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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1306919
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sumo1
Name: small ubiquitin-like modifier 1
Acc ID: CHEBI:30621
Term: diarsenic trioxide
Definition: An arsenic oxide in which arsenic and oxygen atoms are present in the ratio 2:3.
Chemical ID: MESH:C006632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sumo1affects localizationISOSUMO1 (Homo sapiens)6480464CTDArsenic Trioxide affects the localization of SUMO1 proteinPMID:29774349 PMID:9834237
Sumo1decreases expressionISOSUMO1 (Homo sapiens)6480464CTDArsenic Trioxide results in decreased expression of SUMO1 mRNAPMID:17530438
Sumo1increases expressionISOSUMO1 (Homo sapiens)6480464CTDArsenic Trioxide results in increased expression of SUMO1 proteinPMID:32240679
Sumo1multiple interactionsISOSUMO1 (Homo sapiens)6480464CTD[Arsenic Trioxide affects the reaction [SUMO2 protein binds to PML protein]] promotes the reaction [SUMO1 protein binds to PML protein]; [Arsenic Trioxide promotes the reaction [SUMO1 protein binds to PML protein]] which results in increased ubiquitination of PML protein; [monomethylarsonous acid co-treated with dimethylarsinous acid co-treated with Arsenic Trioxide] results in increased localization of SUMO1 protein; Arsenic Trioxide promotes the reaction [SUMO1 protein binds to PML protein]; Arsenic Trioxide promotes the reaction [Tretinoin results in increased expression of SUMO1 mRNA]; Arsenic Trioxide results in increased localization of [MECOM protein co-treated with SUMO1 protein]; PML protein affects the reaction [Arsenic Trioxide results in increased expression of SUMO1 protein]; RNF4 protein affects the reaction [Arsenic Trioxide results in increased expression of SUMO1 protein]; SENP1 protein promotes the reaction [Arsenic Trioxide promotes the reaction [SUMO1 protein binds to PML protein]]; SUMO1 protein promotes the reaction [Arsenic Trioxide results in increased ubiquitination of PML protein]; SUMO2 protein mutant form inhibits the reaction [Arsenic Trioxide promotes the reaction [SUMO1 protein binds to PML protein]]; UBE2I protein affects the reaction [Arsenic Trioxide results in increased expression of SUMO1 protein]PMID:10673743 PMID:20943951 PMID:23770046 PMID:26060329 PMID:29774349 PMID:32240679 PMID:9834237
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