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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1315198
Species: Mus musculus
RGD Object: Gene
Symbol: Dhcr24
Name: 24-dehydrocholesterol reductase
Acc ID: CHEBI:64022
Term: nebivolol
Definition: A racemate consisting of equal amounts of (R,S,S,S)-nebivolol and (S,R,R,R)-nebivolol. A cardioselective beta blocker, it has vasodilatory activity but lacks intrinsic sympathomimetic and membrane-stabilising activity. It is used as the hydrochloride salt for the management of hypertension, and as an adjunct to standard therapy in elderly patients with stable chronic heart failure.
Chemical ID: MESH:D000068577
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dhcr24increases expressionISODHCR24 (Homo sapiens)6480464CTDNebivolol results in increased expression of DHCR24 mRNAPMID:17467819
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