GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Mbd4 | decreases expression | ISO | MBD4 (Homo sapiens) | 6480464 | CTD | Estradiol results in decreased expression of MBD4 mRNA; Estradiol results in decreased expression of MBD4 protein | PMID:22952798 | Mbd4 | increases expression | ISO | MBD4 (Homo sapiens) | 6480464 | CTD | Estradiol results in increased expression of MBD4 mRNA | PMID:30684530 | Mbd4 | increases methylation | ISO | MBD4 (Homo sapiens) | 6480464 | CTD | Estradiol results in increased methylation of MBD4 promoter | PMID:35747940 | Mbd4 | multiple interactions | ISO | MBD4 (Homo sapiens) | 6480464 | CTD | [Estradiol co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in increased methylation of MBD4 promoter; Estradiol promotes the reaction [sodium arsenite results in decreased expression of MBD4 protein]; sodium arsenite promotes the reaction [Estradiol results in decreased expression of MBD4 mRNA]; sodium arsenite promotes the reaction [Estradiol results in decreased expression of MBD4 protein] | PMID:22952798 PMID:35747940 | | ||||||||||||||||||||||
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