GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Irak4 | decreases activity | ISO | IRAK4 (Homo sapiens) | 6480464 | CTD | Protein Kinase Inhibitors results in decreased activity of IRAK4 protein | PMID:28003376 | Irak4 | decreases activity | ISO | Irak4 (Mus musculus) | 6480464 | CTD | Protein Kinase Inhibitors results in decreased activity of IRAK4 protein | PMID:28003376 | Irak4 | multiple interactions | ISO | IRAK4 (Homo sapiens) | 6480464 | CTD | [Protein Kinase Inhibitors results in decreased activity of IRAK4 protein] inhibits the reaction [resiquimod promotes the reaction [IRF5 protein binds to CXCL10 promoter]]; [Protein Kinase Inhibitors results in decreased activity of IRAK4 protein] inhibits the reaction [resiquimod promotes the reaction [IRF5 protein binds to TNF promoter]]; [Protein Kinase Inhibitors results in decreased activity of IRAK4 protein] inhibits the reaction [resiquimod results in increased expression of IL6 protein]; [Protein Kinase Inhibitors results in decreased activity of IRAK4 protein] inhibits the reaction [resiquimod results in increased expression of TNF protein]; [Protein Kinase Inhibitors results in decreased activity of IRAK4 protein] inhibits the reaction [resiquimod results in increased phosphorylation of IKBKB protein]; Protein Kinase Inhibitors results in decreased phosphorylation of and results in decreased activity of IRAK4 protein | PMID:28924041 | | ||||||||||||||||||||||
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