results in decreased expression of HSD3B2 mRNA CTD PMID:26934552 NCBI chr 1:119,507,203...119,515,058
Ensembl chr 1:119,507,198...119,515,054 		JBrowse link
G HSF1 heat shock transcription factor 1 increases activity EXP Diclofenac results in increased activity of HSF1 protein CTD PMID:34170685 NCBI chr 8:144,291,604...144,314,720
Ensembl chr 8:144,291,591...144,314,720 		JBrowse link
G HSP90AA1 heat shock protein 90 alpha family class A member 1 multiple interactions ISO Diclofenac inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of HSP90AA1 mRNA] CTD PMID:23939143 NCBI chr14:102,080,742...102,139,749
Ensembl chr14:102,080,742...102,139,699 		JBrowse link
G HSPA1A heat shock protein family A (Hsp70) member 1A multiple interactions
affects expression
increases expression		 ISO Diclofenac inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of HSPA1A mRNA]
[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of HSPA1A mRNA
Diclofenac affects the expression of HSPA1A mRNA
Diclofenac results in increased expression of HSPA1A mRNA		 CTD PMID:19022234 PMID:23939143 PMID:25014874 PMID:26934552 PMID:37844793 NCBI chr 6:31,815,543...31,817,942
Ensembl chr 6:31,815,543...31,817,946 		JBrowse link
G HSPA1B heat shock protein family A (Hsp70) member 1B increases expression
multiple interactions		 ISO Diclofenac results in increased expression of HSPA1B mRNA
[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of HSPA1B mRNA		 CTD PMID:26934552 PMID:37844793 NCBI chr 6:31,827,738...31,830,254
Ensembl chr 6:31,827,738...31,830,254 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 increases expression
multiple interactions		 ISO
EXP		 Diclofenac results in increased expression of HSPA5 mRNA
[Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of HSPA5 protein		 CTD PMID:25014874 PMID:25772430 PMID:27313093 NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382 		JBrowse link
G HSPA8 heat shock protein family A (Hsp70) member 8 multiple interactions
increases expression		 ISO Diclofenac inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of HSPA8 mRNA]
Diclofenac results in increased expression of HSPA8 mRNA		 CTD PMID:23939143 PMID:26934552 NCBI chr11:123,057,489...123,062,462
Ensembl chr11:123,057,489...123,063,230 		JBrowse link
G HSPB1 heat shock protein family B (small) member 1 decreases expression ISO Diclofenac results in decreased expression of HSPB1 mRNA CTD PMID:26934552 NCBI chr 7:76,302,673...76,304,292
Ensembl chr 7:76,302,673...76,305,813 		JBrowse link
G HSPB8 heat shock protein family B (small) member 8 increases expression ISO Diclofenac results in increased expression of HSPB8 mRNA CTD PMID:26934552 NCBI chr12:119,178,931...119,194,746
Ensembl chr12:119,171,555...119,224,855 		JBrowse link
G IARS1 isoleucyl-tRNA synthetase 1 decreases expression ISO Diclofenac results in decreased expression of IARS1 mRNA CTD PMID:35537566 NCBI chr 9:92,210,207...92,293,697
Ensembl chr 9:92,210,207...92,293,854 		JBrowse link
G IBTK inhibitor of Bruton tyrosine kinase increases expression ISO Diclofenac results in increased expression of IBTK mRNA CTD PMID:26934552 NCBI chr 6:82,169,987...82,247,744
Ensembl chr 6:82,169,986...82,247,754 		JBrowse link
G ICAM1 intercellular adhesion molecule 1 multiple interactions
increases expression
decreases expression
affects expression		 ISO
EXP		 Amlodipine inhibits the reaction [Diclofenac results in decreased expression of ICAM1 protein]
Diclofenac results in increased expression of ICAM1 mRNA
Diclofenac results in decreased expression of ICAM1 mRNA
Diclofenac affects the expression of ICAM1 mRNA		 CTD PMID:14716214 PMID:18460984 PMID:24752500 PMID:26934552 NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615 		JBrowse link
G ID2 inhibitor of DNA binding 2 increases expression ISO Diclofenac results in increased expression of ID2 mRNA CTD PMID:26934552 NCBI chr 2:8,682,056...8,684,461
Ensembl chr 2:8,678,845...8,684,461 		JBrowse link
G ID3 inhibitor of DNA binding 3 increases expression ISO Diclofenac results in increased expression of ID3 mRNA CTD PMID:26934552 NCBI chr 1:23,557,926...23,559,501
Ensembl chr 1:23,557,926...23,559,501 		JBrowse link
G IDH2 isocitrate dehydrogenase (NADP(+)) 2 decreases expression ISO Diclofenac results in decreased expression of IDH2 mRNA CTD PMID:26934552 NCBI chr15:90,083,045...90,102,468
Ensembl chr15:90,083,045...90,102,477 		JBrowse link
G IER3 immediate early response 3 increases expression ISO Diclofenac results in increased expression of IER3 mRNA CTD PMID:26934552 NCBI chr 6:30,743,199...30,744,547
Ensembl chr 6:30,743,199...30,744,548 		JBrowse link
G IFI27 interferon alpha inducible protein 27 decreases expression EXP Diclofenac results in decreased expression of IFI27 mRNA CTD PMID:19192274 NCBI chr14:94,105,894...94,116,690
Ensembl chr14:94,104,836...94,116,695 		JBrowse link
G IFI35 interferon induced protein 35 decreases expression EXP Diclofenac results in decreased expression of IFI35 mRNA CTD PMID:19192274 NCBI chr17:43,006,784...43,014,456
Ensembl chr17:43,006,740...43,014,456 		JBrowse link
G IFI44 interferon induced protein 44 decreases expression EXP
ISO		 Diclofenac results in decreased expression of IFI44 mRNA CTD PMID:19192274 PMID:35537566 NCBI chr 1:78,649,789...78,664,078
