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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 12373160
Species: Canis lupus familiaris
RGD Object: Gene
Symbol: TNF
Name: tumor necrosis factor
Acc ID: CHEBI:132230
Term: marbofloxacin
Definition: A fluoroquinolone antibiotic that is 7-oxo-2,3-dihydro-7H-[1,3,4]oxadiazino[6,5,4-ij]quinoline substituted at positions 6, 9 and 10 by carboxy, fluoro and 4-methylpiperazin-1-yl groups, respectively. A synthetic, broad spectrum bactericidal agent, it is used in veterinary medicine, although its mechanism of action is not thoroughly understood.
Chemical ID: MESH:C080260
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TNFincreases expressionEXP 6480464CTDmarbofloxacin results in increased expression of TNF mRNA; marbofloxacin results in increased expression of TNF proteinPMID:31005593
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