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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1304606
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Agr2
Name: anterior gradient 2, protein disulphide isomerase family member
Acc ID: CHEBI:49900
Term: arsenous acid
Definition: An arsenic oxoacid consisting of three hydroxy groups attached to a central arsenic atom.
Chemical ID: MESH:C032793
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Agr2decreases response to substanceISOAGR2 (Homo sapiens)6480464CTDAGR2 protein results in decreased susceptibility to Arsenic TrioxidePMID:20707922
Agr2increases expressionISOAGR2 (Homo sapiens)6480464CTDArsenic Trioxide results in increased expression of AGR2 mRNAPMID:22521957
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