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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1306565
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Map3k5
Name: mitogen-activated protein kinase kinase kinase 5
Acc ID: CHEBI:45863
Term: paclitaxel
Definition: A tetracyclic diterpenoid isolated originally from the bark of the Pacific yew tree, Taxus brevifolia. It is a mitotic inhibitor used in cancer chemotherapy. Note that the use of the former generic name 'taxol' is now limited, as Taxol is a registered trade mark.
Chemical ID: MESH:D017239
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Map3k5multiple interactionsISOMAP3K5 (Homo sapiens)6480464CTDMAP3K5 protein affects the reaction [Paclitaxel results in increased activity of CASP3 protein]; MAP3K5 protein affects the reaction [Paclitaxel results in increased cleavage of PARP1 protein]PMID:10075725
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