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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1306029
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Klf7
Name: KLF transcription factor 7
Acc ID: CHEBI:17747
Term: bis(2-ethylhexyl) phthalate
Definition: A phthalate ester that is the bis(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.
Chemical ID: MESH:D004051
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Klf7decreases expressionISOKLF7 (Homo sapiens)6480464CTDDiethylhexyl Phthalate results in decreased expression of KLF7 mRNA; Diethylhexyl Phthalate results in decreased expression of KLF7 proteinPMID:37734194
Klf7multiple interactionsISOKLF7 (Homo sapiens)6480464CTDKLF7 protein inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of TP53 mRNA]; KLF7 protein inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of TP53 protein]; KLF7 protein inhibits the reaction [Diethylhexyl Phthalate results in increased expression of CCR2 mRNA]; KLF7 protein inhibits the reaction [Diethylhexyl Phthalate results in increased expression of CTNNB1 mRNA]; KLF7 protein inhibits the reaction [Diethylhexyl Phthalate results in increased expression of CTNNB1 protein]; KLF7 protein inhibits the reaction [Diethylhexyl Phthalate results in increased expression of MYD88 mRNA]PMID:37734194
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