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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1306715
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rev1
Name: REV1, DNA directed polymerase
Acc ID: CHEBI:30614
Term: benzo[a]pyrene diol epoxide I
Definition: An epoxide that has formula C20H14O3.
Chemical ID: MESH:D015123
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects response to substanceISORGD:13154926480464CTDREV1 protein affects the susceptibility to 7, 8-Dihydro-7, 8-dihydroxybenzo(a)pyrene 9, 10-oxide

PMID:22331492
multiple interactionsISORGD:13154926480464CTDREV1 protein affects the reaction [7, 8-Dihydro-7, 8-dihydroxybenzo(a)pyrene 9, 10-oxide results in increased phosphorylation of CHEK1 protein], REV1 protein affects the reaction [7, 8-Dihydro-7, 8-dihydroxybenzo(a)pyrene 9, 10-oxide results in increased phosphorylation of H2AX protein]

PMID:22331492
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.