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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1309599
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Akr1e2
Name: aldo-keto reductase family 1, member E2
Acc ID: CHEBI:25812
Term: ozone
Definition: An elemental molecule with formula O3. An explosive, pale blue gas (b.p. -112degreeC) that has a characteristic, pungent odour, it is continuously produced in the upper atmosphere by the action of solar ultraviolet radiation on atmospheric oxygen. It is an antimicrobial agent used in the production of bottled water, as well as in the treatment of meat, poultry and other foodstuffs.
Chemical ID: MESH:D010126
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akr1e2multiple interactionsISOAKR1E2 (Homo sapiens)6480464CTD[Ozone results in increased abundance of Soot metabolite] which results in decreased expression of AKR1E2 mRNAPMID:28410501
Akr1e2multiple interactionsISOAkr1e1 (Mus musculus)6480464CTD[Air Pollutants results in increased abundance of Ozone] which results in increased expression of AKR1E1 mRNAPMID:27106289
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