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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1332548
Species: Mus musculus
RGD Object: Gene
Symbol: Ppargc1a
Name: peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppargc1aincreases expressionEXP 6480464CTDValproic Acid results in increased expression of PPARGC1A mRNAPMID:24489787
Ppargc1aaffects expressionISOPPARGC1A (Homo sapiens)6480464CTDValproic Acid affects the expression of PPARGC1A mRNAPMID:25979313
Ppargc1adecreases expressionISOPPARGC1A (Homo sapiens)6480464CTDValproic Acid results in decreased expression of PPARGC1A mRNAPMID:27089845
Ppargc1adecreases methylationISOPPARGC1A (Homo sapiens)6480464CTDValproic Acid results in decreased methylation of PPARGC1A genePMID:29154799
Ppargc1aincreases expressionISOPPARGC1A (Homo sapiens)6480464CTDValproic Acid results in increased expression of PPARGC1A mRNAPMID:23179753 PMID:24383497 PMID:26272509 PMID:27188386 PMID:28001369 PMID:29154799
Ppargc1amultiple interactionsISOPPARGC1A (Homo sapiens)6480464CTD[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPARGC1A mRNAPMID:27188386
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