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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1307332
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Srxn1
Name: sulfiredoxin 1
Acc ID: CHEBI:4911
Term: etoposide
Definition: A furonaphthodioxole that has formula C29H32O13.
Chemical ID: MESH:D005047
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Srxn1increases expressionISOSRXN1 (Homo sapiens)6480464CTDEtoposide results in increased expression of SRXN1 proteinPMID:27982581
Srxn1increases expressionISOSrxn1 (Mus musculus)6480464CTDEtoposide results in increased expression of SRXN1 mRNA; Etoposide results in increased expression of SRXN1 proteinPMID:22003191 PMID:27358234
Srxn1multiple interactionsISOSRXN1 (Homo sapiens)6480464CTDNFE2L2 protein affects the reaction [Etoposide results in increased expression of SRXN1 protein]; TP53 protein affects the reaction [Etoposide results in increased expression of SRXN1 protein]PMID:27982581
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