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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1344540
Species: Homo sapiens
RGD Object: Gene
Symbol: IL1RN
Name: interleukin 1 receptor antagonist
Acc ID: CHEBI:63791
Term: lenalidomide
Definition: A dicarboximide that consists of 1-oxoisoindoline bearing an amino substituent at position 4 and a 2,6-dioxopiperidin-3-yl group at position 2. Inhibits the secretion of TNF-alpha.
Chemical ID: MESH:C467567
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IL1RNmultiple interactionsISOIl1rn (Mus musculus)6480464CTDlenalidomide promotes the reaction [SOD1 gene mutant form results in increased expression of IL1RN mRNA]PMID:16510725
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