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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1344192
Species: Homo sapiens
RGD Object: Gene
Symbol: TNF
Name: tumor necrosis factor
Acc ID: CHEBI:10033
Term: warfarin
Definition: A racemate comprising equal amounts of (R)- and (S)-warfarin. Extensively used as both an anticoagulant drug and as a pesticide against rats and mice.
Chemical ID: MESH:D014859
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TNFdecreases expressionISOTnf (Rattus norvegicus)6480464CTDWarfarin results in decreased expression of TNF mRNAPMID:22342526 PMID:26742017
TNFdecreases secretionISOTnf (Rattus norvegicus)6480464CTDWarfarin results in decreased secretion of TNF proteinPMID:22342526 PMID:26742017
TNFincreases expressionISOTnf (Rattus norvegicus)6480464CTDWarfarin results in increased expression of TNFPMID:21565690
TNFmultiple interactionsISOTnf (Rattus norvegicus)6480464CTD[Warfarin co-treated with Vitamin K] results in increased expression of TNF mRNAPMID:23117658
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