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GENE - TERM ANNOTATION REPORT

RGD ID: 11885058
Species: Pan paniscus
RGD Object: Gene
Symbol: TNF
Name: tumor necrosis factor
Acc ID: DOID:8947
Term: diabetic retinopathy
Definition: Disease of the RETINA as a complication of DIABETES MELLITUS. It is characterized by the progressive microvascular complications, such as ANEURYSM, interretinal EDEMA, and intraocular PATHOLOGIC NEOVASCULARIZATION.
Definition Source(s): MESH:D003930
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TNF ISOTNF (Homo sapiens)9068941RGDassociated with Diabetes Mellitus, Type 2PMID:22105495 REF_RGD_ID:7364856
TNF ISOTNF (Homo sapiens)9068941RGDprotein:increased expression:serum, vitreous humourPMID:16284605 REF_RGD_ID:7401212
TNFdisease_progressionISOTNF (Homo sapiens)9068941RGDassociated with Diabetes Mellitus, Type 1;protein:increased expression:platelet:PMID:10540181 REF_RGD_ID:7394805
TNFno_associationISOTNF (Homo sapiens)9068941RGDassociated with Diabetes Mellitus, Type 2;DNA:polymorphism:promoter:-302A>G (human) PMID:16979413 REF_RGD_ID:8548772
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