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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1304606
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Agr2
Name: anterior gradient 2, protein disulphide isomerase family member
Acc ID: CHEBI:17823
Term: calcitriol
Definition: A hydroxycalciol that is calcidiol in which the pro-S hydrogen of calcidiol is replaced by a hydroxy group. It is the active form of vitamin D3, produced fom calciol via hydoxylation in the liver to form calcidiol, which is subsequently oxidised in the kidney to give calcitriol.
Chemical ID: MESH:D002117
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Agr2increases expressionISOAGR2 (Homo sapiens)6480464CTDCalcitriol results in increased expression of AGR2 mRNAPMID:21592394
Agr2multiple interactionsISOAGR2 (Homo sapiens)6480464CTD[Testosterone co-treated with Calcitriol] results in increased expression of AGR2 mRNAPMID:21592394
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