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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1304603
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nrf1
Name: nuclear respiratory factor 1
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nrf1increases expressionEXP 6480464CTDResveratrol results in increased expression of NRF1 mRNA; Resveratrol results in increased expression of NRF1 proteinPMID:20429690 PMID:20438809 PMID:32619457
Nrf1multiple interactionsEXP 6480464CTDdorsomorphin inhibits the reaction [Resveratrol results in increased expression of NRF1 mRNA]; Resveratrol affects the reaction [Benzo(a)pyrene affects the expression of NRF1 mRNA]; Resveratrol affects the reaction [Benzo(a)pyrene affects the expression of NRF1 protein]; Resveratrol inhibits the reaction [Dietary Fats results in decreased expression of NRF1 mRNA]PMID:20438809 PMID:21632075 PMID:32619457
Nrf1decreases expressionISONrf1 (Mus musculus)6480464CTDresveratrol results in decreased expression of NRF1 mRNAPMID:21270273
Nrf1increases expressionISONRF1 (Homo sapiens)6480464CTDresveratrol results in increased expression of NRF1 mRNAPMID:22105178 PMID:24041027
Nrf1increases expressionISONrf1 (Mus musculus)6480464CTDResveratrol results in increased expression of NRF1 mRNA; Resveratrol results in increased expression of NRF1 proteinPMID:20561979 PMID:24041027 PMID:34216621
Nrf1multiple interactionsISONRF1 (Homo sapiens)6480464CTD1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Resveratrol results in increased expression of NRF1 mRNA]; [Plant Extracts co-treated with Resveratrol] results in increased expression of NRF1 mRNA; Fulvestrant inhibits the reaction [Resveratrol results in increased expression of NRF1 mRNA]; HMOX1 mutant form inhibits the reaction [Resveratrol results in increased expression of NRF1 mRNA]; Resveratrol inhibits the reaction [Hydrogen Peroxide results in decreased expression of NRF1 mRNA]; Resveratrol promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NRF1 mRNA]; tin protoporphyrin IX inhibits the reaction [Resveratrol promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NRF1 mRNA]]; tin protoporphyrin IX inhibits the reaction [Resveratrol results in increased expression of NRF1 mRNA]PMID:22105178 PMID:23557933 PMID:23859249 PMID:24041027
Nrf1multiple interactionsISONrf1 (Mus musculus)6480464CTD[Dietary Fats co-treated with Resveratrol] results in increased expression of NRF1 mRNA; [lipopolysaccharide, E coli O55-B5 co-treated with Resveratrol] results in increased expression of NRF1 mRNA; SIRT1 protein affects the reaction [Resveratrol results in increased expression of NRF1 mRNA]; STK11 protein affects the reaction [Resveratrol results in increased expression of NRF1 mRNA]; tin protoporphyrin IX inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Resveratrol] results in increased expression of NRF1 mRNA]; tin protoporphyrin IX inhibits the reaction [Resveratrol results in increased expression of NRF1 mRNA]PMID:24041027 PMID:29197120 PMID:34216621
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