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GENE - TERM ANNOTATION REPORT

RGD ID: 12248301
Species: Canis lupus familiaris
RGD Object: Gene
Symbol: ENG
Name: endoglin
Acc ID: DOID:12466
Term: secondary hyperparathyroidism
Definition: Abnormally elevated PARATHYROID HORMONE secretion as a response to HYPOCALCEMIA. It is caused by chronic KIDNEY FAILURE or other abnormalities in the controls of bone and mineral metabolism, leading to various BONE DISEASES, such as RENAL OSTEODYSTROPHY.
Definition Source(s): MESH:D006962
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ENG ISOENG (Homo sapiens)9068941RGDassociated with Renal Insufficiency, Chronic; protein:increased expression:parathyroid gland, vasculature (human)PMID:18398016 REF_RGD_ID:7248778
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