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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:etoposide
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Accession:CHEBI:4911 term browser browse the term
Definition:A furonaphthodioxole that has formula C29H32O13.
Synonyms:exact_synonym: (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside
 related_synonym: 4'-Demethylepipodophyllotoxin 9-(4,6-O-(R)-ethylidene-beta-D-glucopyranoside);   4-demethylepipodophyllotoxin beta-D-ethylideneglucoside;   9-((4,6-O-Ethylidine-beta-D-glucopyranosyl)oxy)-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,4-dimethyloxyphenyl)furo(3',4'':6,7)naptho-(2,3-d)-1,3-dioxol-6(5aH)-one;   Eposin;   Etopophos;   Etoposido;   Formula=C29H32O13;   InChI=1S/C29H32O13/c1-11-36-9-20-27(40-11)24(31)25(32)29(41-20)42-26-14-7-17-16(38-10-39-17)6-13(14)21(22-15(26)8-37-28(22)33)12-4-18(34-2)23(30)19(5-12)35-3/h4-7,11,15,20-22,24-27,29-32H,8-10H2,1-3H3/t11-,15+,20-,21-,22+,24-,25-,26-,27-,29+/m1/s1;   InChIKey=VJJPUSNTGOMMGY-MRVIYFEKSA-N;   Lastet;   SMILES=[H][C@]12COC(=O)[C@]1([H])[C@H](c1cc(OC)c(O)c(OC)c1)c1cc3OCOc3cc1[C@H]2O[C@@H]1O[C@@H]2CO[C@@H](C)O[C@H]2[C@H](O)[C@H]1O;   Toposar;   VP-16;   Vepesid;   etoposidum;   trans-Etoposide
 xref: CAS:33419-42-0;   DrugBank:DB00773;   Drug_Central:1112;   KEGG:C01576;   KEGG:D00125;   LINCS:LSM-6348
 xref_mesh: MESH:D005047
 xref: Patent:US3524844;   Wikipedia:Etoposide


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etoposide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 affects response to substance
multiple interactions
increases expression
EXP ABCB1 exon polymorphism affects the susceptibility to Etoposide
[[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of ABCB1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of ABCB1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [Celecoxib results in decreased expression of ABCB1] which results in increased susceptibility to Etoposide
Etoposide results in increased expression of ABCB1 mRNA; Etoposide results in increased expression of ABCB1 protein
CTD PMID:12969965 PMID:15239124 PMID:19047049 PMID:19562670 PMID:27570640 PMID:27840903 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
Ensembl chr 7:87,503,017...87,713,323
JBrowse link
G ABCC1 ATP binding cassette subfamily C member 1 affects response to substance
decreases response to substance
multiple interactions
decreases uptake
increases expression
EXP
ISO
ABCC1 protein affects the susceptibility to Etoposide
ABCC1 protein results in decreased susceptibility to Etoposide; ABCC1 results in decreased susceptibility to Etoposide
[GCLC protein co-treated with GCLM protein] promotes the reaction [ABCC1 protein results in decreased susceptibility to Etoposide]; [MYCN protein affects the expression of ABCC1 mRNA] which affects the susceptibility to Etoposide; GSTP1 protein promotes the reaction [ABCC1 protein results in decreased susceptibility to Etoposide]; hesperetin inhibits the reaction [ABCC1 protein results in decreased susceptibility to Etoposide]; naringenin inhibits the reaction [ABCC1 protein results in decreased susceptibility to Etoposide]; resveratrol inhibits the reaction [ABCC1 protein results in decreased susceptibility to Etoposide]; Silymarin inhibits the reaction [ABCC1 protein results in decreased susceptibility to Etoposide]; Tocopherols inhibits the reaction [ABCC1 protein affects the export of Etoposide]; verlukast inhibits the reaction [ABCC1 protein results in decreased susceptibility to Etoposide]
ABCC1 protein results in decreased uptake of Etoposide
Etoposide results in increased expression of ABCC1 mRNA
Glucose inhibits the reaction [Sodium Azide inhibits the reaction [ABCC1 protein results in decreased uptake of Etoposide]]; Sodium Azide inhibits the reaction [ABCC1 protein results in decreased uptake of Etoposide]; Verapamil inhibits the reaction [ABCC1 protein results in decreased susceptibility to Etoposide]; Verapamil inhibits the reaction [ABCC1 protein results in decreased uptake of Etoposide]
CTD PMID:7954421 PMID:8968083 PMID:9334814 PMID:10348353 PMID:10856430 PMID:10900222 PMID:11778547 PMID:15180633 PMID:15460906 PMID:15617835 PMID:15999103 PMID:16156793 PMID:16217747 NCBI chr16:15,949,616...16,143,062
Ensembl chr16:15,949,577...16,143,074
Ensembl chr16:15,949,577...16,143,074
JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 affects transport
multiple interactions
EXP ABCC2 protein affects the transport of Etoposide
Probenecid promotes the reaction [ABCC2 protein affects the transport of Etoposide]
CTD PMID:15751272 PMID:15849751 NCBI chr10:99,782,602...99,853,741
Ensembl chr10:99,782,640...99,852,594
JBrowse link
G ABCC3 ATP binding cassette subfamily C member 3 decreases response to substance EXP ABCC3 protein results in decreased susceptibility to Etoposide CTD PMID:15884115 NCBI chr17:50,634,881...50,692,253
Ensembl chr17:50,634,777...50,692,253
JBrowse link
G ABCG2 ATP binding cassette subfamily G member 2 (Junior blood group) multiple interactions EXP [ERBB2 results in increased expression of ABCG2] which results in decreased susceptibility to Etoposide; ABCG2 mutant form inhibits the reaction [ERBB2 results in decreased susceptibility to Etoposide] CTD PMID:21712253 NCBI chr 4:88,090,264...88,231,626
Ensembl chr 4:88,090,150...88,231,628
JBrowse link
G ABHD4 abhydrolase domain containing 4, N-acyl phospholipase B increases expression ISO Etoposide results in increased expression of ABHD4 mRNA CTD PMID:25270620 NCBI chr14:22,598,238...22,612,864
Ensembl chr14:22,598,237...22,613,215
JBrowse link
G ABRA actin binding Rho activating protein increases expression EXP Etoposide results in increased expression of ABRA mRNA CTD PMID:29397400 NCBI chr 8:106,759,483...106,809,073
Ensembl chr 8:106,759,483...106,770,244
JBrowse link
G ACADM acyl-CoA dehydrogenase medium chain affects response to substance EXP ACADM protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 1:75,724,709...75,763,679
Ensembl chr 1:75,724,347...75,787,575
JBrowse link
G ACE2 angiotensin I converting enzyme 2 increases expression EXP Etoposide results in increased expression of ACE2 mRNA CTD PMID:29397400 NCBI chr  X:15,518,197...15,602,158
Ensembl chr  X:15,561,033...15,602,148
Ensembl chr  X:15,561,033...15,602,148
JBrowse link
G ACO1 aconitase 1 increases expression ISO Etoposide results in increased expression of ACO1 mRNA CTD PMID:25270620 NCBI chr 9:32,384,643...32,454,769
Ensembl chr 9:32,384,603...32,454,769
JBrowse link
G ACSL3 acyl-CoA synthetase long chain family member 3 affects response to substance EXP ACSL3 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 2:222,861,036...222,944,639
Ensembl chr 2:222,860,942...222,944,639
JBrowse link
G ACTA1 actin alpha 1, skeletal muscle decreases expression EXP Etoposide results in decreased expression of ACTA1 mRNA CTD PMID:29397400 NCBI chr 1:229,431,245...229,434,094
Ensembl chr 1:229,431,245...229,434,098
JBrowse link
G AGRN agrin increases expression EXP Etoposide results in increased expression of AGRN mRNA CTD PMID:17374387 NCBI chr 1:1,020,102...1,056,119
Ensembl chr 1:1,020,120...1,056,118
JBrowse link
G AHCYL1 adenosylhomocysteinase like 1 affects response to substance EXP AHCYL1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 1:109,984,765...110,023,742
Ensembl chr 1:109,984,765...110,023,742
JBrowse link
G AHI1 Abelson helper integration site 1 increases expression EXP Etoposide results in increased expression of AHI1 protein alternative form CTD PMID:19379585 NCBI chr 6:135,283,532...135,497,771
Ensembl chr 6:135,283,532...135,497,765
JBrowse link
G AKAP12 A-kinase anchoring protein 12 affects response to substance EXP AKAP12 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 6:151,239,815...151,358,559
Ensembl chr 6:151,239,967...151,358,559
JBrowse link
G AKT1 AKT serine/threonine kinase 1 increases response to substance
increases phosphorylation
multiple interactions
EXP AKT1 protein modified form results in increased susceptibility to Etoposide
Etoposide results in increased phosphorylation of AKT1 protein
Etoposide results in increased phosphorylation of and results in increased activity of AKT1 protein; pepstatin inhibits the reaction [AKT1 protein modified form results in increased susceptibility to Etoposide]; PTEN protein inhibits the reaction [Etoposide results in increased phosphorylation of and results in increased activity of AKT1 protein]
CTD PMID:17699715 PMID:17935137 PMID:27769712 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G ALAD aminolevulinate dehydratase multiple interactions EXP [Cyclophosphamide co-treated with Carmustine co-treated with Etoposide] results in decreased activity of ALAD protein CTD PMID:19162187 NCBI chr 9:113,386,312...113,401,301
Ensembl chr 9:113,386,312...113,401,290
JBrowse link
G ALAS1 5'-aminolevulinate synthase 1 increases expression ISO Etoposide results in increased expression of ALAS1 mRNA CTD PMID:25270620 NCBI chr 3:52,198,083...52,214,327
Ensembl chr 3:52,198,086...52,214,327
JBrowse link
G ALDH3A1 aldehyde dehydrogenase 3 family member A1 affects response to substance EXP ALDH3A1 protein affects the susceptibility to Etoposide CTD PMID:15905174 NCBI chr17:19,737,984...19,748,390
Ensembl chr17:19,737,984...19,748,943
JBrowse link
G ALDOC aldolase, fructose-bisphosphate C affects response to substance
multiple interactions
EXP
ISO
ALDOC protein affects the susceptibility to Etoposide
[Etoposide co-treated with Cisplatin co-treated with Bleomycin] results in decreased expression of ALDOC protein
CTD PMID:16217747 PMID:29733421 NCBI chr17:28,573,115...28,576,963
Ensembl chr17:28,573,115...28,576,948
JBrowse link
G ALPG alkaline phosphatase, germ cell affects response to substance EXP ALPG protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 2:232,406,844...232,410,714
Ensembl chr 2:232,406,844...232,410,714
JBrowse link
G ALPP alkaline phosphatase, placental affects response to substance EXP ALPP protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 2:232,378,751...232,382,889
Ensembl chr 2:232,378,724...232,382,889
JBrowse link
G ANK1 ankyrin 1 increases expression EXP Etoposide results in increased expression of ANK1 mRNA CTD PMID:29397400 NCBI chr 8:41,653,225...41,896,741
Ensembl chr 8:41,653,220...41,896,762
JBrowse link
G ANKRD10 ankyrin repeat domain 10 decreases expression EXP Etoposide results in decreased expression of ANKRD10 mRNA CTD PMID:21527772 NCBI chr13:110,878,540...110,915,071
Ensembl chr13:110,878,540...110,915,069
JBrowse link
G ANKRD27 ankyrin repeat domain 27 decreases expression ISO Etoposide results in decreased expression of ANKRD27 mRNA CTD PMID:25270620 NCBI chr19:32,597,005...32,675,215
Ensembl chr19:32,597,006...32,676,597
JBrowse link
G ANKRD28 ankyrin repeat domain 28 affects response to substance EXP ANKRD28 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 3:15,667,236...15,859,814
Ensembl chr 3:15,667,236...15,859,771
JBrowse link
G ANXA4 annexin A4 increases expression EXP Etoposide results in increased expression of ANXA4 mRNA CTD PMID:17374387 NCBI chr 2:69,643,808...69,827,112
Ensembl chr 2:69,644,425...69,827,112
JBrowse link
G ANXA7 annexin A7 multiple interactions ISO [Etoposide co-treated with Cisplatin co-treated with Bleomycin] results in decreased expression of ANXA7 protein CTD PMID:29733421 NCBI chr10:73,375,101...73,414,058
Ensembl chr10:73,375,101...73,414,076
JBrowse link
G APAF1 apoptotic peptidase activating factor 1 increases expression ISO Etoposide results in increased expression of APAF1 mRNA CTD PMID:25270620 NCBI chr12:98,645,141...98,735,433
Ensembl chr12:98,645,141...98,735,433
Ensembl chr12:98,645,141...98,735,433
JBrowse link
G APEX1 apurinic/apyrimidinic endodeoxyribonuclease 1 decreases response to substance EXP APEX1 protein results in decreased susceptibility to Etoposide CTD PMID:20856196 NCBI chr14:20,455,226...20,457,767
Ensembl chr14:20,455,191...20,457,772
JBrowse link
G APLP1 amyloid beta precursor like protein 1 decreases expression ISO Etoposide results in decreased expression of APLP1 mRNA CTD PMID:25270620 NCBI chr19:35,868,570...35,879,795
Ensembl chr19:35,867,899...35,879,791
Ensembl chr19:35,867,899...35,879,791
JBrowse link
G APOBEC3C apolipoprotein B mRNA editing enzyme catalytic subunit 3C affects response to substance EXP APOBEC3C protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr22:39,014,236...39,020,352
Ensembl chr22:39,014,257...39,020,352
JBrowse link
G APOL2 apolipoprotein L2 increases expression ISO Etoposide results in increased expression of APOL8 mRNA CTD PMID:25270620 NCBI chr22:36,226,209...36,239,954
Ensembl chr22:36,226,209...36,239,954
JBrowse link
G AQP1 aquaporin 1 (Colton blood group) decreases expression ISO Etoposide results in decreased expression of AQP1 mRNA CTD PMID:25270620 NCBI chr 7:30,911,853...30,925,516
Ensembl chr 7:30,911,853...30,925,517
Ensembl chr 7:30,911,853...30,925,517
JBrowse link
G AR androgen receptor multiple interactions
increases degradation
EXP calpain inhibitor 2 inhibits the reaction [Etoposide results in increased degradation of AR protein]; CAST inhibits the reaction [Etoposide results in increased degradation of AR protein]; Etoposide inhibits the reaction [Androgens results in increased activity of AR protein]; Etoposide inhibits the reaction [Metribolone results in increased activity of AR protein] CTD PMID:18726991 PMID:28377212 PMID:30818834 NCBI chr  X:67,544,021...67,730,619
Ensembl chr  X:67,544,021...67,730,619
JBrowse link
G AREG amphiregulin increases expression
decreases expression
EXP
ISO
Etoposide results in increased expression of AREG mRNA; Etoposide results in increased expression of AREG protein
Etoposide results in decreased expression of AREG mRNA
CTD PMID:15228094 PMID:25270620 NCBI chr 4:74,445,136...74,455,005
Ensembl chr 4:74,445,136...74,455,005
JBrowse link
G ARG2 arginase 2 decreases expression EXP Etoposide results in decreased expression of ARG2 mRNA CTD PMID:29397400 NCBI chr14:67,619,920...67,651,708
Ensembl chr14:67,619,920...67,651,708
JBrowse link
G ARHGDIB Rho GDP dissociation inhibitor beta increases expression EXP Etoposide results in increased expression of ARHGDIB mRNA CTD PMID:21527772 NCBI chr12:14,942,015...14,961,601
Ensembl chr12:14,942,031...14,961,728
JBrowse link
G ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 increases response to substance ISO ARIH1 mutant form results in increased susceptibility to Etoposide CTD PMID:25624349 NCBI chr15:72,474,330...72,602,987
Ensembl chr15:72,474,330...72,602,987
JBrowse link
G ARL6IP5 ADP ribosylation factor like GTPase 6 interacting protein 5 increases response to substance
decreases expression
EXP ARL6IP5 protein results in increased susceptibility to Etoposide
Etoposide results in decreased expression of ARL6IP5
CTD PMID:19492242 NCBI chr 3:69,084,937...69,106,092
Ensembl chr 3:69,084,937...69,106,092
JBrowse link
G ARSA arylsulfatase A decreases expression ISO Etoposide results in decreased expression of ARSA mRNA CTD PMID:25270620 NCBI chr22:50,622,754...50,628,152
Ensembl chr22:50,622,754...50,628,173
JBrowse link
G ASAH1 N-acylsphingosine amidohydrolase 1 affects response to substance EXP ASAH1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 8:18,055,992...18,084,961
Ensembl chr 8:18,055,992...18,084,998
JBrowse link
G ATF2 activating transcription factor 2 multiple interactions EXP Etoposide results in increased phosphorylation of and results in increased activity of ATF2 protein CTD PMID:12663670 NCBI chr 2:175,072,259...175,168,203
Ensembl chr 2:175,072,250...175,168,382
JBrowse link
G ATF4 activating transcription factor 4 decreases expression ISO Etoposide results in decreased expression of ATF4 mRNA CTD PMID:25270620 NCBI chr22:39,514,494...39,522,686
Ensembl chr22:39,519,672...39,522,683
Ensembl chr22:39,519,672...39,522,683
JBrowse link
G ATM ATM serine/threonine kinase multiple interactions ISO
EXP
Etoposide results in increased phosphorylation of and results in increased activity of ATM protein
Etoposide results in increased phosphorylation of and affects the localization of ATM protein; pifithrin inhibits the reaction [Etoposide results in increased phosphorylation of and affects the localization of ATM protein]
CTD PMID:22242153 PMID:26259609 NCBI chr11:108,222,484...108,369,102
Ensembl chr11:108,222,832...108,369,102
Ensembl chr11:108,222,832...108,369,102
JBrowse link
G ATP13A4 ATPase 13A4 decreases expression ISO Etoposide results in decreased expression of ATP13A4 mRNA CTD PMID:25270620 NCBI chr 3:193,398,967...193,593,114
Ensembl chr 3:193,398,967...193,593,111
JBrowse link
G ATP1A1 ATPase Na+/K+ transporting subunit alpha 1 affects response to substance EXP ATP1A1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 1:116,372,986...116,410,259
Ensembl chr 1:116,372,668...116,410,261
JBrowse link
G ATP1A2 ATPase Na+/K+ transporting subunit alpha 2 decreases expression EXP Etoposide results in decreased expression of ATP1A2 mRNA CTD PMID:29397400 NCBI chr 1:160,115,759...160,143,591
Ensembl chr 1:160,115,759...160,143,591
JBrowse link
G ATP1B4 ATPase Na+/K+ transporting family member beta 4 increases expression EXP Etoposide results in increased expression of ATP1B4 mRNA CTD PMID:29397400 NCBI chr  X:120,362,085...120,383,237
Ensembl chr  X:120,362,085...120,383,249
JBrowse link
G ATP5ME ATP synthase membrane subunit e multiple interactions ISO [Etoposide co-treated with Cisplatin co-treated with Bleomycin] results in increased expression of ATP5ME protein CTD PMID:29733421 NCBI chr 4:672,436...674,276
Ensembl chr 4:672,436...674,330
JBrowse link
G ATP5PO ATP synthase peripheral stalk subunit OSCP decreases expression ISO Etoposide results in decreased expression of ATP5O protein CTD PMID:29733421 NCBI chr21:33,903,453...33,915,804
Ensembl chr21:33,903,453...33,915,814
JBrowse link
G ATP6V0A4 ATPase H+ transporting V0 subunit a4 affects response to substance EXP ATP6V0A4 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 7:138,706,294...138,799,839
Ensembl chr 7:138,706,294...138,799,560
JBrowse link
G ATP6V1A ATPase H+ transporting V1 subunit A decreases expression
multiple interactions
ISO Etoposide results in decreased expression of ATP6V1A protein
[Etoposide co-treated with Cisplatin co-treated with Bleomycin] results in decreased expression of ATP6V1A protein
CTD PMID:29733421 NCBI chr 3:113,747,035...113,812,056
Ensembl chr 3:113,747,033...113,812,056
JBrowse link
G ATP7A ATPase copper transporting alpha decreases response to substance EXP ATP7A protein results in decreased susceptibility to Etoposide CTD PMID:17510416 NCBI chr  X:77,910,693...78,050,395
Ensembl chr  X:77,910,656...78,050,395
JBrowse link
G ATR ATR serine/threonine kinase increases phosphorylation ISO Etoposide results in increased phosphorylation of ATR protein CTD PMID:22242153 NCBI chr 3:142,449,235...142,578,793
Ensembl chr 3:142,449,007...142,578,733
JBrowse link
G ATXN1 ataxin 1 decreases expression EXP Etoposide results in decreased expression of ATXN1 mRNA CTD PMID:24211769 NCBI chr 6:16,299,112...16,761,490
Ensembl chr 6:16,299,112...16,761,491
JBrowse link
G AURKA aurora kinase A decreases expression ISO Etoposide results in decreased expression of AURKA mRNA CTD PMID:25270620 NCBI chr20:56,369,390...56,392,308
Ensembl chr20:56,369,389...56,392,337
JBrowse link
G AVPI1 arginine vasopressin induced 1 affects response to substance EXP AVPI1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr10:97,677,422...97,687,432
Ensembl chr10:97,677,424...97,687,241
JBrowse link
G AVPR1A arginine vasopressin receptor 1A increases expression EXP Etoposide results in increased expression of AVPR1A mRNA CTD PMID:29397400 NCBI chr12:63,142,759...63,151,201
Ensembl chr12:63,142,759...63,150,942
Ensembl chr12:63,142,759...63,150,942
JBrowse link
G AXL AXL receptor tyrosine kinase increases expression EXP Etoposide results in increased expression of AXL mRNA CTD PMID:21527772 NCBI chr19:41,219,223...41,261,766
Ensembl chr19:41,219,223...41,261,766
JBrowse link
G BACE2 beta-secretase 2 affects response to substance EXP BACE2 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr21:41,168,160...41,282,530
Ensembl chr21:41,167,801...41,282,530
JBrowse link
G BAG2 BAG cochaperone 2 affects response to substance EXP BAG2 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 6:57,172,326...57,189,833
Ensembl chr 6:57,172,326...57,189,833
JBrowse link
G BAK1 BCL2 antagonist/killer 1 increases activity
increases response to substance
affects response to substance
multiple interactions
affects expression
EXP
ISO
Etoposide results in increased activity of BAK1 protein
BAK1 protein results in increased susceptibility to Etoposide
BAK1 protein affects the susceptibility to Etoposide
nimesulide inhibits the reaction [Etoposide results in increased activity of BAK1 protein]
Etoposide affects the expression of BAK1 protein
CTD PMID:15215046 PMID:16077961 PMID:17688235 PMID:21745461 NCBI chr 6:33,572,552...33,580,296
Ensembl chr 6:33,572,547...33,580,293
JBrowse link
G BAMBI BMP and activin membrane bound inhibitor affects response to substance EXP BAMBI protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr10:28,677,521...28,682,932
Ensembl chr10:28,677,510...28,682,932
JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions
increases expression
decreases folding
affects response to substance
EXP
ISO
[ABT-737 co-treated with Etoposide] affects the folding of and results in increased activity of BAX protein; [Cisplatin co-treated with Etoposide] affects the localization of BAX protein; [Doxorubicin co-treated with Vincristine co-treated with Etoposide co-treated with Mitotane] results in decreased expression of BAX protein; [IL4 protein co-treated with VCAM1 protein] inhibits the reaction [Etoposide results in decreased folding of BAX protein]; [RASSF1 co-treated with Etoposide] affects the folding of and results in increased activity of BAX protein; [VCAM1 protein co-treated with IL4 protein] inhibits the reaction [Etoposide inhibits the reaction [BAX protein binds to BCL2L1 protein]]; Etoposide inhibits the reaction [BAX protein binds to BCL2L1 protein]; Etoposide results in increased activity of and affects the localization of BAX protein; Etoposide results in increased cleavage of and results in increased expression of BAX protein; Nicotine inhibits the reaction [[Cisplatin co-treated with Etoposide] affects the localization of BAX protein]; nimesulide inhibits the reaction [Etoposide results in increased activity of and affects the localization of BAX protein]
Etoposide results in increased expression of BAX mRNA; Etoposide results in increased expression of BAX protein
BAX protein affects the susceptibility to Etoposide
CTD PMID:9815696 PMID:10620629 PMID:15131059 PMID:16077961 PMID:16120219 PMID:18676776 PMID:21527772 PMID:21745461 PMID:21880625 PMID:29397400 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BBC3 BCL2 binding component 3 increases expression
multiple interactions
affects response to substance
EXP
ISO
Etoposide results in increased expression of BBC3 mRNA; Etoposide results in increased expression of BBC3 protein
entinostat promotes the reaction [Etoposide results in increased expression of BBC3 protein]; Etoposide promotes the reaction [entinostat results in increased expression of BBC3 protein]; Etoposide promotes the reaction [trichostatin A results in increased expression of BBC3 protein]; Etoposide promotes the reaction [UF010 compound results in increased expression of BBC3 protein]; trichostatin A promotes the reaction [Etoposide results in increased expression of BBC3 protein]; UF010 compound promotes the reaction [Etoposide results in increased expression of BBC3 protein]
BBC3 protein affects the susceptibility to Etoposide
CTD PMID:20477944 PMID:21801448 PMID:25699604 NCBI chr19:47,220,822...47,232,998
Ensembl chr19:47,220,822...47,232,766
JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions
decreases expression
EXP
ISO
[Doxorubicin co-treated with Vincristine co-treated with Etoposide co-treated with Mitotane] results in decreased expression of BCL2 protein; [Etoposide co-treated with Ciprofloxacin] results in decreased expression of BCL2 protein; BCL2 protein inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; BCL2 protein inhibits the reaction [Etoposide results in increased degradation of PARP1 protein]; BCL2 protein results in decreased susceptibility to [Cisplatin co-treated with Etoposide]
Etoposide results in decreased expression of BCL2 mRNA; Etoposide results in decreased expression of BCL2 protein
[G(M3) Ganglioside results in increased expression of BCL2 protein] which results in decreased susceptibility to Etoposide; BCL2 protein affects the reaction [[Etoposide results in increased activity of GSK3B protein] which results in increased activity of CASP3 protein]; Lithium Chloride inhibits the reaction [Etoposide results in decreased expression of BCL2 mRNA]; Lithium Chloride inhibits the reaction [Etoposide results in decreased expression of BCL2 protein]
CTD PMID:8840993 PMID:9815696 PMID:12063570 PMID:15917659 PMID:16571667 PMID:19408126 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BCL2L1 BCL2 like 1 multiple interactions
affects expression
decreases response to substance
EXP [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of BCL2L1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of BCL2L1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [VCAM1 protein co-treated with IL4 protein] inhibits the reaction [Etoposide inhibits the reaction [BAX protein binds to BCL2L1 protein]]; BCL2L1 protein inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; BCL2L1 protein inhibits the reaction [Etoposide results in increased degradation of PARP1 protein]; BCL2L1 protein results in decreased susceptibility to [Cisplatin co-treated with Etoposide]; Etoposide inhibits the reaction [BAX protein binds to BCL2L1 protein]
Etoposide affects the expression of BCL2L1 protein
BCL2L1 protein results in decreased susceptibility to Etoposide
CTD PMID:8840993 PMID:10620629 PMID:11468182 PMID:15215046 PMID:15917659 PMID:19047049 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989
JBrowse link
G BCL2L2 BCL2 like 2 decreases response to substance EXP BCL2L2 results in decreased susceptibility to Etoposide CTD PMID:14973057 NCBI chr14:23,306,833...23,311,751
Ensembl chr14:23,298,790...23,311,759
Ensembl chr14:23,298,790...23,311,759
JBrowse link
G BCL6B BCL6B transcription repressor multiple interactions ISO [Etoposide co-treated with Cisplatin co-treated with Bleomycin] results in decreased expression of BCL6B mRNA CTD PMID:29733421 NCBI chr17:7,023,050...7,029,644
Ensembl chr17:7,023,050...7,030,290
JBrowse link
G BDNF brain derived neurotrophic factor increases expression