Ensembl chr 1:78,649,796...78,664,078 		JBrowse link
G IFI44L interferon induced protein 44 like decreases expression EXP Diclofenac results in decreased expression of IFI44L mRNA CTD PMID:19192274 NCBI chr 1:78,620,448...78,646,145
Ensembl chr 1:78,619,902...78,646,145 		JBrowse link
G IFI6 interferon alpha inducible protein 6 decreases expression EXP Diclofenac results in decreased expression of IFI6 mRNA CTD PMID:19192274 NCBI chr 1:27,666,064...27,672,192
Ensembl chr 1:27,666,064...27,672,212 		JBrowse link
G IFIH1 interferon induced with helicase C domain 1 decreases expression EXP Diclofenac results in decreased expression of IFIH1 mRNA CTD PMID:19192274 NCBI chr 2:162,267,074...162,318,684
Ensembl chr 2:162,267,074...162,318,684 		JBrowse link
G IFIT1 interferon induced protein with tetratricopeptide repeats 1 decreases expression EXP Diclofenac results in decreased expression of IFIT1 mRNA CTD PMID:19192274 NCBI chr10:89,392,623...89,406,487
Ensembl chr10:89,392,546...89,406,487 		JBrowse link
G IFIT3 interferon induced protein with tetratricopeptide repeats 3 decreases expression EXP Diclofenac results in decreased expression of IFIT3 mRNA CTD PMID:19192274 NCBI chr10:89,327,997...89,340,968
Ensembl chr10:89,327,307...89,377,473 		JBrowse link
G IFITM2 interferon induced transmembrane protein 2 increases expression ISO Diclofenac results in increased expression of IFITM2 mRNA CTD PMID:26934552 NCBI chr11:307,816...309,395
Ensembl chr11:303,655...309,397 		JBrowse link
G IFITM3 interferon induced transmembrane protein 3 increases expression ISO Diclofenac results in increased expression of IFITM3 mRNA CTD PMID:26934552 NCBI chr11:319,676...320,860
Ensembl chr11:319,676...329,475 		JBrowse link
G IFNA13 interferon alpha 13 increases expression ISO Diclofenac results in increased expression of IFNA9 mRNA CTD PMID:26934552 NCBI chr 9:21,367,372...21,368,057
Ensembl chr 9:21,367,372...21,368,057 		JBrowse link
G IFNG interferon gamma multiple interactions
decreases expression		 ISO
EXP		 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; Diclofenac inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IFNG protein]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in decreased expression of NFKBIA protein]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IFNG mRNA]; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IFNG protein]; RELA mutant form inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; SN50 peptide inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[Diclofenac co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[TNF protein co-treated with IFNG protein] promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [IFNG protein promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; 2-aminoethoxydiphenyl borate inhibits the reaction [[Diclofenac co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein]; 2-aminoethoxydiphenyl borate inhibits the reaction [[TNF protein co-treated with IFNG protein] promotes the reaction [Diclofenac results in increased activity of CASP3 protein]]; [Diclofenac co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein; [TNF protein co-treated with IFNG protein] promotes the reaction [Diclofenac affects the abundance of Calcium]; [TNF protein co-treated with IFNG protein] promotes the reaction [Diclofenac results in increased activity of CASP3 protein]; Calcium promotes the reaction [[Diclofenac co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein]; IFNG protein promotes the reaction [Diclofenac results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [[Diclofenac co-treated with IFNG protein] results in increased phosphorylation of STAT1 protein]
Diclofenac results in decreased expression of IFNG mRNA		 CTD PMID:19393675 PMID:22285467 PMID:23395999 PMID:23939143 PMID:26609140 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740 		JBrowse link
G IFRD1 interferon related developmental regulator 1 decreases expression ISO Diclofenac results in decreased expression of IFRD1 mRNA CTD PMID:35537566 NCBI chr 7:112,423,174...112,477,203
Ensembl chr 7:112,422,887...112,481,017 		JBrowse link
G IGF1R insulin like growth factor 1 receptor affects expression EXP Diclofenac affects the expression of IGF1R mRNA CTD PMID:24752500 NCBI chr15:98,648,539...98,964,530
Ensembl chr15:98,648,539...98,964,530 		JBrowse link
G IGF2R insulin like growth factor 2 receptor multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of IGF2R mRNA CTD PMID:37844793 NCBI chr 6:159,969,082...160,111,504
Ensembl chr 6:159,969,082...160,113,507 		JBrowse link
G IGFBP1 insulin like growth factor binding protein 1 affects expression
increases expression		 EXP
ISO		 Diclofenac affects the expression of IGFBP1 mRNA
Diclofenac results in increased expression of IGFBP1 mRNA		 CTD PMID:24752500 PMID:26934552 NCBI chr 7:45,888,488...45,893,660
Ensembl chr 7:45,888,360...45,893,660 		JBrowse link
G IGFBP2 insulin like growth factor binding protein 2 decreases expression ISO Diclofenac results in decreased expression of IGFBP2 mRNA CTD PMID:26934552 NCBI chr 2:216,632,828...216,664,436
Ensembl chr 2:216,632,828...216,664,436 		JBrowse link
