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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1322378
Species: Mus musculus
RGD Object: Gene
Symbol: Cda
Name: cytidine deaminase
Acc ID: CHEBI:175901
Term: gemcitabine
Definition: A 2'-deoxycytidine having geminal fluoro substituents in the 2'-position. An inhibitor of ribonucleotide reductase, gemcitabine is used in the treatment of various carcinomas, particularly non-small cell lung cancer, pancreatic cancer, bladder cancer and breast cancer.
Chemical ID: MESH:C056507
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdaaffects response to substanceISOCDA (Homo sapiens)6480464CTDCDA protein affects the susceptibility to GemcitabinePMID:18728667
Cdamultiple interactionsISOCDA (Homo sapiens)6480464CTD[Crizotinib results in decreased expression of CDA protein] which results in increased susceptibility to Gemcitabine; CDA protein affects the susceptibility to [Gemcitabine co-treated with Mitomycin]; CDA protein affects the susceptibility to [Gemcitabine co-treated with Oxaliplatin]PMID:18728667 PMID:22973962
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