multiple interactions
EXP Etoposide results in increased expression of BDNF mRNA
HIPK2 mutant form inhibits the reaction [Etoposide results in increased expression of BDNF mRNA]
CTD PMID:20573984 NCBI chr11:27,654,893...27,722,030
Ensembl chr11:27,654,893...27,722,058
JBrowse link
G BID BH3 interacting domain death agonist multiple interactions
increases expression
increases cleavage
EXP CASP9 mutant form inhibits the reaction [Etoposide results in increased cleavage of BID protein]; Estradiol inhibits the reaction [Etoposide results in increased expression of BID mRNA] CTD PMID:19426747 PMID:21801448 NCBI chr22:17,734,138...17,774,665
Ensembl chr22:17,734,138...17,774,770
JBrowse link
G BIK BCL2 interacting killer increases response to substance EXP BIK protein results in increased susceptibility to Etoposide CTD PMID:16007125 NCBI chr22:43,110,750...43,129,712
Ensembl chr22:43,110,750...43,129,712
JBrowse link
G BIN1 bridging integrator 1 increases response to substance EXP BIN1 protein results in increased susceptibility to Etoposide CTD PMID:21447800 NCBI chr 2:127,048,023...127,107,154
Ensembl chr 2:127,048,027...127,107,288
JBrowse link
G BIN3 bridging integrator 3 affects response to substance EXP BIN3 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 8:22,620,418...22,669,148
Ensembl chr 8:22,620,418...22,669,148
JBrowse link
G BIRC2 baculoviral IAP repeat containing 2 affects response to substance
decreases response to substance
increases expression
EXP BIRC2 protein affects the susceptibility to Etoposide
BIRC2 protein results in decreased susceptibility to Etoposide
Etoposide results in increased expression of BIRC2 mRNA
CTD PMID:10815900 PMID:14970392 PMID:15050749 PMID:16217747 NCBI chr11:102,347,214...102,378,670
Ensembl chr11:102,347,211...102,378,670
JBrowse link
G BIRC3 baculoviral IAP repeat containing 3 decreases response to substance
decreases expression
multiple interactions
EXP BIRC3 protein results in decreased susceptibility to Etoposide
Etoposide results in decreased expression of BIRC3 mRNA
[Etoposide co-treated with KN 62] results in decreased expression of BIRC3 protein
CTD PMID:14666661 PMID:15050749 PMID:16120219 NCBI chr11:102,317,373...102,339,403
Ensembl chr11:102,317,450...102,339,403
JBrowse link
G BIRC5 baculoviral IAP repeat containing 5 multiple interactions
decreases response to substance
increases expression
EXP [FOXO3 protein results in decreased expression of BIRC5 protein] which results in increased susceptibility to Etoposide; BIRC5 protein inhibits the reaction [FOXO3 protein results in increased susceptibility to Etoposide]; BIRC5 protein results in decreased susceptibility to [Cisplatin co-treated with Etoposide]; Estradiol inhibits the reaction [Etoposide results in increased expression of BIRC5 mRNA]
BIRC5 protein results in decreased susceptibility to Etoposide
CTD PMID:15917659 PMID:16322251 PMID:16364925 PMID:16382892 PMID:19211844 PMID:19426747 NCBI chr17:78,214,253...78,225,635
Ensembl chr17:78,214,186...78,225,636
JBrowse link
G BIRC7 baculoviral IAP repeat containing 7 decreases response to substance EXP BIRC7 protein results in decreased susceptibility to Etoposide CTD PMID:17437058 NCBI chr20:63,235,905...63,240,495
Ensembl chr20:63,235,883...63,240,495
JBrowse link
G BLM BLM RecQ like helicase decreases expression EXP Etoposide results in decreased expression of BLM mRNA CTD PMID:24211769 NCBI chr15:90,717,346...90,816,166
Ensembl chr15:90,717,346...90,816,166
JBrowse link
G BMP6 bone morphogenetic protein 6 multiple interactions EXP Etoposide inhibits the reaction [BMP6 protein results in increased expression of HAMP mRNA] CTD PMID:25633564 NCBI chr 6:7,726,099...7,881,728
Ensembl chr 6:7,726,099...7,881,728
JBrowse link
G BRCA1 BRCA1 DNA repair associated multiple interactions
increases expression
decreases expression
EXP BRCA1 protein mutant form inhibits the reaction [Etoposide results in increased expression of CDK2 protein]; BRCA1 protein mutant form inhibits the reaction [Etoposide results in increased expression of RAD52 protein]; BRCA1 protein mutant form inhibits the reaction [Etoposide results in increased expression of RAD54L protein]; BRCA1 protein mutant form inhibits the reaction [Etoposide results in increased expression of XRCC2 protein]; BRCA1 protein mutant form inhibits the reaction [Etoposide results in increased expression of XRCC3 protein]; BRCA1 protein mutant form inhibits the reaction [Etoposide results in increased expression of XRCC4 protein]; pifithrin inhibits the reaction [Etoposide results in increased expression of and affects the localization of BRCA1 protein]
Etoposide results in increased expression of BRCA1 protein
Etoposide results in decreased expression of BRCA1 mRNA
CTD PMID:15607317 PMID:16417649 PMID:26259609 NCBI chr17:43,044,295...43,125,364
Ensembl chr17:43,044,295...43,170,245
JBrowse link
G BSCL2 BSCL2 lipid droplet biogenesis associated, seipin increases expression ISO Etoposide results in increased expression of BSCL2 mRNA CTD PMID:22003191 PMID:25270620 NCBI chr11:62,690,262...62,709,537
Ensembl chr11:62,690,275...62,709,845
JBrowse link
G BTG2 BTG anti-proliferation factor 2 multiple interactions
increases expression
ISO
EXP
TRP53 protein affects the reaction [Etoposide results in increased expression of BTG2 mRNA]
TP53 promotes the reaction [Etoposide results in increased expression of BTG2 protein]
Etoposide results in increased expression of BTG2 mRNA; Etoposide results in increased expression of BTG2 protein
CTD PMID:21382384 PMID:22003191 PMID:24211769 PMID:27358234 NCBI chr 1:203,305,519...203,309,602
Ensembl chr 1:203,305,491...203,309,602
JBrowse link
G BTG3 BTG anti-proliferation factor 3 decreases expression EXP Etoposide results in decreased expression of BTG3 mRNA CTD PMID:24211769 NCBI chr21:17,593,653...17,612,940
Ensembl chr21:17,593,653...17,612,947
Ensembl chr21:17,593,653...17,612,947
JBrowse link
G BUB1 BUB1 mitotic checkpoint serine/threonine kinase decreases expression EXP Etoposide results in decreased expression of BUB1 mRNA CTD PMID:16120219 NCBI chr 2:110,637,528...110,678,063
Ensembl chr 2:110,637,528...110,678,063
JBrowse link
G BUB1B BUB1 mitotic checkpoint serine/threonine kinase B decreases expression EXP Etoposide results in decreased expression of BUB1B mRNA CTD PMID:16120219 NCBI chr15:40,161,069...40,221,123
Ensembl chr15:40,161,023...40,221,136
Ensembl chr15:40,161,023...40,221,136
JBrowse link
G C1QBP complement C1q binding protein decreases response to substance EXP C1QBP protein results in decreased susceptibility to Etoposide CTD PMID:25354864 NCBI chr17:5,432,777...5,439,155
Ensembl chr17:5,432,777...5,448,830
JBrowse link
G C4orf19 chromosome 4 open reading frame 19 affects response to substance EXP C4ORF19 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 4:37,453,454...37,596,146
Ensembl chr 4:37,453,925...37,623,495
JBrowse link
G C5orf22 chromosome 5 open reading frame 22 affects response to substance EXP C5ORF22 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 5:31,532,275...31,555,053
Ensembl chr 5:31,532,287...31,555,053
JBrowse link
G C7orf26 chromosome 7 open reading frame 26 decreases expression EXP Etoposide results in decreased expression of C7ORF26 mRNA CTD PMID:24211769 NCBI chr 7:6,590,021...6,608,726
Ensembl chr 7:6,590,021...6,608,726
JBrowse link
G CAB39 calcium binding protein 39 decreases expression EXP Etoposide results in decreased expression of CAB39 mRNA CTD PMID:17374387 NCBI chr 2:230,712,842...230,821,075
Ensembl chr 2:230,712,842...230,821,075
JBrowse link
G CADPS2 calcium dependent secretion activator 2 affects response to substance EXP CADPS2 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 7:122,318,411...122,886,500
Ensembl chr 7:122,318,411...122,886,759
JBrowse link
G CALCA calcitonin related polypeptide alpha multiple interactions
decreases response to substance
EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [CALCA protein results in decreased susceptibility to Etoposide] CTD PMID:16222118 NCBI chr11:14,966,668...14,972,361
Ensembl chr11:14,966,668...14,972,354
Ensembl chr11:14,966,668...14,972,354
JBrowse link
G CALM1 calmodulin 1 increases expression EXP Etoposide results in increased expression of CALM1 mRNA CTD PMID:29397400 NCBI chr14:90,396,502...90,408,268
Ensembl chr14:90,396,502...90,408,268
JBrowse link
G CARD10 caspase recruitment domain family member 10 multiple interactions
increases expression
EXP Estradiol inhibits the reaction [Etoposide results in increased expression of CARD10 mRNA] CTD PMID:19426747 NCBI chr22:37,490,362...37,519,415
Ensembl chr22:37,490,362...37,519,542
JBrowse link
G CASP2 caspase 2 increases expression
increases splicing
EXP Etoposide results in increased expression of CASP2 mRNA alternative form
Etoposide results in increased splicing of CASP2 mRNA
CTD PMID:14757846 NCBI chr 7:143,288,351...143,307,696
Ensembl chr 7:143,288,215...143,307,696
JBrowse link
G CASP3 caspase 3 affects expression
increases cleavage
multiple interactions
increases activity
increases expression
EXP
ISO
Etoposide affects the expression of CASP3 protein
Etoposide results in increased cleavage of CASP3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Etoposide results in increased cleavage of CASP3 protein]; 3',4'-dihydroxyflavone analog inhibits the reaction [Etoposide results in increased cleavage of CASP3 protein]; [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of ABCB1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of BCL2L1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of ABCB1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of BCL2L1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [CASP8 co-treated with TP53] affects the reaction [Etoposide results in increased cleavage of CASP3 protein]; [Etoposide co-treated with Mifepristone] results in increased activity of CASP3 protein; [RASSF1 co-treated with Etoposide] results in increased cleavage of CASP3 protein; [STAT1 protein results in increased activity of CASP3 protein] which results in increased susceptibility to Etoposide; Acetylcysteine inhibits the reaction [Etoposide results in increased cleavage of CASP3 protein]; Aspirin inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; BCL2 protein inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; BCL2L1 protein inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; benzyloxycarbonyl-valyl-alanyl-aspartyl-fluoromethane inhibits the reaction [Etoposide results in increased cleavage of CASP3 protein]; CASP8 mutant form inhibits the reaction [Etoposide results in increased cleavage of CASP3 protein]; CD40LG protein inhibits the reaction [Etoposide promotes the reaction [CASP3 protein results in increased cleavage of PARP1 protein]]; CDKN1A mutant form inhibits the reaction [Aspirin inhibits the reaction [Etoposide results in increased activity of CASP3 protein]]; Dehydroascorbic Acid promotes the reaction [Etoposide results in increased activity of CASP3 protein]; Etoposide promotes the reaction [CASP3 protein results in increased cleavage of PARP1 protein]; Etoposide promotes the reaction [Gold results in increased activity of CASP3 protein]; Etoposide promotes the reaction [Nanotubes, Carbon results in increased activity of CASP3 protein]; Etoposide promotes the reaction [Silver results in increased activity of CASP3 protein]; Etoposide results in increased cleavage of and results in increased activity of CASP3 protein; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [Etoposide results in increased cleavage of CASP3 protein]; nimesulide inhibits the reaction [Etoposide results in increased cleavage of CASP3 protein]; Oxygen deficiency inhibits the reaction [Etoposide results in increased expression of CASP3 protein]; palbociclib inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; pifithrin promotes the reaction [Etoposide results in increased activity of CASP3 protein]; pifithrin promotes the reaction [Etoposide results in increased cleavage of CASP3 protein]; Tetrachlorodibenzodioxin inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; TMSB4X protein inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; TP73 mutant form inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; TP73 mutant form inhibits the reaction [Etoposide results in increased cleavage of CASP3 protein]; Wortmannin promotes the reaction [Etoposide results in increased cleavage of and results in increased activity of CASP3 protein]
[Etoposide results in increased activity of GSK3B protein] which results in increased activity of CASP3 protein; Etoposide results in increased activity of CASP3 protein
2-tert-butylhydroquinone inhibits the reaction [Etoposide results in increased cleavage of and results in increased activity of CASP3 protein]; BCL2 protein affects the reaction [[Etoposide results in increased activity of GSK3B protein] which results in increased activity of CASP3 protein]; Etoposide results in increased cleavage of and results in increased activity of CASP3 protein; HIPK2 gene mutant form promotes the reaction [Etoposide results in increased activity of CASP3 protein]; Metoclopramide inhibits the reaction [Etoposide results in increased activity of CASP3 protein]
CTD PMID:8840993 PMID:10759716 PMID:12871656 PMID:15215046 PMID:15924153 PMID:16014620 PMID:16192531 PMID:16364925 PMID:16545138 PMID:16844113 PMID:16951922 PMID:17516866 PMID:17935137 PMID:18056177 PMID:18649362 PMID:19047049 PMID:19408126 PMID:19662097 PMID:19760634 PMID:20299546 PMID:20573984 PMID:21617849 PMID:21745461 PMID:21745629 PMID:21801448 PMID:21880625 PMID:22275372 PMID:22302033 PMID:23144690 PMID:25447644 PMID:26259609 PMID:29027213 PMID:30217652 PMID:30890322 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CASP7 caspase 7 multiple interactions
increases activity
EXP
ISO
[STAT1 protein results in increased activity of CASP7 protein] which results in increased susceptibility to Etoposide; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [Etoposide results in increased activity of CASP7 protein]; palbociclib inhibits the reaction [Etoposide results in increased activity of CASP7 protein]; pifithrin promotes the reaction [Etoposide results in increased activity of CASP7 protein]; Tetrachlorodibenzodioxin inhibits the reaction [Etoposide results in increased activity of CASP7 protein]; TP73 mutant form inhibits the reaction [Etoposide results in increased activity of CASP7 protein]
2-tert-butylhydroquinone inhibits the reaction [Etoposide results in increased activity of CASP7 protein]
CTD PMID:18056177 PMID:18649362 PMID:20299546 PMID:21801448 PMID:22275372 PMID:22302033 PMID:26259609 NCBI chr10:113,679,194...113,730,909
Ensembl chr10:113,679,162...113,730,907
JBrowse link
G CASP8 caspase 8 multiple interactions
increases response to substance
increases cleavage
increases activity
decreases response to substance
EXP 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Etoposide results in increased activity of CASP8 protein]; [CASP8 co-treated with TP53] affects the reaction [Etoposide results in increased cleavage of and results in increased activity of CASP9 protein]; [CASP8 co-treated with TP53] affects the reaction [Etoposide results in increased cleavage of CASP3 protein]; [CASP8 co-treated with TP53] affects the reaction [Etoposide results in increased cleavage of PARP1 protein]; [CASP8 co-treated with TP53] inhibits the reaction [CASP8 protein mutant form results in decreased susceptibility to Etoposide]; acetyl-leucyl-glutamyl-histidyl-aspartal inhibits the reaction [Etoposide results in increased activity of CASP8 protein]; CASP8 mutant form inhibits the reaction [Etoposide results in increased cleavage of CASP3 protein]; CASP8 mutant form inhibits the reaction [Etoposide results in increased cleavage of CASP9 protein]; Etoposide results in increased cleavage of and results in increased activity of CASP8 protein; Etoposide results in increased expression of and results in increased cleavage of CASP8 protein; Lithium inhibits the reaction [Etoposide results in increased activity of CASP8 protein]; nimesulide inhibits the reaction [Etoposide results in increased cleavage of and results in increased activity of CASP8 protein]; TP73 mutant form inhibits the reaction [Etoposide results in increased cleavage of CASP8 protein]
CASP8 protein results in increased susceptibility to Etoposide
CTD PMID:15475000 PMID:21745461 PMID:21801448 PMID:22010212 NCBI chr 2:201,233,443...201,287,711
Ensembl chr 2:201,233,443...201,287,711
JBrowse link
G CASP9 caspase 9 multiple interactions
increases cleavage
increases activity
affects expression
EXP [CASP8 co-treated with TP53] affects the reaction [Etoposide results in increased cleavage of and results in increased activity of CASP9 protein]; [Cisplatin co-treated with Etoposide] results in increased activity of CASP9 protein; CASP8 mutant form inhibits the reaction [Etoposide results in increased cleavage of CASP9 protein]; CASP9 mutant form inhibits the reaction [Etoposide results in increased cleavage of BID protein]; Etoposide results in increased cleavage of and results in increased activity of CASP9 protein; HTATIP2 protein promotes the reaction [Etoposide results in increased activity of CASP9 protein]; MYC protein promotes the reaction [Etoposide results in increased cleavage of CASP9 protein]; Nicotine inhibits the reaction [[Cisplatin co-treated with Etoposide] results in increased activity of CASP9 protein]; nimesulide inhibits the reaction [Etoposide results in increased cleavage of and results in increased activity of CASP9 protein]; TMSB4X protein inhibits the reaction [Etoposide results in increased cleavage of and results in increased activity of CASP9 protein]; Wortmannin promotes the reaction [Etoposide results in increased cleavage of CASP9 protein]
Etoposide affects the expression of CASP9 protein
CTD PMID:12925536 PMID:15215046 PMID:16364925 PMID:16799960 PMID:17935137 PMID:18056177 PMID:18676776 PMID:21324178 PMID:21745461 PMID:21801448 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
G CASQ2 calsequestrin 2 decreases expression EXP Etoposide results in decreased expression of CASQ2 mRNA CTD PMID:29397400 NCBI chr 1:115,700,021...115,768,714
Ensembl chr 1:115,700,021...115,768,714
Ensembl chr 1:115,700,021...115,768,714
JBrowse link
G CAST calpastatin multiple interactions EXP CAST inhibits the reaction [Etoposide results in increased degradation of AR protein] CTD PMID:18726991 NCBI chr 5:96,662,037...96,774,683
Ensembl chr 5:96,525,267...96,779,595
JBrowse link
G CAT catalase increases response to substance
increases activity
EXP CAT results in increased susceptibility to Etoposide
Etoposide results in increased activity of CAT protein
CTD PMID:21689642 PMID:25451571 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CCDC51 coiled-coil domain containing 51 decreases expression EXP Etoposide results in decreased expression of CCDC51 mRNA CTD PMID:24211769 NCBI chr 3:48,432,170...48,446,652
Ensembl chr 3:48,432,164...48,440,456
JBrowse link
G CCDC6 coiled-coil domain containing 6 increases response to substance
decreases response to substance
EXP CCDC6 results in increased susceptibility to Etoposide
CCDC6 results in decreased susceptibility to Etoposide
CTD PMID:22363533 PMID:22655027 NCBI chr10:59,788,747...59,906,556
Ensembl chr10:59,788,747...59,906,556
JBrowse link
G CCL3 C-C motif chemokine ligand 3 increases expression EXP Etoposide results in increased expression of CCL3 protein CTD PMID:10540334 NCBI chr17:36,088,256...36,090,143
Ensembl chr17:36,088,256...36,090,169
JBrowse link
G CCN2 cellular communication network factor 2 increases expression EXP Etoposide results in increased expression of CCN2 mRNA CTD PMID:29397400 NCBI chr 6:131,948,176...131,951,372
Ensembl chr 6:131,948,176...131,951,372
JBrowse link
G CCNA2 cyclin A2 multiple interactions
decreases expression
EXP Etoposide affects the expression of and affects the localization of CCNA2 protein
Etoposide results in decreased expression of CCNA2 mRNA; Etoposide results in decreased expression of CCNA2 protein
CTD PMID:16120219 PMID:17390037 NCBI chr 4:121,816,444...121,823,883
Ensembl chr 4:121,816,444...121,823,883
Ensembl chr 4:121,816,444...121,823,883
JBrowse link
G CCNB1 cyclin B1 decreases expression EXP Etoposide results in decreased expression of CCNB1 mRNA; Etoposide results in decreased expression of CCNB1 protein CTD PMID:16120219 NCBI chr 5:69,167,150...69,178,245
Ensembl chr 5:69,167,135...69,178,245
JBrowse link
G CCND1 cyclin D1 increases expression EXP Etoposide results in increased expression of CCND1 mRNA CTD PMID:16120219 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G CCNG1 cyclin G1 increases expression ISO Etoposide results in increased expression of CCNG1 mRNA CTD PMID:25270620 NCBI chr 5:163,437,571...163,448,199
Ensembl chr 5:163,437,569...163,446,151
JBrowse link
G CCNG2 cyclin G2 increases expression EXP Etoposide results in increased expression of CCNG2 mRNA CTD PMID:18754885 NCBI chr 4:77,157,207...77,170,060
Ensembl chr 4:77,157,207...77,433,388
JBrowse link
G CCS copper chaperone for superoxide dismutase increases expression EXP Etoposide results in increased expression of CCS mRNA CTD PMID:21527772 NCBI chr11:66,593,162...66,606,019
Ensembl chr11:66,593,153...66,606,019
JBrowse link
G CCT8 chaperonin containing TCP1 subunit 8 multiple interactions ISO [Etoposide co-treated with Cisplatin co-treated with Bleomycin] results in decreased expression of CCT8 protein CTD PMID:29733421 NCBI chr21:29,056,326...29,073,648
Ensembl chr21:29,055,805...29,073,797
JBrowse link
G CD274 CD274 molecule increases expression EXP Etoposide results in increased expression of CD274 protein CTD PMID:17920123 NCBI chr 9:5,450,542...5,470,554
Ensembl chr 9:5,450,503...5,470,566
JBrowse link
G CD40LG CD40 ligand multiple interactions
decreases response to substance
EXP CD40LG protein inhibits the reaction [Etoposide promotes the reaction [CASP3 protein results in increased cleavage of PARP1 protein]]
CD40LG protein results in decreased susceptibility to Etoposide
CTD PMID:16545138 NCBI chr  X:136,648,158...136,660,390
Ensembl chr  X:136,648,158...136,660,390
Ensembl chr  X:136,648,158...136,660,390
JBrowse link
G CD44 CD44 molecule (Indian blood group) affects response to substance
multiple interactions
EXP CD44 protein affects the susceptibility to Etoposide
[[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of ABCB1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of BCL2L1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of ABCB1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of BCL2L1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in decreased susceptibility to Etoposide; [[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in decreased susceptibility to Etoposide; Resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in decreased susceptibility to Etoposide]; Resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in decreased susceptibility to Etoposide]
CTD PMID:15215046 PMID:19047049 NCBI chr11:35,139,168...35,232,402
Ensembl chr11:35,138,882...35,232,402
Ensembl chr11:35,138,882...35,232,402
JBrowse link
G CD55 CD55 molecule (Cromer blood group) affects response to substance EXP CD55 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 1:207,321,674...207,360,966
Ensembl chr 1:207,321,376...207,386,804
Ensembl chr 1:207,321,376...207,386,804
JBrowse link
G CD59 CD59 molecule (CD59 blood group) multiple interactions EXP [Cisplatin co-treated with Etoposide] results in decreased expression of CD59 protein CTD PMID:21826740 NCBI chr11:33,703,010...33,736,479
Ensembl chr11:33,703,010...33,736,491
Ensembl chr11:33,703,010...33,736,491
JBrowse link
G CDC25A cell division cycle 25A decreases expression EXP Etoposide results in decreased expression of CDC25A mRNA CTD PMID:24211769 NCBI chr 3:48,157,146...48,188,417
Ensembl chr 3:48,157,146...48,188,417
JBrowse link
G CDC25C cell division cycle 25C decreases expression EXP Etoposide results in decreased expression of CDC25C mRNA CTD PMID:16120219 NCBI chr 5:138,285,265...138,338,355
Ensembl chr 5:138,285,265...138,338,355
JBrowse link
G CDC42BPG CDC42 binding protein kinase gamma increases expression ISO Etoposide results in increased expression of CDC42BPG mRNA CTD PMID:25270620 NCBI chr11:64,823,052...64,844,686
Ensembl chr11:64,823,052...64,844,653
JBrowse link
G CDC45 cell division cycle 45 decreases expression EXP Etoposide results in decreased expression of CDC45 mRNA CTD PMID:16120219 NCBI chr22:19,479,294...19,520,612
Ensembl chr22:19,479,457...19,520,612
JBrowse link
G CDC6 cell division cycle 6 decreases expression EXP Etoposide results in decreased expression of CDC6 mRNA CTD PMID:16120219 NCBI chr17:40,287,878...40,304,657
Ensembl chr17:40,287,879...40,304,657
JBrowse link
G CDK2 cyclin dependent kinase 2 multiple interactions
increases expression
affects response to substance
EXP BRCA1 protein mutant form inhibits the reaction [Etoposide results in increased expression of CDK2 protein]; CDK2 affects the reaction [Etoposide results in increased phosphorylation of TPI1 protein]
CDK2 protein affects the susceptibility to Etoposide
CTD PMID:16217747 PMID:16417649 PMID:20149834 NCBI chr12:55,966,830...55,972,789
Ensembl chr12:55,966,781...55,972,789
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A multiple interactions
increases expression
EXP
ISO
[Etoposide results in increased susceptibility to Benzo(a)pyrene] which results in increased expression of CDKN1A protein; [RASSF1 co-treated with Etoposide] results in increased expression of CDKN1A protein; CDKN1A mutant form inhibits the reaction [Aspirin inhibits the reaction [Etoposide results in increased activity of CASP3 protein]]; CDKN1A protein affects the reaction [Etoposide results in decreased expression of UBE2C protein]; entinostat promotes the reaction [Etoposide results in increased expression of CDKN1A protein]; Etoposide promotes the reaction [entinostat results in increased expression of CDKN1A protein]; Etoposide promotes the reaction [trichostatin A results in increased expression of CDKN1A protein]; Etoposide promotes the reaction [UF010 compound results in increased expression of CDKN1A protein]; KEAP1 protein affects the reaction [Etoposide results in increased expression of CDKN1A protein]; Resveratrol inhibits the reaction [Etoposide results in increased expression of CDKN1A mRNA]; TP53 affects the reaction [Etoposide results in increased expression of CDKN1A mRNA]; TP53 promotes the reaction [Etoposide results in increased expression of CDKN1A protein]; TP53 protein promotes the reaction [[Etoposide results in increased susceptibility to Benzo(a)pyrene] which results in increased expression of CDKN1A protein]; TP53 protein promotes the reaction [Etoposide results in increased expression of CDKN1A protein]; trichostatin A promotes the reaction [Etoposide results in increased expression of CDKN1A protein]; UF010 compound promotes the reaction [Etoposide results in increased expression of CDKN1A protein]