G IGFBP3 insulin like growth factor binding protein 3 affects expression EXP Diclofenac affects the expression of IGFBP3 mRNA CTD PMID:24752500 NCBI chr 7:45,912,245...45,921,272
Ensembl chr 7:45,912,245...45,921,874 		JBrowse link
G IKBKB inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions ISO Diclofenac inhibits the reaction [Freund's Adjuvant results in increased phosphorylation of IKBKB protein] CTD PMID:25935278 NCBI chr 8:42,271,302...42,332,460
Ensembl chr 8:42,271,302...42,332,460 		JBrowse link
G IKBKE inhibitor of nuclear factor kappa B kinase subunit epsilon increases expression ISO Diclofenac results in increased expression of IKBKE mRNA CTD PMID:26934552 NCBI chr 1:206,470,476...206,496,889
Ensembl chr 1:206,470,476...206,496,889 		JBrowse link
G IKBKG inhibitor of nuclear factor kappa B kinase regulatory subunit gamma affects expression EXP Diclofenac affects the expression of IKBKG mRNA CTD PMID:24752500 NCBI chr  X:154,541,238...154,565,046
Ensembl chr  X:154,541,199...154,565,046 		JBrowse link
G IL10 interleukin 10 increases response to substance
multiple interactions		 EXP
ISO		 IL10 gene polymorphism results in increased susceptibility to Diclofenac
[Gum Arabic co-treated with Water deficiency co-treated with Diclofenac] results in increased expression of IL10 protein; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL10 protein]		 CTD PMID:15122773 PMID:23939143 PMID:31042592 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541 		JBrowse link
G IL12RB1 interleukin 12 receptor subunit beta 1 increases expression ISO Diclofenac results in increased expression of IL12RB1 mRNA CTD PMID:30723492 NCBI chr19:18,058,995...18,098,816
Ensembl chr19:18,058,995...18,098,944 		JBrowse link
G IL13RA1 interleukin 13 receptor subunit alpha 1 increases expression ISO Diclofenac results in increased expression of IL13RA1 mRNA CTD PMID:26934552 NCBI chr  X:118,727,606...118,805,228
Ensembl chr  X:118,727,133...118,794,535 		JBrowse link
G IL16 interleukin 16 decreases expression ISO Diclofenac results in decreased expression of IL16 mRNA CTD PMID:35537566 NCBI chr15:81,182,712...81,314,058
Ensembl chr15:81,159,575...81,314,058 		JBrowse link
G IL17A interleukin 17A increases expression
multiple interactions		 ISO Diclofenac results in increased expression of IL17A protein
Diclofenac inhibits the reaction [Freund's Adjuvant results in increased expression of IL17A protein]		 CTD PMID:22285467 PMID:25450234 NCBI chr 6:52,186,375...52,190,638
Ensembl chr 6:52,186,375...52,190,638 		JBrowse link
G IL18 interleukin 18 multiple interactions
increases expression		 ISO diacerein inhibits the reaction [Diclofenac results in increased expression of IL18 protein] CTD PMID:38582345 NCBI chr11:112,143,260...112,164,094
Ensembl chr11:112,143,251...112,164,096 		JBrowse link
G IL18BP interleukin 18 binding protein increases expression ISO Diclofenac results in increased expression of IL18BP mRNA CTD PMID:26934552 NCBI chr11:71,998,909...72,008,200
Ensembl chr11:71,998,613...72,007,315 		JBrowse link
G IL1A interleukin 1 alpha multiple interactions
increases expression		 EXP [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Diclofenac
Diclofenac results in increased expression of IL1A mRNA		 CTD PMID:19362101 PMID:32816093 NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493 		JBrowse link
G IL1B interleukin 1 beta multiple interactions
increases expression		 EXP
ISO		 Diclofenac inhibits the reaction [IL1B protein results in increased activity of PTGS2 protein]
Diclofenac inhibits the reaction [Freund's Adjuvant results in increased expression of IL1B protein]
Diclofenac results in increased expression of IL1B mRNA
Diclofenac results in increased expression of IL1B mRNA; Diclofenac results in increased expression of IL1B protein
3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; [Water deficiency co-treated with Diclofenac] results in increased expression of IL1B protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; diacerein inhibits the reaction [Diclofenac results in increased expression of IL1B protein]; Diclofenac inhibits the reaction [Freund's Adjuvant results in increased expression of IL1B protein]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in decreased expression of NFKBIA protein]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL1B mRNA]; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL1B protein]; Gum Arabic inhibits the reaction [[Water deficiency co-treated with Diclofenac] results in increased expression of IL1B protein]; RELA mutant form inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; SN50 peptide inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]		 CTD PMID:15135310 PMID:15705740 PMID:19393675 PMID:22285467 PMID:23395999 More... NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL1R1 interleukin 1 receptor type 1 affects expression
increases expression		 EXP
ISO		 Diclofenac affects the expression of IL1R1 mRNA
Diclofenac results in increased expression of IL1R1 mRNA		 CTD PMID:24752500 PMID:26934552 NCBI chr 2:102,070,390...102,179,874
Ensembl chr 2:102,064,544...102,179,874 		JBrowse link
G IL1R2 interleukin 1 receptor type 2 increases expression ISO Diclofenac results in increased expression of IL1R2 mRNA CTD PMID:26934552 PMID:30723492 NCBI chr 2:101,991,960...102,028,544
