Gene Term Annotation Report - Rat Genome Database

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GENE - TERM ANNOTATION REPORT

RGD ID:	1303178
Species:	Rattus norvegicus
RGD Object:	Gene
Symbol:	Nanog
Name:	Nanog homeobox

Acc ID:	GO:0019827
Term:	stem cell population maintenance
Definition:	The process by which an organism or tissue maintains a population of stem cells of a single type. This can be achieved by a number of mechanisms: stem cell asymmetric division maintains stem cell numbers; stem cell symmetric division increases them; maintenance of a stem cell niche maintains the conditions for commitment to the stem cell fate for some types of stem cell; stem cells may arise de novo from other cell types.
Definition Source(s):	GOC:mah, ISBN:0878932437

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Nanog		IEP		9589811	RGD
Nanog	acts_upstream_of_or_within	ISO	Nanog (Mus musculus)	1624291	RGD	MGI:1924054 PMID:17938240	PMID:17938240
Nanog	involved_in	ISO	NANOG (Homo sapiens)	1624291	RGD	PMID:15108323	PMID:15108323
Nanog	involved_in	ISO	Nanog (Mus musculus)	1624291	RGD	PMID:15108323 PMID:25825768	PMID:15108323 PMID:25825768
Nanog	involved_in	IEA	UniProtKB:Q80Z64 or ensembl:ENSMUSP00000012540	1600115	Ensembl	GO_REF:0000107	GO_REF:0000107
Nanog	involved_in	IBA	MGI:1919200 or PANTHER:PTN002802927 or Nanog (Rattus norvegicus) or UniProtKB:Q9H9S0	1600115	GO_Central	GO_REF:0000033	GO_REF:0000033

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