Etoposide results in increased expression of CDKN1A mRNA; Etoposide results in increased expression of CDKN1A protein
[CDKN2A gene mutant form results in increased expression of CDKN2A protein alternative form] inhibits the reaction [Etoposide results in increased expression of CDKN1A protein]; TRP53 affects the reaction [Etoposide results in increased expression of CDKN1A mRNA]
cordycepin inhibits the reaction [Etoposide results in increased expression of CDKN1A mRNA]; Etoposide promotes the reaction [Niacin deficiency results in increased expression of CDKN1A protein]; mithramycin A inhibits the reaction [Etoposide results in increased expression of CDKN1A mRNA]; salubrinal inhibits the reaction [Etoposide results in increased expression of CDKN1A mRNA]
CTD PMID:14601052 PMID:16120219 PMID:16882877 PMID:17516866 PMID:21212465 PMID:21526190 PMID:21527772 PMID:21617849 PMID:21801448 PMID:21880625 PMID:23690541 PMID:24067374 PMID:24211769 PMID:25078064 PMID:25699604 PMID:25914138 PMID:26055805 PMID:27129209 PMID:27358234 PMID:27982581 PMID:29471073 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,339
Ensembl chr 6:36,676,460...36,687,339
JBrowse link
G CDKN1B cyclin dependent kinase inhibitor 1B increases expression
multiple interactions
EXP Etoposide results in increased expression of CDKN1B protein
wortmannin promotes the reaction [Etoposide results in increased expression of CDKN1B protein]
CTD PMID:17935137 NCBI chr12:12,717,368...12,722,369
Ensembl chr12:12,715,058...12,722,369
JBrowse link
G CDKN2A cyclin dependent kinase inhibitor 2A multiple interactions
increases expression
ISO [CDKN2A gene mutant form results in increased expression of CDKN2A protein alternative form] inhibits the reaction [Etoposide results in increased expression of CDKN1A protein]; [CDKN2A gene mutant form results in increased expression of CDKN2A protein alternative form] inhibits the reaction [Etoposide results in increased expression of TRP53 protein]
Etoposide results in increased expression of CDKN2A mRNA
cordycepin inhibits the reaction [Etoposide results in increased expression of CDKN2A mRNA]; mithramycin A inhibits the reaction [Etoposide results in increased expression of CDKN2A mRNA]; salubrinal inhibits the reaction [Etoposide results in increased expression of CDKN2A mRNA]
CTD PMID:21526190 PMID:23690541 NCBI chr 9:21,967,752...21,995,324
Ensembl chr 9:21,967,753...21,995,301
Ensembl chr 9:21,967,753...21,995,301
JBrowse link
G CDKN3 cyclin dependent kinase inhibitor 3 decreases expression EXP Etoposide results in decreased expression of CDKN3 mRNA CTD PMID:16120219 NCBI chr14:54,396,873...54,420,218
Ensembl chr14:54,396,849...54,420,218
JBrowse link
G CEACAM1 CEA cell adhesion molecule 1 increases expression EXP Etoposide results in increased expression of CEACAM1 mRNA CTD PMID:17374387 NCBI chr19:42,507,306...42,528,482
Ensembl chr19:42,507,304...42,561,234
JBrowse link
G CEBPA CCAAT enhancer binding protein alpha decreases expression
increases degradation
EXP Etoposide results in decreased expression of CEBPA mRNA; Etoposide results in decreased expression of CEBPA protein
Etoposide results in increased degradation of CEBPA protein
CTD PMID:19662097 NCBI chr19:33,299,934...33,302,564
Ensembl chr19:33,299,934...33,302,534
JBrowse link
G CEBPZ CCAAT enhancer binding protein zeta decreases expression EXP Etoposide results in decreased expression of CEBPZ mRNA CTD PMID:17374387 NCBI chr 2:37,201,612...37,231,596
Ensembl chr 2:37,201,612...37,231,596
JBrowse link
G CEL carboxyl ester lipase increases expression EXP Etoposide results in increased expression of CEL mRNA CTD PMID:21527772 NCBI chr 9:133,061,981...133,071,861
Ensembl chr 9:133,061,978...133,071,863
Ensembl chr 9:133,061,978...133,071,863
JBrowse link
G CENPF centromere protein F decreases expression EXP Etoposide results in decreased expression of CENPF mRNA CTD PMID:16120219 NCBI chr 1:214,603,195...214,664,571
Ensembl chr 1:214,603,195...214,664,571
JBrowse link
G CERCAM cerebral endothelial cell adhesion molecule increases expression ISO Etoposide results in increased expression of CERCAM mRNA CTD PMID:25270620 NCBI chr 9:128,405,994...128,437,351
Ensembl chr 9:128,411,751...128,437,351
JBrowse link
G CES1 carboxylesterase 1 increases expression ISO Etoposide results in increased expression of CES1D mRNA CTD PMID:25270620 NCBI chr16:55,802,851...55,833,127
Ensembl chr16:55,802,851...55,833,337
JBrowse link
G CETP cholesteryl ester transfer protein multiple interactions
increases expression
EXP [Tretinoin co-treated with Etoposide] results in increased expression of CETP mRNA; Etoposide promotes the reaction [NR1H2 protein results in increased expression of CETP mRNA]; Etoposide promotes the reaction [NR1H3 protein results in increased expression of CETP mRNA]; Etoposide promotes the reaction [RXRA protein results in increased expression of CETP mRNA]; NR1H2 mutant form inhibits the reaction [Etoposide results in increased expression of CETP mRNA]; NR1H3 mutant form inhibits the reaction [Etoposide results in increased expression of CETP mRNA]; Tretinoin promotes the reaction [Etoposide promotes the reaction [RXRA protein results in increased expression of CETP mRNA]]; Tretinoin promotes the reaction [Etoposide results in increased expression of CETP protein]
Etoposide results in increased expression of CETP mRNA; Etoposide results in increased expression of CETP protein
CTD PMID:25914138 NCBI chr16:56,961,950...56,983,845
Ensembl chr16:56,961,923...56,983,845
JBrowse link
G CFLAR CASP8 and FADD like apoptosis regulator increases expression EXP Etoposide results in increased expression of CFLAR protein CTD PMID:14601052 NCBI chr 2:201,116,164...201,176,687
Ensembl chr 2:201,116,154...201,176,687
JBrowse link
G CGREF1 cell growth regulator with EF-hand domain 1 increases expression ISO Etoposide results in increased expression of CGREF1 mRNA CTD PMID:25270620 NCBI chr 2:27,099,353...27,119,128
Ensembl chr 2:27,098,889...27,119,128
JBrowse link
G CHAC1 ChaC glutathione specific gamma-glutamylcyclotransferase 1 decreases expression ISO Etoposide results in decreased expression of CHAC1 mRNA CTD PMID:25270620 NCBI chr15:40,942,137...40,956,518
Ensembl chr15:40,952,962...40,956,512
JBrowse link
G CHAF1A chromatin assembly factor 1 subunit A decreases expression EXP Etoposide results in decreased expression of CHAF1A mRNA CTD PMID:24211769 NCBI chr19:4,402,596...4,448,322
Ensembl chr19:4,402,640...4,445,018
JBrowse link
G CHEK1 checkpoint kinase 1 affects response to substance
multiple interactions
EXP CHEK1 protein affects the susceptibility to Etoposide
TP53 protein affects the reaction [CHEK1 protein affects the susceptibility to Etoposide]
CTD PMID:18698031 NCBI chr11:125,624,910...125,676,255
Ensembl chr11:125,625,665...125,676,255
JBrowse link
G CHEK2 checkpoint kinase 2 increases phosphorylation
multiple interactions
ISO
EXP
Etoposide results in increased phosphorylation of CHEK2 protein
4-fluoro-2-(4-(4-(2-hydroxypropan-2-yl)pyrrolidin-3-ylamino)-6,7-dimethoxyquinazolin-2-yl)phenol inhibits the reaction [Etoposide results in increased phosphorylation of CHEK2 protein]; pifithrin inhibits the reaction [Etoposide results in increased phosphorylation of CHEK2 protein]
CTD PMID:21186793 PMID:22242153 PMID:26259609 NCBI chr22:28,687,743...28,741,866
Ensembl chr22:28,687,743...28,742,422
JBrowse link
G CHI3L1 chitinase 3 like 1 decreases response to substance EXP CHI3L1 results in decreased susceptibility to Etoposide CTD PMID:20506295 NCBI chr 1:203,178,931...203,186,704
Ensembl chr 1:203,178,931...203,186,704
JBrowse link
G CIAPIN1 cytokine induced apoptosis inhibitor 1 decreases response to substance EXP CIAPIN1 protein results in decreased susceptibility to Etoposide CTD PMID:18389626 NCBI chr16:57,428,187...57,447,385
Ensembl chr16:57,428,187...57,447,420
JBrowse link
G CKM creatine kinase, M-type decreases expression EXP Etoposide results in decreased expression of CKM mRNA CTD PMID:29397400 NCBI chr19:45,306,413...45,322,875
Ensembl chr19:45,306,413...45,322,875
JBrowse link
G CKMT1B creatine kinase, mitochondrial 1B affects response to substance EXP CKMT1B protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr15:43,592,857...43,599,406
Ensembl chr15:43,593,054...43,604,901
JBrowse link
G COA7 cytochrome c oxidase assembly factor 7 decreases expression EXP Etoposide results in decreased expression of COA7 mRNA CTD PMID:24211769 NCBI chr 1:52,684,449...52,698,347
Ensembl chr 1:52,684,449...52,698,347
JBrowse link
G COBL cordon-bleu WH2 repeat protein decreases expression ISO Etoposide results in decreased expression of COBL mRNA CTD PMID:25270620 NCBI chr 7:51,016,212...51,316,809
Ensembl chr 7:51,016,212...51,316,818
JBrowse link
G COL15A1 collagen type XV alpha 1 chain affects response to substance EXP COL15A1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 9:98,943,392...99,070,787
Ensembl chr 9:98,943,179...99,070,792
JBrowse link
G COL4A1 collagen type IV alpha 1 chain decreases expression ISO Etoposide results in decreased expression of COL4A1 mRNA CTD PMID:25270620 NCBI chr13:110,148,963...110,307,157
Ensembl chr13:110,148,963...110,307,157
JBrowse link
G COL9A3 collagen type IX alpha 3 chain affects response to substance EXP COL9A3 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr20:62,817,050...62,841,159
Ensembl chr20:62,816,244...62,841,159
JBrowse link
G COX6A2 cytochrome c oxidase subunit 6A2 decreases expression EXP Etoposide results in decreased expression of COX6A2 mRNA CTD PMID:29397400 NCBI chr16:31,427,731...31,428,360
Ensembl chr16:31,427,731...31,428,360
JBrowse link
G CPS1 carbamoyl-phosphate synthase 1 affects response to substance EXP CPS1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 2:210,477,685...210,679,107
Ensembl chr 2:210,477,682...210,679,107
JBrowse link
G CPT2 carnitine palmitoyltransferase 2 decreases expression EXP Etoposide results in decreased expression of CPT2 mRNA CTD PMID:24211769 NCBI chr 1:53,196,824...53,214,197
Ensembl chr 1:53,196,792...53,214,197
JBrowse link
G CRABP2 cellular retinoic acid binding protein 2 increases expression EXP Etoposide results in increased expression of CRABP2 mRNA CTD PMID:21527772 NCBI chr 1:156,699,606...156,705,784
Ensembl chr 1:156,699,606...156,705,816
JBrowse link
G CREB1 cAMP responsive element binding protein 1 multiple interactions ISO
EXP
Etoposide results in increased expression of and results in increased phosphorylation of CREB1 protein; HIPK2 gene mutant form inhibits the reaction [Etoposide results in increased expression of and results in increased phosphorylation of CREB1 protein] CTD PMID:20573984 NCBI chr 2:207,529,943...207,605,988
Ensembl chr 2:207,529,737...207,605,988
JBrowse link
G CREM cAMP responsive element modulator affects response to substance EXP CREM protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr10:35,126,830...35,212,958
Ensembl chr10:35,126,791...35,212,958
JBrowse link
G CRIP2 cysteine rich protein 2 increases expression ISO Etoposide results in increased expression of CRIP2 mRNA CTD PMID:25270620 NCBI chr14:105,472,945...105,480,170
Ensembl chr14:105,472,962...105,480,170
Ensembl chr14:105,472,962...105,480,170
JBrowse link
G CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 affects response to substance EXP CSGALNACT1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 8:19,404,161...19,757,908
Ensembl chr 8:19,404,161...19,758,029
JBrowse link
G CST1 cystatin SN affects response to substance EXP CST1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr20:23,747,562...23,750,935
Ensembl chr20:23,747,553...23,751,268
JBrowse link
G CTH cystathionine gamma-lyase affects response to substance EXP CTH protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 1:70,411,268...70,441,949
Ensembl chr 1:70,411,218...70,439,851
JBrowse link
G CTNNB1 catenin beta 1 multiple interactions EXP [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of ABCB1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of BCL2L1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in decreased susceptibility to Etoposide; resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in decreased susceptibility to Etoposide] CTD PMID:19047049 NCBI chr 3:41,199,422...41,240,445
Ensembl chr 3:41,194,741...41,260,096
JBrowse link
G CXCL12 C-X-C motif chemokine ligand 12 decreases expression EXP Etoposide results in decreased expression of CXCL12 mRNA; Etoposide results in decreased expression of CXCL12 protein CTD PMID:22363485 NCBI chr10:44,292,088...44,385,097
Ensembl chr10:44,370,165...44,386,493
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 increases expression
multiple interactions
EXP Etoposide results in increased expression of CXCL8 mRNA; Etoposide results in increased expression of CXCL8 protein
SB 203580 inhibits the reaction [Etoposide results in increased expression of CXCL8 protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Etoposide results in increased expression of CXCL8 protein]
CTD PMID:10540334 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716
JBrowse link
G CYCS cytochrome c, somatic affects localization EXP Etoposide affects the localization of CYCS protein CTD PMID:10759716 NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 increases expression
multiple interactions
EXP Etoposide results in increased expression of CYP1A1 mRNA; Etoposide results in increased expression of CYP1A1 protein
Etoposide promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; TP53 protein promotes the reaction [Etoposide promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]]; TP53 protein promotes the reaction [Etoposide results in increased expression of CYP1A1 protein]
CTD PMID:29471073 PMID:31542801 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 increases expression EXP Etoposide results in increased expression of CYP1A2 mRNA CTD PMID:31542801 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
JBrowse link
G CYP26A1 cytochrome P450 family 26 subfamily A member 1 decreases response to substance EXP CYP26A1 protein results in decreased susceptibility to Etoposide CTD PMID:15703382 NCBI chr10:93,073,475...93,077,885
Ensembl chr10:93,073,475...93,077,885
JBrowse link
G CYP27B1 cytochrome P450 family 27 subfamily B member 1 increases expression EXP Etoposide results in increased expression of CYP27B1 mRNA CTD PMID:17716971 NCBI chr12:57,762,334...57,767,078
Ensembl chr12:57,762,334...57,768,986
JBrowse link
G CYP2C18 cytochrome P450 family 2 subfamily C member 18 increases expression ISO Etoposide results in increased expression of CYP2C55 mRNA CTD PMID:25270620 NCBI chr10:94,683,729...94,736,190
Ensembl chr10:94,683,729...94,736,190
JBrowse link
G CYP2C8 cytochrome P450 family 2 subfamily C member 8 increases expression ISO Etoposide results in increased expression of CYP2C29 mRNA CTD PMID:25270620 NCBI chr10:95,036,772...95,069,497
Ensembl chr10:95,036,772...95,069,497
JBrowse link
G CYP2S1 cytochrome P450 family 2 subfamily S member 1 decreases expression ISO Etoposide results in decreased expression of CYP2S1 mRNA CTD PMID:25270620 NCBI chr19:41,193,219...41,207,539
Ensembl chr19:41,193,210...41,207,539
JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 multiple interactions
increases expression
decreases methylation
affects response to substance
EXP [Etoposide results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; Cyclosporine inhibits the reaction [CYP3A4 protein results in decreased methylation of Etoposide]; Dexamethasone inhibits the reaction [CYP3A4 protein results in decreased methylation of Etoposide]; Erythromycin inhibits the reaction [CYP3A4 protein results in decreased methylation of Etoposide]; Midazolam inhibits the reaction [CYP3A4 protein results in decreased methylation of Etoposide]
Etoposide results in increased expression of CYP3A4 mRNA
CYP3A4 gene polymorphism affects the susceptibility to Etoposide; CYP3A4 protein affects the susceptibility to Etoposide
CTD PMID:8114683 PMID:12969965 PMID:17279585 PMID:25455453 PMID:31542801 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
JBrowse link
G CYP3A5 cytochrome P450 family 3 subfamily A member 5 affects response to substance
decreases methylation
EXP CYP3A5 gene polymorphism affects the susceptibility to Etoposide
CYP3A5 protein results in decreased methylation of Etoposide
CTD PMID:8114683 PMID:12969965 NCBI chr 7:99,648,194...99,679,996
Ensembl chr 7:99,648,194...99,679,998
JBrowse link
G CYREN cell cycle regulator of NHEJ affects localization EXP Etoposide affects the localization of CYREN protein alternative form CTD PMID:24610814 NCBI chr 7:135,092,303...135,170,821
Ensembl chr 7:135,092,363...135,170,795
JBrowse link
G DAB2 DAB adaptor protein 2 affects response to substance EXP DAB2 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 5:39,371,677...39,424,980
Ensembl chr 5:39,371,675...39,462,300
JBrowse link
G DBF4 DBF4 zinc finger decreases expression ISO Etoposide results in decreased expression of DBF4 mRNA CTD PMID:25270620 NCBI chr 7:87,876,493...87,909,553
Ensembl chr 7:87,876,216...87,909,553
JBrowse link
G DBN1 drebrin 1 affects response to substance EXP DBN1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 5:177,456,610...177,480,368
Ensembl chr 5:177,456,608...177,474,401
JBrowse link
G DCAF4 DDB1 and CUL4 associated factor 4 increases expression ISO Etoposide results in increased expression of DCAF4 mRNA CTD PMID:25270620 NCBI chr14:72,926,337...72,962,098
Ensembl chr14:72,926,377...72,959,703
JBrowse link
G DCT dopachrome tautomerase affects response to substance EXP DCT protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr13:94,436,811...94,549,406
Ensembl chr13:94,436,811...94,479,682
JBrowse link
G DDIT4 DNA damage inducible transcript 4 affects response to substance EXP DDIT4 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr10:72,273,924...72,276,036
Ensembl chr10:72,273,924...72,276,036
JBrowse link
G DDR1 discoidin domain receptor tyrosine kinase 1 increases expression ISO Etoposide results in increased expression of DDR1 mRNA CTD PMID:25270620 NCBI chr 6:30,880,958...30,900,156
Ensembl chr 6:30,876,421...30,900,156
JBrowse link
G DES desmin decreases expression EXP Etoposide results in decreased expression of DES mRNA CTD PMID:29397400 NCBI chr 2:219,418,377...219,426,734
Ensembl chr 2:219,418,377...219,426,734
JBrowse link
G DKK3 dickkopf WNT signaling pathway inhibitor 3 affects response to substance EXP DKK3 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr11:11,963,036...12,009,827
Ensembl chr11:11,956,207...12,009,769
JBrowse link
G DMD dystrophin affects response to substance
decreases expression
EXP DMD protein affects the susceptibility to Etoposide
Etoposide results in decreased expression of DMD mRNA
CTD PMID:16217747 PMID:29397400 NCBI chr  X:31,119,219...33,339,460
Ensembl chr  X:31,097,677...33,339,441
JBrowse link
G DMRT1 doublesex and mab-3 related transcription factor 1 decreases expression ISO Etoposide results in decreased expression of DMRT1 mRNA CTD PMID:25270620 NCBI chr 9:841,647...969,090
Ensembl chr 9:841,690...969,090
JBrowse link
G DNMT1 DNA methyltransferase 1 decreases response to substance ISO
EXP
DNMT1 protein results in decreased susceptibility to Etoposide CTD PMID:18314485 NCBI chr19:10,133,346...10,194,953
Ensembl chr19:10,133,345...10,231,286
Ensembl chr19:10,133,345...10,231,286
JBrowse link
G DNMT3B DNA methyltransferase 3 beta decreases response to substance EXP DNMT3B protein results in decreased susceptibility to Etoposide CTD PMID:18314485 NCBI chr20:32,762,385...32,809,356
Ensembl chr20:32,762,385...32,809,356
JBrowse link
G DPP7 dipeptidyl peptidase 7 multiple interactions EXP Etoposide promotes the reaction [[DPP7 protein results in increased cleavage of Dipeptides] which results in increased abundance of 4-nitroaniline] CTD PMID:16725115 NCBI chr 9:137,110,540...137,117,980
Ensembl chr 9:137,110,546...137,115,177
JBrowse link
G DPYSL2 dihydropyrimidinase like 2 decreases expression ISO Etoposide results in decreased expression of DPYSL2 protein CTD PMID:29733421 NCBI chr 8:26,514,031...26,658,175
Ensembl chr 8:26,514,031...26,658,178
JBrowse link
G DPYSL4 dihydropyrimidinase like 4 increases expression EXP Etoposide results in increased expression of DPYSL4 mRNA CTD PMID:21527772 NCBI chr10:132,184,983...132,205,759
Ensembl chr10:132,186,948...132,205,759
JBrowse link
G DUSP2 dual specificity phosphatase 2 affects response to substance EXP DUSP2 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 2:96,143,166...96,145,468
Ensembl chr 2:96,143,169...96,145,440
JBrowse link
G DUSP4 dual specificity phosphatase 4 affects response to substance
increases expression
EXP DUSP4 protein affects the susceptibility to Etoposide
Etoposide results in increased expression of DUSP4 mRNA
CTD PMID:16217747 PMID:29397400 NCBI chr 8:29,333,064...29,350,684
Ensembl chr 8:29,333,064...29,350,684
JBrowse link
G E2F1 E2F transcription factor 1 multiple interactions EXP E2F1 protein affects the reaction [Etoposide results in increased expression of HIC1 mRNA]; Etoposide promotes the reaction [E2F1 protein binds to HIC1 promoter] CTD PMID:19491197 NCBI chr20:33,675,477...33,686,385
Ensembl chr20:33,675,477...33,686,385
JBrowse link
G EDN1 endothelin 1 multiple interactions EXP EDN1 mutant form inhibits the reaction [VEGFC protein results in decreased susceptibility to Etoposide] CTD PMID:24184161 NCBI chr 6:12,256,463...12,297,194
Ensembl chr 6:12,290,361...12,297,194
JBrowse link
G EDNRB endothelin receptor type B decreases expression ISO Etoposide results in decreased expression of EDNRB mRNA CTD PMID:25270620 NCBI chr13:77,895,481...77,975,527
Ensembl chr13:77,895,481...77,975,529
JBrowse link
G EFS embryonal Fyn-associated substrate increases expression ISO Etoposide results in increased expression of EFS mRNA CTD PMID:25270620 NCBI chr14:23,356,402...23,365,207
Ensembl chr14:23,356,403...23,365,752
JBrowse link
G EGF epidermal growth factor multiple interactions EXP [EGF protein results in decreased expression of TOP2A protein] which results in decreased susceptibility to Etoposide CTD PMID:16969495 NCBI chr 4:109,912,883...110,013,766
Ensembl chr 4:109,912,883...110,013,766
JBrowse link
G EGFL8 EGF like domain multiple 8 affects response to substance EXP EGFL8 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 6:32,164,595...32,168,281
Ensembl chr 6:32,164,595...32,168,281
JBrowse link
G EGFR epidermal growth factor receptor decreases expression EXP Etoposide results in decreased expression of EGFR mRNA; Etoposide results in decreased expression of EGFR protein CTD PMID:15228094 NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628
JBrowse link
G EI24 EI24 autophagy associated transmembrane protein increases expression EXP Etoposide results in increased expression of EI24 mRNA CTD PMID:17374387 NCBI chr11:125,569,216...125,584,684
Ensembl chr11:125,569,280...125,584,684
JBrowse link
G EIF2S2 eukaryotic translation initiation factor 2 subunit beta decreases expression ISO Etoposide results in decreased expression of EIF2S2 mRNA CTD PMID:25270620 NCBI chr20:34,088,309...34,112,243
Ensembl chr20:34,088,309...34,112,243
JBrowse link
G EIF3A eukaryotic translation initiation factor 3 subunit A increases response to substance EXP
ISO
EIF3A results in increased susceptibility to Etoposide CTD PMID:21610145 NCBI chr10:119,033,670...119,080,817
Ensembl chr10:119,033,670...119,080,823
JBrowse link
G EMP1 epithelial membrane protein 1 increases expression EXP Etoposide results in increased expression of EMP1 mRNA CTD PMID:21527772 NCBI chr12:13,196,726...13,219,941
Ensembl chr12:13,196,723...13,219,941
JBrowse link
G EMP2 epithelial membrane protein 2 affects response to substance EXP EMP2 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr16:10,528,422...10,580,598
Ensembl chr16:10,528,422...10,580,632
JBrowse link
G EMP3 epithelial membrane protein 3 increases expression EXP Etoposide results in increased expression of EMP3 mRNA CTD PMID:21527772 NCBI chr19:48,325,504...48,330,554
Ensembl chr19:48,321,509...48,330,553
JBrowse link
G EN2 engrailed homeobox 2 affects response to substance EXP EN2 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 7:155,458,129...155,464,831
Ensembl chr 7:155,458,129...155,464,831
JBrowse link
G ENO1 enolase 1 decreases expression ISO Etoposide results in decreased expression of ENO1 protein CTD PMID:29733421 NCBI chr 1:8,861,000...8,878,686
Ensembl chr 1:8,861,000...8,879,190
JBrowse link
G ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2 decreases expression ISO Etoposide results in decreased expression of ENTPD2 mRNA CTD PMID:25270620 NCBI chr 9:137,048,107...137,054,061
Ensembl chr 9:137,048,107...137,054,061
JBrowse link
G EP300 E1A binding protein p300 multiple interactions EXP [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of ABCB1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of BCL2L1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of ABCB1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of BCL2L1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in decreased susceptibility to Etoposide; [[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in decreased susceptibility to Etoposide; resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in decreased susceptibility to Etoposide]; resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in decreased susceptibility to Etoposide] CTD PMID:19047049 NCBI chr22:41,092,592...41,180,077
Ensembl chr22:41,092,592...41,180,077
JBrowse link
G EPB41L3 erythrocyte membrane protein band 4.1 like 3 affects response to substance EXP EPB41L3 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr18:5,392,386...5,630,663
Ensembl chr18:5,392,381...5,630,700
JBrowse link
G EPHX1 epoxide hydrolase 1 increases expression ISO Etoposide results in increased expression of EPHX1 mRNA CTD PMID:21382384 PMID:25270620 NCBI chr 1:225,810,124...225,845,563
Ensembl chr 1:225,810,092...225,845,563
JBrowse link
G EPM2AIP1 EPM2A interacting protein 1 increases expression EXP Etoposide results in increased expression of EPM2AIP1 mRNA CTD PMID:17374387 NCBI chr 3:36,985,043...36,993,131
Ensembl chr 3:36,985,043...36,993,131
JBrowse link
G EPO erythropoietin multiple interactions EXP EPO protein results in increased susceptibility to [Organoplatinum Compounds co-treated with Etoposide] CTD PMID:18403296 NCBI chr 7:100,720,468...100,723,700
Ensembl chr 7:100,720,468...100,723,700
JBrowse link
