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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1348334
Species: Homo sapiens
RGD Object: Gene
Symbol: PDE8B
Name: phosphodiesterase 8B
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PDE8Baffects methylationEXP 6480464CTDBenzo(a)pyrene affects the methylation of PDE8B promoterPMID:27901495
PDE8Bdecreases expressionEXP 6480464CTDBenzo(a)pyrene results in decreased expression of PDE8B mRNAPMID:20106945
PDE8Bincreases methylationEXP 6480464CTDBenzo(a)pyrene results in increased methylation of PDE8B exonPMID:27901495
PDE8Bdecreases expressionISOPde8b (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of PDE8B mRNAPMID:21569818
PDE8Bincreases methylationISOPde8b (Mus musculus)6480464CTDBenzo(a)pyrene results in increased methylation of PDE8B intronPMID:27901495
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