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GENE - TERM ANNOTATION REPORT

RGD ID: 1319837
Species: Homo sapiens
RGD Object: Gene
Symbol: POLR2B
Name: RNA polymerase II subunit B
Acc ID: GO:0005665
Term: RNA polymerase II, core complex
Definition: RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template.
Definition Source(s): GOC:krc, GOC:mtg_sensu
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
POLR2Bpart_ofIBAFB:FBgn0262955 or PANTHER:PTN000466005 or PomBase:SPAC23G3.01 or SGD:S000005677 or TAIR:locus:2119013 or UniProtKB:P30876 or UniProtKB:Q583H5150520179GO_Central GO_REF:0000033
POLR2Bpart_ofIEAPANTHER:PTHR20856:SF7150520179TreeGrafter GO_REF:0000118
POLR2Bpart_ofIDA 150520179UniProt PMID:9852112

PMID:9852112
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