G ERBB2 erb-b2 receptor tyrosine kinase 2 multiple interactions
decreases expression
decreases response to substance
affects response to substance
EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ERBB2 results in decreased susceptibility to Etoposide]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [ERBB2 results in decreased susceptibility to Etoposide]; [ERBB2 results in increased expression of ABCG2] which results in decreased susceptibility to Etoposide; ABCG2 mutant form inhibits the reaction [ERBB2 results in decreased susceptibility to Etoposide]; Curcumin analog inhibits the reaction [ERBB2 protein results in decreased susceptibility to Etoposide]
Etoposide results in decreased expression of ERBB2 mRNA
ERBB2 protein results in decreased susceptibility to Etoposide; ERBB2 results in decreased susceptibility to Etoposide
ERBB2 protein affects the susceptibility to Etoposide
CTD PMID:10327070 PMID:15228094 PMID:21712253 PMID:25866362 NCBI chr17:39,688,094...39,728,660
Ensembl chr17:39,687,914...39,730,426
JBrowse link
G ERBB3 erb-b2 receptor tyrosine kinase 3 affects response to substance
decreases expression
EXP ERBB3 protein affects the susceptibility to Etoposide
Etoposide results in decreased expression of ERBB3 mRNA
CTD PMID:15228094 PMID:16217747 PMID:29397400 NCBI chr12:56,080,108...56,103,505
Ensembl chr12:56,076,799...56,103,505
JBrowse link
G ERBB4 erb-b2 receptor tyrosine kinase 4 decreases expression EXP Etoposide results in decreased expression of ERBB4 mRNA CTD PMID:15228094 NCBI chr 2:211,375,717...212,538,802
Ensembl chr 2:211,375,717...212,538,841
JBrowse link
G EREG epiregulin increases expression EXP Etoposide results in increased expression of EREG mRNA CTD PMID:15228094 NCBI chr 4:74,365,145...74,388,749
Ensembl chr 4:74,365,145...74,388,749
JBrowse link
G ERVFRD-1 endogenous retrovirus group FRD member 1, envelope affects response to substance EXP ERVFRD-1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 6:11,102,489...11,111,725
Ensembl chr 6:11,102,489...11,111,725
JBrowse link
G ESR1 estrogen receptor 1 multiple interactions EXP Etoposide inhibits the reaction [Estradiol results in increased activity of ESR1 protein] CTD PMID:30818834 NCBI chr 6:151,654,148...152,129,619
Ensembl chr 6:151,656,691...152,129,619
JBrowse link
G ESR2 estrogen receptor 2 increases response to substance
multiple interactions
EXP ESR2 protein results in increased susceptibility to Etoposide
TP53 protein inhibits the reaction [ESR2 protein results in increased susceptibility to Etoposide]
CTD PMID:20623183 NCBI chr14:64,226,707...64,338,631
Ensembl chr14:64,084,232...64,338,112
JBrowse link
G ESRP1 epithelial splicing regulatory protein 1 affects response to substance EXP ESRP1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 8:94,640,999...94,707,466
Ensembl chr 8:94,641,074...94,707,466
JBrowse link
G ESRRA estrogen related receptor alpha multiple interactions EXP Etoposide inhibits the reaction [XCT790 results in decreased activity of ESRRA protein]; Etoposide promotes the reaction [PPARGC1A protein results in increased activity of ESRRA protein] CTD PMID:30818834 NCBI chr11:64,305,524...64,316,743
Ensembl chr11:64,305,497...64,316,743
Ensembl chr11:64,305,497...64,316,743
JBrowse link
G ETV6 ETS variant transcription factor 6 increases response to substance
increases mutagenesis
EXP ETV6 gene mutant form results in increased susceptibility to Etoposide
Etoposide results in increased mutagenesis of ETV6 gene
CTD PMID:15217836 PMID:28624474 NCBI chr12:11,649,601...11,895,386
Ensembl chr12:11,649,674...11,895,377
Ensembl chr12:11,649,674...11,895,377
JBrowse link
G EXOC4 exocyst complex component 4 increases expression ISO Etoposide results in increased expression of EXOC4 mRNA CTD PMID:25270620 NCBI chr 7:133,253,075...134,067,137
Ensembl chr 7:133,253,073...134,066,589
JBrowse link
G F11R F11 receptor increases expression EXP Etoposide results in increased expression of F11R mRNA CTD PMID:29397400 NCBI chr 1:160,995,211...161,021,152
Ensembl chr 1:160,995,211...161,021,343
JBrowse link
G F2R coagulation factor II thrombin receptor affects response to substance EXP F2R protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 5:76,716,126...76,735,770
Ensembl chr 5:76,716,126...76,735,770
JBrowse link
G F3 coagulation factor III, tissue factor increases expression EXP Etoposide results in increased expression of F3 mRNA CTD PMID:12542493 NCBI chr 1:94,529,173...94,541,759
Ensembl chr 1:94,529,173...94,541,759
JBrowse link
G FADS3 fatty acid desaturase 3 increases expression EXP Etoposide results in increased expression of FADS3 mRNA CTD PMID:21527772 NCBI chr11:61,873,526...61,892,224
Ensembl chr11:61,873,519...61,892,051
JBrowse link
G FAM171A1 family with sequence similarity 171 member A1 affects response to substance EXP FAM171A1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr10:15,211,643...15,374,532
Ensembl chr10:15,211,643...15,371,289
JBrowse link
G FAS Fas cell surface death receptor multiple interactions
increases expression
EXP
ISO
3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Etoposide results in increased expression of and affects the localization of FAS protein]; Etoposide results in increased expression of and affects the localization of FAS protein; Lithium inhibits the reaction [Etoposide results in increased expression of and affects the localization of FAS protein]
Etoposide results in increased expression of FAS mRNA
Etoposide results in increased expression of FAS mRNA; Etoposide results in increased expression of FAS protein
CTD PMID:12513834 PMID:15475000 PMID:16192531 PMID:29397400 NCBI chr10:88,968,429...89,017,059
Ensembl chr10:88,990,531...89,017,059
JBrowse link
G FASLG Fas ligand multiple interactions
increases expression
increases activity
EXP
ISO
[linsidomine results in increased abundance of Nitric Oxide] inhibits the reaction [Etoposide results in increased activity of FASLG promoter]; [S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] inhibits the reaction [Etoposide results in increased activity of FASLG promoter]; [S-Nitrosoglutathione results in increased abundance of Nitric Oxide] inhibits the reaction [Etoposide results in increased activity of FASLG promoter]; [spermine nitric oxide complex results in increased abundance of Nitric Oxide] inhibits the reaction [Etoposide results in increased activity of FASLG promoter]; Nitric Oxide inhibits the reaction [Etoposide results in increased activity of FASLG promoter]
Etoposide results in increased expression of FASL mRNA
CTD PMID:10811113 PMID:12513834 NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876
JBrowse link
G FASN fatty acid synthase increases expression EXP Etoposide results in increased expression of FASN mRNA CTD PMID:17089011 NCBI chr17:82,078,338...82,098,303
Ensembl chr17:82,078,338...82,098,294
JBrowse link
G FBL fibrillarin affects localization EXP Etoposide analog affects the localization of FBL protein CTD PMID:10942594 NCBI chr19:39,834,458...39,846,395
Ensembl chr19:39,834,458...39,846,379
JBrowse link
G FDFT1 farnesyl-diphosphate farnesyltransferase 1 affects response to substance EXP FDFT1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 8:11,795,582...11,839,309
Ensembl chr 8:11,795,573...11,839,304
JBrowse link
G FDXR ferredoxin reductase increases expression EXP Etoposide results in increased expression of FDXR mRNA CTD PMID:17374387 NCBI chr17:74,862,497...74,872,994
Ensembl chr17:74,862,497...74,873,031
JBrowse link
G FGF2 fibroblast growth factor 2 affects response to substance EXP FGF2 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 4:122,826,708...122,898,236
Ensembl chr 4:122,826,708...122,898,236
JBrowse link
G FHL1 four and a half LIM domains 1 affects response to substance EXP FHL1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr  X:136,146,702...136,211,359
Ensembl chr  X:136,146,702...136,211,359
JBrowse link
G FHL2 four and a half LIM domains 2 decreases expression EXP Etoposide results in decreased expression of FHL2 mRNA CTD PMID:29397400 NCBI chr 2:105,357,712...105,438,529
Ensembl chr 2:105,357,712...105,438,513
JBrowse link
G FLNC filamin C increases expression EXP Etoposide results in increased expression of FLNC mRNA CTD PMID:21527772 NCBI chr 7:128,830,406...128,859,272
Ensembl chr 7:128,830,377...128,859,274
Ensembl chr 7:128,830,377...128,859,274
JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit decreases response to substance
increases expression
multiple interactions
ISO
EXP
FOS protein results in decreased susceptibility to Etoposide
Etoposide results in increased expression of FOS
[Etoposide co-treated with Cyclic AMP] results in increased expression of FOS mRNA; Acetylcysteine inhibits the reaction [Etoposide results in increased expression of FOS]
CTD PMID:10711420 PMID:18314485 PMID:23824011 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230
JBrowse link
G FOSL1 FOS like 1, AP-1 transcription factor subunit increases expression ISO Etoposide results in increased expression of FOSL1 mRNA CTD PMID:25270620 NCBI chr11:65,892,049...65,900,545
Ensembl chr11:65,892,049...65,900,573
JBrowse link
G FOXF2 forkhead box F2 affects response to substance EXP FOXF2 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 6:1,389,576...1,395,603
Ensembl chr 6:1,389,576...1,395,603
JBrowse link
G FOXJ2 forkhead box J2 decreases expression EXP Etoposide results in decreased expression of FOXJ2 mRNA CTD PMID:24211769 NCBI chr12:8,032,680...8,055,522
Ensembl chr12:8,032,716...8,055,517
JBrowse link
G FOXO1 forkhead box O1 increases phosphorylation
multiple interactions
EXP Etoposide results in increased phosphorylation of FOXO1 protein
wortmannin inhibits the reaction [Etoposide results in increased phosphorylation of FOXO1 protein]
CTD PMID:17935137 NCBI chr13:40,555,667...40,666,641
Ensembl chr13:40,555,667...40,666,641
Ensembl chr13:40,555,667...40,666,641
JBrowse link
G FOXO3 forkhead box O3 increases phosphorylation
increases response to substance
multiple interactions
EXP Etoposide results in increased phosphorylation of FOXO3 protein
FOXO3 protein results in increased susceptibility to Etoposide
[FOXO3 protein results in decreased expression of BIRC5 protein] which results in increased susceptibility to Etoposide; BIRC5 protein inhibits the reaction [FOXO3 protein results in increased susceptibility to Etoposide]; wortmannin inhibits the reaction [Etoposide results in increased phosphorylation of FOXO3 protein]
CTD PMID:17935137 PMID:19211844 NCBI chr 6:108,559,825...108,684,774
Ensembl chr 6:108,559,835...108,684,774
JBrowse link
G FTH1 ferritin heavy chain 1 multiple interactions
increases expression
ISO HIPK2 protein promotes the reaction [Etoposide results in increased expression of FTH1 mRNA] CTD PMID:20980392 NCBI chr11:61,964,285...61,967,634
Ensembl chr11:61,959,718...61,967,634
JBrowse link
G FUT8 fucosyltransferase 8 affects response to substance EXP FUT8 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr14:65,410,592...65,744,122
Ensembl chr14:65,410,592...65,744,121
JBrowse link
G FYN FYN proto-oncogene, Src family tyrosine kinase affects response to substance
decreases expression
EXP
ISO
FYN protein affects the susceptibility to Etoposide
Etoposide results in decreased expression of FYN mRNA
CTD PMID:16217747 PMID:25270620 NCBI chr 6:111,660,332...111,873,452
Ensembl chr 6:111,660,332...111,873,452
JBrowse link
G FZD1 frizzled class receptor 1 decreases expression EXP Etoposide results in decreased expression of FZD1 mRNA CTD PMID:24211769 NCBI chr 7:91,264,433...91,271,326
Ensembl chr 7:91,264,433...91,271,326
JBrowse link
G FZD5 frizzled class receptor 5 decreases expression ISO Etoposide results in decreased expression of FZD5 mRNA CTD PMID:25270620 NCBI chr 2:207,753,889...207,769,906
Ensembl chr 2:207,762,598...207,769,906
JBrowse link
G GADD45A growth arrest and DNA damage inducible alpha increases response to substance
increases expression
EXP GADD45A protein results in increased susceptibility to Etoposide
Etoposide results in increased expression of GADD45A mRNA
CTD PMID:19003803 PMID:21527772 PMID:29397400 PMID:31542801 NCBI chr 1:67,685,201...67,688,334
Ensembl chr 1:67,685,201...67,688,334
JBrowse link
G GANAB glucosidase II alpha subunit decreases expression
multiple interactions
ISO Etoposide results in decreased expression of GANAB protein
[Etoposide co-treated with Cisplatin co-treated with Bleomycin] results in decreased expression of GANAB protein
CTD PMID:29733421 NCBI chr11:62,624,829...62,646,613
Ensembl chr11:62,624,826...62,646,726
JBrowse link
G GAPDH glyceraldehyde-3-phosphate dehydrogenase increases expression ISO Etoposide results in increased expression of GAPDH protein CTD PMID:29733421 NCBI chr12:6,534,517...6,538,371
Ensembl chr12:6,534,512...6,538,374
JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit multiple interactions EXP [GCLC protein co-treated with GCLM protein] promotes the reaction [ABCC1 protein results in decreased susceptibility to Etoposide]; [GCLC protein co-treated with GCLM protein] results in decreased susceptibility to Etoposide CTD PMID:10900222 NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970
JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit multiple interactions EXP [GCLC protein co-treated with GCLM protein] promotes the reaction [ABCC1 protein results in decreased susceptibility to Etoposide]; [GCLC protein co-treated with GCLM protein] results in decreased susceptibility to Etoposide CTD PMID:10900222 NCBI chr 1:93,885,199...93,910,370
Ensembl chr 1:93,885,199...93,909,456
JBrowse link
G GDF15 growth differentiation factor 15 multiple interactions
increases expression
EXP Etoposide promotes the reaction [[TP53 protein binds to GDF15 promoter] which results in increased expression of GDF15 mRNA]
[Etoposide results in increased expression of TP53 protein] which results in increased expression of GDF15 protein; Etoposide results in increased expression of GDF15 mRNA; Etoposide results in increased expression of GDF15 protein
CTD PMID:11895857 PMID:16120219 PMID:24211769 PMID:29397400 NCBI chr19:18,382,170...18,389,176
Ensembl chr19:18,374,731...18,389,176
JBrowse link
G GJA1 gap junction protein alpha 1 multiple interactions
increases response to substance
ISO GJA1 protein affects the reaction [Simvastatin results in increased susceptibility to Etoposide]; Tetradecanoylphorbol Acetate affects the reaction [GJA1 protein results in increased susceptibility to Etoposide] CTD PMID:23978459 NCBI chr 6:121,435,646...121,449,727
Ensembl chr 6:121,435,595...121,449,727
JBrowse link
G GJA5 gap junction protein alpha 5 decreases expression EXP Etoposide results in decreased expression of GJA5 mRNA CTD PMID:29397400 NCBI chr 1:147,756,199...147,781,127
Ensembl chr 1:147,756,199...147,773,362
JBrowse link
G GLS2 glutaminase 2 increases expression EXP Etoposide results in increased expression of GLS2 mRNA CTD PMID:21527772 PMID:29397400 NCBI chr12:56,470,952...56,488,161
Ensembl chr12:56,470,944...56,488,414
JBrowse link
G GPIHBP1 glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1 decreases expression ISO Etoposide results in decreased expression of GPIHBP1 mRNA CTD PMID:25270620 NCBI chr 8:143,213,218...143,217,170
Ensembl chr 8:143,213,218...143,217,170
JBrowse link
G GPM6B glycoprotein M6B affects response to substance EXP GPM6B protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr  X:13,770,922...13,938,713
Ensembl chr  X:13,770,939...13,938,638
JBrowse link
G GPNMB glycoprotein nmb increases expression EXP Etoposide results in increased expression of GPNMB mRNA CTD PMID:29397400 NCBI chr 7:23,246,766...23,275,110
Ensembl chr 7:23,235,967...23,275,108
JBrowse link
G GPR37 G protein-coupled receptor 37 affects response to substance EXP GPR37 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 7:124,743,885...124,765,792
Ensembl chr 7:124,743,885...124,765,792
JBrowse link
G GPSM2 G protein signaling modulator 2 affects response to substance EXP GPSM2 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 1:108,875,350...108,934,545
Ensembl chr 1:108,875,350...108,934,545
JBrowse link
G GPX1 glutathione peroxidase 1 increases expression EXP Etoposide results in increased expression of GPX1 mRNA CTD PMID:29397400 NCBI chr 3:49,357,176...49,358,353
Ensembl chr 3:49,357,176...49,358,358
JBrowse link
G GPX3 glutathione peroxidase 3 increases expression ISO Etoposide results in increased expression of GPX3 mRNA CTD PMID:25270620 NCBI chr 5:151,020,591...151,028,988
Ensembl chr 5:151,020,438...151,028,992
JBrowse link
G GRIA3 glutamate ionotropic receptor AMPA type subunit 3 increases expression ISO Etoposide results in increased expression of GRIA3 mRNA CTD PMID:25270620 NCBI chr  X:123,184,278...123,490,915
Ensembl chr  X:123,184,153...123,490,915
JBrowse link
G GRPEL1 GrpE like 1, mitochondrial decreases expression EXP Etoposide results in decreased expression of GRPEL1 mRNA CTD PMID:24211769 NCBI chr 4:7,058,895...7,068,064
Ensembl chr 4:7,058,895...7,068,064
JBrowse link
G GSK3B glycogen synthase kinase 3 beta multiple interactions
increases activity
ISO BCL2 protein affects the reaction [[Etoposide results in increased activity of GSK3B protein] which results in increased activity of CASP3 protein]
[Etoposide results in increased activity of GSK3B protein] which results in increased activity of CASP3 protein; Etoposide results in increased activity of GSK3B protein
CTD PMID:19408126 NCBI chr 3:119,821,321...120,095,823
Ensembl chr 3:119,821,323...120,094,417
Ensembl chr 3:119,821,323...120,094,417
Ensembl chr 3:119,821,323...120,094,417
JBrowse link
G GSTM1 glutathione S-transferase mu 1 affects response to substance EXP GSTM1 gene polymorphism affects the susceptibility to Etoposide CTD PMID:15713801 NCBI chr 1:109,687,817...109,693,745
Ensembl chr 1:109,687,814...109,709,039
JBrowse link
G GSTM4 glutathione S-transferase mu 4 affects response to substance EXP GSTM4 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 1:109,656,076...109,665,497
Ensembl chr 1:109,656,099...109,674,836
JBrowse link
G GSTP1 glutathione S-transferase pi 1 multiple interactions
decreases response to substance
affects response to substance
EXP Curcumin inhibits the reaction [GSTP1 protein results in decreased susceptibility to Etoposide]; Ethacrynic Acid inhibits the reaction [GSTP1 protein results in decreased susceptibility to Etoposide]; GSTP1 protein promotes the reaction [ABCC1 protein results in decreased susceptibility to Etoposide]; Sulfinpyrazone inhibits the reaction [GSTP1 protein results in decreased susceptibility to Etoposide]; verlukast inhibits the reaction [GSTP1 protein results in decreased susceptibility to Etoposide]
GSTP1 gene polymorphism affects the susceptibility to Etoposide
CTD PMID:10900222 PMID:12969965 PMID:15999103 NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656
Ensembl chr11:67,583,742...67,586,656
JBrowse link
G GSTT2 glutathione S-transferase theta 2 (gene/pseudogene) affects response to substance EXP GSTT2 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr22:23,980,134...23,983,915
Ensembl chr22:23,980,058...23,983,915
JBrowse link
G H2AX H2A.X variant histone multiple interactions
decreases response to substance
increases expression
increases phosphorylation
EXP
ISO
Celecoxib inhibits the reaction [Etoposide results in increased phosphorylation of H2AX protein]; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [Etoposide results in increased phosphorylation of H2AX protein]; nimesulide inhibits the reaction [Etoposide results in increased phosphorylation of H2AX protein]; palbociclib inhibits the reaction [Etoposide results in increased expression of H2AX protein]; pifithrin promotes the reaction [Etoposide results in increased expression of H2AX protein]
H2AX protein results in decreased susceptibility to Etoposide
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Etoposide results in increased expression of H2AX protein]; TOP2B protein affects the reaction [Etoposide results in increased expression of H2AX protein]
4,4'-(1,2-dimethyl-1,2-ethanediyl)bis-2,6-piperazinedione inhibits the reaction [Etoposide results in increased expression of H2AX protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Etoposide results in increased expression of H2AX protein]; Bortezomib inhibits the reaction [Etoposide results in increased expression of H2AX protein]; Razoxane inhibits the reaction [Etoposide results in increased expression of H2AX protein]
CTD PMID:17875725 PMID:20643100 PMID:20978201 PMID:21555580 PMID:21745461 PMID:22302033 PMID:25078064 PMID:26259609 PMID:32482060 NCBI chr11:119,093,874...119,095,465
Ensembl chr11:119,093,854...119,095,467
JBrowse link
G HAL histidine ammonia-lyase decreases expression ISO Etoposide results in decreased expression of HAL mRNA CTD PMID:25270620 NCBI chr12:95,972,662...95,996,344
Ensembl chr12:95,972,662...95,996,365
JBrowse link
G HAMP hepcidin antimicrobial peptide decreases expression
multiple interactions
ISO
EXP
Etoposide results in decreased expression of HAMP mRNA
Etoposide inhibits the reaction [BMP6 protein results in increased expression of HAMP mRNA]
CTD PMID:25270620 PMID:25633564 NCBI chr19:35,282,528...35,285,143
Ensembl chr19:35,280,716...35,285,143
JBrowse link
G HBEGF heparin binding EGF like growth factor increases expression EXP Etoposide results in increased expression of HBEGF mRNA CTD PMID:15228094 NCBI chr 5:140,332,843...140,346,603
Ensembl chr 5:140,332,843...140,346,603
JBrowse link
G HBP1 HMG-box transcription factor 1 decreases expression EXP Etoposide results in decreased expression of HBP1 mRNA CTD PMID:24211769 NCBI chr 7:107,168,987...107,202,523
Ensembl chr 7:107,168,961...107,202,522
JBrowse link
G HDAC4 histone deacetylase 4 affects response to substance EXP HDAC4 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 2:239,048,168...239,401,649
Ensembl chr 2:239,048,168...239,401,654
JBrowse link
G HEPH hephaestin affects response to substance EXP HEPH protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr  X:66,162,526...66,268,863
Ensembl chr  X:66,162,549...66,268,867
JBrowse link
G HIC1 HIC ZBTB transcriptional repressor 1 multiple interactions
increases expression
EXP E2F1 protein affects the reaction [Etoposide results in increased expression of HIC1 mRNA]; Etoposide promotes the reaction [E2F1 protein binds to HIC1 promoter] CTD PMID:19491197 NCBI chr17:2,055,103...2,063,241
Ensembl chr17:2,054,154...2,063,241
JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha multiple interactions EXP HIF1A mutant form inhibits the reaction [Oxygen deficiency results in decreased susceptibility to Etoposide] CTD PMID:23144690 NCBI chr14:61,695,513...61,748,259
Ensembl chr14:61,695,513...61,748,259
JBrowse link
G HIPK2 homeodomain interacting protein kinase 2 increases activity
multiple interactions
decreases response to substance
EXP
ISO
Etoposide results in increased activity of HIPK2 protein
HIPK2 gene mutant form inhibits the reaction [Etoposide results in increased expression of and results in increased phosphorylation of CREB1 protein]; HIPK2 gene mutant form promotes the reaction [Etoposide results in increased activity of CASP3 protein]; HIPK2 protein promotes the reaction [Etoposide results in increased expression of FTH1 mRNA]; HIPK2 protein promotes the reaction [Etoposide results in increased expression of NQO1 mRNA]
HIPK2 results in decreased susceptibility to Etoposide
HIPK2 mutant form inhibits the reaction [Etoposide results in increased expression of BDNF mRNA]
CTD PMID:20573984 PMID:20980392 NCBI chr 7:139,561,570...139,777,998
Ensembl chr 7:139,561,570...139,777,998
JBrowse link
G HLA-A major histocompatibility complex, class I, A affects expression EXP Etoposide affects the expression of HLA-A mRNA CTD PMID:25811541 NCBI chr 6:29,942,532...29,945,870
Ensembl chr 6:29,941,260...29,945,884
JBrowse link
G HLA-B major histocompatibility complex, class I, B affects expression EXP Etoposide affects the expression of HLA-B mRNA CTD PMID:25811541 NCBI chr 6:31,353,875...31,357,179
Ensembl chr 6:31,269,491...31,357,188
Ensembl chr 6:31,269,491...31,357,188
JBrowse link
G HLA-E major histocompatibility complex, class I, E affects expression EXP Etoposide affects the expression of HLA-E mRNA CTD PMID:25811541 NCBI chr 6:30,489,508...30,494,194
Ensembl chr 6:30,489,509...30,494,194
JBrowse link
G HMCES 5-hydroxymethylcytosine binding, ES cell specific decreases expression ISO Etoposide results in decreased expression of HMCES mRNA CTD PMID:25270620 NCBI chr 3:129,278,832...129,306,186
Ensembl chr 3:129,278,828...129,306,186
JBrowse link
G HMG20B high mobility group 20B affects response to substance EXP HMG20B protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr19:3,572,916...3,579,083
Ensembl chr19:3,572,777...3,579,088
JBrowse link
G HMGA2 high mobility group AT-hook 2 affects response to substance EXP HMGA2 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr12:65,824,460...65,966,291
Ensembl chr12:65,824,460...65,966,291
Ensembl chr12:65,824,460...65,966,291
JBrowse link
G HMGB1 high mobility group box 1 decreases response to substance
increases secretion
EXP HMGB1 protein results in decreased susceptibility to Etoposide
Etoposide results in increased secretion of HMGB1 protein
CTD PMID:27807322 NCBI chr13:30,456,704...30,617,597
Ensembl chr13:30,456,704...30,617,597
JBrowse link
G HNRNPH2 heterogeneous nuclear ribonucleoprotein H2 decreases expression ISO Etoposide results in decreased expression of HNRNPH2 protein CTD PMID:29733421 NCBI chr  X:101,408,222...101,414,133
Ensembl chr  X:101,408,222...101,414,133
JBrowse link
G HOXA5 homeobox A5 affects response to substance EXP HOXA5 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 7:27,141,052...27,143,681
Ensembl chr 7:27,141,052...27,143,681
JBrowse link
G HSP90AA1 heat shock protein 90 alpha family class A member 1 multiple interactions ISO [Bleomycin co-treated with Cisplatin co-treated with Etoposide] results in increased expression of HSP90AA1 protein CTD PMID:24478030 NCBI chr14:102,080,742...102,139,749
Ensembl chr14:102,080,738...102,139,699
Ensembl chr14:102,080,738...102,139,699
JBrowse link
G HSP90B1 heat shock protein 90 beta family member 1 multiple interactions ISO [Bleomycin co-treated with Cisplatin co-treated with Etoposide] results in increased expression of HSP90B1 protein CTD PMID:24478030 NCBI chr12:103,930,410...103,947,926
Ensembl chr12:103,930,107...103,953,645
JBrowse link
G HSPA2 heat shock protein family A (Hsp70) member 2 affects response to substance EXP HSPA2 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr14:64,535,905...64,543,237
Ensembl chr14:64,535,905...64,546,173
JBrowse link
