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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1307261
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gsdmd
Name: gasdermin D
Acc ID: CHEBI:7569
Term: nigericin
Definition: A polyether antibiotic which affects ion transport and ATPase activity in mitochondria. It is produced by Streptomyces hygroscopicus.
Chemical ID: MESH:D009550
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gsdmdmultiple interactionsEXP 6480464CTDNigericin inhibits the reaction [peiminine inhibits the reaction [Particulate Matter results in increased cleavage of GSDMD protein]]PMID:36898572
Gsdmdmultiple interactionsISOGsdmd (Mus musculus)6480464CTD[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Nigericin] results in increased cleavage of GSDMD protein; [Lipopolysaccharides co-treated with Nigericin] results in increased cleavage of and results in increased secretion of GSDMD protein; Chlorquinaldol inhibits the reaction [[Lipopolysaccharides co-treated with Nigericin] results in increased cleavage of and results in increased secretion of GSDMD protein]; lonidamine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Nigericin] results in increased cleavage of GSDMD protein]PMID:36002070 PMID:36577999
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