Ensembl chr 2:101,991,960...102,028,544 		JBrowse link
G IL1RN interleukin 1 receptor antagonist increases secretion
decreases expression
increases expression
multiple interactions		 EXP
ISO		 Diclofenac results in increased secretion of IL1RN protein
Diclofenac results in decreased expression of IL1RN mRNA
Diclofenac results in increased expression of IL1RN mRNA
Lipopolysaccharides inhibits the reaction [Diclofenac results in increased secretion of IL1RN protein]		 CTD PMID:9491209 PMID:26934552 PMID:35537566 NCBI chr 2:113,099,360...113,134,014
Ensembl chr 2:113,099,315...113,134,016 		JBrowse link
G IL2 interleukin 2 multiple interactions EXP Diclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL2 protein] CTD PMID:29777833 NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725 		JBrowse link
G IL23A interleukin 23 subunit alpha decreases expression EXP Diclofenac results in decreased expression of IL23A mRNA CTD PMID:19192274 NCBI chr12:56,338,884...56,340,410
Ensembl chr12:56,334,174...56,340,410 		JBrowse link
G IL24 interleukin 24 increases expression EXP Diclofenac results in increased expression of IL24 mRNA CTD PMID:32816093 NCBI chr 1:206,897,443...206,904,139
Ensembl chr 1:206,897,443...206,904,139 		JBrowse link
G IL2RG interleukin 2 receptor subunit gamma increases expression ISO Diclofenac results in increased expression of IL2RG mRNA CTD PMID:26934552 NCBI chr  X:71,107,404...71,111,577
Ensembl chr  X:71,107,404...71,112,108 		JBrowse link
G IL33 interleukin 33 decreases expression
increases expression		 ISO Diclofenac results in decreased expression of IL33 mRNA
Diclofenac results in increased expression of IL33 mRNA		 CTD PMID:26934552 NCBI chr 9:6,215,149...6,257,983
Ensembl chr 9:6,215,786...6,257,983 		JBrowse link
G IL4 interleukin 4 increases response to substance EXP IL4 gene polymorphism results in increased susceptibility to Diclofenac CTD PMID:15122773 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678 		JBrowse link
G IL5 interleukin 5 multiple interactions EXP Diclofenac inhibits the reaction [nickel sulfate results in increased secretion of IL5 protein] CTD PMID:15663561 NCBI chr 5:132,541,445...132,556,815
Ensembl chr 5:132,541,445...132,556,838 		JBrowse link
G IL6 interleukin 6 multiple interactions
increases expression
decreases expression		 EXP
ISO		 [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Diclofenac; Diclofenac affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL6 protein]; Diclofenac inhibits the reaction [Mustard Gas results in increased secretion of IL6 protein]; lipopolysaccharide, Escherichia coli O111 B4 inhibits the reaction [Diclofenac results in increased expression of IL6 protein]
Diclofenac results in increased expression of IL6 mRNA
Diclofenac results in decreased expression of IL6 mRNA; Diclofenac results in decreased expression of IL6 protein
Diclofenac results in increased expression of IL6 mRNA; Diclofenac results in increased expression of IL6 protein
Diclofenac inhibits the reaction [Carrageenan results in increased expression of IL6 protein]; Diclofenac inhibits the reaction [Freund's Adjuvant results in increased expression of IL6 protein]; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA]; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 protein]		 CTD PMID:19192274 PMID:19362101 PMID:23506792 PMID:23939143 PMID:24412305 More... NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G IMMT inner membrane mitochondrial protein affects expression ISO Diclofenac affects the expression of IMMT mRNA CTD PMID:26934552 NCBI chr 2:86,143,936...86,195,462
Ensembl chr 2:86,143,932...86,195,472 		JBrowse link
G INHBB inhibin subunit beta B increases expression ISO Diclofenac results in increased expression of INHBB mRNA CTD PMID:26934552 PMID:30723492 NCBI chr 2:120,346,136...120,351,803
Ensembl chr 2:120,346,136...120,351,803 		JBrowse link
G INKA2 inka box actin regulator 2 increases expression ISO Diclofenac results in increased expression of FAM212B mRNA CTD PMID:35537566 NCBI chr 1:111,722,064...111,755,797
Ensembl chr 1:111,680,630...111,755,824 		JBrowse link
G INMT indolethylamine N-methyltransferase decreases expression ISO Diclofenac results in decreased expression of INMT mRNA CTD PMID:26934552 NCBI chr 7:30,752,135...30,757,602
Ensembl chr 7:30,697,985...30,757,602 		JBrowse link
G INSL3 insulin like 3 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of INSL3 mRNA CTD PMID:37844793 NCBI chr19:17,816,512...17,821,519
Ensembl chr19:17,816,512...17,821,574 		JBrowse link
G INSL6 insulin like 6 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of INSL6 mRNA CTD PMID:37844793 NCBI chr 9:4,991,976...5,185,639
Ensembl chr 9:5,123,880...5,185,647 		JBrowse link
G INSR insulin receptor affects expression EXP Diclofenac affects the expression of INSR mRNA CTD PMID:24752500 NCBI chr19:7,112,265...7,294,414
Ensembl chr19:7,112,255...7,294,414 		JBrowse link
G IQCF1 IQ motif containing F1 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of IQCF1 mRNA CTD PMID:37844793 NCBI chr 3:51,894,876...51,903,353
Ensembl chr 3:51,894,876...51,903,353 		JBrowse link