G HSPE1 heat shock protein family E (Hsp10) member 1 increases expression ISO Etoposide results in increased expression of HSPE1 protein CTD PMID:29733421 NCBI chr 2:197,500,379...197,503,449
Ensembl chr 2:197,500,140...197,503,449
JBrowse link
G HTATIP2 HIV-1 Tat interactive protein 2 affects response to substance
increases response to substance
multiple interactions
EXP
ISO
HTATIP2 protein affects the susceptibility to Etoposide
HTATIP2 protein results in increased susceptibility to Etoposide
HTATIP2 protein promotes the reaction [Etoposide results in increased activity of CASP9 protein]; HTATIP2 protein promotes the reaction [Etoposide results in increased activity of PARP1 protein]
CTD PMID:16217747 PMID:16799960 NCBI chr11:20,363,714...20,383,782
Ensembl chr11:20,363,685...20,383,783
Ensembl chr11:20,363,685...20,383,783
JBrowse link
G HTR4 5-hydroxytryptamine receptor 4 affects response to substance EXP HTR4 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 5:148,451,032...148,654,527
Ensembl chr 5:148,451,032...148,677,235
JBrowse link
G IER5 immediate early response 5 increases expression EXP Etoposide results in increased expression of IER5 mRNA CTD PMID:21527772 NCBI chr 1:181,088,700...181,092,900
Ensembl chr 1:181,088,700...181,092,900
JBrowse link
G IFITM1 interferon induced transmembrane protein 1 affects response to substance EXP IFITM1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr11:314,040...315,272
Ensembl chr11:313,506...315,272
JBrowse link
G IGDCC4 immunoglobulin superfamily DCC subclass member 4 increases expression ISO Etoposide results in increased expression of IGDCC4 mRNA CTD PMID:25270620 NCBI chr15:65,381,484...65,422,947
Ensembl chr15:65,381,484...65,422,947
JBrowse link
G IGF1R insulin like growth factor 1 receptor affects response to substance EXP IGF1R protein affects the susceptibility to Etoposide CTD PMID:15499378 NCBI chr15:98,648,539...98,964,530
Ensembl chr15:98,648,539...98,964,530
JBrowse link
G IGFBP7 insulin like growth factor binding protein 7 affects response to substance EXP IGFBP7 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 4:57,030,773...57,110,385
Ensembl chr 4:57,030,773...57,110,385
JBrowse link
G IGH immunoglobulin heavy locus increases mutagenesis EXP Etoposide results in increased mutagenesis of IGH gene CTD PMID:28624474 NCBI chr14:105,586,437...106,879,844 JBrowse link
G IGSF11 immunoglobulin superfamily member 11 decreases expression ISO Etoposide results in decreased expression of IGSF11 mRNA CTD PMID:25270620 NCBI chr 3:118,900,557...119,146,064
Ensembl chr 3:118,900,557...119,146,068
JBrowse link
G IKBKB inhibitor of nuclear factor kappa B kinase subunit beta affects response to substance ISO IKBKB protein affects the susceptibility to Etoposide CTD PMID:20159942 NCBI chr 8:42,270,727...42,332,460
Ensembl chr 8:42,271,302...42,332,653
Ensembl chr 8:42,271,302...42,332,653
JBrowse link
G IL1B interleukin 1 beta increases expression ISO Etoposide results in increased expression of IL1B mRNA CTD PMID:18523641 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL4 interleukin 4 decreases response to substance
multiple interactions
EXP IL4 protein results in decreased susceptibility to Etoposide
[IL4 protein co-treated with VCAM1 protein] inhibits the reaction [Etoposide results in decreased folding of BAX protein]; [VCAM1 protein co-treated with IL4 protein] inhibits the reaction [Etoposide inhibits the reaction [BAX protein binds to BCL2L1 protein]]; [VCAM1 protein co-treated with IL4 protein] results in decreased susceptibility to Etoposide
CTD PMID:10620629 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678
JBrowse link
G IL6 interleukin 6 multiple interactions
increases expression
increases secretion
ISO (4-(5-(4-fluorophenyl)-2-methylsulfanyl-3H-imidazol-4-yl)pyridin-2-yl)-(1-phenylethyl)amine inhibits the reaction [Etoposide results in increased expression of IL6 mRNA]; (4-(5-(4-fluorophenyl)-2-methylsulfanyl-3H-imidazol-4-yl)pyridin-2-yl)-(1-phenylethyl)amine inhibits the reaction [Etoposide results in increased secretion of IL6 protein]
Etoposide results in increased expression of IL6 mRNA; Etoposide results in increased expression of IL6 protein
CTD PMID:15135310 PMID:17003255 PMID:18523641 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G INKA2 inka box actin regulator 2 increases expression ISO Etoposide results in increased expression of INKA2 mRNA CTD PMID:25270620 NCBI chr 1:111,722,064...111,755,797
Ensembl chr 1:111,680,630...111,755,824
JBrowse link
G INSIG1 insulin induced gene 1 affects response to substance EXP INSIG1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 7:155,297,878...155,310,235
Ensembl chr 7:155,297,776...155,310,235
JBrowse link
G IRS2 insulin receptor substrate 2 affects response to substance EXP IRS2 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr13:109,752,695...109,786,583
Ensembl chr13:109,752,695...109,786,583
JBrowse link
G IRX4 iroquois homeobox 4 decreases expression EXP Etoposide results in decreased expression of IRX4 mRNA CTD PMID:29397400 NCBI chr 5:1,877,413...1,887,179
Ensembl chr 5:1,877,413...1,887,236
JBrowse link
G ISG15 ISG15 ubiquitin like modifier increases expression EXP Etoposide results in increased expression of ISG15 mRNA CTD PMID:21527772 NCBI chr 1:1,013,497...1,014,540
Ensembl chr 1:1,001,138...1,014,540
JBrowse link
G ISG20 interferon stimulated exonuclease gene 20 affects response to substance EXP ISG20 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr15:88,635,614...88,656,483
Ensembl chr15:88,636,153...88,656,483
JBrowse link
G ISG20L2 interferon stimulated exonuclease gene 20 like 2 decreases expression EXP Etoposide results in decreased expression of ISG20L2 mRNA CTD PMID:24211769 NCBI chr 1:156,721,891...156,728,766
Ensembl chr 1:156,721,891...156,728,799
Ensembl chr 1:156,721,891...156,728,799
JBrowse link
G ITGA2B integrin subunit alpha 2b increases expression EXP Etoposide results in increased expression of ITGA2B mRNA CTD PMID:21527772 NCBI chr17:44,372,181...44,389,649
Ensembl chr17:44,372,180...44,389,649
JBrowse link
G ITGB3 integrin subunit beta 3 increases response to substance EXP ITGB3 protein results in increased susceptibility to Etoposide CTD PMID:21332719 NCBI chr17:47,253,827...47,313,743
Ensembl chr17:47,253,846...47,313,735
Ensembl chr17:47,253,846...47,313,735
Ensembl chr17:47,253,846...47,313,735
JBrowse link
G ITPR1 inositol 1,4,5-trisphosphate receptor type 1 affects response to substance EXP ITPR1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 3:4,493,348...4,847,506
Ensembl chr 3:4,493,345...4,847,840
JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP [Etoposide co-treated with Cyclic AMP] results in increased expression of JUN mRNA CTD PMID:10711420 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,780,791...58,784,047
Ensembl chr 1:58,780,791...58,784,047
JBrowse link
G KCNAB2 potassium voltage-gated channel subfamily A regulatory beta subunit 2 affects response to substance EXP KCNAB2 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 1:5,992,639...6,101,186
Ensembl chr 1:5,990,927...6,101,193
JBrowse link
G KCNE3 potassium voltage-gated channel subfamily E regulatory subunit 3 decreases expression ISO Etoposide results in decreased expression of KCNE3 mRNA CTD PMID:25270620 NCBI chr11:74,454,841...74,467,729
Ensembl chr11:74,454,841...74,467,729
JBrowse link
G KCNN2 potassium calcium-activated channel subfamily N member 2 decreases expression EXP Etoposide results in decreased expression of KCNN2 mRNA CTD PMID:29397400 NCBI chr 5:114,055,978...114,496,500
Ensembl chr 5:114,055,926...114,496,500
Ensembl chr 5:114,055,926...114,496,500
JBrowse link
G KEAP1 kelch like ECH associated protein 1 decreases response to substance
multiple interactions
increases response to substance
EXP KEAP1 protein results in decreased susceptibility to Etoposide
KEAP1 protein affects the reaction [Etoposide results in increased expression of CDKN1A protein]
KEAP1 mRNA results in increased susceptibility to Etoposide
CTD PMID:22684020 PMID:26708503 PMID:27982581 NCBI chr19:10,486,125...10,503,356
Ensembl chr19:10,486,125...10,503,558
JBrowse link
G KIF1A kinesin family member 1A increases expression EXP Etoposide results in increased expression of KIF1A mRNA CTD PMID:21527772 NCBI chr 2:240,713,767...240,821,403
Ensembl chr 2:240,713,761...240,824,293
Ensembl chr 2:240,713,761...240,824,293
JBrowse link
G KIF20A kinesin family member 20A decreases expression EXP Etoposide results in decreased expression of KIF20A mRNA CTD PMID:24211769 NCBI chr 5:138,179,112...138,187,723
Ensembl chr 5:138,178,719...138,187,723
JBrowse link
G KIF23 kinesin family member 23 decreases expression ISO Etoposide results in decreased expression of KIF23 mRNA CTD PMID:25270620 NCBI chr15:69,414,325...69,448,427
Ensembl chr15:69,414,246...69,448,427
JBrowse link
G KIT KIT proto-oncogene, receptor tyrosine kinase increases expression
multiple interactions
ISO Etoposide results in increased expression of KIT protein
[Etoposide co-treated with Cisplatin co-treated with Bleomycin] results in increased expression of KIT protein
CTD PMID:29733421 NCBI chr 4:54,657,957...54,740,715
Ensembl chr 4:54,657,918...54,740,715
JBrowse link
G KLF5 Kruppel like factor 5 increases expression EXP Etoposide results in increased expression of KLF5 mRNA CTD PMID:29397400 NCBI chr13:73,054,976...73,077,538
Ensembl chr13:73,054,976...73,077,541
JBrowse link
G KLF6 Kruppel like factor 6 decreases expression EXP Etoposide results in decreased expression of KLF6 mRNA CTD PMID:24211769 NCBI chr10:3,775,996...3,785,209
Ensembl chr10:3,775,996...3,785,281
JBrowse link
G KLHL26 kelch like family member 26 increases expression ISO Etoposide results in increased expression of KLHL26 mRNA CTD PMID:25270620 NCBI chr19:18,637,028...18,671,721
Ensembl chr19:18,637,025...18,671,721
JBrowse link
G KLK2 kallikrein related peptidase 2 multiple interactions EXP Etoposide inhibits the reaction [Dihydrotestosterone results in increased expression of KLK2 mRNA] CTD PMID:20601956 NCBI chr19:50,873,439...50,880,567
Ensembl chr19:50,861,568...50,880,567
JBrowse link
G KLK3 kallikrein related peptidase 3 multiple interactions EXP Etoposide inhibits the reaction [Dihydrotestosterone results in increased expression of KLK3 mRNA] CTD PMID:20601956 NCBI chr19:50,854,915...50,860,764
Ensembl chr19:50,854,915...50,860,764
JBrowse link
G KMT2A lysine methyltransferase 2A increases response to substance
increases mutagenesis
increases cleavage
EXP KMT2A gene mutant form results in increased susceptibility to Etoposide
Etoposide results in increased mutagenesis of KMT2A gene
Etoposide results in increased cleavage of KMT2A gene
CTD PMID:14712291 PMID:24086652 PMID:28624474 NCBI chr11:118,436,492...118,526,832
Ensembl chr11:118,436,490...118,526,832
JBrowse link
G KRT19 keratin 19 increases expression EXP Etoposide results in increased expression of KRT19 mRNA CTD PMID:29397400 NCBI chr17:41,523,617...41,528,308
Ensembl chr17:41,523,617...41,528,308
JBrowse link
G KRT80 keratin 80 increases expression EXP Etoposide results in increased expression of KRT80 mRNA CTD PMID:21527772 NCBI chr12:52,168,996...52,192,014
Ensembl chr12:52,168,996...52,192,014
JBrowse link
G KYNU kynureninase affects response to substance EXP KYNU protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 2:142,877,664...143,055,833
Ensembl chr 2:142,877,657...143,055,833
JBrowse link
G LANCL1 LanC like 1 affects response to substance EXP LANCL1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 2:210,431,251...210,477,618
Ensembl chr 2:210,431,249...210,477,652
JBrowse link
G LAP3 leucine aminopeptidase 3 decreases expression ISO Etoposide results in decreased expression of LAP3 mRNA CTD PMID:25270620 NCBI chr 4:17,577,198...17,607,970
Ensembl chr 4:17,577,192...17,607,972
JBrowse link
G LCN2 lipocalin 2 increases response to substance ISO LCN2 protein results in increased susceptibility to Etoposide CTD PMID:19860839 NCBI chr 9:128,149,453...128,153,453
Ensembl chr 9:128,149,071...128,153,453
JBrowse link
G LDB3 LIM domain binding 3 decreases expression EXP Etoposide results in decreased expression of LDB3 mRNA CTD PMID:29397400 NCBI chr10:86,666,788...86,736,072
Ensembl chr10:86,668,507...86,736,072
Ensembl chr10:86,668,507...86,736,072
JBrowse link
G LGALS3 galectin 3 affects response to substance EXP LGALS3 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr14:55,129,252...55,145,430
Ensembl chr14:55,124,110...55,145,423
JBrowse link
G LGALS7 galectin 7 increases expression EXP Etoposide results in increased expression of LGALS7 mRNA CTD PMID:21527772 NCBI chr19:38,770,968...38,773,517
Ensembl chr19:38,770,971...38,773,492
Ensembl chr19:38,770,971...38,773,492
JBrowse link
G LHX1 LIM homeobox 1 multiple interactions
decreases expression
ISO [Etoposide co-treated with Cisplatin co-treated with Bleomycin] results in decreased expression of LHX1 mRNA
Etoposide results in decreased expression of LHX1 mRNA
CTD PMID:29733421 NCBI chr17:36,937,475...36,944,612
Ensembl chr17:36,936,785...36,944,612
JBrowse link
G LHX2 LIM homeobox 2 decreases expression EXP Etoposide results in decreased expression of LHX2 mRNA CTD PMID:24211769 NCBI chr 9:124,011,759...124,033,301
Ensembl chr 9:124,001,670...124,033,301
JBrowse link
G LIF LIF interleukin 6 family cytokine increases expression EXP Etoposide results in increased expression of LIF mRNA CTD PMID:29397400 NCBI chr22:30,240,453...30,257,487
Ensembl chr22:30,240,453...30,246,759
JBrowse link
G LIMCH1 LIM and calponin homology domains 1 affects response to substance EXP LIMCH1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 4:41,359,607...41,700,044
Ensembl chr 4:41,359,607...41,700,044
JBrowse link
G LIPA lipase A, lysosomal acid type affects response to substance EXP LIPA protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr10:89,213,571...89,251,926
Ensembl chr10:89,213,569...89,414,557
JBrowse link
G LRRC47 leucine rich repeat containing 47 decreases expression EXP Etoposide results in decreased expression of LRRC47 mRNA CTD PMID:24211769 NCBI chr 1:3,778,559...3,796,498
Ensembl chr 1:3,778,559...3,796,498
JBrowse link
G LTBR lymphotoxin beta receptor multiple interactions
increases expression
EXP Estradiol inhibits the reaction [Etoposide results in increased expression of LTBR mRNA] CTD PMID:19426747 NCBI chr12:6,375,160...6,391,571
Ensembl chr12:6,375,045...6,391,571
JBrowse link
G LXN latexin increases response to substance ISO LXN protein results in increased susceptibility to Etoposide CTD PMID:25341047 NCBI chr 3:158,666,414...158,672,722
Ensembl chr 3:158,645,822...158,672,648
JBrowse link
G LY6E lymphocyte antigen 6 family member E affects response to substance EXP LY6E protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 8:143,018,529...143,022,409
Ensembl chr 8:143,017,982...143,023,832
JBrowse link
G MACF1 microtubule actin crosslinking factor 1 affects response to substance EXP MACF1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 1:39,084,167...39,487,138
Ensembl chr 1:39,081,316...39,487,177
JBrowse link
G MAGEA12 MAGE family member A12 affects response to substance EXP MAGEA12 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr  X:152,733,757...152,737,669
Ensembl chr  X:152,733,757...152,737,669
JBrowse link
G MAGEA6 MAGE family member A6 affects response to substance EXP MAGEA6 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr  X:152,766,136...152,769,747
Ensembl chr  X:152,766,136...152,769,747
JBrowse link
G MAGEC1 MAGE family member C1 affects response to substance EXP MAGEC1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr  X:141,903,877...141,909,401
Ensembl chr  X:141,903,894...141,909,374
JBrowse link
G MAN2B1 mannosidase alpha class 2B member 1 increases expression ISO Etoposide results in increased expression of MAN2B1 mRNA CTD PMID:25270620 NCBI chr19:12,646,511...12,666,742
Ensembl chr19:12,646,511...12,666,742
JBrowse link
G MAP2K3 mitogen-activated protein kinase kinase 3 increases expression EXP Etoposide results in increased expression of MAP2K3 mRNA CTD PMID:17374387 NCBI chr17:21,284,679...21,315,240
Ensembl chr17:21,284,672...21,315,232
JBrowse link
G MAP3K5 mitogen-activated protein kinase kinase kinase 5 decreases expression EXP Etoposide results in decreased expression of MAP3K5 mRNA CTD PMID:17374387 NCBI chr 6:136,557,046...136,793,098
Ensembl chr 6:136,557,046...136,792,477
JBrowse link
G MAP7 microtubule associated protein 7 affects response to substance EXP MAP7 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 6:136,342,734...136,550,422
Ensembl chr 6:136,342,281...136,550,819
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions
increases phosphorylation
EXP 3',4'-dihydroxyflavone analog inhibits the reaction [Etoposide results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Etoposide results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Etoposide results in increased phosphorylation of MAPK1 protein] CTD PMID:16014620 PMID:19720055 PMID:26046675 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680
JBrowse link
G MAPK12 mitogen-activated protein kinase 12 increases activity
affects response to substance
multiple interactions
EXP Etoposide results in increased activity of MAPK12 protein
MAPK12 protein affects the susceptibility to Etoposide
[MAPK12 protein results in increased phosphorylation of TOP2A protein] which results in increased susceptibility to Etoposide; [MAPK12 protein results in increased stability of TOP2A protein] which results in increased susceptibility to Etoposide
CTD PMID:21878638 NCBI chr22:50,252,901...50,261,683
Ensembl chr22:50,245,450...50,261,716
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation
EXP 3',4'-dihydroxyflavone analog inhibits the reaction [Etoposide results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [Etoposide results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Etoposide results in increased phosphorylation of MAPK3 protein] CTD PMID:16014620 PMID:19720055 PMID:26046675 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MAPKAPK2 MAPK activated protein kinase 2 multiple interactions
increases phosphorylation
ISO (4-(5-(4-fluorophenyl)-2-methylsulfanyl-3H-imidazol-4-yl)pyridin-2-yl)-(1-phenylethyl)amine inhibits the reaction [Etoposide results in increased phosphorylation of MAPKAPK2 protein] CTD PMID:17003255 NCBI chr 1:206,684,905...206,734,283
Ensembl chr 1:206,684,944...206,734,283
Ensembl chr 1:206,684,944...206,734,283
JBrowse link
G MATN2 matrilin 2 affects response to substance EXP MATN2 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 8:97,869,064...98,036,724
Ensembl chr 8:97,868,840...98,036,724
JBrowse link
G MBP myelin basic protein affects response to substance EXP MBP protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr18:76,978,833...77,133,708
Ensembl chr18:76,978,827...77,133,683
JBrowse link
G MCAM melanoma cell adhesion molecule increases expression ISO Etoposide results in increased expression of MCAM mRNA CTD PMID:25270620 NCBI chr11:119,305,759...119,317,130
Ensembl chr11:119,308,529...119,321,521
JBrowse link
G MCL1 MCL1 apoptosis regulator, BCL2 family member multiple interactions
decreases expression
EXP wortmannin promotes the reaction [Etoposide results in decreased expression of MCL1 protein] CTD PMID:17935137 NCBI chr 1:150,574,558...150,579,610
Ensembl chr 1:150,574,551...150,579,738
Ensembl chr 1:150,574,551...150,579,738
JBrowse link
G MCM10 minichromosome maintenance 10 replication initiation factor decreases expression EXP Etoposide results in decreased expression of MCM10 mRNA CTD PMID:24211769 NCBI chr10:13,161,558...13,211,110
Ensembl chr10:13,161,554...13,211,104
Ensembl chr10:13,161,554...13,211,104
JBrowse link
G MCM2 minichromosome maintenance complex component 2 decreases expression EXP Etoposide results in decreased expression of MCM2 mRNA CTD PMID:16120219 NCBI chr 3:127,598,411...127,622,436
Ensembl chr 3:127,598,410...127,622,436
JBrowse link
G MCM6 minichromosome maintenance complex component 6 decreases expression EXP Etoposide results in decreased expression of MCM6 mRNA CTD PMID:16120219 NCBI chr 2:135,839,626...135,876,443
Ensembl chr 2:135,839,626...135,876,443
JBrowse link
G MCM7 minichromosome maintenance complex component 7 decreases expression EXP Etoposide results in decreased expression of MCM7 mRNA CTD PMID:16120219 NCBI chr 7:100,092,728...100,101,397
Ensembl chr 7:100,092,728...100,101,940
JBrowse link
G MCM8 minichromosome maintenance 8 homologous recombination repair factor decreases expression EXP Etoposide results in decreased expression of MCM8 mRNA CTD PMID:16120219 NCBI chr20:5,950,652...6,000,941
Ensembl chr20:5,950,652...5,998,977
JBrowse link
G MDFIC MyoD family inhibitor domain containing affects response to substance EXP MDFIC protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 7:114,922,154...115,019,917
Ensembl chr 7:114,922,359...115,019,202
Ensembl chr 7:114,922,359...115,019,202
JBrowse link
G MDH2 malate dehydrogenase 2 multiple interactions ISO [Etoposide co-treated with Cisplatin co-treated with Bleomycin] results in decreased expression of MDH2 protein CTD PMID:29733421 NCBI chr 7:76,048,106...76,067,508
Ensembl chr 7:76,048,051...76,067,508
JBrowse link
G MDM2 MDM2 proto-oncogene multiple interactions
decreases expression
increases phosphorylation
increases expression
decreases response to substance
EXP
ISO
benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Etoposide promotes the reaction [MDM2 protein binds to TOP2A protein]]; Cadmium Chloride affects the reaction [Etoposide results in increased phosphorylation of MDM2 protein]; Etoposide promotes the reaction [MDM2 protein binds to TOP2A protein]; wortmannin promotes the reaction [Etoposide results in increased phosphorylation of MDM2 protein]
Etoposide results in decreased expression of MDM2 protein
Etoposide results in increased expression of MDM2 mRNA; Etoposide results in increased expression of MDM2 protein
Tetrachlorodibenzodioxin inhibits the reaction [Etoposide results in increased expression of MDM2 protein]
MDM2 promoter SNP results in decreased susceptibility to Etoposide
CTD PMID:15459018 PMID:16120219 PMID:17575151 PMID:17935137 PMID:18096571 PMID:25078064 PMID:25744307 PMID:26259609 PMID:31542801 NCBI chr12:68,808,149...68,850,686
Ensembl chr12:68,808,177...68,850,686
JBrowse link
G ME2 malic enzyme 2 decreases expression ISO Etoposide results in decreased expression of ME2 protein CTD PMID:29733421 NCBI chr18:50,878,702...50,954,257
Ensembl chr18:50,879,080...50,954,257
JBrowse link
G MIR135B microRNA 135b increases expression EXP Etoposide results in increased expression of MIR135B mRNA CTD PMID:27570640 NCBI chr 1:205,448,302...205,448,398
Ensembl chr 1:205,448,302...205,448,398
JBrowse link
G MIR139 microRNA 139 increases expression EXP Etoposide results in increased expression of MIR139 mRNA CTD PMID:29397400 NCBI chr11:72,615,063...72,615,130
Ensembl chr11:72,615,063...72,615,130
JBrowse link
G MIR182 microRNA 182 increases expression EXP Etoposide results in increased expression of MIR182 mRNA CTD PMID:29397400 NCBI chr 7:129,770,383...129,770,492
Ensembl chr 7:129,770,383...129,770,492
JBrowse link
G MIR196B microRNA 196b increases expression EXP Etoposide results in increased expression of MIR196B mRNA CTD PMID:27570640 NCBI chr 7:27,169,480...27,169,563
Ensembl chr 7:27,169,480...27,169,563
JBrowse link
G MIR34C microRNA 34c increases expression EXP Etoposide results in increased expression of MIR34C mRNA CTD PMID:29397400 NCBI chr11:111,513,439...111,513,515
Ensembl chr11:111,513,439...111,513,515
JBrowse link
G MIR4423 microRNA 4423 increases expression EXP Etoposide results in increased expression of MIR4423 mRNA CTD PMID:29397400 NCBI chr 1:85,133,794...85,133,873
Ensembl chr 1:85,133,794...85,133,873
JBrowse link
G MIR654 microRNA 654 increases response to substance EXP MIR654 mRNA results in increased susceptibility to Etoposide CTD PMID:20145152 NCBI chr14:101,040,219...101,040,299
Ensembl chr14:101,040,219...101,040,299
JBrowse link
G MIR765 microRNA 765 increases response to substance EXP MIR765 mRNA results in increased susceptibility to Etoposide CTD PMID:20145152 NCBI chr 1:156,936,131...156,936,244
Ensembl chr 1:156,936,131...156,936,244
JBrowse link
G MLANA melan-A affects response to substance EXP MLANA protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 9:5,890,889...5,910,606
Ensembl chr 9:5,890,889...5,910,606
JBrowse link
G MLLT11 MLLT11 transcription factor 7 cofactor affects response to substance EXP MLLT11 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 1:151,060,397...151,069,544
Ensembl chr 1:151,060,397...151,069,544
Ensembl chr 1:151,060,397...151,069,544
JBrowse link
G MMP1 matrix metallopeptidase 1 decreases expression
multiple interactions
EXP Etoposide results in decreased expression of MMP1 protein
pifithrin inhibits the reaction [Etoposide results in decreased expression of MMP1 protein]
CTD PMID:18557930 NCBI chr11:102,789,919...102,798,160
Ensembl chr11:102,789,919...102,798,160
JBrowse link
G MOCOS molybdenum cofactor sulfurase affects response to substance EXP MOCOS protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr18:36,187,497...36,272,157
Ensembl chr18:36,187,497...36,272,157
JBrowse link
G MPO myeloperoxidase increases metabolic processing EXP MPO protein results in increased metabolism of Etoposide CTD PMID:16841962 NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935
JBrowse link
G MPZL1 myelin protein zero like 1 decreases expression EXP Etoposide results in decreased expression of MPZL1 mRNA CTD PMID:24211769 NCBI chr 1:167,721,982...167,791,919
Ensembl chr 1:167,721,192...167,791,919
JBrowse link
G MR1 major histocompatibility complex, class I-related increases expression
affects expression
EXP Etoposide results in increased expression of MR1 mRNA
Etoposide affects the expression of MR1 mRNA
CTD PMID:21527772 PMID:25811541 NCBI chr 1:181,033,387...181,061,938
Ensembl chr 1:181,033,425...181,061,938
JBrowse link
G MRAS muscle RAS oncogene homolog decreases expression ISO Etoposide results in decreased expression of MRAS mRNA CTD PMID:25270620 NCBI chr 3:138,347,648...138,405,535
Ensembl chr 3:138,347,648...138,405,534
JBrowse link
G MRC1 mannose receptor C-type 1 decreases expression ISO Etoposide results in decreased expression of MRC1 mRNA CTD PMID:25270620 NCBI chr10:17,809,348...17,911,164
Ensembl chr10:17,809,348...17,911,164
JBrowse link
G MRM2 mitochondrial rRNA methyltransferase 2 decreases expression EXP Etoposide results in decreased expression of MRM2 mRNA CTD PMID:24211769 NCBI chr 7:2,234,195...2,242,205
Ensembl chr 7:2,234,195...2,242,205
Ensembl chr 7:2,234,195...2,242,205
Ensembl chr 7:2,234,195...2,242,205
JBrowse link
