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GENE - TERM ANNOTATION REPORT

RGD ID: 1306707
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Prkra
Name: protein activator of interferon induced protein kinase EIF2AK2
Acc ID: GO:0070578
Term: RISC-loading complex
Definition: A trimeric protein complex required for the formation of a mature RNA-induced silencing complex (RISC). In humans the complex is composed of the endonuclease Dicer (DICER1), TRBP (TARBP2) and the Argonaute protein Ago2 (EIF2C2/AGO2). Within the complex, Dicer and TRBP are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto Ago2. Ago2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from Dicer and TRBP. This complex has endoribonuclease activity.
Definition Source(s): GOC:ab, GOC:BHF, GOC:nc, GOC:rph, PMID:18178619, PMID:19820710
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Prkrapart_ofISOPRKRA (Homo sapiens)1624291RGD PMID:23661684

PMID:23661684
Prkrapart_ofIEAUniProtKB:O75569 or ensembl:ENSP000003181761600115EnsemblGO_REF:0000107

GO_REF:0000107
Prkrapart_ofIBAFB:FBgn0031951 or FB:FBgn0032515 or MGI:103027 or PANTHER:PTN005287422 or UniProtKB:O75569 or UniProtKB:Q156331600115GO_CentralGO_REF:0000033

GO_REF:0000033
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