G IRAK4 interleukin 1 receptor associated kinase 4 increases expression ISO Diclofenac results in increased expression of IRAK4 mRNA CTD PMID:26934552 NCBI chr12:43,758,951...43,789,541
Ensembl chr12:43,758,944...43,798,307 		JBrowse link
G IRF7 interferon regulatory factor 7 decreases expression EXP Diclofenac results in decreased expression of IRF7 mRNA CTD PMID:19192274 NCBI chr11:612,555...615,950
Ensembl chr11:612,553...615,983 		JBrowse link
G IRGM immunity related GTPase M increases expression ISO Diclofenac results in increased expression of IRGM1 mRNA CTD PMID:26934552 NCBI chr 5:150,846,521...150,902,402
Ensembl chr 5:150,846,521...150,900,736 		JBrowse link
G IRS1 insulin receptor substrate 1 affects expression EXP
ISO		 Diclofenac affects the expression of IRS1 mRNA CTD PMID:24752500 PMID:26934552 NCBI chr 2:226,731,312...226,799,820
Ensembl chr 2:226,731,312...226,799,820 		JBrowse link
G ISG15 ISG15 ubiquitin like modifier decreases expression EXP Diclofenac results in decreased expression of ISG15 mRNA CTD PMID:19192274 NCBI chr 1:1,013,497...1,014,540
Ensembl chr 1:1,001,138...1,014,540 		JBrowse link
G ISG20 interferon stimulated exonuclease gene 20 decreases expression EXP Diclofenac results in decreased expression of ISG20 mRNA CTD PMID:19192274 NCBI chr15:88,635,632...88,656,483
Ensembl chr15:88,635,670...88,656,483 		JBrowse link
G ISYNA1 inositol-3-phosphate synthase 1 increases expression ISO Diclofenac results in increased expression of ISYNA1 mRNA CTD PMID:26934552 NCBI chr19:18,434,388...18,438,133
Ensembl chr19:18,434,388...18,438,167 		JBrowse link
G ITGA2 integrin subunit alpha 2 affects expression EXP Diclofenac affects the expression of ITGA2 mRNA CTD PMID:24752500 NCBI chr 5:52,989,352...53,094,779
Ensembl chr 5:52,989,340...53,094,779 		JBrowse link
G ITGAL integrin subunit alpha L increases expression ISO Diclofenac results in increased expression of ITGAL mRNA CTD PMID:26934552 NCBI chr16:30,472,742...30,523,185
Ensembl chr16:30,472,658...30,523,567 		JBrowse link
G ITGAM integrin subunit alpha M increases expression ISO Diclofenac results in increased expression of ITGAM mRNA CTD PMID:27671914 NCBI chr16:31,259,975...31,332,877
Ensembl chr16:31,259,967...31,332,892 		JBrowse link
G ITGAX integrin subunit alpha X decreases expression ISO Diclofenac results in decreased expression of ITGAX mRNA CTD PMID:35537566 NCBI chr16:31,355,176...31,382,999
Ensembl chr16:31,355,134...31,382,999 		JBrowse link
G ITGB1 integrin subunit beta 1 affects expression EXP Diclofenac affects the expression of ITGB1 mRNA CTD PMID:24752500 NCBI chr10:32,900,318...32,958,230
Ensembl chr10:32,887,273...33,005,792 		JBrowse link
G ITGB2 integrin subunit beta 2 increases expression ISO Diclofenac results in increased expression of ITGB2 mRNA CTD PMID:26934552 NCBI chr21:44,885,953...44,928,815
Ensembl chr21:44,885,953...44,931,989 		JBrowse link
G ITGB3 integrin subunit beta 3 multiple interactions EXP Diclofenac inhibits the reaction [TNF protein results in increased expression of ITGB3 protein] CTD PMID:19691487 NCBI chr17:47,253,827...47,313,743
Ensembl chr17:47,253,827...47,313,743 		JBrowse link
G ITIH3 inter-alpha-trypsin inhibitor heavy chain 3 increases expression ISO Diclofenac results in increased expression of ITIH3 mRNA CTD PMID:26934552 NCBI chr 3:52,794,796...52,808,797
Ensembl chr 3:52,794,768...52,808,799 		JBrowse link
G ITIH4 inter-alpha-trypsin inhibitor heavy chain 4 increases expression ISO Diclofenac results in increased expression of ITIH4 mRNA CTD PMID:26934552 NCBI chr 3:52,812,962...52,830,672
Ensembl chr 3:52,812,962...52,830,688 		JBrowse link
G ITM2A integral membrane protein 2A increases expression EXP Diclofenac results in increased expression of ITM2A mRNA CTD PMID:17379860 NCBI chr  X:79,360,384...79,367,334
Ensembl chr  X:79,360,384...79,367,667 		JBrowse link
G JADE2 jade family PHD finger 2 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of JADE2 mRNA CTD PMID:37844793 NCBI chr 5:134,523,952...134,583,227
Ensembl chr 5:134,524,312...134,583,230 		JBrowse link
G JADE3 jade family PHD finger 3 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of JADE3 mRNA CTD PMID:37844793 NCBI chr  X:46,912,301...47,061,242
Ensembl chr  X:46,912,276...47,061,242 		JBrowse link
G JDP2 Jun dimerization protein 2 decreases expression ISO Diclofenac results in decreased expression of JDP2 mRNA CTD PMID:35537566 NCBI chr14:75,426,943...75,474,107
Ensembl chr14:75,427,716...75,474,111 		JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit affects expression
increases expression		 EXP
ISO		 Diclofenac affects the expression of JUN mRNA
Diclofenac results in increased expression of JUN mRNA		 CTD PMID:24752500 PMID:26934552 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048 		JBrowse link
G JUNB JunB proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of JUNB mRNA CTD PMID:37844793 NCBI chr19:12,791,486...12,793,315
Ensembl chr19:12,791,486...12,793,315 		JBrowse link
G JUND JunD proto-oncogene, AP-1 transcription factor subunit increases expression EXP
ISO		 Diclofenac results in increased expression of JUND mRNA CTD PMID:19022234 NCBI chr19:18,279,694...18,281,622
Ensembl chr19:18,279,694...18,281,622 		JBrowse link