G MSC musculin decreases expression ISO Etoposide results in decreased expression of MSC mRNA CTD PMID:25270620 NCBI chr 8:71,841,560...71,844,412
Ensembl chr 8:71,841,549...71,844,468
JBrowse link
G MSH6 mutS homolog 6 decreases expression EXP Etoposide results in decreased expression of MSH6 mRNA CTD PMID:24211769 NCBI chr 2:47,783,145...47,806,954
Ensembl chr 2:47,695,530...47,810,101
Ensembl chr 2:47,695,530...47,810,101
JBrowse link
G MT-ND4 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4 increases expression EXP Etoposide results in increased expression of ND4 mRNA CTD PMID:26259609 NCBI chr MT:10,760...12,137
Ensembl chr MT:10,760...12,137
JBrowse link
G MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase decreases expression ISO Etoposide results in decreased expression of MTHFD2 mRNA CTD PMID:25270620 NCBI chr 2:74,198,591...74,217,565
Ensembl chr 2:74,198,610...74,217,565
Ensembl chr 2:74,198,610...74,217,565
JBrowse link
G MTOR mechanistic target of rapamycin kinase increases phosphorylation EXP Etoposide results in increased phosphorylation of MTOR protein CTD PMID:27769712 NCBI chr 1:11,106,535...11,273,497
Ensembl chr 1:11,106,535...11,262,551
JBrowse link
G MTUS1 microtubule associated scaffold protein 1 affects response to substance EXP MTUS1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 8:17,643,794...17,801,521
Ensembl chr 8:17,643,795...17,800,917
JBrowse link
G MXI1 MAX interactor 1, dimerization protein affects response to substance EXP MXI1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr10:110,207,605...110,287,365
Ensembl chr10:110,207,605...110,287,365
JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor decreases expression
increases response to substance
multiple interactions
EXP Etoposide results in decreased expression of MYC; Etoposide results in decreased expression of MYC mRNA
MYC protein results in increased susceptibility to Etoposide
MYC protein promotes the reaction [Etoposide results in increased cleavage of CASP9 protein]
CTD PMID:9454737 PMID:21324178 PMID:21527772 NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951
JBrowse link
G MYCN MYCN proto-oncogene, bHLH transcription factor multiple interactions
decreases response to substance
EXP [MYCN protein affects the expression of ABCC1 mRNA] which affects the susceptibility to Etoposide
MYCN protein results in decreased susceptibility to Etoposide
CTD PMID:10348353 NCBI chr 2:15,940,550...15,947,004
Ensembl chr 2:15,940,550...15,947,007
JBrowse link
G MYH7 myosin heavy chain 7 decreases expression EXP Etoposide results in decreased expression of MYH7 mRNA CTD PMID:29397400 NCBI chr14:23,412,740...23,435,677
Ensembl chr14:23,412,740...23,435,660
JBrowse link
G MYL2 myosin light chain 2 decreases expression EXP Etoposide results in decreased expression of MYL2 mRNA CTD PMID:29397400 NCBI chr12:110,910,845...110,920,579
Ensembl chr12:110,910,819...110,921,443
JBrowse link
G MYL3 myosin light chain 3 decreases expression EXP Etoposide results in decreased expression of MYL3 mRNA CTD PMID:29397400 NCBI chr 3:46,857,872...46,863,444
Ensembl chr 3:46,835,111...46,882,172
JBrowse link
G MYOM2 myomesin 2 decreases expression EXP Etoposide results in decreased expression of MYOM2 mRNA CTD PMID:29397400 NCBI chr 8:2,045,046...2,145,456
Ensembl chr 8:2,045,046...2,165,552
JBrowse link
G MYOT myotilin increases expression EXP Etoposide results in increased expression of MYOT mRNA CTD PMID:29397400 NCBI chr 5:137,867,282...137,887,851
Ensembl chr 5:137,867,858...137,887,851
Ensembl chr 5:137,867,858...137,887,851
JBrowse link
G MYT1 myelin transcription factor 1 decreases expression EXP Etoposide results in decreased expression of MYT1 mRNA CTD PMID:16120219 NCBI chr20:64,164,452...64,242,253
Ensembl chr20:64,102,394...64,242,253
JBrowse link
G NABP2 nucleic acid binding protein 2 multiple interactions
increases acetylation
EXP C646 compound inhibits the reaction [Etoposide results in increased acetylation of NABP2 protein] CTD PMID:26170237 NCBI chr12:56,222,012...56,229,858
Ensembl chr12:56,222,015...56,229,854
JBrowse link
G NAP1L1 nucleosome assembly protein 1 like 1 affects response to substance EXP NAP1L1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr12:76,036,585...76,084,687
Ensembl chr12:76,036,585...76,084,735
Ensembl chr12:76,036,585...76,084,735
JBrowse link
G NCK2 NCK adaptor protein 2 decreases expression EXP Etoposide results in decreased expression of NCK2 mRNA CTD PMID:17374387 NCBI chr 2:105,744,649...105,894,274
Ensembl chr 2:105,744,912...105,894,274
JBrowse link
G NECTIN2 nectin cell adhesion molecule 2 decreases expression ISO Etoposide results in decreased expression of NECTIN2 mRNA CTD PMID:25270620 NCBI chr19:44,846,297...44,889,223
Ensembl chr19:44,846,175...44,889,223
JBrowse link
G NEDD9 neural precursor cell expressed, developmentally down-regulated 9 affects response to substance EXP NEDD9 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 6:11,183,298...11,382,348
Ensembl chr 6:11,183,298...11,382,348
JBrowse link
G NEK2 NIMA related kinase 2 decreases expression EXP Etoposide results in decreased expression of NEK2 mRNA CTD PMID:16120219 NCBI chr 1:211,658,256...211,675,625
Ensembl chr 1:211,658,657...211,675,630
JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 decreases response to substance
multiple interactions
EXP NFE2L2 mRNA results in decreased susceptibility to Etoposide
NFE2L2 protein affects the reaction [Etoposide results in increased expression of SRXN1 protein]; NFE2L2 protein affects the reaction [Etoposide results in increased expression of TP53 protein]
CTD PMID:26708503 PMID:27982581 NCBI chr 2:177,230,303...177,265,131
Ensembl chr 2:177,227,595...177,392,697
JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions
increases degradation
EXP wortmannin inhibits the reaction [Etoposide results in increased degradation of NFKBIA protein] CTD PMID:12637521 PMID:17935137 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,511...35,404,749
Ensembl chr14:35,401,511...35,404,749
JBrowse link
G NIBAN1 niban apoptosis regulator 1 affects response to substance EXP NIBAN1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 1:184,791,032...184,974,508
Ensembl chr 1:184,790,724...184,974,508
JBrowse link
G NIT2 nitrilase family member 2 multiple interactions ISO [Etoposide co-treated with Cisplatin co-treated with Bleomycin] results in decreased expression of NIT2 protein CTD PMID:29733421 NCBI chr 3:100,334,757...100,361,635
Ensembl chr 3:100,334,739...100,361,635
JBrowse link
G NMT2 N-myristoyltransferase 2 affects response to substance EXP NMT2 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr10:15,104,588...15,168,693
Ensembl chr10:15,102,584...15,168,693
JBrowse link
G NOS2 nitric oxide synthase 2 increases expression ISO
EXP
Etoposide results in increased expression of NOS2 mRNA
Etoposide results in increased expression of NOS2 protein
CTD PMID:15135310 PMID:26259609 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G NPAS1 neuronal PAS domain protein 1 increases expression EXP Etoposide results in increased expression of NPAS1 mRNA CTD PMID:21527772 NCBI chr19:47,019,837...47,045,775
Ensembl chr19:47,019,837...47,045,775
JBrowse link
G NPNT nephronectin increases expression ISO Etoposide results in increased expression of NPNT mRNA CTD PMID:25270620 NCBI chr 4:105,895,453...105,971,671
Ensembl chr 4:105,894,775...106,004,027
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 affects response to substance
increases expression
multiple interactions
EXP
ISO
NQO1 protein affects the susceptibility to Etoposide
Etoposide results in increased expression of NQO1 mRNA
HIPK2 protein promotes the reaction [Etoposide results in increased expression of NQO1 mRNA]
CTD PMID:16217747 PMID:20980392 PMID:29397400 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668
JBrowse link
G NR0B1 nuclear receptor subfamily 0 group B member 1 decreases expression ISO Etoposide results in decreased expression of NR0B1 mRNA CTD PMID:25270620 NCBI chr  X:30,304,206...30,309,390
Ensembl chr  X:30,304,206...30,309,390
JBrowse link
G NR1H2 nuclear receptor subfamily 1 group H member 2 affects localization
affects response to substance
multiple interactions
EXP Etoposide affects the localization of NR1H2 protein
NR1H2 protein affects the susceptibility to Etoposide
Etoposide promotes the reaction [NR1H2 protein results in increased expression of CETP mRNA]; NR1H2 mutant form inhibits the reaction [Etoposide results in increased expression of CETP mRNA]
CTD PMID:25914138 NCBI chr19:50,376,457...50,383,388
Ensembl chr19:50,329,653...50,383,388
JBrowse link
G NR1H3 nuclear receptor subfamily 1 group H member 3 multiple interactions
affects response to substance
increases expression
EXP Etoposide promotes the reaction [NR1H3 protein results in increased expression of CETP mRNA]; Etoposide results in increased expression of and affects the localization of NR1H3 protein; NR1H3 mutant form inhibits the reaction [Etoposide results in increased expression of CETP mRNA]
NR1H3 protein affects the susceptibility to Etoposide
Etoposide results in increased expression of NR1H3 mRNA
CTD PMID:25914138 NCBI chr11:47,248,300...47,269,033
Ensembl chr11:47,248,300...47,269,033
JBrowse link
G NR1I2 nuclear receptor subfamily 1 group I member 2 affects response to substance
multiple interactions
increases activity
EXP NR1I2 protein affects the susceptibility to Etoposide
[Etoposide results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA
CTD PMID:17279585 PMID:25455453 NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,485
JBrowse link
G NR1I3 nuclear receptor subfamily 1 group I member 3 multiple interactions EXP Etoposide inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased activity of NR1I3 protein] CTD PMID:30818834 NCBI chr 1:161,229,666...161,238,623
Ensembl chr 1:161,229,666...161,238,302
Ensembl chr 1:161,229,666...161,238,302
JBrowse link
G NRAP nebulin related anchoring protein decreases expression EXP Etoposide results in decreased expression of NRAP mRNA CTD PMID:29397400 NCBI chr10:113,588,714...113,664,046
Ensembl chr10:113,588,716...113,664,127
Ensembl chr10:113,588,716...113,664,127
JBrowse link
G NRG1 neuregulin 1 increases expression EXP Etoposide results in increased expression of NRG1 mRNA CTD PMID:29397400 NCBI chr 8:31,639,245...32,774,046
Ensembl chr 8:31,639,222...32,855,666
JBrowse link
G NRIP1 nuclear receptor interacting protein 1 affects response to substance
decreases expression
EXP NRIP1 protein affects the susceptibility to Etoposide
Etoposide results in decreased expression of NRIP1 mRNA; Etoposide results in decreased expression of NRIP1 protein
CTD PMID:16217747 PMID:25914138 NCBI chr21:14,961,235...15,065,903
Ensembl chr21:14,961,235...15,065,936
JBrowse link
G NUPR1 nuclear protein 1, transcriptional regulator affects response to substance
decreases expression
EXP
ISO
NUPR1 protein affects the susceptibility to Etoposide
Etoposide results in decreased expression of NUPR1 mRNA
CTD PMID:16217747 PMID:25270620 NCBI chr16:28,532,708...28,538,974
Ensembl chr16:28,532,708...28,539,174
Ensembl chr16:28,532,708...28,539,174
JBrowse link
G OAT ornithine aminotransferase multiple interactions ISO [Etoposide co-treated with Cisplatin co-treated with Bleomycin] results in decreased expression of OAT protein CTD PMID:29733421 NCBI chr10:124,397,303...124,418,923
Ensembl chr10:124,397,303...124,418,976
JBrowse link
G OCA2 OCA2 melanosomal transmembrane protein affects response to substance EXP OCA2 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr15:27,719,008...28,099,342
Ensembl chr15:27,754,875...28,099,315
JBrowse link
G OGG1 8-oxoguanine DNA glycosylase decreases expression
multiple interactions
ISO Etoposide results in decreased expression of OGG1 mRNA
wogonin inhibits the reaction [Etoposide results in decreased expression of OGG1 mRNA]
CTD PMID:23872129 NCBI chr 3:9,749,952...9,788,246
Ensembl chr 3:9,749,944...9,788,219
JBrowse link
G P2RX7 purinergic receptor P2X 7 increases expression ISO Etoposide results in increased expression of P2RX7 mRNA CTD PMID:25270620 NCBI chr12:121,132,819...121,188,032
Ensembl chr12:121,132,819...121,188,032
JBrowse link
G PABPC1 poly(A) binding protein cytoplasmic 1 decreases expression ISO Etoposide results in decreased expression of PABPC1 protein CTD PMID:29733421 NCBI chr 8:100,702,916...100,722,088
Ensembl chr 8:100,685,816...100,722,809
JBrowse link
G PALB2 partner and localizer of BRCA2 decreases expression EXP Etoposide results in decreased expression of PALB2 mRNA CTD PMID:24211769 NCBI chr16:23,603,162...23,641,337
Ensembl chr16:23,603,160...23,641,310
JBrowse link
G PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 increases expression ISO Etoposide results in increased expression of PAPSS2 mRNA CTD PMID:25270620 NCBI chr10:87,659,878...87,747,705
Ensembl chr10:87,659,613...87,747,705
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 increases cleavage
multiple interactions
increases degradation
ISO
EXP
Etoposide results in increased cleavage of PARP1 protein
3',4'-dihydroxyflavone analog inhibits the reaction [Etoposide results in increased cleavage of PARP1 protein]; [CASP8 co-treated with TP53] affects the reaction [Etoposide results in increased cleavage of PARP1 protein]; [Colforsin co-treated with Theophylline] inhibits the reaction [Etoposide results in increased cleavage of PARP1 protein]; BCL2 protein inhibits the reaction [Etoposide results in increased degradation of PARP1 protein]; BCL2L1 protein inhibits the reaction [Etoposide results in increased degradation of PARP1 protein]; benzyloxycarbonyl-valyl-alanyl-aspartyl-fluoromethane inhibits the reaction [Etoposide results in increased cleavage of PARP1 protein]; CD40LG protein inhibits the reaction [Etoposide promotes the reaction [CASP3 protein results in increased cleavage of PARP1 protein]]; Etoposide promotes the reaction [CASP3 protein results in increased cleavage of PARP1 protein]; HTATIP2 protein promotes the reaction [Etoposide results in increased activity of PARP1 protein]; Nicotine inhibits the reaction [Etoposide results in increased cleavage of PARP1 protein]; PTEN protein modified form promotes the reaction [Etoposide results in increased cleavage of PARP1 protein]; PTEN protein promotes the reaction [Etoposide results in increased cleavage of PARP1 protein]; Wortmannin promotes the reaction [Etoposide results in increased cleavage of PARP1 protein]
Niacin deficiency affects the reaction [Etoposide results in increased cleavage of PARP1 protein]
CTD PMID:8840993 PMID:9454737 PMID:12690110 PMID:16014620 PMID:16545138 PMID:16799960 PMID:16807353 PMID:16844113 PMID:17516866 PMID:17935137 PMID:20457658 PMID:21801448 PMID:25447644 PMID:26259609 PMID:30890322 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093
JBrowse link
G PBK PDZ binding kinase affects response to substance EXP PBK protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 8:27,809,624...27,837,817
Ensembl chr 8:27,809,624...27,838,082
JBrowse link
G PCBP2 poly(rC) binding protein 2 multiple interactions ISO [Etoposide co-treated with Cisplatin co-treated with Bleomycin] results in decreased expression of PCBP2 protein CTD PMID:29733421 NCBI chr12:53,452,102...53,481,162
Ensembl chr12:53,452,102...53,481,162
JBrowse link
G PCBP4 poly(rC) binding protein 4 decreases expression ISO Etoposide results in decreased expression of PCBP4 mRNA CTD PMID:25270620 NCBI chr 3:51,957,454...51,967,466
Ensembl chr 3:51,957,454...51,974,016
JBrowse link
G PCK2 phosphoenolpyruvate carboxykinase 2, mitochondrial decreases expression ISO Etoposide results in decreased expression of PCK2 mRNA CTD PMID:25270620 NCBI chr14:24,094,311...24,104,125
Ensembl chr14:24,094,053...24,110,598
JBrowse link
G PDE2A phosphodiesterase 2A decreases expression ISO Etoposide results in decreased expression of PDE2A mRNA CTD PMID:25270620 NCBI chr11:72,576,141...72,674,422
Ensembl chr11:72,576,141...72,674,591
JBrowse link
G PDE4B phosphodiesterase 4B affects response to substance EXP PDE4B protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 1:65,792,510...66,374,579
Ensembl chr 1:65,792,514...66,374,579
JBrowse link
G PDGFC platelet derived growth factor C affects response to substance EXP PDGFC protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 4:156,760,454...156,971,799
Ensembl chr 4:156,760,454...156,971,799
JBrowse link
G PDIA3 protein disulfide isomerase family A member 3 multiple interactions ISO [Bleomycin co-treated with Cisplatin co-treated with Etoposide] results in increased expression of PDIA3 protein CTD PMID:24478030 NCBI chr15:43,746,438...43,773,278
Ensembl chr15:43,746,410...43,773,278
JBrowse link
G PDK1 pyruvate dehydrogenase kinase 1 decreases expression EXP Etoposide results in decreased expression of PDK1 mRNA CTD PMID:29397400 NCBI chr 2:172,555,373...172,672,698
Ensembl chr 2:172,555,373...172,608,669
JBrowse link
G PDK4 pyruvate dehydrogenase kinase 4 increases expression EXP Etoposide results in increased expression of PDK4 mRNA CTD PMID:29397400 NCBI chr 7:95,583,499...95,596,516
Ensembl chr 7:95,583,499...95,596,516
JBrowse link
G PDLIM3 PDZ and LIM domain 3 increases expression EXP Etoposide results in increased expression of PDLIM3 mRNA CTD PMID:29397400 NCBI chr 4:185,500,660...185,535,507
Ensembl chr 4:185,500,660...185,535,612
Ensembl chr 4:185,500,660...185,535,612
JBrowse link
G PELO pelota mRNA surveillance and ribosome rescue factor decreases expression EXP Etoposide results in decreased expression of PELO mRNA CTD PMID:24211769 NCBI chr 5:52,787,916...52,804,044
Ensembl chr 5:52,787,916...52,804,044
JBrowse link
G PERP p53 apoptosis effector related to PMP22 increases expression ISO Etoposide results in increased expression of PERP mRNA CTD PMID:21382384 PMID:25270620 NCBI chr 6:138,088,505...138,107,419
Ensembl chr 6:138,088,505...138,107,419
JBrowse link
G PHGDH phosphoglycerate dehydrogenase affects response to substance EXP PHGDH protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 1:119,711,934...119,744,218
Ensembl chr 1:119,648,411...119,744,218
Ensembl chr 1:119,648,411...119,744,218
JBrowse link
G PHLDA3 pleckstrin homology like domain family A member 3 increases expression ISO Etoposide results in increased expression of PHLDA3 mRNA CTD PMID:25270620 NCBI chr 1:201,464,278...201,469,188
Ensembl chr 1:201,464,278...201,469,237
JBrowse link
G PIGA phosphatidylinositol glycan anchor biosynthesis class A multiple interactions EXP [Cisplatin co-treated with Etoposide] results in increased mutagenesis of PIGA CTD PMID:21826740 NCBI chr  X:15,319,451...15,335,554
Ensembl chr  X:15,319,452...15,335,554
Ensembl chr  X:15,319,452...15,335,554
JBrowse link
G PIP5K1B phosphatidylinositol-4-phosphate 5-kinase type 1 beta affects response to substance EXP PIP5K1B protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 9:68,705,240...69,009,176
Ensembl chr 9:68,705,240...69,009,176
JBrowse link
G PLAU plasminogen activator, urokinase increases expression EXP Etoposide results in increased expression of PLAU mRNA CTD PMID:21527772 NCBI chr10:73,909,182...73,917,497
Ensembl chr10:73,909,177...73,917,496
JBrowse link
G PLK1 polo like kinase 1 decreases expression ISO Etoposide results in decreased expression of PLK1 mRNA CTD PMID:25270620 NCBI chr16:23,678,889...23,690,367
Ensembl chr16:23,677,656...23,690,367
JBrowse link
G PLK2 polo like kinase 2 increases expression EXP Etoposide results in increased expression of PLK2 mRNA CTD PMID:21527772 NCBI chr 5:58,453,982...58,460,086
Ensembl chr 5:58,453,982...58,460,139
JBrowse link
G PLK3 polo like kinase 3 increases expression EXP Etoposide results in increased expression of PLK3 mRNA CTD PMID:17374387 NCBI chr 1:44,799,952...44,805,995
Ensembl chr 1:44,800,377...44,805,990
JBrowse link
G PLP1 proteolipid protein 1 affects response to substance EXP PLP1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr  X:103,776,506...103,792,619
Ensembl chr  X:103,773,718...103,792,619
JBrowse link
G PLPP2 phospholipid phosphatase 2 decreases expression ISO Etoposide results in decreased expression of PLPP2 mRNA CTD PMID:25270620 NCBI chr19:281,043...291,413
Ensembl chr19:281,040...291,403
JBrowse link
G PM20D1 peptidase M20 domain containing 1 increases expression ISO Etoposide results in increased expression of PM20D1 mRNA CTD PMID:25270620 NCBI chr 1:205,828,025...205,850,132
Ensembl chr 1:205,828,025...205,850,132
JBrowse link
G PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression EXP Etoposide results in increased expression of PMAIP1 mRNA CTD PMID:21801448 NCBI chr18:59,899,996...59,904,305
Ensembl chr18:59,899,948...59,904,306
Ensembl chr18:59,899,948...59,904,306
JBrowse link
G PMEL premelanosome protein affects response to substance EXP PMEL protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr12:55,954,105...55,966,709
Ensembl chr12:55,954,105...55,973,317
JBrowse link
G PMP2 peripheral myelin protein 2 affects response to substance EXP PMP2 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 8:81,440,326...81,447,439
Ensembl chr 8:81,440,326...81,447,439
JBrowse link
G PMP22 peripheral myelin protein 22 affects response to substance EXP PMP22 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr17:15,229,779...15,265,326
Ensembl chr17:15,229,773...15,272,292
Ensembl chr17:15,229,773...15,272,292
JBrowse link
G POLQ DNA polymerase theta decreases response to substance ISO POLQ results in decreased susceptibility to Etoposide CTD PMID:21883722 NCBI chr 3:121,431,431...121,545,988
Ensembl chr 3:121,431,427...121,546,641
JBrowse link
G POLR1H RNA polymerase I subunit H decreases response to substance
multiple interactions
EXP POLR1H protein results in decreased susceptibility to Etoposide
Verapamil inhibits the reaction [POLR1H protein results in decreased susceptibility to Etoposide]
CTD PMID:14726695 NCBI chr 6:30,061,265...30,064,907
Ensembl chr 6:30,058,899...30,064,909
JBrowse link
G POMZP3 POM121 and ZP3 fusion affects response to substance EXP POMZP3 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 7:76,609,986...76,627,279
Ensembl chr 7:76,609,986...76,627,261
JBrowse link
G POSTN periostin increases expression EXP Etoposide results in increased expression of POSTN mRNA CTD PMID:29397400 NCBI chr13:37,562,585...37,598,839
Ensembl chr13:37,562,583...37,598,844
JBrowse link
G PPARGC1A PPARG coactivator 1 alpha increases expression
multiple interactions
EXP Etoposide results in increased expression of PPARGC1A mRNA
Etoposide promotes the reaction [PPARGC1A protein results in increased activity of ESRRA protein]
CTD PMID:26259609 PMID:30818834 NCBI chr 4:23,792,021...24,472,905
Ensembl chr 4:23,755,041...23,904,089
JBrowse link
G PPARGC1B PPARG coactivator 1 beta increases expression EXP Etoposide results in increased expression of PPARGC1B mRNA CTD PMID:26259609 NCBI chr 5:149,730,302...149,857,861
Ensembl chr 5:149,730,298...149,855,022
JBrowse link
G PPM1D protein phosphatase, Mg2+/Mn2+ dependent 1D increases expression EXP Etoposide results in increased expression of PPM1D protein CTD PMID:25078064 NCBI chr17:60,600,187...60,666,280
Ensembl chr17:60,600,183...60,666,280
JBrowse link
G PPP1R13L protein phosphatase 1 regulatory subunit 13 like decreases response to substance
multiple interactions
increases expression
EXP PPP1R13L results in decreased susceptibility to Etoposide
Etoposide results in increased expression of and results in increased localization of PPP1R13L protein
Etoposide results in increased expression of PPP1R13L mRNA
CTD PMID:17570360 PMID:19299014 NCBI chr19:45,379,634...45,406,361
Ensembl chr19:45,379,638...45,406,349
JBrowse link
G PRC1 protein regulator of cytokinesis 1 decreases expression EXP Etoposide results in decreased expression of PRC1 mRNA CTD PMID:17374387 NCBI chr15:90,966,038...90,994,576
Ensembl chr15:90,966,040...90,995,629
JBrowse link
G PRDX1 peroxiredoxin 1 decreases expression ISO Etoposide results in decreased expression of PRDX1 protein CTD PMID:29733421 NCBI chr 1:45,511,051...45,522,890
Ensembl chr 1:45,511,036...45,523,047
Ensembl chr 1:45,511,036...45,523,047
JBrowse link
G PRKAB1 protein kinase AMP-activated non-catalytic subunit beta 1 increases expression EXP Etoposide results in increased expression of PRKAB1 mRNA CTD PMID:24211769 NCBI chr12:119,667,864...119,681,624
Ensembl chr12:119,667,864...119,681,624
JBrowse link
G PRKCD protein kinase C delta multiple interactions EXP Etoposide results in increased cleavage of and results in increased activity of PRKCD protein CTD PMID:19662097 NCBI chr 3:53,161,209...53,192,717
Ensembl chr 3:53,156,009...53,192,717
JBrowse link
G PRKCZ protein kinase C zeta increases response to substance EXP PRKCZ protein results in increased susceptibility to Etoposide CTD PMID:21863889 NCBI chr 1:2,050,411...2,185,395
Ensembl chr 1:2,050,411...2,185,395
JBrowse link
G PRKDC protein kinase, DNA-activated, catalytic subunit increases phosphorylation
multiple interactions
EXP Etoposide results in increased phosphorylation of PRKDC protein
PRKDC protein promotes the reaction [Etoposide results in increased phosphorylation of SP1 protein]
CTD PMID:17441964 NCBI chr 8:47,773,111...47,960,136
Ensembl chr 8:47,773,111...47,960,178
Ensembl chr 8:47,773,111...47,960,178
JBrowse link
G PRKX protein kinase X-linked increases expression EXP Etoposide results in increased expression of PRKX mRNA CTD PMID:29397400 NCBI chr  X:3,604,340...3,713,649
Ensembl chr  X:3,604,340...3,713,649
JBrowse link
G PRNP prion protein decreases response to substance EXP PRNP protein results in decreased susceptibility to Etoposide CTD PMID:15386405 NCBI chr20:4,686,456...4,701,588
Ensembl chr20:4,686,350...4,701,590
JBrowse link
G PROCR protein C receptor increases expression EXP Etoposide results in increased expression of PROCR mRNA CTD PMID:21527772 NCBI chr20:35,172,072...35,215,989
Ensembl chr20:35,172,072...35,216,240
JBrowse link
G PSMD13 proteasome 26S subunit, non-ATPase 13 multiple interactions ISO [Etoposide co-treated with Cisplatin co-treated with Bleomycin] results in decreased expression of PSMD13 protein CTD PMID:29733421 NCBI chr11:236,972...252,984
Ensembl chr11:236,966...252,984
JBrowse link
G PTEN phosphatase and tensin homolog multiple interactions
increases response to substance
EXP PTEN protein inhibits the reaction [Etoposide results in increased phosphorylation of and results in increased activity of AKT1 protein]; PTEN protein modified form promotes the reaction [Etoposide results in increased cleavage of PARP1 protein]; PTEN protein promotes the reaction [Etoposide results in increased cleavage of PARP1 protein]; wortmannin inhibits the reaction [PTEN protein results in increased susceptibility to Etoposide] CTD PMID:16807353 PMID:17935137 NCBI chr10:87,863,625...87,971,930
