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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1307261
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gsdmd
Name: gasdermin D
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gsdmdmultiple interactionsEXP 6480464CTD[Benzo(a)pyrene co-treated with Dibutyl Phthalate] results in increased expression of GSDMD mRNA; [Benzo(a)pyrene co-treated with Dibutyl Phthalate] results in increased expression of GSDMD proteinPMID:36592837
Gsdmdaffects methylationISOGSDMD (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of GSDMD 5' UTR; Benzo(a)pyrene affects the methylation of GSDMD intronPMID:27901495 PMID:30157460
Gsdmddecreases methylationISOGSDMD (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased methylation of GSDMD exon; Benzo(a)pyrene results in decreased methylation of GSDMD promoterPMID:27901495
Gsdmdincreases expressionISOGsdmd (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of GSDMD mRNAPMID:20713471 PMID:21569818 PMID:22228805
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