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GENE - TERM ANNOTATION REPORT

RGD ID: 1321640
Species: Mus musculus
RGD Object: Gene
Symbol: Tnfrsf11a
Name: tumor necrosis factor receptor superfamily, member 11a, NFKB activator
Acc ID: DOID:5408
Term: Paget's disease of bone
Definition: A bone formation disease that has_material_basis_in hyperactive osteoclast which results_in abnormal osteoblast bone formation located_in skull, located_in pelvis, located_in vertebral column, located_in set of limbs. (DO)
Definition Source(s): http://en.wikipedia.org/wiki/Paget%27s_disease_of_bone "DO" "DO", http://orthoinfo.aaos.org/topic.cfm?topic=A00076 "DO" "DO", http://www.mayoclinic.com/health/pagets-disease-of-bone/DS00485 "DO" "DO", http://www.nlm.nih.gov/medlineplus/pagetsdiseaseofbone.html "DO" "DO", https://pubmed.ncbi.nlm.nih.gov/37180975/ "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfrsf11a ISOTNFRSF11A (Homo sapiens)1599463RGDPaget disease of bone, OMIM:602080  
Tnfrsf11a ISOTNFRSF11A (Homo sapiens)11554173CTDCTD Direct Evidence: marker/mechanismPMID:20436471
Tnfrsf11a ISOTNFRSF11A (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Bone Paget disease | ClinVar Annotator: match by term: Paget disease of bonePMID:24033266 PMID:25741868 PMID:28492532
Tnfrsf11a IAGP 13592920MouseDOOMIM:167250 | OMIM:602080 | OMIM:606263 
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