Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1347215
Species: Homo sapiens
RGD Object: Gene
Symbol: TIMP1
Name: TIMP metallopeptidase inhibitor 1
Acc ID: CHEBI:9927
Term: valsartan
Definition: A monocarboxylic acid amide consisting of L-valine in which the amino hydrogens have been replaced by a pentanoyl and a [2'-(1H-tetrazol-5-yl)biphenyl]-4-yl]methyl group. It exhibits antihypertensive activity.
Chemical ID: MESH:C081489
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TIMP1multiple interactionsEXP 6480464CTDValsartan inhibits the reaction [AGT protein results in increased expression of TIMP1 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of TIMP1 protein]PMID:12846741
TIMP1decreases expressionISOTimp1 (Rattus norvegicus)6480464CTDValsartan results in decreased expression of TIMP1 mRNA; Valsartan results in decreased expression of TIMP1 proteinPMID:21051829
TIMP1multiple interactionsISOTimp1 (Rattus norvegicus)6480464CTD[Valsartan co-treated with Fosinopril] results in decreased expression of TIMP1 mRNA; [Valsartan co-treated with Fosinopril] results in decreased expression of TIMP1 protein; Valsartan inhibits the reaction [Dimethylnitrosamine results in increased expression of TIMP1 mRNA]PMID:15504291 PMID:21051829
Go Back to source page   Continue to Ontology report