GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ncoa1 | multiple interactions | EXP | | 6480464 | CTD | Tamoxifen inhibits the reaction [ESR2 protein binds to NCOA1 protein]; Tamoxifen inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to NCOA1 protein]] | PMID:19460436 | Ncoa1 | increases expression | ISO | NCOA1 (Homo sapiens) | 6480464 | CTD | Tamoxifen results in increased expression of NCOA1 mRNA | PMID:19432593 PMID:20332317 | Ncoa1 | multiple interactions | ISO | NCOA1 (Homo sapiens) | 6480464 | CTD | [NCOA1 protein binds to ESR1 protein] which results in increased susceptibility to Tamoxifen; [Tamoxifen co-treated with ESR2 protein] results in decreased expression of NCOA1 mRNA; Tamoxifen inhibits the reaction [ESR1 protein binds to NCOA1 protein] | PMID:19059307 PMID:20332105 PMID:23665804 | | ||||||||||||||||||||||
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