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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1307705
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pak4
Name: p21 (RAC1) activated kinase 4
Acc ID: CHEBI:93751
Term: PF-3758309
Definition: A member of the class of thienopyrimidines that is thieno[3,2-d]pyrimidine substituted by methyl and (5-{[(1S)-2-(dimethylamino)-1-phenylethyl]carbamoyl}-6,6-dimethyl-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)amino groups at positions 2 and 4, respectively. It is a potent inhibitor of PAK4 and inhibits the growth of multiple human tumor xenografts.
Chemical ID: MESH:C550923
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pak4decreases expressionISOPAK4 (Homo sapiens)6480464CTDPF 3758309 results in decreased expression of PAK4 proteinPMID:29048629
Pak4increases response to substanceISOPAK4 (Homo sapiens)6480464CTDPAK4 protein results in increased susceptibility to PF 3758309PMID:29048629
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