G KAT6B lysine acetyltransferase 6B affects expression EXP Diclofenac affects the expression of KAT6B mRNA CTD PMID:24752500 NCBI chr10:74,824,936...75,032,624
Ensembl chr10:74,824,927...75,032,624 		JBrowse link
G KBTBD11 kelch repeat and BTB domain containing 11 increases expression ISO Diclofenac results in increased expression of KBTBD11 mRNA CTD PMID:30723492 NCBI chr 8:1,973,677...2,006,936
Ensembl chr 8:1,973,677...2,006,936 		JBrowse link
G KHDC3L KH domain containing 3 like, subcortical maternal complex member increases expression ISO Diclofenac results in increased expression of KHDC3 mRNA CTD PMID:30723492 NCBI chr 6:73,362,658...73,364,171
Ensembl chr 6:73,362,658...73,364,171 		JBrowse link
G KIF5C kinesin family member 5C increases expression ISO Diclofenac results in increased expression of KIF5C mRNA CTD PMID:30723492 NCBI chr 2:148,875,227...149,026,759
Ensembl chr 2:148,875,227...149,026,759 		JBrowse link
G KIT KIT proto-oncogene, receptor tyrosine kinase multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in increased expression of KIT mRNA CTD PMID:37844793 NCBI chr 4:54,657,957...54,740,715
Ensembl chr 4:54,657,267...54,740,783 		JBrowse link
G KLF4 KLF transcription factor 4 decreases expression ISO Diclofenac results in decreased expression of KLF4 mRNA CTD PMID:35537566 NCBI chr 9:107,484,852...107,489,769
Ensembl chr 9:107,484,852...107,490,482 		JBrowse link
G KLHL33 kelch like family member 33 decreases expression ISO Diclofenac results in decreased expression of KLHL33 mRNA CTD PMID:35537566 NCBI chr14:20,425,852...20,436,166
Ensembl chr14:20,425,852...20,436,166 		JBrowse link
G KLK1 kallikrein 1 increases expression ISO Diclofenac results in increased expression of KLK1 protein CTD PMID:23506792 NCBI chr19:50,819,146...50,823,787
Ensembl chr19:50,819,146...50,823,787 		JBrowse link
G KNDC1 kinase non-catalytic C-lobe domain containing 1 increases expression ISO Diclofenac results in increased expression of KNDC1 mRNA CTD PMID:30723492 NCBI chr10:133,160,219...133,226,412
Ensembl chr10:133,160,219...133,226,412 		JBrowse link
G KNG1 kininogen 1 multiple interactions
increases expression		 ISO [Diclofenac co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of KNG1 protein; lipopolysaccharide, E coli O55-B5 promotes the reaction [Diclofenac results in increased expression of KNG1 protein] CTD PMID:25772430 NCBI chr 3:186,717,359...186,744,410
Ensembl chr 3:186,717,348...186,744,410 		JBrowse link
G KRAS KRAS proto-oncogene, GTPase affects expression EXP Diclofenac affects the expression of KRAS mRNA CTD PMID:24752500 NCBI chr12:25,205,246...25,250,929
Ensembl chr12:25,205,246...25,250,936 		JBrowse link
G LAX1 lymphocyte transmembrane adaptor 1 decreases expression ISO Diclofenac results in decreased expression of LAX1 mRNA CTD PMID:26934552 NCBI chr 1:203,765,183...203,776,372
Ensembl chr 1:203,765,177...203,778,175 		JBrowse link
G LBP lipopolysaccharide binding protein increases expression
affects expression
decreases expression		 ISO Diclofenac results in increased expression of LBP protein
Diclofenac affects the expression of LBP mRNA
Diclofenac results in decreased expression of LBP mRNA		 CTD PMID:26934552 NCBI chr20:38,346,482...38,377,013
Ensembl chr20:38,346,482...38,377,013 		JBrowse link
G LCE1D late cornified envelope 1D decreases expression ISO Diclofenac results in decreased expression of LCE1D mRNA CTD PMID:26934552 NCBI chr 1:152,796,721...152,798,181
Ensembl chr 1:152,796,721...152,798,181 		JBrowse link
G LCN2 lipocalin 2 increases expression
increases secretion
multiple interactions		 ISO Diclofenac results in increased expression of LCN2 mRNA
Diclofenac results in increased secretion of LCN2 protein
diacerein inhibits the reaction [Diclofenac results in increased secretion of LCN2 protein]; Diclofenac inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of LCN2 protein]; Diclofenac promotes the reaction [Buthionine Sulfoximine results in increased expression of LCN2 mRNA]		 CTD PMID:23939143 PMID:26934552 PMID:38582345 NCBI chr 9:128,149,453...128,153,453
Ensembl chr 9:128,149,071...128,153,453 		JBrowse link
G LCP2 lymphocyte cytosolic protein 2 increases expression ISO Diclofenac results in increased expression of LCP2 mRNA CTD PMID:26934552 NCBI chr 5:170,246,233...170,297,777
Ensembl chr 5:170,246,233...170,297,815 		JBrowse link
G LDHA lactate dehydrogenase A increases expression ISO Diclofenac results in increased expression of LDHA protein CTD PMID:25772430 NCBI chr11:18,394,563...18,408,425
Ensembl chr11:18,394,560...18,408,425 		JBrowse link
G LEAP2 liver enriched antimicrobial peptide 2 increases expression ISO Diclofenac results in increased expression of LEAP2 mRNA CTD PMID:26934552 NCBI chr 5:132,873,668...132,875,046
Ensembl chr 5:132,873,444...132,875,046 		JBrowse link
G LEPR leptin receptor affects expression
increases expression		 ISO Diclofenac affects the expression of LEPR mRNA
Diclofenac results in increased expression of LEPR protein		 CTD PMID:26934552 NCBI chr 1:65,420,652...65,641,559
Ensembl chr 1:65,420,652...65,641,559 		JBrowse link
G LGALS3 galectin 3 increases expression ISO Diclofenac results in increased expression of LGALS3 mRNA CTD PMID:26934552 NCBI chr14:55,129,252...55,145,430
