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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1311809
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pik3r4
Name: phosphoinositide-3-kinase, regulatory subunit 4
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pik3r4decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of PIK3R4 mRNAPMID:25181051 PMID:30816183 PMID:32528016
Pik3r4multiple interactionsEXP 6480464CTD[bisphenol A co-treated with Genistein] results in increased methylation of PIK3R4 genePMID:28505145
Pik3r4decreases expressionISOPIK3R4 (Homo sapiens)6480464CTDbisphenol A results in decreased expression of PIK3R4 proteinPMID:31675489
Pik3r4decreases methylationISOPIK3R4 (Homo sapiens)6480464CTDbisphenol A results in decreased methylation of PIK3R4 genePMID:31601247
Pik3r4decreases methylationISOPik3r4 (Mus musculus)6480464CTDbisphenol A results in decreased methylation of PIK3R4 promoterPMID:27312807
Pik3r4increases expressionISOPik3r4 (Mus musculus)6480464CTDbisphenol A results in increased expression of PIK3R4 mRNAPMID:33221593
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