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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1313517
Species: Homo sapiens
RGD Object: Gene
Symbol: ATF6
Name: activating transcription factor 6
Acc ID: CHEBI:75142
Term: N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal
Definition: A tripeptide that is L-leucyl-L-leucyl-L-leucine in which the C-terminal carboxy group has been reduced to the corresponding aldehyde and the N-terminal amino group is protected as its benzyloxycarbonyl derivative.
Chemical ID: MESH:C072553
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ATF6increases expressionEXP 6480464CTDbenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of ATF6 proteinPMID:27638906
ATF6multiple interactionsEXP 6480464CTD4-phenylbutyric acid inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of ATF6 protein]; ATF6 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of ACE2 protein]; ATF6 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased cleavage of CTSD protein]PMID:27638906
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