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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1312342
Species: Mus musculus
RGD Object: Gene
Symbol: Sfn
Name: stratifin
Acc ID: CHEBI:50131
Term: 5-aza-2'-deoxycytidine
Definition: A 2'-deoxyribonucleoside that has formula C8H12N4O4.
Chemical ID: MESH:C014347
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sfndecreases methylationISOSfn (Rattus norvegicus)6480464CTDDecitabine results in decreased methylation of SFN promoterPMID:15979784
Sfnincreases expressionISOSfn (Rattus norvegicus)6480464CTDDecitabine results in increased expression of SFN mRNAPMID:15979784
Sfnincreases expressionISOSFN (Homo sapiens)6480464CTDDecitabine results in increased expression of SFN proteinPMID:22534328 PMID:25189999
Sfnmultiple interactionsISOSFN (Homo sapiens)6480464CTD[Estradiol co-treated with Medroxyprogesterone Acetate co-treated with Bucladesine co-treated with Decitabine] results in increased expression of SFN mRNAPMID:22534328
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