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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1306620
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Map2k3
Name: mitogen activated protein kinase kinase 3
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Map2k3increases phosphorylationEXP 6480464CTDCadmium Chloride results in increased phosphorylation of MAP2K3 proteinPMID:18021293 PMID:18703135
Map2k3multiple interactionsEXP 6480464CTDAcetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAP2K3 protein]PMID:18703135
Map2k3increases expressionISOMAP2K3 (Homo sapiens)6480464CTDCadmium Chloride results in increased expression of MAP2K3 mRNAPMID:12160620 PMID:32512071
Map2k3increases phosphorylationISOMAP2K3 (Homo sapiens)6480464CTDCadmium Chloride results in increased phosphorylation of MAP2K3 proteinPMID:18703135
Map2k3multiple interactionsISOMAP2K3 (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAP2K3 protein]PMID:18703135
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