Ensembl chr10:87,863,625...87,971,930
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
EXP Etoposide results in increased expression of PTGS2 protein
PTGS2 mutant form inhibits the reaction [VEGFC protein results in decreased susceptibility to Etoposide]
CTD PMID:24184161 PMID:26259609 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
JBrowse link
G PUS3 pseudouridine synthase 3 decreases expression EXP Etoposide results in decreased expression of PUS3 mRNA CTD PMID:24211769 NCBI chr11:125,893,485...125,903,219
Ensembl chr11:125,893,485...125,903,221
JBrowse link
G PYGM glycogen phosphorylase, muscle associated decreases expression EXP Etoposide results in decreased expression of PYGM mRNA CTD PMID:29397400 NCBI chr11:64,746,389...64,760,715
Ensembl chr11:64,746,389...64,759,974
JBrowse link
G RAB17 RAB17, member RAS oncogene family affects response to substance EXP RAB17 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 2:237,574,322...237,591,121
Ensembl chr 2:237,574,322...237,601,614
JBrowse link
G RAB20 RAB20, member RAS oncogene family affects response to substance EXP RAB20 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr13:110,523,066...110,561,722
Ensembl chr13:110,523,066...110,561,722
JBrowse link
G RAD51 RAD51 recombinase affects localization ISO Etoposide affects the localization of RAD51 protein CTD PMID:9885240 NCBI chr15:40,694,774...40,732,340
Ensembl chr15:40,694,774...40,732,340
JBrowse link
G RAD52 RAD52 homolog, DNA repair protein multiple interactions
increases expression
EXP BRCA1 protein mutant form inhibits the reaction [Etoposide results in increased expression of RAD52 protein]
Etoposide results in increased expression of RAD52 mRNA; Etoposide results in increased expression of RAD52 protein
CTD PMID:16417649 PMID:19799994 NCBI chr12:911,028...991,195
Ensembl chr12:911,736...990,053
JBrowse link
G RAD54L RAD54 like increases expression
multiple interactions
EXP Etoposide results in increased expression of RAD54L protein
BRCA1 protein mutant form inhibits the reaction [Etoposide results in increased expression of RAD54L protein]
CTD PMID:16417649 NCBI chr 1:46,247,688...46,278,477
Ensembl chr 1:46,246,461...46,278,480
JBrowse link
G RASIP1 Ras interacting protein 1 affects response to substance EXP RASIP1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr19:48,720,585...48,740,610
Ensembl chr19:48,720,585...48,740,610
JBrowse link
G RASSF1 Ras association domain family member 1 multiple interactions
increases response to substance
EXP [RASSF1 co-treated with Etoposide] affects the folding of and results in increased activity of BAX protein; [RASSF1 co-treated with Etoposide] results in increased cleavage of CASP3 protein; [RASSF1 co-treated with Etoposide] results in increased expression of CDKN1A protein; ABT-737 promotes the reaction [RASSF1 results in increased susceptibility to Etoposide] CTD PMID:21880625 NCBI chr 3:50,329,786...50,340,836
Ensembl chr 3:50,329,782...50,340,980
JBrowse link
G RB1 RB transcriptional corepressor 1 affects response to substance
decreases phosphorylation
multiple interactions
EXP RB1 protein affects the susceptibility to Etoposide
Etoposide results in decreased phosphorylation of RB1 protein
[Colforsin co-treated with Theophylline] inhibits the reaction [Etoposide results in decreased phosphorylation of RB1 protein]
CTD PMID:9454737 PMID:17640669 NCBI chr13:48,303,751...48,481,890
Ensembl chr13:48,303,744...48,599,436
Ensembl chr13:48,303,744...48,599,436
JBrowse link
G RBM17 RNA binding motif protein 17 decreases response to substance EXP RBM17 protein results in decreased susceptibility to Etoposide CTD PMID:16061639 NCBI chr10:6,089,034...6,117,447
Ensembl chr10:6,089,034...6,117,457
JBrowse link
G RBM34 RNA binding motif protein 34 decreases expression EXP Etoposide results in decreased expression of RBM34 mRNA CTD PMID:24211769 NCBI chr 1:235,131,183...235,161,280
Ensembl chr 1:235,131,183...235,161,283
JBrowse link
G RCAN1 regulator of calcineurin 1 affects response to substance EXP RCAN1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr21:34,516,442...34,615,123
Ensembl chr21:34,513,142...34,615,113
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions EXP [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of ABCB1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of BCL2L1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in decreased susceptibility to Etoposide; resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in decreased susceptibility to Etoposide] CTD PMID:19047049 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,597...65,663,090
JBrowse link
G RETSAT retinol saturase increases expression EXP Etoposide results in increased expression of RETSAT mRNA CTD PMID:21527772 NCBI chr 2:85,341,955...85,354,528
Ensembl chr 2:85,341,955...85,354,531
JBrowse link
G RFC1 replication factor C subunit 1 decreases expression EXP Etoposide results in decreased expression of RFC1 mRNA CTD PMID:24211769 NCBI chr 4:39,287,456...39,366,381
Ensembl chr 4:39,287,456...39,366,375
JBrowse link
G RGCC regulator of cell cycle increases expression EXP Etoposide results in increased expression of RGCC mRNA CTD PMID:29397400 NCBI chr13:41,457,411...41,470,876
Ensembl chr13:41,457,550...41,470,871
JBrowse link
G RIPK2 receptor interacting serine/threonine kinase 2 multiple interactions
increases expression
EXP Estradiol inhibits the reaction [Etoposide results in increased expression of RIPK2 mRNA] CTD PMID:19426747 NCBI chr 8:89,757,816...89,791,064
Ensembl chr 8:89,757,806...89,791,064
JBrowse link
G RIPPLY3 ripply transcriptional repressor 3 increases expression EXP Etoposide results in increased expression of RIPPLY3 mRNA CTD PMID:21527772 NCBI chr21:37,006,150...37,019,662
Ensembl chr21:37,006,150...37,019,662
JBrowse link
G RNF113A ring finger protein 113A decreases expression EXP Etoposide results in decreased expression of RNF113A mRNA CTD PMID:24211769 NCBI chr  X:119,870,475...119,871,733
Ensembl chr  X:119,870,475...119,871,733
JBrowse link
G ROBO1 roundabout guidance receptor 1 affects response to substance EXP ROBO1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 3:78,597,239...79,767,998
Ensembl chr 3:78,597,239...79,767,998
JBrowse link
G ROBO3 roundabout guidance receptor 3 increases expression EXP Etoposide results in increased expression of ROBO3 mRNA CTD PMID:21527772 NCBI chr11:124,865,432...124,881,471
Ensembl chr11:124,865,432...124,881,471
JBrowse link
G ROPN1 rhophilin associated tail protein 1 affects response to substance EXP ROPN1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 3:123,968,521...123,992,170
Ensembl chr 3:123,968,521...123,992,178
JBrowse link
G RPL6 ribosomal protein L6 decreases response to substance EXP RPL6 protein results in decreased susceptibility to Etoposide CTD PMID:15846068 NCBI chr12:112,405,181...112,418,850
Ensembl chr12:112,405,190...112,418,838
JBrowse link
G RPS27L ribosomal protein S27 like increases expression EXP Etoposide results in increased expression of RPS27L protein CTD PMID:18056458 NCBI chr15:63,148,249...63,157,477
Ensembl chr15:63,125,872...63,158,021
JBrowse link
G RRAS RAS related increases expression EXP Etoposide results in increased expression of RRAS mRNA CTD PMID:21527772 NCBI chr19:49,635,292...49,640,143
Ensembl chr19:49,635,292...49,640,143
JBrowse link
G RRM2B ribonucleotide reductase regulatory TP53 inducible subunit M2B increases expression EXP Etoposide results in increased expression of RRM2B mRNA CTD PMID:21704725 NCBI chr 8:102,204,501...102,238,961
Ensembl chr 8:102,204,502...102,238,961
Ensembl chr 8:102,204,502...102,238,961
JBrowse link
G RTKN rhotekin increases expression ISO Etoposide results in increased expression of RTKN mRNA CTD PMID:25270620 NCBI chr 2:74,425,835...74,441,937
Ensembl chr 2:74,425,835...74,442,422
JBrowse link
G RUNX1 RUNX family transcription factor 1 increases response to substance
increases mutagenesis
EXP RUNX1 gene mutant form results in increased susceptibility to Etoposide
Etoposide results in increased mutagenesis of RUNX1 gene
CTD PMID:15217836 PMID:28624474 NCBI chr21:34,787,801...35,049,334
Ensembl chr21:34,787,801...36,004,667
JBrowse link
G RUNX3 RUNX family transcription factor 3 increases response to substance EXP RUNX3 protein results in increased susceptibility to Etoposide CTD PMID:15756676 NCBI chr 1:24,899,511...24,965,158
Ensembl chr 1:24,899,511...24,965,121
JBrowse link
G RXRA retinoid X receptor alpha multiple interactions EXP Etoposide promotes the reaction [RXRA protein results in increased expression of CETP mRNA]; Tretinoin promotes the reaction [Etoposide promotes the reaction [RXRA protein results in increased expression of CETP mRNA]] CTD PMID:25914138 NCBI chr 9:134,326,455...134,440,585
Ensembl chr 9:134,317,098...134,440,585
JBrowse link
G RYR2 ryanodine receptor 2 decreases expression EXP Etoposide results in decreased expression of RYR2 mRNA CTD PMID:29397400 NCBI chr 1:237,042,184...237,833,988
Ensembl chr 1:237,042,184...237,833,988
JBrowse link
G S100P S100 calcium binding protein P affects response to substance
increases response to substance
EXP S100P protein affects the susceptibility to Etoposide
S100P protein results in increased susceptibility to Etoposide
CTD PMID:16217747 PMID:18636193 NCBI chr 4:6,693,878...6,697,170
Ensembl chr 4:6,693,878...6,697,170
JBrowse link
G SCN3B sodium voltage-gated channel beta subunit 3 increases expression ISO Etoposide results in increased expression of SCN3B mRNA CTD PMID:25270620 NCBI chr11:123,629,187...123,654,624
Ensembl chr11:123,629,187...123,655,244
JBrowse link
G SCN4B sodium voltage-gated channel beta subunit 4 increases expression EXP Etoposide results in increased expression of SCN4B mRNA CTD PMID:29397400 NCBI chr11:118,133,377...118,152,823
Ensembl chr11:118,133,377...118,152,888
JBrowse link
G SDC1 syndecan 1 increases expression EXP Etoposide results in increased expression of SDC1 mRNA CTD PMID:17374387 NCBI chr 2:20,200,797...20,225,475
Ensembl chr 2:20,200,797...20,225,433
JBrowse link
G SDHAF1 succinate dehydrogenase complex assembly factor 1 decreases expression EXP Etoposide results in decreased expression of SDHAF1 mRNA CTD PMID:24211769 NCBI chr19:35,995,188...35,996,312
Ensembl chr19:35,995,188...35,996,312
Ensembl chr19:35,995,188...35,996,312
JBrowse link
G SERPINE2 serpin family E member 2 increases expression ISO Etoposide results in increased expression of SERPINE2 mRNA CTD PMID:25270620 NCBI chr 2:223,975,045...224,039,286
Ensembl chr 2:223,975,045...224,039,318
JBrowse link
G SESN1 sestrin 1 increases expression EXP Etoposide results in increased expression of SESN1 mRNA CTD PMID:24211769 NCBI chr 6:108,984,309...109,094,846
Ensembl chr 6:108,986,437...109,094,819
JBrowse link
G SFN stratifin increases expression EXP Etoposide results in increased expression of SFN mRNA CTD PMID:21527772 NCBI chr 1:26,863,149...26,864,456
Ensembl chr 1:26,863,149...26,864,456
JBrowse link
G SLBP stem-loop binding protein decreases expression EXP Etoposide results in decreased expression of SLBP mRNA CTD PMID:24211769 NCBI chr 4:1,692,731...1,715,876
Ensembl chr 4:1,692,731...1,712,344
JBrowse link
G SLC16A6 solute carrier family 16 member 6 affects response to substance EXP SLC16A6 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr17:68,267,026...68,291,439
Ensembl chr17:68,267,026...68,291,267
JBrowse link
G SLC1A5 solute carrier family 1 member 5 decreases expression EXP Etoposide results in decreased expression of SLC1A5 mRNA CTD PMID:24211769 NCBI chr19:46,774,883...46,788,594
Ensembl chr19:46,774,883...46,788,594
JBrowse link
G SLC22A18 solute carrier family 22 member 18 affects response to substance EXP SLC22A18 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr11:2,899,691...2,925,246
Ensembl chr11:2,899,721...2,925,246
JBrowse link
G SLC27A3 solute carrier family 27 member 3 affects response to substance EXP SLC27A3 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 1:153,775,407...153,780,157
Ensembl chr 1:153,774,354...153,780,157
JBrowse link
G SLC2A6 solute carrier family 2 member 6 increases expression EXP Etoposide results in increased expression of SLC2A6 mRNA CTD PMID:21527772 NCBI chr 9:133,471,094...133,479,127
Ensembl chr 9:133,471,094...133,479,127
JBrowse link
G SLC35F2 solute carrier family 35 member F2 decreases expression ISO Etoposide results in decreased expression of SLC35F2 mRNA CTD PMID:25270620 NCBI chr11:107,790,991...107,858,787
Ensembl chr11:107,790,991...107,928,293
JBrowse link
G SLC45A3 solute carrier family 45 member 3 multiple interactions EXP Etoposide inhibits the reaction [Dihydrotestosterone results in increased expression of SLC45A3 mRNA] CTD PMID:20601956 NCBI chr 1:205,657,851...205,680,509
Ensembl chr 1:205,657,851...205,680,509
JBrowse link
G SLC4A11 solute carrier family 4 member 11 increases expression ISO Etoposide results in increased expression of SLC4A11 mRNA CTD PMID:25270620 NCBI chr20:3,227,417...3,241,484
Ensembl chr20:3,227,417...3,239,559
JBrowse link
G SLC7A11 solute carrier family 7 member 11 affects response to substance EXP SLC7A11 protein affects the susceptibility to Etoposide CTD PMID:31226288 NCBI chr 4:138,164,097...138,242,349
Ensembl chr 4:138,164,097...138,242,349
JBrowse link
G SLC7A3 solute carrier family 7 member 3 decreases expression ISO Etoposide results in decreased expression of SLC7A3 mRNA CTD PMID:25270620 NCBI chr  X:70,925,579...70,931,096
Ensembl chr  X:70,925,579...70,931,125
JBrowse link
G SLC7A5 solute carrier family 7 member 5 affects response to substance EXP SLC7A5 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr16:87,830,022...87,869,507
Ensembl chr16:87,830,023...87,869,507
JBrowse link
G SLC8A1 solute carrier family 8 member A1 decreases expression EXP Etoposide results in decreased expression of SLC8A1 mRNA CTD PMID:29397400 NCBI chr 2:40,094,523...40,512,452
Ensembl chr 2:40,097,270...40,611,053
JBrowse link
G SLC9A3R1 SLC9A3 regulator 1 increases expression ISO Etoposide results in increased expression of SLC9A3R1 mRNA CTD PMID:25270620 NCBI chr17:74,748,628...74,769,353
Ensembl chr17:74,748,628...74,769,353
JBrowse link
G SLCO2B1 solute carrier organic anion transporter family member 2B1 multiple interactions EXP Etoposide inhibits the reaction [SLCO2B1 protein results in increased uptake of Cascade Blue] CTD PMID:30863990 NCBI chr11:75,151,107...75,206,549
Ensembl chr11:75,100,563...75,206,549
JBrowse link
G SMAD2 SMAD family member 2 multiple interactions
increases phosphorylation
EXP 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Etoposide results in increased phosphorylation of SMAD2 protein] CTD PMID:22363485 NCBI chr18:47,808,957...47,931,188
Ensembl chr18:47,808,957...47,931,146
JBrowse link
G SMPDL3A sphingomyelin phosphodiesterase acid like 3A affects response to substance EXP SMPDL3A protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 6:122,788,456...122,809,720
Ensembl chr 6:122,789,049...122,809,720
JBrowse link
G SOD2 superoxide dismutase 2 increases expression
decreases response to substance
EXP Etoposide results in increased expression of SOD2 protein
SOD2 protein results in decreased susceptibility to Etoposide
CTD PMID:10759716 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
Ensembl chr 6:159,669,069...159,762,529
Ensembl chr 6:159,669,069...159,762,529
JBrowse link
G SOHLH1 spermatogenesis and oogenesis specific basic helix-loop-helix 1 decreases expression ISO Etoposide results in decreased expression of SOHLH1 mRNA CTD PMID:29733421 NCBI chr 9:135,691,862...135,702,112
Ensembl chr 9:135,693,407...135,704,498
Ensembl chr 9:135,693,407...135,704,498
JBrowse link
G SORBS1 sorbin and SH3 domain containing 1 affects response to substance EXP SORBS1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr10:95,311,773...95,561,439
Ensembl chr10:95,311,771...95,561,414
JBrowse link
G SORBS2 sorbin and SH3 domain containing 2 affects response to substance EXP SORBS2 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 4:185,585,444...185,956,372
Ensembl chr 4:185,585,444...185,956,652
JBrowse link
G SORT1 sortilin 1 affects response to substance EXP SORT1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 1:109,309,575...109,397,940
Ensembl chr 1:109,309,568...109,397,918
JBrowse link
G SOX10 SRY-box transcription factor 10 affects response to substance EXP SOX10 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr22:37,972,312...37,984,555
Ensembl chr22:37,970,686...37,987,422
JBrowse link
G SP1 Sp1 transcription factor increases phosphorylation
increases expression
increases activity
multiple interactions
EXP
ISO
Etoposide results in increased phosphorylation of SP1 protein
Etoposide results in increased expression of SP1 mRNA
Etoposide results in increased activity of SP1 protein
cordycepin inhibits the reaction [Etoposide results in increased activity of SP1 protein]; cordycepin inhibits the reaction [Etoposide results in increased expression of SP1 mRNA]
PRKDC protein promotes the reaction [Etoposide results in increased phosphorylation of SP1 protein]; wortmannin inhibits the reaction [Etoposide results in increased phosphorylation of SP1 protein]
CTD PMID:17441964 PMID:23690541 NCBI chr12:53,380,176...53,416,446
Ensembl chr12:53,380,176...53,416,446
JBrowse link
G SPATA18 spermatogenesis associated 18 increases expression EXP Etoposide results in increased expression of SPATA18 mRNA CTD PMID:21527772 PMID:29397400 NCBI chr 4:52,051,304...52,097,299
Ensembl chr 4:52,051,304...52,097,299
JBrowse link
G SPP1 secreted phosphoprotein 1 affects response to substance
decreases expression
EXP
ISO
SPP1 protein affects the susceptibility to Etoposide
Etoposide results in decreased expression of SPP1 mRNA
CTD PMID:16217747 PMID:25270620 NCBI chr 4:87,975,714...87,983,411
Ensembl chr 4:87,975,650...87,983,426
JBrowse link
G SPTSSA serine palmitoyltransferase small subunit A affects response to substance EXP SPTSSA protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr14:34,432,788...34,462,240
Ensembl chr14:34,432,788...34,462,240
JBrowse link
G SRXN1 sulfiredoxin 1 increases expression
multiple interactions
ISO
EXP
Etoposide results in increased expression of SRXN1 mRNA; Etoposide results in increased expression of SRXN1 protein
NFE2L2 protein affects the reaction [Etoposide results in increased expression of SRXN1 protein]; TP53 protein affects the reaction [Etoposide results in increased expression of SRXN1 protein]
CTD PMID:22003191 PMID:27358234 PMID:27982581 NCBI chr20:646,615...653,200
Ensembl chr20:646,615...653,370
Ensembl chr20:646,615...653,370
JBrowse link
G ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 decreases response to substance ISO ST3GAL5 protein results in decreased susceptibility to Etoposide CTD PMID:16571667 NCBI chr 2:85,837,120...85,889,034
Ensembl chr 2:85,837,120...85,905,199
JBrowse link
G ST6GALNAC2 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 affects response to substance EXP ST6GALNAC2 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr17:76,565,377...76,586,128
Ensembl chr17:76,565,377...76,586,956
JBrowse link
G ST7 suppression of tumorigenicity 7 affects response to substance EXP ST7 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 7:116,953,501...117,230,176
Ensembl chr 7:116,953,238...117,230,103
Ensembl chr 7:116,953,238...117,230,103
JBrowse link
G STAT1 signal transducer and activator of transcription 1 multiple interactions EXP [STAT1 protein results in increased activity of CASP3 protein] which results in increased susceptibility to Etoposide; [STAT1 protein results in increased activity of CASP7 protein] which results in increased susceptibility to Etoposide CTD PMID:18649362 NCBI chr 2:190,968,989...191,014,197
Ensembl chr 2:190,908,460...191,020,960
Ensembl chr 2:190,908,460...191,020,960
JBrowse link
G STC1 stanniocalcin 1 increases expression EXP Etoposide results in increased expression of STC1 mRNA CTD PMID:29397400 NCBI chr 8:23,841,929...23,854,806
Ensembl chr 8:23,841,929...23,854,806
JBrowse link
G STIP1 stress induced phosphoprotein 1 increases expression ISO Etoposide results in increased expression of STIP1 protein CTD PMID:29733421 NCBI chr11:64,185,272...64,204,543
Ensembl chr11:64,185,272...64,204,543
JBrowse link
G STK17A serine/threonine kinase 17a increases expression ISO Etoposide results in increased expression of STK17A mRNA CTD PMID:21489989 NCBI chr 7:43,583,108...43,627,379
Ensembl chr 7:43,582,758...43,650,713
JBrowse link
G STMN1 stathmin 1 affects response to substance EXP STMN1 affects the susceptibility to Etoposide CTD PMID:17172428 NCBI chr 1:25,884,179...25,906,880
Ensembl chr 1:25,884,181...25,906,991
JBrowse link
G STMN2 stathmin 2 decreases expression ISO Etoposide results in decreased expression of STMN2 mRNA CTD PMID:25270620 NCBI chr 8:79,611,117...79,666,162
Ensembl chr 8:79,610,814...79,666,175
Ensembl chr 8:79,610,814...79,666,175
JBrowse link
G STOM stomatin increases expression EXP Etoposide results in increased expression of STOM mRNA CTD PMID:21527772 NCBI chr 9:121,338,987...121,370,250
Ensembl chr 9:121,338,987...121,370,304
JBrowse link
G SYTL1 synaptotagmin like 1 increases expression ISO Etoposide results in increased expression of SYTL1 mRNA CTD PMID:25270620 NCBI chr 1:27,342,022...27,353,932
Ensembl chr 1:27,342,020...27,353,937
JBrowse link
G TAP1 transporter 1, ATP binding cassette subfamily B member increases expression EXP Etoposide results in increased expression of TAP1 mRNA CTD PMID:17374387 PMID:21527772 NCBI chr 6:32,845,209...32,853,704
Ensembl chr 6:32,845,209...32,853,978
JBrowse link
G TAX1BP3 Tax1 binding protein 3 increases expression EXP Etoposide results in increased expression of TAX1BP3 mRNA CTD PMID:17374387 NCBI chr17:3,662,895...3,668,578
Ensembl chr17:3,662,895...3,668,679
JBrowse link
G TBC1D8 TBC1 domain family member 8 increases expression ISO Etoposide results in increased expression of TBC1D8 mRNA CTD PMID:25270620 NCBI chr 2:101,006,435...101,195,321
Ensembl chr 2:101,007,617...101,252,866
Ensembl chr 2:101,007,617...101,252,866
JBrowse link
G TBL1X transducin beta like 1 X-linked decreases expression ISO Etoposide results in decreased expression of TBL1X mRNA CTD PMID:25270620 NCBI chr  X:9,463,295...9,719,740
Ensembl chr  X:9,463,295...9,741,037
JBrowse link
G TBPL1 TATA-box binding protein like 1 affects localization ISO Etoposide affects the localization of TBPL1 protein CTD PMID:17085973 NCBI chr 6:133,952,174...133,990,432
Ensembl chr 6:133,952,170...133,990,432
JBrowse link
G TCAP titin-cap decreases expression EXP Etoposide results in decreased expression of TCAP mRNA CTD PMID:29397400 NCBI chr17:39,665,349...39,666,554
Ensembl chr17:39,665,349...39,666,554
Ensembl chr17:39,665,349...39,666,554
JBrowse link
G TCFL5 transcription factor like 5 affects response to substance EXP TCFL5 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr20:62,841,005...62,861,822
Ensembl chr20:62,841,005...62,861,822
JBrowse link
G TCP1 t-complex 1 multiple interactions ISO [Etoposide co-treated with Cisplatin co-treated with Bleomycin] results in decreased expression of TCP1 protein CTD PMID:29733421 NCBI chr 6:159,778,498...159,789,602
Ensembl chr 6:159,778,498...159,789,703
JBrowse link
G TDRD3 tudor domain containing 3 affects response to substance EXP TDRD3 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr13:60,396,457...60,573,879
Ensembl chr13:60,396,457...60,573,878
JBrowse link
G TENT5A terminal nucleotidyltransferase 5A affects response to substance EXP TENT5A protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 6:81,745,730...81,752,681
Ensembl chr 6:81,491,439...81,752,774
JBrowse link
G TEX264 testis expressed 264, ER-phagy receptor decreases expression ISO Etoposide results in decreased expression of TEX264 mRNA CTD PMID:25270620 NCBI chr 3:51,671,252...51,704,323
Ensembl chr 3:51,662,693...51,704,323
JBrowse link
G TFAM transcription factor A, mitochondrial increases expression EXP Etoposide results in increased expression of TFAM mRNA CTD PMID:26259609 NCBI chr10:58,385,409...58,399,220
Ensembl chr10:58,385,345...58,399,220
JBrowse link
G TFAP2A transcription factor AP-2 alpha affects response to substance
increases response to substance
EXP TFAP2A protein affects the susceptibility to Etoposide
TFAP2A protein results in increased susceptibility to Etoposide
CTD PMID:16204029 PMID:16217747 NCBI chr 6:10,396,677...10,419,897
Ensembl chr 6:10,393,186...10,419,659
JBrowse link
G TFEC transcription factor EC decreases expression EXP Etoposide results in decreased expression of TFEC mRNA CTD PMID:24211769 NCBI chr 7:115,935,152...116,159,891
Ensembl chr 7:115,935,148...116,159,896
JBrowse link
G TFF3 trefoil factor 3 affects response to substance EXP TFF3 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr21:42,311,667...42,315,409
Ensembl chr21:42,311,667...42,315,651
JBrowse link
G TFPI tissue factor pathway inhibitor affects response to substance EXP TFPI protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 2:187,464,230...187,554,501
Ensembl chr 2:187,464,230...187,565,760
JBrowse link
G TFPI2 tissue factor pathway inhibitor 2 affects response to substance EXP TFPI2 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 7:93,885,396...93,890,753
Ensembl chr 7:93,885,396...93,890,753
JBrowse link
G TGDS TDP-glucose 4,6-dehydratase affects response to substance EXP TGDS protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr13:94,574,054...94,596,274
Ensembl chr13:94,574,054...94,596,242
JBrowse link
G TGFA transforming growth factor alpha increases expression EXP Etoposide results in increased expression of TGFA mRNA CTD PMID:15228094 NCBI chr 2:70,447,284...70,553,826
Ensembl chr 2:70,447,284...70,554,193
JBrowse link
G TGIF2 TGFB induced factor homeobox 2 decreases expression ISO Etoposide results in decreased expression of TGIF2 mRNA CTD PMID:25270620 NCBI chr20:36,573,464...36,593,950
Ensembl chr20:36,573,488...36,593,950
JBrowse link
G THBS4 thrombospondin 4 increases expression EXP Etoposide results in increased expression of THBS4 mRNA CTD PMID:29397400 NCBI chr 5:79,991,332...80,083,753
Ensembl chr 5:79,991,311...80,083,287
JBrowse link
G TIPIN TIMELESS interacting protein decreases expression EXP Etoposide results in decreased expression of TIPIN mRNA CTD PMID:24211769 NCBI chr15:66,334,974...66,387,273
Ensembl chr15:66,336,191...66,386,746
JBrowse link
G TM7SF3 transmembrane 7 superfamily member 3 increases expression ISO Etoposide results in increased expression of TM7SF3 mRNA CTD PMID:25270620 NCBI chr12:26,966,524...27,014,427
Ensembl chr12:26,971,579...27,014,434
JBrowse link
G TMBIM4 transmembrane BAX inhibitor motif containing 4 increases expression ISO Etoposide results in increased expression of TMBIM4 mRNA CTD PMID:25270620 NCBI chr12:66,135,846...66,169,996
