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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1307403
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bmi1
Name: BMI1 proto-oncogene, polycomb ring finger
Acc ID: CHEBI:254496
Term: 7,12-dimethyltetraphene
Definition: A tetraphene having methyl substituents at the 7- and 12-positions. It is a potent carcinogen and is present in tobacco smoke.
Chemical ID: MESH:D015127
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bmi1increases expressionISOBmi1 (Mus musculus)6480464CTD9,10-Dimethyl-1,2-benzanthracene results in increased expression of BMI1 mRNA; 9,10-Dimethyl-1,2-benzanthracene results in increased expression of BMI1 proteinPMID:24792773
Bmi1multiple interactionsISOBmi1 (Mus musculus)6480464CTDButyric Acid inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of BMI1 mRNA]; Butyric Acid inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of BMI1 protein]; Glucaric Acid inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of BMI1 mRNA]; Glucaric Acid inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of BMI1 protein]; Niacinamide inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of BMI1 mRNA]; Niacinamide inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of BMI1 protein]PMID:24792773
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