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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1310152
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tfr2
Name: transferrin receptor 2
Acc ID: CHEBI:82664
Term: iron(0)
Definition: An elemental iron in which the atom has an oxidation state of zero.
Chemical ID: MESH:D007501
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tfr2decreases expressionEXP 6480464CTDIron deficiency results in decreased expression of TFR2 proteinPMID:20164366 PMID:22457245
Tfr2affects metabolic processingISOTfr2 (Mus musculus)6480464CTDTFR2 protein affects the metabolism of IronPMID:17194590 PMID:17241880
Tfr2affects response to substanceISOTFR2 (Homo sapiens)6480464CTDTFR2 protein affects the susceptibility to IronPMID:16893896
Tfr2increases uptakeISOTfr2 (Mus musculus)6480464CTDTFR2 protein mutant form results in increased uptake of IronPMID:16935854
Tfr2multiple interactionsISOTFR2 (Homo sapiens)6480464CTD[HFE protein binds to TFR2 protein] which affects the susceptibility to IronPMID:16893896
Tfr2multiple interactionsISOTfr2 (Mus musculus)6480464CTD[HBB-B1 gene mutant form results in increased abundance of Iron] which results in decreased expression of TFR2 mRNA; [HBB-B2 gene mutant form results in increased abundance of Iron] which results in decreased expression of TFR2 mRNA; [HFE gene mutant form co-treated with TFR2 gene mutant form] results in increased abundance of Iron; Iron inhibits the reaction [Diethylnitrosamine results in decreased expression of TFR2 protein]PMID:17018382 PMID:19061943 PMID:22383097
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