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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1308336
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rps6ka5
Name: ribosomal protein S6 kinase A5
Acc ID: CHEBI:27958
Term: cocaine
Definition: A tropane alkaloid obtained from leaves of the South American shrub Erythroxylon coca.
Chemical ID: MESH:D003042
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rps6ka5increases expressionEXP 6480464CTDCocaine results in increased expression of RPS6KA5 mRNA; Cocaine results in increased expression of RPS6KA5 proteinPMID:17898221 PMID:25100957
Rps6ka5affects response to substanceISORps6ka5 (Mus musculus)6480464CTDRPS6KA5 affects the susceptibility to CocainePMID:16339038
Rps6ka5increases activityISORps6ka5 (Mus musculus)6480464CTDCocaine results in increased activity of RPS6KA5 proteinPMID:16339038
Rps6ka5multiple interactionsISORps6ka5 (Mus musculus)6480464CTDCocaine results in increased phosphorylation of and results in increased activity of RPS6KA5 protein; SL 327 inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of RPS6KA5 protein]PMID:16339038
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