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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1320897
Species: Mus musculus
RGD Object: Gene
Symbol: Ripk1
Name: receptor (TNFRSF)-interacting serine-threonine kinase 1
Acc ID: CHEBI:81584
Term: 2,2',4,4'-Tetrabromodiphenyl ether
Definition: An organobromine compound that has formula C12H6Br4O.
Chemical ID: MESH:C511295
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ripk1decreases expressionISORIPK1 (Homo sapiens)6480464CTD2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of RIPK1 mRNAPMID:27589474 PMID:37357614
Ripk1multiple interactionsISORIPK1 (Homo sapiens)6480464CTD[Cadmium co-treated with 2,2',4,4'-tetrabromodiphenyl ether] results in decreased expression of RIPK1 mRNA; GSK872 affects the reaction [[Cadmium co-treated with 2,2',4,4'-tetrabromodiphenyl ether] results in decreased expression of RIPK1 mRNA]; GSK872 inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of RIPK1 mRNA]PMID:37357614
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