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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1308314
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nlrp3
Name: NLR family, pyrin domain containing 3
Acc ID: CHEBI:38221
Term: fumonisin B1
Definition: A diester that results from the condensation of the 1-carboxy groups of two molecules of propane-1,2,3-tricarboxylic acid with hydroxy groups at positions 14 and 15 of (2S,3S,5R,10R,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,5,10,14,15-pentol.
Chemical ID: MESH:C056933
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nlrp3increases expressionISONlrp3 (Mus musculus)6480464CTDfumonisin B1 results in increased expression of NLRP3 mRNA; fumonisin B1 results in increased expression of NLRP3 proteinPMID:36309173
Nlrp3multiple interactionsISONlrp3 (Mus musculus)6480464CTDdeoxynivalenol promotes the reaction [fumonisin B1 results in increased expression of NLRP3 mRNA]; deoxynivalenol promotes the reaction [fumonisin B1 results in increased expression of NLRP3 protein]; fumonisin B1 promotes the reaction [deoxynivalenol results in increased expression of NLRP3 mRNA]; fumonisin B1 promotes the reaction [deoxynivalenol results in increased expression of NLRP3 protein]PMID:36309173
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