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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1305476
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mki67
Name: marker of proliferation Ki-67
Acc ID: CHEBI:49900
Term: arsenous acid
Definition: An arsenic oxoacid consisting of three hydroxy groups attached to a central arsenic atom.
Chemical ID: MESH:C032793
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mki67decreases expressionISOMKI67 (Homo sapiens)6480464CTDArsenic Trioxide results in decreased expression of MKI67 mRNA; Arsenic Trioxide results in decreased expression of MKI67 proteinPMID:27318970 PMID:30091188
Mki67decreases expressionISOMki67 (Mus musculus)6480464CTDArsenic Trioxide results in decreased expression of MKI67 proteinPMID:31421153
Mki67multiple interactionsISOMKI67 (Homo sapiens)6480464CTD3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [Arsenic Trioxide results in decreased expression of MKI67 mRNA]PMID:27318970
Mki67multiple interactionsISOMki67 (Mus musculus)6480464CTDFOXO3 protein affects the reaction [Arsenic Trioxide results in decreased expression of MKI67 protein]PMID:31421153
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