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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1323180
Species: Mus musculus
RGD Object: Gene
Symbol: Tet2
Name: tet methylcytosine dioxygenase 2
Acc ID: CHEBI:34372
Term: 4,4'-sulfonyldiphenol
Definition: A sulfone that is diphenyl sulfone in which both of the para hydrogens have been replaced by hydroxy groups.
Chemical ID: MESH:C543008
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tet2decreases expressionISOTET2 (Homo sapiens)6480464CTDbisphenol S results in decreased expression of TET2 mRNA; bisphenol S results in decreased expression of TET2 proteinPMID:32105160 PMID:37315367
Tet2increases expressionISOTET2 (Homo sapiens)6480464CTDbisphenol S results in increased expression of TET2 mRNAPMID:31601247
Tet2increases methylationISOTET2 (Homo sapiens)6480464CTDbisphenol S results in increased methylation of TET2 promoterPMID:32105160
Tet2multiple interactionsISOTET2 (Homo sapiens)6480464CTD[KDM2A protein co-treated with bisphenol S] results in decreased expression of and results in decreased activity of TET2 protein; [KDM2A protein co-treated with bisphenol S] results in decreased expression of TET2 mRNA; bisphenol S promotes the reaction [KDM2A protein binds to TET2 promoter]; bisphenol S promotes the reaction [TET2 protein results in increased abundance of 5-hydroxymethylcytosine]; bisphenol S results in decreased expression of and results in decreased activity of TET2 protein; DNMT1 protein promotes the reaction [bisphenol S results in decreased expression of TET2 protein]; DNMT1 protein promotes the reaction [bisphenol S results in increased methylation of TET2 promoter]; DNMT3A protein promotes the reaction [bisphenol S results in decreased expression of TET2 protein]; ESR1 protein promotes the reaction [bisphenol S results in decreased expression of TET2 mRNA]; ESR1 protein promotes the reaction [bisphenol S results in decreased expression of TET2 protein]; ESR1 protein promotes the reaction [bisphenol S results in increased methylation of TET2 promoter]; TET2 protein inhibits the reaction [bisphenol S results in decreased abundance of 5-hydroxymethylcytosine]PMID:32105160 PMID:37315367
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