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GENE - TERM ANNOTATION REPORT

RGD ID: 1305120
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dennd2d
Name: DENN domain containing 2D
Acc ID: GO:0005085
Term: guanyl-nucleotide exchange factor activity
Definition: Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions.
Definition Source(s): GOC:kd, GOC:mah, PMID:23303910, PMID:27218782
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dennd2denablesISODENND2D (Homo sapiens)1624291RGD PMID:20937701

PMID:20937701
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