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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 12320140
Species: Canis lupus familiaris
RGD Object: Gene
Symbol: RUNX2
Name: RUNX family transcription factor 2
Acc ID: CHEBI:17154
Term: nicotinamide
Definition: A pyridinecarboxamide that is pyridine in which the hydrogen at position 3 is replaced by a carboxamide group.
Chemical ID: MESH:D009536
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
RUNX2decreases expressionEXP 6480464CTDNiacinamide results in decreased expression of RUNX2 proteinPMID:22539994
RUNX2increases acetylationEXP 6480464CTDNiacinamide results in increased acetylation of RUNX2 proteinPMID:22539994
RUNX2multiple interactionsEXP 6480464CTDNiacinamide inhibits the reaction [SIRT1 protein binds to RUNX2 protein]; Resveratrol inhibits the reaction [Niacinamide inhibits the reaction [SIRT1 protein binds to RUNX2 protein]]; Resveratrol inhibits the reaction [Niacinamide results in decreased expression of RUNX2 protein]; Resveratrol inhibits the reaction [Niacinamide results in increased acetylation of RUNX2 protein]PMID:22539994
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