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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1311551
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Amfr
Name: autocrine motility factor receptor
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Amfraffects expressionISOAMFR (Homo sapiens)6480464CTDValproic Acid affects the expression of AMFR mRNAPMID:25979313
Amfrdecreases expressionISOAmfr (Mus musculus)6480464CTDValproic Acid results in decreased expression of AMFR mRNAPMID:20546886
Amfrincreases methylationISOAMFR (Homo sapiens)6480464CTDValproic Acid results in increased methylation of AMFR genePMID:29154799
Amfrmultiple interactionsISOAMFR (Homo sapiens)6480464CTDValproic Acid promotes the reaction [Estradiol results in increased expression of AMFR mRNA]PMID:19772891
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