Ensembl chr12:66,135,846...66,170,072
JBrowse link
G TMC6 transmembrane channel like 6 affects response to substance EXP TMC6 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr17:78,107,397...78,132,427
Ensembl chr17:78,107,397...78,132,407
Ensembl chr17:78,107,397...78,132,407
Ensembl chr17:78,107,397...78,132,407
JBrowse link
G TMEM185B transmembrane protein 185B decreases expression EXP Etoposide results in decreased expression of TMEM185B mRNA CTD PMID:24211769 NCBI chr 2:120,217,479...120,223,400
Ensembl chr 2:120,217,479...120,223,400
JBrowse link
G TMEM204 transmembrane protein 204 decreases expression ISO Etoposide results in decreased expression of TMEM204 mRNA CTD PMID:25270620 NCBI chr16:1,528,678...1,555,568
Ensembl chr16:1,528,688...1,555,580
JBrowse link
G TMEM47 transmembrane protein 47 affects response to substance EXP TMEM47 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr  X:34,627,075...34,657,285
Ensembl chr  X:34,627,075...34,657,285
JBrowse link
G TMEM97 transmembrane protein 97 affects response to substance EXP TMEM97 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr17:28,319,041...28,328,685
Ensembl chr17:28,319,200...28,328,685
JBrowse link
G TMPRSS2 transmembrane serine protease 2 multiple interactions EXP Etoposide inhibits the reaction [Dihydrotestosterone results in increased expression of TMPRSS2 mRNA] CTD PMID:20601956 NCBI chr21:41,464,305...41,508,158
Ensembl chr21:41,464,305...41,531,116
Ensembl chr21:41,464,305...41,531,116
JBrowse link
G TMSB4X thymosin beta 4 X-linked multiple interactions
decreases response to substance
EXP TMSB4X protein inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; TMSB4X protein inhibits the reaction [Etoposide results in increased cleavage of and results in increased activity of CASP9 protein]
TMSB4X protein results in decreased susceptibility to Etoposide
CTD PMID:16364925 NCBI chr  X:12,975,110...12,977,223
Ensembl chr  X:12,975,110...12,977,227
JBrowse link
G TNF tumor necrosis factor increases expression ISO Etoposide results in increased expression of TNF mRNA CTD PMID:15135310 PMID:18523641 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TNFRSF10B TNF receptor superfamily member 10b multiple interactions
increases expression
EXP Etoposide promotes the reaction [TP53 protein binds to TNFRSF10B promoter]
Etoposide results in increased expression of TNFRSF10B mRNA
CTD PMID:15964798 NCBI chr 8:23,020,133...23,069,031
Ensembl chr 8:23,020,133...23,069,031
JBrowse link
G TNFRSF11B TNF receptor superfamily member 11b increases expression ISO Etoposide results in increased expression of TNFRSF11B mRNA CTD PMID:11459812 NCBI chr 8:118,923,557...118,951,885
Ensembl chr 8:118,923,557...118,951,885
JBrowse link
G TNFRSF12A TNF receptor superfamily member 12A multiple interactions
increases expression
EXP Estradiol inhibits the reaction [Etoposide results in increased expression of TNFRSF12A mRNA] CTD PMID:19426747 NCBI chr16:3,020,368...3,022,383
Ensembl chr16:3,018,445...3,022,383
JBrowse link
G TNFRSF14 TNF receptor superfamily member 14 increases expression EXP Etoposide results in increased expression of TNFRSF14 mRNA CTD PMID:21527772 NCBI chr 1:2,556,371...2,563,829
Ensembl chr 1:2,555,639...2,565,382
JBrowse link
G TNFRSF1A TNF receptor superfamily member 1A affects response to substance ISO TNFRSF1A protein affects the susceptibility to Etoposide CTD PMID:20159942 NCBI chr12:6,328,771...6,342,076
Ensembl chr12:6,328,757...6,342,114
JBrowse link
G TNFSF11 TNF superfamily member 11 decreases expression ISO Etoposide results in decreased expression of TNFSF11 mRNA CTD PMID:11459812 NCBI chr13:42,562,736...42,608,013
Ensembl chr13:42,562,736...42,608,013
JBrowse link
G TNFSF9 TNF superfamily member 9 increases expression EXP Etoposide results in increased expression of TNFSF9 mRNA CTD PMID:17374387 NCBI chr19:6,531,026...6,535,924
Ensembl chr19:6,531,026...6,535,924
JBrowse link
G TNKS tankyrase affects response to substance EXP TNKS protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 8:9,555,230...9,782,346
Ensembl chr 8:9,555,912...9,782,346
JBrowse link
G TOP2A DNA topoisomerase II alpha affects binding
decreases activity
multiple interactions
affects activity
decreases expression
increases response to substance
affects response to substance
decreases response to substance
EXP
ISO
Etoposide binds to TOP2A protein
Etoposide analog results in decreased activity of TOP2A protein; Etoposide metabolite results in decreased activity of TOP2A protein; Etoposide results in decreased activity of TOP2A protein
[Ciprofloxacin binds to TOP2A protein] inhibits the reaction [Etoposide binds to TOP2A protein]; [EGF protein results in decreased expression of TOP2A protein] which results in decreased susceptibility to Etoposide; [MAPK12 protein results in increased phosphorylation of TOP2A protein] which results in increased susceptibility to Etoposide; [MAPK12 protein results in increased stability of TOP2A protein] which results in increased susceptibility to Etoposide; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Etoposide promotes the reaction [MDM2 protein binds to TOP2A protein]]; delphinidin results in decreased susceptibility to [Etoposide affects the activity of TOP2A protein]; Etoposide metabolite inhibits the reaction [TOP2A protein binds to Nucleic Acids, Nucleotides, and Nucleosides]; Etoposide metabolite inhibits the reaction [TOP2A protein results in increased hydrolysis of Adenosine Triphosphate]; Etoposide promotes the reaction [MDM2 protein binds to TOP2A protein]; TOP2A results in decreased susceptibility to [Carboplatin co-treated with Etoposide co-treated with Ifosfamide]; TOP2A results in decreased susceptibility to [Cisplatin co-treated with Etoposide]
Etoposide results in decreased expression of TOP2A protein
TOP2A protein results in increased susceptibility to Etoposide
TOP2A protein modified form affects the susceptibility to Etoposide
TOP2A gene mutant form results in decreased susceptibility to Etoposide; TOP2A protein mutant form results in decreased susceptibility to Etoposide
CTD PMID:10856430 PMID:11325482 PMID:11470519 PMID:11531262 PMID:11676865 PMID:12569090 PMID:15211611 PMID:16969495 PMID:17575151 PMID:19182879 PMID:21056033 PMID:21413765 PMID:21878638 PMID:24650156 PMID:26198043 PMID:27422292 PMID:27533850 PMID:31512855 NCBI chr17:40,388,525...40,417,902
Ensembl chr17:40,388,525...40,417,896
JBrowse link
G TOP2B DNA topoisomerase II beta decreases response to substance
decreases activity
affects response to substance
decreases expression
multiple interactions
increases response to substance
EXP
ISO
TOP2B protein mutant form results in decreased susceptibility to Etoposide
Etoposide results in decreased activity of TOP2B protein
TOP2B protein affects the susceptibility to Etoposide
Etoposide results in decreased expression of TOP2B protein
TOP2B protein affects the reaction [Etoposide results in increased expression of H2AX protein]
TOP2B protein mutant form results in increased susceptibility to Etoposide
CTD PMID:10856430 PMID:15322234 PMID:16239602 PMID:17875725 PMID:26198043 PMID:27422292 NCBI chr 3:25,597,905...25,664,907
Ensembl chr 3:25,597,905...25,664,907
JBrowse link
G TOP3A DNA topoisomerase III alpha decreases expression EXP Etoposide results in decreased expression of TOP3A mRNA CTD PMID:24211769 NCBI chr17:18,269,958...18,314,996
Ensembl chr17:18,271,428...18,315,007
JBrowse link
G TOR1A torsin family 1 member A decreases expression EXP Etoposide results in decreased expression of TOR1A mRNA CTD PMID:24211769 NCBI chr 9:129,812,942...129,824,136
Ensembl chr 9:129,812,942...129,824,244
JBrowse link
G TP53 tumor protein p53 increases acetylation
increases expression
multiple interactions
increases activity
increases phosphorylation
affects response to substance
increases response to substance
EXP
ISO
Etoposide results in increased acetylation of TP53 protein; Etoposide results in increased acetylation of TP53 protein mutant form
Etoposide results in increased expression of TRP53 protein
[CDKN2A gene mutant form results in increased expression of CDKN2A protein alternative form] inhibits the reaction [Etoposide results in increased expression of TRP53 protein]; Etoposide results in increased phosphorylation of and results in increased activity of TRP53 protein; TRP53 affects the reaction [Etoposide results in increased expression of CDKN1A mRNA]; TRP53 affects the reaction [Etoposide results in increased expression of TPT1 mRNA]; TRP53 affects the reaction [Etoposide results in increased expression of TPT1 protein]; TRP53 protein affects the reaction [Etoposide results in increased expression of BTG2 mRNA]
Etoposide results in increased activity of TP53 protein
Etoposide results in increased phosphorylation of TP53 protein
TRP53 protein affects the susceptibility to Etoposide
2,4,4'-trichlorobiphenyl inhibits the reaction [Etoposide results in increased expression of TP53 protein]; 2,4,5,2',5'-pentachlorobiphenyl inhibits the reaction [Etoposide results in increased expression of TP53 protein]; 3,4,5,3',4'-pentachlorobiphenyl inhibits the reaction [Etoposide results in increased expression of TP53 protein]; [CASP8 co-treated with TP53] affects the reaction [Etoposide results in increased cleavage of and results in increased activity of CASP9 protein]; [CASP8 co-treated with TP53] affects the reaction [Etoposide results in increased cleavage of CASP3 protein]; [CASP8 co-treated with TP53] affects the reaction [Etoposide results in increased cleavage of PARP1 protein]; [CASP8 co-treated with TP53] inhibits the reaction [CASP8 protein mutant form results in decreased susceptibility to Etoposide]; [Doxorubicin co-treated with Vincristine co-treated with Etoposide co-treated with Mitotane] results in decreased expression of TP53 protein; [Etoposide results in increased acetylation of TP53 protein mutant form] which results in increased expression of UBE2C protein; [TP53 protein results in increased susceptibility to Etoposide] which results in decreased chemical synthesis of benzo(a)pyrene 7,8-dihydrodiol; Cadmium Chloride affects the reaction [Etoposide results in increased phosphorylation of TP53 protein]; entinostat promotes the reaction [Etoposide results in increased expression of and results in increased acetylation of TP53 protein]; Etoposide promotes the reaction [[TP53 protein binds to GDF15 promoter] which results in increased expression of GDF15 mRNA]; Etoposide promotes the reaction [entinostat results in increased expression of TP53 protein]; Etoposide promotes the reaction [TP53 protein binds to TNFRSF10B promoter]; Etoposide promotes the reaction [TP53 protein results in increased chemical synthesis of benzo(a)pyrene 7,8-dihydrodiol]; Etoposide promotes the reaction [trichostatin A results in increased expression of TP53 protein]; Etoposide promotes the reaction [UF010 compound results in increased expression of TP53 protein]; Etoposide results in increased expression of and results in increased acetylation of TP53 protein; Etoposide results in increased phosphorylation of and affects the localization of TP53 protein; Etoposide results in increased phosphorylation of and results in increased activity of TP53 protein; NFE2L2 protein affects the reaction [Etoposide results in increased expression of TP53 protein]; Oxygen deficiency inhibits the reaction [Etoposide results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [Etoposide results in increased activity of TP53 protein]; Tetrachlorodibenzodioxin inhibits the reaction [Etoposide results in increased acetylation of TP53 protein]; Tetrachlorodibenzodioxin inhibits the reaction [Etoposide results in increased phosphorylation of and results in increased activity of TP53 protein]; TP53 affects the reaction [Etoposide results in increased expression of CDKN1A mRNA]; TP53 affects the reaction [Etoposide results in increased expression of TPT1 mRNA]; TP53 promotes the reaction [Etoposide results in increased expression of BTG2 protein]; TP53 promotes the reaction [Etoposide results in increased expression of CDKN1A protein]; TP53 protein affects the reaction [CHEK1 protein affects the susceptibility to Etoposide]; TP53 protein affects the reaction [Etoposide results in decreased expression of UBE2C mRNA]; TP53 protein affects the reaction [Etoposide results in increased expression of SRXN1 protein]; TP53 protein inhibits the reaction [ESR2 protein results in increased susceptibility to Etoposide]; TP53 protein inhibits the reaction [Etoposide results in decreased expression of UBE2C protein]; TP53 protein promotes the reaction [[Etoposide results in increased susceptibility to Benzo(a)pyrene] which results in increased expression of CDKN1A protein]; TP53 protein promotes the reaction [Etoposide promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]]; TP53 protein promotes the reaction [Etoposide results in increased expression of CDKN1A protein]; TP53 protein promotes the reaction [Etoposide results in increased expression of CYP1A1 protein]; trichostatin A promotes the reaction [Etoposide results in increased expression of and results in increased acetylation of TP53 protein]; UF010 compound promotes the reaction [Etoposide results in increased expression of and results in increased acetylation of TP53 protein]
[Etoposide results in increased expression of TP53 protein] which results in increased expression of GDF15 protein; Etoposide results in increased expression of TP53 protein
cordycepin promotes the reaction [Etoposide results in increased expression of TP53 protein]; Etoposide promotes the reaction [Acetaminophen results in increased phosphorylation of TP53 protein]; Etoposide results in increased expression of and results in increased phosphorylation of TP53 protein; Niacin deficiency inhibits the reaction [Etoposide results in increased expression of TP53 protein]; Tetrachlorodibenzodioxin inhibits the reaction [Etoposide results in increased expression of and results in increased phosphorylation of TP53 protein]
TP53 protein results in increased susceptibility to Etoposide; TP53 results in increased susceptibility to Etoposide
CTD PMID:9815696 PMID:11895857 PMID:12082016 PMID:15131059 PMID:15459018 PMID:15964798 PMID:16120219 PMID:16330492 PMID:16882877 PMID:17516866 PMID:18698031 PMID:19751709 PMID:20299546 PMID:20477944 PMID:20623183 PMID:20655369 PMID:21212465 PMID:21526190 PMID:21552291 PMID:21801448 PMID:22003191 PMID:22010212 PMID:22242153 PMID:23144690 PMID:23690541 PMID:24067374 PMID:25078064 PMID:25699604 PMID:25744307 PMID:26259609 PMID:27129209 PMID:27358234 PMID:27982581 PMID:29471073 PMID:30818834 PMID:31542801 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538
Ensembl chr17:7,661,779...7,687,538
JBrowse link
G TP53BP1 tumor protein p53 binding protein 1 increases expression
multiple interactions
EXP Etoposide results in increased expression of TP53BP1 protein
pifithrin inhibits the reaction [Etoposide results in increased expression of and affects the localization of TP53BP1 protein]
CTD PMID:26259609 PMID:27358234 NCBI chr15:43,403,061...43,510,640
Ensembl chr15:43,403,061...43,510,728
JBrowse link
G TP53I3 tumor protein p53 inducible protein 3 increases expression EXP Etoposide results in increased expression of TP53I3 mRNA CTD PMID:17374387 NCBI chr 2:24,077,428...24,085,767
Ensembl chr 2:24,077,433...24,085,861
JBrowse link
G TP53TG1 TP53 target 1 increases expression EXP Etoposide results in increased expression of TP53TG1 mRNA CTD PMID:17374387 NCBI chr 7:87,325,347...87,345,492
Ensembl chr 7:87,322,943...87,345,528
JBrowse link
G TP73 tumor protein p73 multiple interactions
increases expression
EXP [[Etoposide results in increased expression of TP73 protein] which results in increased expression of VDR protein] which results in increased susceptibility to Calcitriol; TP73 mutant form inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; TP73 mutant form inhibits the reaction [Etoposide results in increased activity of CASP7 protein]; TP73 mutant form inhibits the reaction [Etoposide results in increased cleavage of CASP3 protein]; TP73 mutant form inhibits the reaction [Etoposide results in increased cleavage of CASP8 protein]; TP73 protein affects the reaction [Etoposide results in increased expression of VDR mRNA]
Etoposide results in increased expression of TP73 mRNA; Etoposide results in increased expression of TP73 protein
CTD PMID:17716971 PMID:21801448 NCBI chr 1:3,652,516...3,736,201
Ensembl chr 1:3,652,516...3,736,201
JBrowse link
G TPI1 triosephosphate isomerase 1 multiple interactions
increases phosphorylation
EXP CDK2 affects the reaction [Etoposide results in increased phosphorylation of TPI1 protein] CTD PMID:20149834 NCBI chr12:6,866,834...6,870,948
Ensembl chr12:6,867,119...6,870,948
JBrowse link
G TPP2 tripeptidyl peptidase 2 multiple interactions
affects localization
EXP
ISO
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Etoposide affects the localization of TPP2 protein]; SB 203580 inhibits the reaction [Etoposide affects the localization of TPP2 protein]; U 0126 inhibits the reaction [Etoposide affects the localization of TPP2 protein]
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Etoposide affects the localization of TPP2 protein]; Sirolimus promotes the reaction [Etoposide affects the localization of TPP2 protein]; U 0126 inhibits the reaction [Etoposide affects the localization of TPP2 protein]; wortmannin promotes the reaction [Etoposide affects the localization of TPP2 protein]
CTD PMID:20643100 NCBI chr13:102,596,985...102,679,958
Ensembl chr13:102,596,986...102,679,958
JBrowse link
G TPT1 tumor protein, translationally-controlled 1 increases expression
multiple interactions
EXP
ISO
Etoposide results in increased expression of TPT1 mRNA
TRP53 affects the reaction [Etoposide results in increased expression of TPT1 mRNA]; TRP53 affects the reaction [Etoposide results in increased expression of TPT1 protein]
Etoposide results in increased expression of TPT1 mRNA; Etoposide results in increased expression of TPT1 protein
TP53 affects the reaction [Etoposide results in increased expression of TPT1 mRNA]
CTD PMID:24067374 NCBI chr13:45,333,471...45,341,183
Ensembl chr13:45,333,471...45,341,370
Ensembl chr13:45,333,471...45,341,370
JBrowse link
G TRAF2 TNF receptor associated factor 2 affects response to substance ISO TRAF2 protein affects the susceptibility to Etoposide CTD PMID:20159942 NCBI chr 9:136,881,933...136,926,615
Ensembl chr 9:136,881,912...136,926,607
JBrowse link
G TRIB2 tribbles pseudokinase 2 affects response to substance EXP TRIB2 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 2:12,716,936...12,742,734
Ensembl chr 2:12,716,889...12,742,734
JBrowse link
G TRIB3 tribbles pseudokinase 3 decreases expression ISO Etoposide results in decreased expression of TRIB3 mRNA CTD PMID:25270620 NCBI chr20:380,760...397,559
Ensembl chr20:362,835...397,559
JBrowse link
G TRIM2 tripartite motif containing 2 affects response to substance
decreases expression
EXP
ISO
TRIM2 protein affects the susceptibility to Etoposide
Etoposide results in decreased expression of TRIM2 mRNA
CTD PMID:16217747 PMID:25270620 NCBI chr 4:153,152,163...153,339,317
Ensembl chr 4:153,152,163...153,339,319
Ensembl chr 4:153,152,163...153,339,319
JBrowse link
G TRIM38 tripartite motif containing 38 decreases expression EXP Etoposide results in decreased expression of TRIM38 mRNA CTD PMID:24211769 NCBI chr 6:25,962,723...25,991,231
Ensembl chr 6:25,962,802...25,991,231
JBrowse link
G TRPV1 transient receptor potential cation channel subfamily V member 1 increases expression EXP Etoposide results in increased expression of TRPV1 mRNA CTD PMID:29397400 NCBI chr17:3,565,446...3,609,411
Ensembl chr17:3,565,444...3,609,411
JBrowse link
G TTK TTK protein kinase decreases expression EXP Etoposide results in decreased expression of TTK mRNA CTD PMID:16120219 NCBI chr 6:80,004,147...80,042,651
Ensembl chr 6:80,003,887...80,042,527
JBrowse link
G TUBA4A tubulin alpha 4a increases expression EXP Etoposide results in increased expression of TUBA4A mRNA CTD PMID:21527772 NCBI chr 2:219,249,710...219,254,740
Ensembl chr 2:219,249,710...219,278,170
JBrowse link
G TUFM Tu translation elongation factor, mitochondrial decreases expression ISO Etoposide results in decreased expression of TUFM protein CTD PMID:29733421 NCBI chr16:28,842,411...28,846,348
Ensembl chr16:28,842,411...28,846,348
JBrowse link
G TXN2 thioredoxin 2 decreases response to substance EXP TXN2 protein results in decreased susceptibility to Etoposide CTD PMID:12080052 NCBI chr22:36,467,036...36,481,672
Ensembl chr22:36,467,046...36,481,640
JBrowse link
G TXNIP thioredoxin interacting protein increases expression EXP Etoposide results in increased expression of TXNIP protein CTD PMID:18270325 NCBI chr 1:145,992,435...145,996,579
Ensembl chr 1:145,992,435...145,996,579
JBrowse link
G TXNL1 thioredoxin like 1 decreases expression ISO Etoposide results in decreased expression of TXNL1 protein CTD PMID:29733421 NCBI chr18:56,597,209...56,638,635
Ensembl chr18:56,597,209...56,651,600
JBrowse link
G TYMS thymidylate synthetase affects response to substance EXP TYMS gene polymorphism affects the susceptibility to Etoposide CTD PMID:15713801 NCBI chr18:657,653...673,578
Ensembl chr18:657,653...673,578
JBrowse link
G TYRP1 tyrosinase related protein 1 affects response to substance EXP TYRP1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 9:12,693,375...12,710,285
Ensembl chr 9:12,685,439...12,710,285
JBrowse link
G UBE2C ubiquitin conjugating enzyme E2 C decreases expression
multiple interactions
EXP Etoposide results in decreased expression of UBE2C mRNA; Etoposide results in decreased expression of UBE2C protein
[Etoposide results in increased acetylation of TP53 protein mutant form] which results in increased expression of UBE2C protein; CDKN1A protein affects the reaction [Etoposide results in decreased expression of UBE2C protein]; TP53 protein affects the reaction [Etoposide results in decreased expression of UBE2C mRNA]; TP53 protein inhibits the reaction [Etoposide results in decreased expression of UBE2C protein]
CTD PMID:17374387 PMID:27129209 NCBI chr20:45,812,644...45,816,952
Ensembl chr20:45,812,576...45,816,957
JBrowse link
G UBL3 ubiquitin like 3 affects response to substance EXP UBL3 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr13:29,764,371...29,850,617
Ensembl chr13:29,764,371...29,850,617
JBrowse link
G UCP2 uncoupling protein 2 decreases expression EXP Etoposide results in decreased expression of UCP2 mRNA CTD PMID:29397400 NCBI chr11:73,974,671...73,983,202
Ensembl chr11:73,974,672...73,983,246
Ensembl chr11:73,974,672...73,983,246
JBrowse link
G UGT1A1 UDP glucuronosyltransferase family 1 member A1 affects response to substance
increases glucuronidation
EXP UGT1A1 gene polymorphism affects the susceptibility to Etoposide
UGT1A1 protein results in increased glucuronidation of Etoposide
CTD PMID:12969965 PMID:17151191 NCBI chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300
JBrowse link
G UGT1A3 UDP glucuronosyltransferase family 1 member A3 increases glucuronidation EXP UGT1A3 protein results in increased glucuronidation of Etoposide CTD PMID:17151191 NCBI chr 2:233,729,042...233,773,300
Ensembl chr 2:233,729,108...233,773,299
JBrowse link
G UGT1A8 UDP glucuronosyltransferase family 1 member A8 increases glucuronidation EXP UGT1A8 protein results in increased glucuronidation of Etoposide CTD PMID:17151191 NCBI chr 2:233,617,633...233,773,300
Ensembl chr 2:233,617,645...233,773,310
JBrowse link
G UNC5C unc-5 netrin receptor C increases response to substance EXP UNC5C results in increased susceptibility to Etoposide CTD PMID:21600761 NCBI chr 4:95,162,504...95,549,210
Ensembl chr 4:95,162,504...95,549,206
JBrowse link
G UPP2 uridine phosphorylase 2 increases expression ISO Etoposide results in increased expression of UPP2 mRNA CTD PMID:25270620 NCBI chr 2:157,995,179...158,136,154
Ensembl chr 2:157,876,702...158,136,154
JBrowse link
G UTP3 UTP3 small subunit processome component decreases expression EXP Etoposide results in decreased expression of UTP3 mRNA CTD PMID:24211769 NCBI chr 4:70,688,532...70,690,551
Ensembl chr 4:70,688,532...70,690,551
JBrowse link
G VCAM1 vascular cell adhesion molecule 1 multiple interactions
decreases response to substance
EXP [IL4 protein co-treated with VCAM1 protein] inhibits the reaction [Etoposide results in decreased folding of BAX protein]; [VCAM1 protein co-treated with IL4 protein] inhibits the reaction [Etoposide inhibits the reaction [BAX protein binds to BCL2L1 protein]]; [VCAM1 protein co-treated with IL4 protein] results in decreased susceptibility to Etoposide
VCAM1 protein results in decreased susceptibility to Etoposide
CTD PMID:10620629 NCBI chr 1:100,719,742...100,739,045
Ensembl chr 1:100,719,742...100,739,045
JBrowse link
G VCAN versican affects response to substance EXP VCAN protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 5:83,471,744...83,582,302
Ensembl chr 5:83,471,618...83,582,303
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G VDAC1 voltage dependent anion channel 1 multiple interactions ISO Etoposide promotes the reaction [VDAC1 protein binds to VDAC1 protein] CTD PMID:20937774 NCBI chr 5:133,971,871...134,070,987
Ensembl chr 5:133,971,871...134,004,975
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G VDR vitamin D receptor multiple interactions
affects response to substance
increases expression
EXP [[Etoposide results in increased expression of TP73 protein] which results in increased expression of VDR protein] which results in increased susceptibility to Calcitriol; TP73 protein affects the reaction [Etoposide results in increased expression of VDR mRNA]
VDR gene polymorphism affects the susceptibility to Etoposide; VDR intron polymorphism affects the susceptibility to Etoposide
CTD PMID:12969965 PMID:15713801 PMID:17716971 NCBI chr12:47,841,537...47,905,022
Ensembl chr12:47,841,537...47,943,048
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G VEGFA vascular endothelial growth factor A decreases response to substance EXP VEGFA mRNA results in decreased susceptibility to Etoposide CTD PMID:18494554 NCBI chr 6:43,770,209...43,786,487
Ensembl chr 6:43,770,184...43,786,487
JBrowse link
G VEGFC vascular endothelial growth factor C multiple interactions
decreases response to substance
EXP EDN1 mutant form inhibits the reaction [VEGFC protein results in decreased susceptibility to Etoposide]; PTGS2 mutant form inhibits the reaction [VEGFC protein results in decreased susceptibility to Etoposide] CTD PMID:24184161 NCBI chr 4:176,683,538...176,792,922
Ensembl chr 4:176,683,538...176,792,922