Ensembl chr14:55,124,110...55,145,423 		JBrowse link
G LGMN legumain increases expression ISO Diclofenac results in increased expression of LGMN mRNA CTD PMID:26934552 NCBI chr14:92,703,809...92,748,627
Ensembl chr14:92,703,807...92,748,679 		JBrowse link
G LGR4 leucine rich repeat containing G protein-coupled receptor 4 increases expression ISO Diclofenac results in increased expression of LGR4 mRNA CTD PMID:35537566 NCBI chr11:27,365,961...27,472,790
Ensembl chr11:27,365,961...27,472,790 		JBrowse link
G LHX2 LIM homeobox 2 decreases expression ISO Diclofenac results in decreased expression of LHX2 mRNA CTD PMID:35537566 NCBI chr 9:124,011,768...124,033,301
Ensembl chr 9:124,001,670...124,033,301 		JBrowse link
G LIFR LIF receptor subunit alpha decreases expression ISO Diclofenac results in decreased expression of LIFR mRNA CTD PMID:26934552 NCBI chr 5:38,474,668...38,608,403
Ensembl chr 5:38,474,668...38,608,354 		JBrowse link
G LILRB3 leukocyte immunoglobulin like receptor B3 increases expression ISO Diclofenac results in increased expression of PIRB mRNA CTD PMID:26934552 PMID:30723492 NCBI chr19:54,216,278...54,223,007
Ensembl chr19:54,216,278...54,223,506 		JBrowse link
G LIPC lipase C, hepatic type decreases expression ISO Diclofenac results in decreased expression of LIPC mRNA CTD PMID:26934552 NCBI chr15:58,431,991...58,569,844
Ensembl chr15:58,410,569...58,569,844 		JBrowse link
G LITAF lipopolysaccharide induced TNF factor increases expression ISO Diclofenac results in increased expression of LITAF mRNA CTD PMID:26934552 NCBI chr16:11,547,722...11,640,317
Ensembl chr16:11,546,875...11,636,381 		JBrowse link
G LMNB1 lamin B1 increases expression ISO Diclofenac results in increased expression of LMNB1 mRNA CTD PMID:35537566 NCBI chr 5:126,776,623...126,837,020
Ensembl chr 5:126,776,623...126,837,020 		JBrowse link
G LMO4 LIM domain only 4 decreases expression ISO Diclofenac results in decreased expression of LMO4 mRNA CTD PMID:35537566 NCBI chr 1:87,328,880...87,348,923
Ensembl chr 1:87,328,880...87,348,923 		JBrowse link
G LPAR4 lysophosphatidic acid receptor 4 decreases expression ISO Diclofenac results in decreased expression of LPAR4 mRNA CTD PMID:26934552 NCBI chr  X:78,747,720...78,758,714
Ensembl chr  X:78,747,709...78,758,714 		JBrowse link
G LPL lipoprotein lipase increases expression ISO Diclofenac results in increased expression of LPL mRNA CTD PMID:26934552 NCBI chr 8:19,939,253...19,967,259
Ensembl chr 8:19,901,717...19,967,259 		JBrowse link
G LRG1 leucine rich alpha-2-glycoprotein 1 increases expression ISO Diclofenac results in increased expression of LRG1 mRNA CTD PMID:26934552 NCBI chr19:4,536,402...4,540,036
Ensembl chr19:4,536,402...4,540,036 		JBrowse link
G LRP8 LDL receptor related protein 8 increases expression ISO Diclofenac results in increased expression of LRP8 mRNA CTD PMID:35537566 NCBI chr 1:53,242,364...53,328,070
Ensembl chr 1:53,242,364...53,328,469 		JBrowse link
G LTC4S leukotriene C4 synthase increases expression ISO Diclofenac results in increased expression of LTC4S mRNA CTD PMID:30723492 NCBI chr 5:179,793,986...179,796,647
Ensembl chr 5:179,793,980...179,796,647 		JBrowse link
G LXN latexin increases expression EXP Diclofenac results in increased expression of LXN mRNA CTD PMID:19192274 NCBI chr 3:158,666,414...158,672,648
Ensembl chr 3:158,645,822...158,672,648 		JBrowse link
G LY6E lymphocyte antigen 6 family member E decreases expression
increases expression		 EXP
ISO		 Diclofenac results in decreased expression of LY6E mRNA
Diclofenac results in increased expression of LY6E mRNA		 CTD PMID:19192274 PMID:26934552 NCBI chr 8:143,018,529...143,022,409
Ensembl chr 8:143,017,982...143,023,832 		JBrowse link
G LY75 lymphocyte antigen 75 increases expression ISO Diclofenac results in increased expression of LY75 mRNA CTD PMID:26934552 NCBI chr 2:159,803,355...159,904,756
Ensembl chr 2:159,803,355...159,904,756 		JBrowse link
G LYZ lysozyme increases expression ISO Diclofenac results in increased expression of LYZ2 mRNA CTD PMID:26934552 NCBI chr12:69,348,381...69,354,234
Ensembl chr12:69,348,381...69,354,234 		JBrowse link
G MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1 affects expression EXP Diclofenac affects the expression of MAGI1 mRNA CTD PMID:24752500 NCBI chr 3:65,353,526...66,038,918
Ensembl chr 3:65,353,525...66,038,918 		JBrowse link
G MALSU1 mitochondrial assembly of ribosomal large subunit 1 multiple interactions ISO [Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of MALSU1 mRNA CTD PMID:37844793 NCBI chr 7:23,299,339...23,311,729
Ensembl chr 7:23,298,739...23,311,729 		JBrowse link
G MAOA monoamine oxidase A affects expression EXP Diclofenac affects the expression of MAOA mRNA CTD PMID:24752500 NCBI chr  X:43,655,006...43,746,817
Ensembl chr  X:43,654,907...43,746,817 		JBrowse link
G MAOB monoamine oxidase B affects expression EXP Diclofenac affects the expression of MAOB mRNA CTD PMID:24752500 NCBI chr  X:43,766,610...43,882,450
Ensembl chr  X:43,766,610...43,882,450 		JBrowse link
G MAP2K3 mitogen-activated protein kinase kinase 3 affects expression EXP Diclofenac affects the expression of MAP2K3 mRNA CTD PMID:24752500 NCBI chr17:21,284,711...21,315,240
