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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1305330
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Alox12b
Name: arachidonate 12-lipoxygenase, 12R type
Acc ID: CHEBI:7553
Term: niclosamide
Definition: A secondary carboxamide resulting from the formal condensation of the carboxy group of 5-chlorosalicylic acid with the amino group of 2-chloro-4-nitroaniline. It is an oral anthelmintic drug approved for use against tapeworm infections.
Chemical ID: MESH:D009534
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Alox12bdecreases response to substanceISOALOX12B (Homo sapiens)6480464CTDALOX12B protein results in decreased susceptibility to NiclosamidePMID:30258081
Alox12bincreases expressionISOALOX12B (Homo sapiens)6480464CTDNiclosamide results in increased expression of ALOX12B mRNAPMID:30258081
Alox12bincreases expressionISOAlox12b (Mus musculus)6480464CTDNiclosamide results in increased expression of ALOX12B mRNAPMID:30258081
Alox12bmultiple interactionsISOALOX12B (Homo sapiens)6480464CTDTP53 gene mutant form inhibits the reaction [Niclosamide results in increased expression of ALOX12B mRNA]; TP53 protein mutant form inhibits the reaction [Niclosamide results in increased expression of ALOX12B mRNA]PMID:30258081
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