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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1344001
Species: Homo sapiens
RGD Object: Gene
Symbol: GDF15
Name: growth differentiation factor 15
Acc ID: CHEBI:4911
Term: etoposide
Definition: A furonaphthodioxole that has formula C29H32O13.
Chemical ID: MESH:D005047
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GDF15increases expressionEXP 6480464CTD[Etoposide results in increased expression of TP53 protein] which results in increased expression of GDF15 protein; Etoposide results in increased expression of GDF15 mRNA; Etoposide results in increased expression of GDF15 proteinPMID:11895857 PMID:16120219 PMID:24211769 PMID:29397400
GDF15multiple interactionsEXP 6480464CTDEtoposide promotes the reaction [[TP53 protein binds to GDF15 promoter] which results in increased expression of GDF15 mRNA]PMID:11895857
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