Ensembl chr17:21,284,672...21,315,232 		JBrowse link
G MAP2K5 mitogen-activated protein kinase kinase 5 affects expression EXP Diclofenac affects the expression of MAP2K5 mRNA CTD PMID:24752500 NCBI chr15:67,542,703...67,807,114
Ensembl chr15:67,542,703...67,807,117 		JBrowse link
G MAP2K6 mitogen-activated protein kinase kinase 6 affects expression EXP Diclofenac affects the expression of MAP2K6 mRNA CTD PMID:24752500 NCBI chr17:69,414,697...69,553,865
Ensembl chr17:69,414,697...69,553,865 		JBrowse link
G MAP3K1 mitogen-activated protein kinase kinase kinase 1 increases expression ISO Diclofenac results in increased expression of MAP3K1 mRNA CTD PMID:26934552 NCBI chr 5:56,815,549...56,896,152
Ensembl chr 5:56,815,549...56,896,152 		JBrowse link
G MAP3K12 mitogen-activated protein kinase kinase kinase 12 decreases expression ISO Diclofenac results in decreased expression of MAP3K12 mRNA CTD PMID:18172885 NCBI chr12:53,479,669...53,501,539
Ensembl chr12:53,479,669...53,500,063 		JBrowse link
G MAP3K7 mitogen-activated protein kinase kinase kinase 7 affects expression EXP Diclofenac affects the expression of MAP3K7 mRNA CTD PMID:24752500 NCBI chr 6:90,513,579...90,587,072
Ensembl chr 6:90,513,573...90,587,086 		JBrowse link
G MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 affects expression EXP Diclofenac affects the expression of MAP4K4 mRNA CTD PMID:24752500 NCBI chr 2:101,697,707...101,894,690
Ensembl chr 2:101,696,850...101,894,690 		JBrowse link
G MAP7D1 MAP7 domain containing 1 increases expression ISO Diclofenac results in increased expression of MAP7D1 mRNA CTD PMID:26934552 NCBI chr 1:36,156,160...36,180,849
Ensembl chr 1:36,155,579...36,180,849 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions
increases phosphorylation		 EXP 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Diclofenac results in increased phosphorylation of MAPK1 protein]; 2-aminoethoxydiphenyl borate inhibits the reaction [Diclofenac results in increased phosphorylation of MAPK1 protein]; Calcium promotes the reaction [Diclofenac results in increased phosphorylation of MAPK1 protein]; pyrazolanthrone inhibits the reaction [Diclofenac results in increased phosphorylation of MAPK1 protein]
Diclofenac analog results in increased phosphorylation of MAPK1 protein; Diclofenac results in increased phosphorylation of MAPK1 protein		 CTD PMID:24104198 PMID:26609140 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK13 mitogen-activated protein kinase 13 affects expression EXP Diclofenac affects the expression of MAPK13 mRNA CTD PMID:24752500 NCBI chr 6:36,130,513...36,144,521
Ensembl chr 6:36,127,809...36,144,524 		JBrowse link
G MAPK14 mitogen-activated protein kinase 14 affects expression EXP Diclofenac affects the expression of MAPK14 mRNA CTD PMID:24752500 NCBI chr 6:36,027,808...36,124,214
Ensembl chr 6:36,027,752...36,122,511 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation		 EXP 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Diclofenac results in increased phosphorylation of MAPK3 protein]; 2-aminoethoxydiphenyl borate inhibits the reaction [Diclofenac results in increased phosphorylation of MAPK3 protein]; Calcium promotes the reaction [Diclofenac results in increased phosphorylation of MAPK3 protein]; pyrazolanthrone inhibits the reaction [Diclofenac results in increased phosphorylation of MAPK3 protein]
Diclofenac analog results in increased phosphorylation of MAPK3 protein; Diclofenac results in increased phosphorylation of MAPK3 protein		 CTD PMID:24104198 PMID:26609140 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 affects expression EXP Diclofenac affects the expression of MAPK8 mRNA CTD PMID:24752500 NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360 		JBrowse link
G MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3 increases expression ISO Diclofenac results in increased expression of MAPK8IP3 mRNA CTD PMID:26934552 NCBI chr16:1,706,195...1,770,351
Ensembl chr16:1,706,166...1,770,351 		JBrowse link
G MAPKAPK3 MAPK activated protein kinase 3 increases expression ISO Diclofenac results in increased expression of MAPKAPK3 mRNA CTD PMID:26934552 NCBI chr 3:50,611,520...50,649,291
Ensembl chr 3:50,611,520...50,649,291 		JBrowse link
G MARCHF1 membrane associated ring-CH-type finger 1 increases expression ISO Diclofenac results in increased expression of MARCHF1 mRNA CTD PMID:26934552 PMID:35537566 NCBI chr 4:163,524,298...164,384,019
Ensembl chr 4:163,524,298...164,384,050 		JBrowse link
G MARCO macrophage receptor with collagenous structure increases expression
decreases expression		 ISO Diclofenac results in increased expression of MARCO mRNA
Diclofenac results in decreased expression of MARCO mRNA		 CTD PMID:26934552 NCBI chr 2:118,942,194...118,994,660
Ensembl chr 2:118,942,194...118,994,660 		JBrowse link
G MASTL microtubule associated serine/threonine kinase like decreases expression ISO Diclofenac results in decreased expression of MASTL mRNA CTD PMID:26934552 PMID:35537566 NCBI chr10:27,154,479...27,187,953
Ensembl chr10:27,154,824...27,187,953 		JBrowse link
G MBL1P mannose binding lectin 1, pseudogene increases expression ISO Diclofenac results in increased expression of MBL1 mRNA CTD PMID:26934552