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Gene: AGR2 (anterior gradient 2, protein disulphide isomerase family member) Homo sapiens
Symbol: AGR2
Name: anterior gradient 2, protein disulphide isomerase family member
Description: Exhibits dystroglycan binding activity; epidermal growth factor receptor binding activity; and protein homodimerization activity. Involved in several processes, including positive regulation of cell-substrate adhesion; positive regulation of protein localization to plasma membrane; and positive regulation of signal transduction. Localizes to the endoplasmic reticulum and extracellular space. Biomarker of breast cancer; in situ carcinoma; and pancreatic ductal carcinoma.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AG-2; AG2; anterior gradient 2 homolog; anterior gradient 2 homolog (xenopus laevis); anterior gradient homolog 2; anterior gradient protein 2 homolog; epididymis secretory protein Li 116; GOB-4; HAG-2; HEL-S-116; HPC8; PDIA17; protein disulfide isomerase family A, member 17; secreted cement gland homolog; secreted cement gland protein XAG-2 homolog; XAG-2
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl716,791,811 - 16,833,433 (-)Ensembl
GRCh38716,791,811 - 16,804,999 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37716,831,437 - 16,844,738 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36716,797,960 - 16,811,133 (-)NCBINCBI36hg18NCBI36
Build 34716,604,675 - 16,617,848NCBI
Celera716,812,569 - 16,825,043 (-)NCBI
Cytogenetic Map7p21.1NCBI
HuRef716,719,359 - 16,731,797 (-)NCBIHuRef
CHM1_1716,833,176 - 16,845,615 (-)NCBICHM1_1
CRA_TCAGchr7v2716,885,921 - 16,898,395 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on AGR2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1312142
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.